CN102824358A - Policresulen compound suppository and preparation method - Google Patents
Policresulen compound suppository and preparation method Download PDFInfo
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- CN102824358A CN102824358A CN201210286939XA CN201210286939A CN102824358A CN 102824358 A CN102824358 A CN 102824358A CN 201210286939X A CN201210286939X A CN 201210286939XA CN 201210286939 A CN201210286939 A CN 201210286939A CN 102824358 A CN102824358 A CN 102824358A
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- policresulen
- sodium hydroxide
- compound suppository
- suppository
- microcrystalline cellulose
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Abstract
The invention discloses a policresulen compound suppository which is characterized by comprising two active components, i.e., policresulen and cinchocaine hydrochloride, and soyabean lecithin, mixed fatty glyceride, microcrystalline cellulose, silica, sodium hydroxide and distilled water. A preparation method for the policresulen compound suppository is easy for commercialized production; the policresulen compound suppository has a golden yellow appearance and is slippery, so pains of patients with hemorrhoids caused by burrs of the suppository is avoided and the policresulen compound suppository is easily accepted by the patients.
Description
Description:
Technical field: the invention belongs to medical technical field, relate to a kind of policresulen compound suppository of treating hemorrhoid and preparation method thereof.
Background technology:
Because the quickening of social life rhythm, the change of competitive pressure and life style, the momental minimizing of people cause the outbreak of hemorrhoid and general, the institute of " ten people, nine hemorrhoid " is arranged.Mostly its pathogenic factor is that the people is standing or during seat, anal orifice and rectal intestine is positioned at the bottom, because the compressing of gravity and internal organs influences the blood backflow, vein is expanded flexing easily, so often stand or the people of seat suffers from hemorrhoid easily.Hypomotility, enterokinesia reduces, and feces is descending slow, also can the constipation of forming the habit property.Podex is caught a cold, is heated, constipation, diarrhoea, excessive consumption of alcohol and eat maror more, all can stimulate anus and rectum.Because of all can making intra-abdominal pressure increase, stiff change, hepatohemia and cardiac function incompensation etc. and diseases such as intraperitoneal tumor, prostate hyperplasia form hemorrhoid.
The means of treatment hemorrhoid have operation, acupuncture and Drug therapy etc. at present.But Most patients tends to select Drug therapy clinically.And policresulen has hemostasis, convergence, epithelium regeneration and germ-resistant effect, makes slough condense and separates the wound surface rapid cleaning.Simultaneously can promote that slough regrows; Cinchocaine hydrochloride can suppress the pain of wound surface, and the anesthetic action persistent period is more of a specified duration because of onset local anesthesia effect rapidly.The two drug combination helps quickly alleviating pain and antibacterial to combine, effectively pain relieving, detumescence.
Summary of the invention:
The object of the present invention is to provide a kind of policresulen compound suppository and preparation method thereof, for hemorrhoid patients provides a kind of medicine.
The present invention is achieved in that
A kind of policresulen compound suppository contains following component: policresulen, cinchocaine hydrochloride, soybean phospholipid, mixed fatty glycerides, microcrystalline Cellulose, silicon dioxide, sodium hydroxide, distilled water.
Said policresulen compound suppository is characterized in that: described policresulen, cinchocaine hydrochloride are active component.
Said mixing-in fat glyceride is 36 types, 38 types or 40 types; Described sodium hydroxide is the sodium hydroxide solution that is mixed with 10M.
Described policresulen compound suppository is characterized in that being made up of the component of following weight content: policresulen is that 3%-8%, cinchocaine hydrochloride are that 0.05%-0.15%, mixed fatty glycerides are that 50%-80%, soybean phospholipid are that 10%-20%, microcrystalline Cellulose are that 3%-8%, silicon dioxide are that 0.1%-0.5%, sodium hydroxide are that 0.1%-1.0%, distilled water are 2.0%-5.0%.
Described policresulen compound suppository is characterized in that by policresulen being that 100g, cinchocaine hydrochloride are that 2.5g, mixed fatty glycerides are that 1424.5g, soybean phospholipid are that 300g, microcrystalline Cellulose are that 100g, silicon dioxide are that 3g, sodium hydroxide are that 20g, distilled water are that 50g supports 1000.
The present invention also provides the method for preparing of policresulen compound suppository, may further comprise the steps;
Step 1: get policresulen solution and regulate PH to 2.5-3.5, get A with the solution of sodium hydroxide preparation written treaty 10M, subsequent use;
Step 2: get cinchocaine hydrochloride and microcrystalline Cellulose and silicon dioxide and cross 200 mesh sieves, mix homogeneously gets B, and is subsequent use;
Step 3: get mixed fatty glycerides and soybean phospholipid with 70 ℃ of-90 ℃ of thawings of water-bath, add A and B then, homogenizing, fill, cooling get final product.
The policresulen compound suppository is an active component with policresulen and cinchocaine hydrochloride among the present invention.Policresulen has broad-spectrum antibacterial action.Can make impaired squamous epithelial cancer and the degeneration under the effect of policresulen of ectopic columnar epithelial cell, come off, be excluded externally, help tissue repair.
Cinchocaine hydrochloride is the amide-type local anesthetic, is a long-acting local anesthetic, with the temporary transient combination rate of nervous tissue greater than ***e.Effect beginning is slow, does not wait in action effective 2-6 hour 15-20 minute incubation period, difference is very big between individuality, have to be shorter than 2-3 hour, has to reach 5-6 hour.Cinchocaine has good penetration property, to the local organization nonirritant.After the present invention processed suppository, maximum characteristics were that the surface has lubricity, and having eliminated ordinary suppository, to have burr poor in use patient compliance, respond well to treatment of hemorrhoid.
The specific embodiment:
Below in conjunction with specific embodiment the present invention is described further, to help understanding content of the present invention.
Specification: every contains policresulen: 100mg, cinchocaine hydrochloride: 2.5mg.
Method for making: step 1: get policresulen solution and regulate PH to 2.5-3.5, get A with the solution of sodium hydroxide preparation written treaty 10M, subsequent use;
Step 2: get cinchocaine hydrochloride and microcrystalline Cellulose and silicon dioxide and cross 200 mesh sieves, mix homogeneously gets B, and is subsequent use;
Step 3: get mixed fatty glycerides and soybean phospholipid with 70 ℃ of-90 ℃ of thawings of water-bath, add A and B then, homogenizing, fill, cooling get final product.
Claims (6)
1. a policresulen compound suppository contains following component: policresulen, cinchocaine hydrochloride, soybean phospholipid, mixed fatty glycerides, microcrystalline Cellulose, silicon dioxide, sodium hydroxide, distilled water.
2. policresulen compound suppository according to claim 1, it is characterized in that: described policresulen, cinchocaine hydrochloride are active component.
3. mixing-in fat glyceride is 36 types, 38 types or 40 types according to claim 1; Described sodium hydroxide is the sodium hydroxide solution that is mixed with 10M.
4. according to claim 1 or claim 2 policresulen compound suppository is characterized in that being made up of the component of following weight content:
Policresulen is that 3%-8%, cinchocaine hydrochloride are that 0.05%-0.15%, mixed fatty glycerides are that 50%-80%, soybean phospholipid are that 10%-20%, microcrystalline Cellulose are that 3%-8%, silicon dioxide are that 0.1%-0.5%, sodium hydroxide are that 0.1%-1.0%, distilled water are 2.0%-5.0%.
5. according to claim 1 or claim 2 policresulen compound suppository is characterized in that by policresulen being that 100g, cinchocaine hydrochloride are that 2.5g, mixed fatty glycerides are that 1424.5g, soybean phospholipid are that 300g, microcrystalline Cellulose are that 100g, silicon dioxide are that 3g, sodium hydroxide are that 20g, distilled water are that 50g supports 1000.
6. like the method for preparing of described policresulen compound suppository one of in the claim 1 to 5: get policresulen solution and regulate PH to 2.5-3.5 with the solution of sodium hydroxide preparation written treaty 10M, A, subsequent use; Get cinchocaine hydrochloride and microcrystalline Cellulose and silicon dioxide and cross 200 mesh sieves, mix homogeneously gets B, and is subsequent use; Get mixed fatty glycerides and soybean phospholipid with 70 ℃ of-90 ℃ of thawings of water-bath, add A and B then, homogenizing, fill, cooling get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210286939XA CN102824358A (en) | 2012-08-14 | 2012-08-14 | Policresulen compound suppository and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210286939XA CN102824358A (en) | 2012-08-14 | 2012-08-14 | Policresulen compound suppository and preparation method |
Publications (1)
| Publication Number | Publication Date |
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| CN102824358A true CN102824358A (en) | 2012-12-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201210286939XA Pending CN102824358A (en) | 2012-08-14 | 2012-08-14 | Policresulen compound suppository and preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963401A (en) * | 2016-05-31 | 2016-09-28 | 海南海神启迈药物开发有限公司 | Policresulen dibucaine hydrochloride suppository and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698581A (en) * | 2003-04-04 | 2005-11-23 | 丛繁滋 | Carrying suppository for cavity/canal drug administration |
| CN101313904A (en) * | 2007-06-01 | 2008-12-03 | 北京德众万全药物技术开发有限公司 | Fenticonazole suppository for treating exterior colpitis |
| CN101837007A (en) * | 2010-04-13 | 2010-09-22 | 四川梓橦宫药业有限公司 | Medicinal composition for curing hemorrhoids and preparation method thereof |
-
2012
- 2012-08-14 CN CN201210286939XA patent/CN102824358A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698581A (en) * | 2003-04-04 | 2005-11-23 | 丛繁滋 | Carrying suppository for cavity/canal drug administration |
| CN101313904A (en) * | 2007-06-01 | 2008-12-03 | 北京德众万全药物技术开发有限公司 | Fenticonazole suppository for treating exterior colpitis |
| CN101837007A (en) * | 2010-04-13 | 2010-09-22 | 四川梓橦宫药业有限公司 | Medicinal composition for curing hemorrhoids and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 贺国芳等: "缓释、控释栓剂研制概况", 《中国药师》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963401A (en) * | 2016-05-31 | 2016-09-28 | 海南海神启迈药物开发有限公司 | Policresulen dibucaine hydrochloride suppository and preparation method thereof |
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Application publication date: 20121219 |