CN101837007A - Medicinal composition for curing hemorrhoids and preparation method thereof - Google Patents
Medicinal composition for curing hemorrhoids and preparation method thereof Download PDFInfo
- Publication number
- CN101837007A CN101837007A CN 201010145462 CN201010145462A CN101837007A CN 101837007 A CN101837007 A CN 101837007A CN 201010145462 CN201010145462 CN 201010145462 CN 201010145462 A CN201010145462 A CN 201010145462A CN 101837007 A CN101837007 A CN 101837007A
- Authority
- CN
- China
- Prior art keywords
- policresulen
- pharmaceutical composition
- composition
- cinchocaine hydrochloride
- accounts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a medicinal composition for curing hemorrhoids, which is a compound preparation prepared by mixing policresulen and cinchocaine hydrochloride serving as active ingredients, and pharmaceutically acceptable auxiliary materials serving as carriers. The weight of the policresulen in medicinal composition accounts for 3 to 10 percent of the total weight of the composition, and the weight of the cinchocaine hydrochloride accounts for 0.1 to 0.8 percent of the total weight of the composition. The invention also discloses a preparation method of the medicinal composition for curing the hemorrhoid. The policresulen serving as a main active material has the effects of stopping bleeding, converging, regenerating epithelium and sterilizing to make necrotic tissues coagulated and separated so as to quickly clean wounds. Meanwhile, due to the adoption of the composition, strong reactive contrafluxion is generated so as to promote the tissues to regenerate. The medicinal composition carries out local anesthesia by adopting the quick-acting cinchocaine hydrochloride for suppressing pain of wounds. The medicinal composition is prepared into an external preparation, which comprises suppository, ointments and the like. The medicinal composition is suitable for curing hemorrhoids, anal fissure and rhagadia, pruritus ani and the like.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition that is used for the treatment of hemorrhoid, it is to be active component with policresulen, cinchocaine hydrochloride, mix the Pharmaceutical composition that forms as carrier with acceptable accessories, and this preparation of drug combination method, this invention belongs to medical technical field.
Background technology
Hemorrhoid are common anorectal diseases, and its sickness rate accounts for 87.25% of all anal and intestinal diseases, and the men and women all can get this disease, and women's sickness rate is 67%, and male's sickness rate is 53.9%; Any age all can fall ill, and wherein the people in 20-40 year comparatively more sees, and increases the weight of with advancing age and gradually, so saying of " ten people, nine hemorrhoid " arranged.Its pathogenic factor is a lot of, and the people is standing or during seat, anal orifice and rectal intestine is positioned at the bottom, because the compressing of gravity and internal organs influence the blood backflow, vein is expanded flexing easily, so often stand or the people of seat suffers from hemorrhoid easily.Hypomotility, enterokinesia reduces, and feces is descending slow, also can the constipation of forming the habit property.Podex is caught a cold, is heated, constipation, diarrhoea, excessive consumption of alcohol and eat maror more, all can stimulate anus and rectum.Because of all can making intra-abdominal pressure increase, hepatitis interstitialis chronica, hepatohemia and cardiac function incompensation etc. and diseases such as intraperitoneal tumor, prostate hyperplasia form hemorrhoid.Also have some living habit problems in addition, such as the diet satiety, often eat meticulous food or suppress just, Asiatic water closet pan is crossed and is waited so long, and all is the reason that forms hemorrhoid.Though hemorrhoid generally can not produce big harm, but still can produce inconvenient influence to daily life.At present, the method for treatment hemorrhoid has operative treatment, acupuncture and moxibustion therapy, and methods such as exercise therapy and Drug therapy, various Therapeutic Method account for very consequence in treatment, but being difficult to effect a radical cure still and having caused very big puzzlement and misery to people of hemorrhoid.
Policresulen has hemostasis, convergence, epithelium regeneration and germ-resistant effect, makes slough condense and separates the wound surface rapid cleaning.Simultaneously, produce the kickback contrafluxion and also therefore impel tissue regeneration.
Cinchocaine hydrochloride is onset local anesthesia effect rapidly, can suppress the pain of wound surface, and the anesthetic action persistent period is more of a specified duration.
Summary of the invention
The object of the present invention is to provide pharmaceutical composition of a kind of effective treatment hemorrhoid and preparation method thereof, for hemorrhoid patients provides a kind of new medicine.
The present invention is achieved in that
A kind of pharmaceutical composition for the treatment of hemorrhoid is the active constituents of medicine that form with policresulen, cinchocaine hydrochloride, mixes the Pharmaceutical composition that forms as carrier with acceptable accessories.
Further scheme is: described pharmaceutical composition Chinese medicine absorption of active ingredient is: policresulen accounts for 3 to 10% of composition total weight, and cinchocaine hydrochloride accounts for 0.1 to 0.8% of composition total weight, and all the other are adjuvant.
More the scheme of You Huaing is: described pharmaceutical composition Chinese medicine absorption of active ingredient is: policresulen accounts for 4 to 6% of composition total weight, and cinchocaine hydrochloride accounts for 0.1 to 0.5% of composition total weight, and all the other are adjuvant.
Further scheme is: described adjuvant is one or more mixture in 36 type mixed fatty glycerides, anhydrous lanolin, calcium sulphate dihydrate, 20% weight fraction sodium hydroxide solution, vaseline, Cera Flava, stearic acid, high fatty alcohol, the glyceryl monostearate.
Further scheme is: described pharmaceutical composition is suppository or ointment.
The present invention also provides the preparation of drug combination method for the treatment of hemorrhoid as previously mentioned, comprises following step:
Step 1, by the said medicine absorption of active ingredient, taking by weighing 36% policresulen solution, is 2.5 to 3.6 with 20% sodium hydroxide solution adjust pH, then concentrating under reduced pressure under 45 to 55 ℃ of conditions, the concentration that makes policresulen is 55 to 62%, add calcium sulfate, stir, it is gone in the drip pan, drying under reduced pressure under in 45 to 55 ℃ of conditions, pulverize then, cross 80 mesh sieves, get the policresulen fine powder; Described solution concentration is mass concentration;
Step 2, cinchocaine hydrochloride is pulverized the back cross 80 to 100 mesh sieves;
Step 3, with policresulen fine powder and the cinchocaine hydrochloride that sieves with the equivalent method mix homogeneously that progressively increases;
Step 4, in order to make the pharmaceutical composition of suppository formulation, should: take by weighing mixed fatty glycerides and lanoline, mix post-heating to 55 ℃, make its fusion complete, temperature is reduced to 38 to 45 ℃ then, and the policresulen and the cinchocaine hydrochloride of insulation and adding mix homogeneously stir;
Step 5, mixture slowly are cooled to 35 to 38 ℃ and pour in the mould, mould is coated with one deck lubricant earlier, lubricant is glycerol and 75 to 95% alcohol mixeding liquids, ratio is 1g: 5/mL, slowly is cooled to 18 to 22 ℃, prunes with cutter and overflows part, opening mold, suppository is released, packed, promptly make the pharmaceutical composition of the treatment hemorrhoid of suppository formulation.
In order to make the pharmaceutical composition of ointment dosage form, can also take by weighing vaseline, Cera Flava, lanoline and be heated to 75 to 85 ℃, make it complete fusion, when temperature is reduced to 50 to 55 ℃, a small amount of repeatedly the policresulen and the cinchocaine hydrochloride of mix homogeneously joined in the fused solution, stir.When being cooled to 40 to 45 ℃, stop to stir, naturally cool to room temperature, be distributed into ointment, promptly make the pharmaceutical composition of the treatment hemorrhoid of ointment dosage form.
Chinese medicine compositions of the present invention is a main component with cinchocaine hydrochloride and policresulen.M-cresol sulfonic acid in the policresulen molecule is borrowed methylene bridges, can have 20 M-cresol sulfonic acids to link together at most.Therefore, it is a peracid body, and molecular surface has very strong negative charge.Necrosis or pathological tissues are had optionally effect, pathological tissues is condensed and be easy to get rid of, but normal squamous epithelial cancer is then unaffected.Policresulen has broad-spectrum antibacterial action, can suppress to comprise common gram positive bacteria, gram negative bacteria, mycete and virus, has the tissue selectivity effect simultaneously.Normal cell has complete cell membrane, and its surface is electronegative, and policresulen repels each other with it, so it is not had influence.After cell sustained damage, surface polarity changed, and policresulen is combination with it, made it degeneration.It is alkaline-resisting not acidproof to be positioned at cervical canal and ectopic columnar epithelial cell, and policresulen can act on it and make its degeneration.
Therefore, even normal squamous epithelial cancer can not be affected in the policresulen of high concentration yet.Impaired squamous epithelial cancer and the degeneration under the effect of policresulen of ectopic columnar epithelial cell, come off, be excreted, help tissue repair.
Cinchocaine hydrochloride is the amide-type local anesthetic, because its hydrochlorate stabilized aqueous solution, but disinfection with high pressure steam and storage for a long time, so its listing medicine mostly is the hydrochlorate preparation.The evidence cinchocaine hydrochloride is identical with the main pharmacodynamics of cinchocaine.Cinchocaine is a long-acting local anesthetic, with the temporary transient combination rate of nervous tissue greater than tetracaine.Effect beginning is slow, does not wait in action effective 2-6 hour 15-20 minute incubation period, difference is very big between individuality, have to be shorter than 2-3 hour, has to reach 5-6 hour.Cinchocaine has good penetration, to the local organization nonirritant.
This pharmaceutical composition is the compound preparation of policresulen and cinchocaine hydrochloride, and its main active substance is a policresulen, has hemostasis, convergence, epithelium regeneration and germ-resistant effect, makes slough condense and separates the wound surface rapid cleaning.Simultaneously, produce the kickback contrafluxion and also therefore impel tissue regeneration.For suppressing initial stage pain, adopted cinchocaine hydrochloride to carry out local anesthesia.Therefore has curative effect preferably.
Through pharmaceutical composition with method preparation of the present invention, 98 hemorrhoid sufferers are treated, use said preparation to have 50 patients to cure after 3 weeks, and the 38 routine observed obvious treatment effects that have; The therapeutic effect that subjective 79.6% sufferer is estimated preparation is very good or good.Mainly showing as the defecation urgency sense aspect side effect increases, slight twinge and slight constriction and pain, and the appearance of side effect is ofer short duration and slight, so patient can continue to use said preparation, and, can obtain good effect to great majority.
The specific embodiment
Embodiment one
Medicine embodiment consumption of the present invention following (weight ratio):
36% policresulen solution 11.17%, cinchocaine hydrochloride 0.10%, 20% sodium hydroxide solution 4.44%, mixed fatty glycerides 60.80%, lanoline 14.15%, calcium sulfate (two hydrations) 9.34%.
A kind of medicine group for the treatment of hemorrhoid does not have the preparation method of hydrate, comprises following step:
Step 1, by above-mentioned prescription, taking by weighing 36% policresulen solution, is 2.7 to 3.3 with 20% sodium hydroxide solution adjust pH, then concentrating under reduced pressure under 50 ℃ of conditions, the concentration that makes policresulen is 60%, add calcium sulfate, stir, it is gone in the drip pan, drying under reduced pressure under 50 ℃ of conditions, pulverize then, cross 80 mesh sieves, get the policresulen fine powder;
Step 2, cinchocaine hydrochloride is pulverized the back cross 100 mesh sieves;
Step 3, with policresulen fine powder and the cinchocaine hydrochloride that sieves with the equivalent method mix homogeneously that progressively increases;
Step 4, take by weighing mixed fatty glycerides and anhydrous lanolin, mix post-heating to 55 ℃, melted fully in about 1 hour, temperature is reduced to 40 ℃ then, and insulation also adds the policresulen and the cinchocaine hydrochloride of mix homogeneously, stirs.
Step 5, the mixture that makes slowly are cooled to 36 ℃ and pour in the mould, mould is coated with one deck lubricant earlier, lubricant is glycerol and 95% alcohol mixeding liquid, ratio is 1g: 5/mL, slow cool to room temperature is pruned with cutter and to be overflowed part, opening mold, suppository is released, promptly made the pharmaceutical composition of the treatment hemorrhoid of suppository formulation.
Embodiment two
Medicine embodiment consumption of the present invention following (weight ratio):
36% policresulen solution 14%, cinchocaine hydrochloride 0.13%, 20% sodium hydroxide solution 4.39%, mixed fatty glycerides 61.39%, anhydrous lanolin 13.15%, calcium sulfate (two hydrations) 8.77%.
A kind of preparation of drug combination method for the treatment of hemorrhoid comprises following step:
Step 1, by above-mentioned prescription, take by weighing 36% policresulen solution, with 20% sodium hydroxide solution adjust pH is 2.7 to 3.3, concentrating under reduced pressure under 45 ℃ of conditions then, and the concentration that makes policresulen is 60% to add calcium sulfate, stir, it is gone in the drip pan, and drying under reduced pressure under 45 ℃ of conditions is pulverized then, cross 90 mesh sieves, get the policresulen fine powder;
Step 2, cinchocaine hydrochloride is pulverized the back cross 100 mesh sieves;
Step 3, with policresulen fine powder and the cinchocaine hydrochloride that sieves with the equivalent method mix homogeneously that progressively increases;
Step 4, take by weighing mixed fatty glycerides and anhydrous lanolin, mix post-heating to 50 ℃, melted fully in about 1 hour, temperature is reduced to 40 ℃ then, and insulation also adds the policresulen and the cinchocaine hydrochloride of mix homogeneously, stirs.
Step 5, the mixture that makes slowly are cooled to 36 ℃ and pour in the mould, mould is coated with one deck lubricant earlier, lubricant is glycerol and 95% alcohol mixeding liquid, ratio is 1g: 5/mL, slow cool to room temperature is pruned with cutter and to be overflowed part, opening mold, suppository is released, promptly made the pharmaceutical composition of the treatment hemorrhoid of suppository formulation.
Embodiment three
Medicine embodiment consumption of the present invention following (weight fraction ratio):
36% policresulen solution 13.8%, cinchocaine hydrochloride 0.5%, 20% sodium hydroxide solution 4.12%, vaseline 59.94%, Cera Flava 2.30%, anhydrous lanolin 11.56%, calcium sulfate (two hydrations) 9.12%.
A kind of preparation of drug combination method for the treatment of hemorrhoid comprises following step:
Step 1, by above-mentioned prescription, taking by weighing 36% policresulen solution, is 2.7 to 3.3 with 20% sodium hydroxide solution adjust pH, then concentrating under reduced pressure under 50 ℃ of conditions, the concentration that makes policresulen is 60%, add calcium sulfate, stir, it is gone in the drip pan, drying under reduced pressure under 50 ℃ of conditions, pulverize then, cross 80 mesh sieves, get the policresulen fine powder;
Step 2, cinchocaine hydrochloride is pulverized the back cross 100 mesh sieves;
Step 3, with policresulen fine powder and the cinchocaine hydrochloride that sieves with the equivalent method mix homogeneously that progressively increases;
Step 4, take by weighing vaseline, Cera Flava, lanoline and be heated to 80 ℃, make it complete fusion, repeatedly above mixture is joined in the fused solution on a small quantity, stir.When being cooled to 40 ℃, stop to stir, naturally cool to room temperature, be distributed into ointment, promptly make the pharmaceutical composition of the treatment hemorrhoid of ointment dosage form.
Claims (7)
1. a pharmaceutical composition for the treatment of hemorrhoid is characterized in that described pharmaceutical composition is the active constituents of medicine that forms with policresulen, cinchocaine hydrochloride, mixes the Pharmaceutical composition that forms with acceptable accessories as carrier.
2. the pharmaceutical composition of treatment hemorrhoid according to claim 1, it is characterized in that described pharmaceutical composition Chinese medicine absorption of active ingredient is: policresulen accounts for 3 to 10% of composition total weight, cinchocaine hydrochloride accounts for 0.1 to 0.8% of composition total weight, and all the other are adjuvant.
3. the pharmaceutical composition of treatment hemorrhoid according to claim 1, the optimum organization consumption that it is characterized in that described pharmaceutical composition Chinese medicine active component is: policresulen accounts for 4 to 6% of composition total weight, and cinchocaine hydrochloride accounts for 0.1 to 0.5% of composition total weight.
4. the pharmaceutical composition of treatment hemorrhoid according to claim 1 is characterized in that described adjuvant is one or more the mixture in 36 type mixed fatty glycerides, anhydrous lanolin, calcium sulfate (dihydrate), 20% weight fraction sodium hydroxide solution, vaseline, Cera Flava, stearic acid, high fatty alcohol, the glyceryl monostearate.
5. according to the pharmaceutical composition of the described treatment hemorrhoid of the arbitrary claim of claim 1 to 4, it is characterized in that described pharmaceutical composition is any one of suppository, ointment.
6. the preparation of drug combination method of the described treatment hemorrhoid of claim 1 to 4 is characterized in that comprising following step:
Step 1 is got 36% policresulen solution, with 20% sodium hydroxide solution adjust pH is 2.5 to 3.6, concentrating under reduced pressure under 45 to 55 ℃ of conditions then, the concentration that makes policresulen is 55 to 62%, adds the calcium sulfate (dihydrate) that accounts for composition total weight 8 to 12%, stir, it is gone in the drip pan, and drying under reduced pressure under in 45 to 55 ℃ of conditions is pulverized then, cross 80 mesh sieves, get the policresulen fine powder;
Step 2 was pulverized 80 to 100 mesh sieves with cinchocaine hydrochloride;
Step 3 with policresulen fine powder and the cinchocaine hydrochloride that sieves with the equivalent method mix homogeneously that progressively increases;
Step 4 takes by weighing the mixed fatty glycerides that accounts for composition total weight 65 to 72% and 12 to 18% lanoline, mix post-heating to 55 ℃, make its fusion complete, temperature is reduced to 38 to 45 ℃ then, the policresulen and the cinchocaine hydrochloride of insulation and adding mix homogeneously stir and make its mix homogeneously.
Step 5 mould is coated with one deck lubricant earlier, and lubricant is glycerol and 75 to 95% alcohol mixeding liquids, and ratio is 1g: 5mL, the mixture that makes slowly cools to 35 to 38 ℃ and pours in the mould, slowly is cooled to 18 to 22 ℃, prunes with cutter and overflows part, opening mold is released suppository, packing.Promptly make the pharmaceutical composition of the treatment hemorrhoid of suppository formulation.
7. the preparation of drug combination method of the described treatment hemorrhoid of claim 1 to 4 is characterized in that comprising following step:
Step 1 is got 36% policresulen solution, with 20% sodium hydroxide solution adjust pH is 2.5 to 3.6, concentrating under reduced pressure under 45 to 55 ℃ of conditions then, the concentration that makes policresulen is 55 to 62%, adds calcium sulfate, stir, it is gone in the drip pan, and drying under reduced pressure under in 45 to 55 ℃ of conditions is pulverized then, cross 80 mesh sieves, get the policresulen fine powder;
Step 2 is pulverized the back with cinchocaine hydrochloride and is crossed 80 to 100 mesh sieves;
Step 3 with policresulen fine powder and the cinchocaine hydrochloride that sieves with the equivalent method mix homogeneously that progressively increases;
Step 4 takes by weighing vaseline, Cera Flava, lanoline and is heated to 75 to 85 ℃, makes it complete fusion, when temperature is reduced to 45 to 50 ℃, repeatedly above medicinal mixture is joined in the fused solution on a small quantity, stirs.
When step 5 is cooled to 40 to 45 ℃, stop to stir, naturally cool to room temperature, be distributed into ointment, promptly make the pharmaceutical composition of the treatment hemorrhoid of ointment dosage form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101454624A CN101837007B (en) | 2010-04-13 | 2010-04-13 | Medicinal composition for curing hemorrhoids and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101454624A CN101837007B (en) | 2010-04-13 | 2010-04-13 | Medicinal composition for curing hemorrhoids and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101837007A true CN101837007A (en) | 2010-09-22 |
| CN101837007B CN101837007B (en) | 2012-05-30 |
Family
ID=42740843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101454624A Active CN101837007B (en) | 2010-04-13 | 2010-04-13 | Medicinal composition for curing hemorrhoids and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101837007B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102824358A (en) * | 2012-08-14 | 2012-12-19 | 江苏远恒药业有限公司 | Policresulen compound suppository and preparation method |
| CN103191163A (en) * | 2013-04-29 | 2013-07-10 | 崔新明 | Skin wound repairing pharmaceutical composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269082A (en) * | 2008-02-25 | 2008-09-24 | 北京阜康仁生物制药科技有限公司 | Pharmaceutical combination treating hemorrhoid |
-
2010
- 2010-04-13 CN CN2010101454624A patent/CN101837007B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269082A (en) * | 2008-02-25 | 2008-09-24 | 北京阜康仁生物制药科技有限公司 | Pharmaceutical combination treating hemorrhoid |
Non-Patent Citations (1)
| Title |
|---|
| 《环球医药信息网》 20090908 环球医药信息网 环球医药信息网－医药转让信息－独家临床批件转让－复方聚甲酚磺醛软膏 1 1-5 , 1 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102824358A (en) * | 2012-08-14 | 2012-12-19 | 江苏远恒药业有限公司 | Policresulen compound suppository and preparation method |
| CN103191163A (en) * | 2013-04-29 | 2013-07-10 | 崔新明 | Skin wound repairing pharmaceutical composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101837007B (en) | 2012-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101837007B (en) | Medicinal composition for curing hemorrhoids and preparation method thereof | |
| US20180311253A1 (en) | Use of par-1 antagonists for preventing and/or treating pelvi-perineal functional pathological conditions | |
| RU2530605C2 (en) | Composition for injections, which contains hydroxychloroquine, for local application in treatment of haemorrhoid | |
| JP2014527971A (en) | pH buffered bioactive glass and method and use thereof | |
| CN102309438A (en) | Midazolam medicament composition as well as preparation method and application thereof | |
| CN101912376B (en) | Matrine vaginal effervescent tablets with bilayer structure and preparation method | |
| CN101342344A (en) | Chinese medicine for treating piles | |
| CN100355437C (en) | Medicine for treating scald and burn and preparing method | |
| IT201900006486A1 (en) | COMPOSITION FOR THE PREVENTION AND TREATMENT OF URINARY CALCULOSIS | |
| CN1970009B (en) | Chinese medicinal suppository for treating piles quickly | |
| CN107648236B (en) | Pharmaceutical composition for preventing or treating ischemia/reperfusion injury and application thereof | |
| CN110403983B (en) | Natural product composition for treating hemorrhoids and preparation method thereof | |
| KR101470282B1 (en) | Pharmaceutical Composition comprising a combination of a salt and sugar for proventing or treating lax vagina syndrome or colpoxerosis disease and the use thereof | |
| CN103585334A (en) | Compound diaper ointment | |
| CN102552295B (en) | Medicine for treating internal and external hemorrhoids and preparation method thereof | |
| CN115590908B (en) | Traditional Chinese medicine composition, antibacterial spray and preparation method | |
| CN104688936A (en) | Traditional Chinese medicine composition for treating burns and scalds and preparation thereof | |
| CN100478007C (en) | Plaster for treating traumatic injuries and rheumatism, and its prepn. method | |
| CN104906210A (en) | Traditional Chinese medicine externally applied lotion for treating colpitis mycotica and preparation method thereof | |
| CN104887701A (en) | Novel fast hemorrhoid removal medicament, namely sodium sulfide-menthol composition and preparation method of novel fast hemorrhoid removal medicament | |
| CN101327233B (en) | Compound external-use formulation for treating gonorrhoea and nongonococcal urethritis | |
| CN113975300A (en) | Prescription for treating anus disease and preparation method thereof | |
| Gupta | Supportive therapies in ano-rectal diseases: Are they really useful? | |
| CN101313970B (en) | Medicament for treating hemorrhoids and use method | |
| RO130546B1 (en) | Ointment for treatment of hemorrhoidal disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP03 | Change of name, title or address |
Address after: 641000 No. 456, Anji street, Neijiang economic and Technological Development Zone, Sichuan Patentee after: Sichuan zitonggong pharmaceutical Limited by Share Ltd Address before: 641006 Neijiang City, Sichuan Province in central music town Vitex dam Patentee before: Sichuan Zitonggong Pharmaceutical Co., Ltd. |