CN101837118A - Compound chicken colibacillosis resisting veterinary drug preparation - Google Patents
Compound chicken colibacillosis resisting veterinary drug preparation Download PDFInfo
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- CN101837118A CN101837118A CN200910019934A CN200910019934A CN101837118A CN 101837118 A CN101837118 A CN 101837118A CN 200910019934 A CN200910019934 A CN 200910019934A CN 200910019934 A CN200910019934 A CN 200910019934A CN 101837118 A CN101837118 A CN 101837118A
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- florfenicol
- cosolvent
- add
- colistin sulfate
- preparation
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract
The invention belongs to a chicken colibacillosis controlling composite in a veterinary drug, which mainly comprises the following components in percentage by weight: 10% of florfenicol, 5% of colistin sulfate, 40% of dextrin and the balance of jiayi powder. The veterinary drug composition is used for treating chicken colibacillosis. The composition has the processing technology that each effective component is accurately weighed according to weight proportion after being dried, the florfenicol is firstly added to be mixed with cosolvent for 10 min, then other components are added for mixing for 20 min, semi-finished products are detected for the quality, sub-packaged and packaged, and the finished products are detected for the quality and put in storage. The use method is that the composition is taken with water in the proportion of 0.1%, and continuous 3-5 days is one course of treatment. The invention has high sensitivity on the chicken colibacillosis, has good effect and low drug resistance, is used conveniently, and has good popularization and application values.
Description
Technical field
The present invention relates to a kind of compound recipe Chinese People's Anti-Japanese Military and Political College's enterobacteria veterinary drug and preparation technology thereof, clinical efficacy.
Background technology
The colibacillosis of fowl mainly is to be caused by escherichia coli, has the advantages that morbidity property is wide, hazardness is big and drug resistance is strong.Though more existing locally adopt bacillus coli vaccines epidemic prevention, e. coli serotype is more, can not wide popularization and application, chicken colibacillosis is still based on medical treatment.It is reported, existing tens kinds of Chinese People's Anti-Japanese Military and Political College's enterobacteria drug, commonly used have kind more than 20, but great majority will produce drug resistance in the use several years even one, two year, and e. coli serotype is more, and drug effect is limited in scope.And rational use of drug just can improve curative effect, reduces drug resistance and enlarge antibacterial range.Rational use of drug comprises common methods such as drug combination, medication by turns, the medication of shuttling back and forth.Drug combination is a most convenient, effective, and the method that welcome by the raiser.
Florfenicol, colistin sulfate all are one of the most frequently used medicines of control avian escherichia coli, and still, these two kinds of medicines use separately following some shortcomings:
1, florfenicol, colistin sulfate have produced the part drug resistance because often use in market in more area, and curative effect is greatly affected.
2, florfenicol itself is water insoluble, often uses as the pre-mixing agent spice.The pre-mixing agent spice is wasted time and energy, and is subjected to the raiser to welcome degree poor; And the now material grain that adopt of poultry, medicine is difficult to evenly admix in the feedstuff, causes local drug concentration too high or too low, thereby brings bad consequence. moreIf can adopt the drinking-water administration, just can not influence and take in dose and delay the state of an illness.
The domestic aqueous solution that florfenicol is also arranged, but need organic solvent dissolution and corresponding enhancing cost, and have certain corrosivity when producing.Because stability reasons, florfenicol oral administration solution also other stronger antimicrobial components such as extremely difficult adding colistin sulfate when composite reagent.
3, the colistin sulfate back that absorbs for oral administration seldom absorbs at intestinal, and drug main will concentrate on intestinal, thereby better to enteritis type escherichia coli curative effect, and relatively poor to general escherichia coli curative effect.Cooperate intestinal to absorb easily, can treat the colibacillary florfenicol of general and then can enlarge antibiotic enclosing, heighten the effect of a treatment.
The composition of medicine of the two does not still have open report on the market at home.Because these two kinds of medicines have synergism mutually, can enlarge Chinese People's Anti-Japanese Military and Political College's enterobacteria scope, and various colibacillosiss are all had better curative effect, and it is safe and effective, can delay chemical sproof generation, it is easy to use to drink water, for huge effect has been brought into play in the control of avian colibacillosis.Just for the consideration of these aspects, carried out the development of soluble powder of the drug regimen of florfenicol, colistin sulfate.
Summary of the invention
Main purpose of the present invention is for a kind of sensitivity, compound recipe Chinese People's Anti-Japanese Military and Political College enterobacteria medicine preparation efficient, easy to use are provided.
For achieving the above object, the present invention has adopted following embodiment through Multitest:
Consisting of of this compound recipe Chinese People's Anti-Japanese Military and Political College enterobacteria veterinary drug preparation: florfenicol, two kinds of main pharmaceutical compositions of colistin sulfate, add cosolvent and adjuvant, wherein florfenicol 5～10% (W/W), colistin sulfate 5～10% (W/W), all the other are cosolvent, adjuvant.
Described cosolvent is: dextrin, the ratio of cosolvent and florfenicol are 1: 2～6 (W/W).
Adjuvant is to add a kind of in beneficial powder, the glucose, and the ratio of adjuvant is 30～50% (W/W).
The invention has the beneficial effects as follows:
The optimal proportion problem with florfenicol and colistin sulfate selected for use through a large amount of test, particularly cosolvent.Owing to make soluble powder, can overcome the deficiency of pre-mixing agent spice inequality, improved bioavailability of medicament and result of use simultaneously, improved the convenience of drug use greatly; The optimal proportion of florfenicol and colistin sulfate has improved clinical efficacy, reaches the optimality price ratio.This product provides a kind of efficient, stable, easy to use Chinese People's Anti-Japanese Military and Political College's enterobacteria medicine for culturing market.
The specific embodiment
In conjunction with a preferred embodiment, the specific embodiment of the present invention is described in detail, and do not limit the scope of the invention to specific details.
One, florfenicol soluble powder
Embodiment 1
| ??100g | |
| Florfenicol | 5g (in effective content) |
| Cosolvent | ??10g |
| Add beneficial powder | Add to 100g |
Preparation method and step: with florfenicol, dextrin, add beneficial powder and dry respectively after by the accurate weighing of proportion, mix 30min, obtain the semi-finished product of mix homogeneously, packing then, packing, quality inspection promptly through quality inspection.Detect the florfenicol dissolubility, dissolubility is very poor.
Embodiment 2
| ??100g | |
| Florfenicol | 5g (in effective content) |
| Cosolvent | ??20g |
| Add beneficial powder | Add to 100g |
Preparation method and step: with florfenicol, dextrin, add beneficial powder and dry respectively after by the accurate weighing of proportion, mix 30min, obtain the semi-finished product of mix homogeneously, packing then, packing, quality inspection promptly through quality inspection.Detect dissolubility, can dissolve fully.
| ??100g | |
| Florfenicol | 5g (in effective content) |
| Cosolvent | ??15g |
| Add beneficial powder | Add to 100g |
Preparation method and step: with florfenicol, dextrin, add beneficial powder and dry respectively after by the accurate weighing of proportion, mix 30min, obtain the semi-finished product of mix homogeneously, packing then, packing, quality inspection promptly through quality inspection.Detect dissolubility, dissolubility is relatively poor.
Situation to sum up: cosolvent and florfenicol optimal proportion are 4: 1.
Two, florfenicol, colistin sulfate soluble powder
Embodiment 1
| ??100g | |
| Florfenicol | 5g (in effective content) |
| Colistin sulfate | 5g (in effective content) |
| Cosolvent | ??20g |
| Add beneficial powder | Add to 100g |
Preparation method and step: with florfenicol, colistin sulfate, dextrin with add and press the accurate weighing of proportion after beneficial powder is dried respectively, add florfenicol and cosolvent mixing 10min earlier, add other composition mixing 20min again, the semi-finished product quality inspection, packing, packing, the finished product quality inspection is promptly.
In use, this preparation 100g is converted water 100L be used for clinical chicken colibacillosis, laying period, forbidden, and withdrawal time is 7.
Chinese People's Anti-Japanese Military and Political College's enterobacteria effective percentage of this preparation is respectively 72%, and cure rate is 55%, compares with 10% florfenicol or 10% colistin sulfate, and effective percentage and cure rate all exceed more than 5%.Curative effect is undesirable.
Embodiment 2
| ?100g | |
| Florfenicol | 5g (in effective content) |
| Colistin sulfate | 10g (in effective content) |
| Cosolvent | ?20g |
| ?100g | |
| Add beneficial powder | Add to 100g |
Preparation method and step: with florfenicol, colistin sulfate, dextrin with add and press the accurate weighing of proportion after beneficial powder is dried respectively, add florfenicol and cosolvent mixing 10min earlier, add other composition mixing 20min again, the semi-finished product quality inspection, packing, packing, the finished product quality inspection is promptly.
In use, this preparation 100g is converted water 100L be used for clinical chicken colibacillosis, laying period, forbidden, and withdrawal time is 7.
It is 84% that Chinese People's Anti-Japanese Military and Political College's enterobacteria effective percentage of this preparation is respectively, and cure rate is 70%, compares with 15% florfenicol or 15% colistin sulfate, and effective percentage and cure rate all exceed more than 7%, and curative effect is medium.
Embodiment 3
| ?100g | |
| Florfenicol | 10g (in effective content) |
| Colistin sulfate | 5g (in effective content) |
| Cosolvent | ?40g |
| Add beneficial powder | Add to 100g |
Preparation method and step: with florfenicol, colistin sulfate, dextrin with add and press the accurate weighing of proportion after beneficial powder is dried respectively, add florfenicol and cosolvent mixing 10min earlier, add other composition mixing 20min again, the semi-finished product quality inspection, packing, packing, the finished product quality inspection is promptly.
In use, this preparation 100g is converted water 100L be used for clinical chicken colibacillosis, laying period, forbidden, and withdrawal time is 7.
It is 95% that Chinese People's Anti-Japanese Military and Political College's enterobacteria effective percentage of this preparation is respectively, and cure rate is 88%, compares with 15% florfenicol or 15% colistin sulfate, and effective percentage and cure rate all exceed more than 18%.Curative effect is very good.
Embodiment 4
| ?100g | |
| Florfenicol | 10g (in effective content) |
| Colistin sulfate | 10g (in effective content) |
| Cosolvent | ?40g |
| Add beneficial powder | Add to 100g |
Preparation method and step: with florfenicol, colistin sulfate, dextrin with add and press the accurate weighing of proportion after beneficial powder is dried respectively, add florfenicol and cosolvent mixing 10min earlier, add other composition mixing 20min again, the semi-finished product quality inspection, packing, packing, the finished product quality inspection is promptly.
In use, this preparation 100g is converted water 100L be used for clinical chicken colibacillosis, laying period, forbidden, and withdrawal time is 7.
It is 96% that Chinese People's Anti-Japanese Military and Political College's enterobacteria effective percentage of this preparation is respectively, and cure rate is 87%, compares with 20% florfenicol or 20% colistin sulfate, and effective percentage and cure rate all exceed more than 13%.The curative effect ideal, but very approaching with embodiment three combination curative effects, and the cost increase, not as embodiment three combination ideals.
Florfenicol 10%, colistin sulfate 5%, dextrin 40% are adopted in this combination, and other have efficient, safe, stable, easy to use characteristics for adding beneficial powder, are a kind of very good Chinese People's Anti-Japanese Military and Political College's enterobacteria compound preparations.
The foregoing description; comprise drug regimen, preparation technology and clinical verification; invention has been described; these descriptions are illustrative but not determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (4)
1. compound chicken colibacillosis resisting veterinary drug preparation.What this was made consists of: florfenicol, two kinds of main pharmaceutical compositions of colistin sulfate, add cosolvent and adjuvant, and wherein florfenicol 10% (W/W), colistin sulfate 5% (W/W), all the other are cosolvent and adjuvant.
2. according to claim 1, described cosolvent is: dextrin, the cosolvent ratio in medicament is 40% (W/W).
3. according to claim 1, adjuvant is glucose, add a kind of in the beneficial powder, and the adjuvant ratio is 45% (W/V).
4. according to claim 1-3, the preparation method of a kind of novel anti escherichia coli pharmaceutical preparation-florfenicol, colistin sulfate soluble powder, it is characterized in that carrying out according to the following steps: with cosolvent and florfenicol mixing 5min, add colistin sulfate and adjuvant again, stirred 15 minutes, make it mix homogeneously, packing promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100199349A CN101837118B (en) | 2009-03-20 | 2009-03-20 | Compound chicken colibacillosis resisting veterinary drug preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100199349A CN101837118B (en) | 2009-03-20 | 2009-03-20 | Compound chicken colibacillosis resisting veterinary drug preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101837118A true CN101837118A (en) | 2010-09-22 |
| CN101837118B CN101837118B (en) | 2012-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100199349A Expired - Fee Related CN101837118B (en) | 2009-03-20 | 2009-03-20 | Compound chicken colibacillosis resisting veterinary drug preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404729A (en) * | 2013-08-09 | 2013-11-27 | 青岛根源生物技术集团有限公司 | Composite microecologics capable of improving growth rate of stichopus japonicus and application of composite microecologics |
| CN103550755A (en) * | 2013-11-04 | 2014-02-05 | 河南牧翔动物药业有限公司 | Florfenicol/colistin sulfate soluble powder and preparation method thereof |
| CN105534914A (en) * | 2016-01-11 | 2016-05-04 | 郭敏 | Soluble enramycin powder and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100434067C (en) * | 2006-09-04 | 2008-11-19 | 杨建彬 | Medicine for treating mixed infection of chicken and pig mycoplasma and other bacteria |
| CN101297958A (en) * | 2007-09-24 | 2008-11-05 | 天津生机集团有限公司 | Medicament composition for preventing and treating colibacillosis of chicken |
-
2009
- 2009-03-20 CN CN2009100199349A patent/CN101837118B/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404729A (en) * | 2013-08-09 | 2013-11-27 | 青岛根源生物技术集团有限公司 | Composite microecologics capable of improving growth rate of stichopus japonicus and application of composite microecologics |
| CN103404729B (en) * | 2013-08-09 | 2015-02-04 | 青岛根源生物技术集团有限公司 | Composite microecologics capable of improving growth rate of stichopus japonicus and application of composite microecologics |
| CN103550755A (en) * | 2013-11-04 | 2014-02-05 | 河南牧翔动物药业有限公司 | Florfenicol/colistin sulfate soluble powder and preparation method thereof |
| CN103550755B (en) * | 2013-11-04 | 2015-05-20 | 河南牧翔动物药业有限公司 | Florfenicol/colistin sulfate soluble powder and preparation method thereof |
| CN105534914A (en) * | 2016-01-11 | 2016-05-04 | 郭敏 | Soluble enramycin powder and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101837118B (en) | 2012-06-13 |
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Granted publication date: 20120613 |
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