CN101327233B - Compound external-use formulation for treating gonorrhoea and nongonococcal urethritis - Google Patents
Compound external-use formulation for treating gonorrhoea and nongonococcal urethritis Download PDFInfo
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- CN101327233B CN101327233B CN2008101408987A CN200810140898A CN101327233B CN 101327233 B CN101327233 B CN 101327233B CN 2008101408987 A CN2008101408987 A CN 2008101408987A CN 200810140898 A CN200810140898 A CN 200810140898A CN 101327233 B CN101327233 B CN 101327233B
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Abstract
The invention relates to a compound external preparation for treating gonorrhea and non-gonorrhea, which is prepared by five raw materials of acorn, cyrtomium rhizome, tetracycline, calcined soda and sodium dodecyl benzene sulphonate. The formulation of the preparation is well prepared, the preparation method is simple, and each drug exerts merit and cooperates to treat gonorrhea and non-gonorrhea synthetically. Compared with the prior art, the preparation can effectively deracinate sexual diseases such as gonorrhea, non-gonorrhea and the like caused by various infections such as male urethritis, prostatitis, female vaginitis, cervical erosion which are resulted from diplococcus gonorrhea, candidaalbicans, mycoplasma, chlamydia, infusorium, etc. The preparation has the advantages of fast efficacy, high healing rate, low recurrence rate, being convenient to carry and use, etc.
Description
Technical field
The invention belongs to medical technical field, particularly a kind of compound external-use preparation that is used for the treatment of gonorrhea and non-pouring.
Background technology
Gonorrhea, non-pouring are listed in a big pertinacious disease of puzzlement sufferer, have characteristics such as rapid onset, course of disease length, the difficulty of curing, easy recurrence, are having a strong impact on human healthy and quality of life.Modern medicine study is thought: the non-pouring of gonorrhea is to be caused by gonococcus, Candida albicans, mycoplasma, chlamydia etc.If untimely treatment, gonococcus can enter back urethra or cervix uteri, causes the inflammation of urogenital tract and near organ to vertical spread, as various infection such as skenitis, urethritis, prostatitis, seminal vesiculitis, epididymitis, endometritis, cervical erosion.Gonococcus also can hide in the glandular tissue deep for a long time, becomes chronic gonorrhea, repeatedly outbreak.Connective fiberization can cause deferent duct, uterine tube stegnosis, block, secondary ectopic pregnancy and male sterility after these infected organ inflammation disappeared.
At present, the medicine and the method for treatment gonorrhea, non-pouring are of a great variety, the inclined to one side external of doctor trained in Western medicine overweights bactericidal antiphlogistic, for oral administration then many, hormones quick with breath, Tri-Biocin are treated, dispenser many again with takes orally, transfusion or intramuscular injection, all be to circulate kill pathogens by the body inner blood, this just causes and can not come kill pathogens with the strong dose thing, and pathogenic bacteria is in order to adapt to surrounding, and self can morph, and produces drug resistance.Simultaneously, the medicine 80% that is used for kill pathogens is discharged to external by Liver and kidney, have only a spot of medicine to reach lesions position by blood capillary, and medicine is behind renal metabolism, and the drug effect usefulness when reaching focus subtracts greatly and is inadequate, and takes for a long time, side effect to human body is big, cause the human body immunocompetence to descend, and be not suitable for continuous use, therefore be difficult to reach the effect of thorough radical cure.Thereby have weak curative effect, take effect slow, treatment time is long, drug resistance by force, obstinate, toxic and side effects is big, especially to defectives such as the damage of liver are bigger.Chinese medicine then thinks, gonorrhea mean urinate not smooth, drop and descending, even disease such as have a pain in the stem and is divided into five types of stranguria, i.e. stranguria with blood, stranguria caused by urinary stone, qi stranguria, stranguria marked by chyluria, stranguria caused by overstrain.Pathogenesis loses for unit is empty down, clear QI being mixed up with turbid QI, and kidney qi is not all right, and pent-up is for drenching.Its dialectical executing is controlled with clearing away heat and promoting diuresis, and it is main removing the humidifying pouring.In the prior art, the prescription of the non-pouring of treatment gonorrhea is a lot, and the determined curative effect person is less, thereby is difficult for promoting.
Summary of the invention
The purpose of this invention is to provide a kind of rapid-action, determined curative effect, cure rate height, the compound external-use preparation that is used for the treatment of gonorrhea and non-pouring that relapse rate is low.
For achieving the above object, external used medicine of the present invention is to be made by the following medicaments in part by weight raw material: 100～200 parts of acorn nuts, 30～50 parts of Rhizoma Osmundae, 10～20 parts of tetracyclines, 70～80 parts of soda, 10～20 parts of dodecylbenzene sodium sulfonate.
Externally applied compound medicinal preparation of the present invention prepares by following step:
(1) gets acorn nut and clean, dry, shell, get Rhizoma Osmundae and mix clearly, clean, dry, the two pulverize separately is made Powdered standby;
(2) get the acorn nut and the Cyrtomium Rhizome of tetracycline, soda, the basic benzene sulfonic acid sodium salt of dodecane and preparation respectively by described prescription proportioning, mixing is milled, and crosses 280 mesh sieves, promptly makes compound external-use powder of the present invention;
When (3) using, with mixed powder by medicated powder: the weight portion proportioning of water=5: 1000～2000 adds water, rocks or stirs, and mixed powder is all dissolved, and promptly makes compound external-use lotion of the present invention.
The inventor passes through the long-term theory research of gonorrhea, non-pouring and a large amount of clinical practices, and widely collecting and Zhen Jian in conjunction with the classical treatise of Chinese and western medical science at all times, think why refractory and easily dying of this disease, more repeatedly, its main cause is: the one, cause the pathogenic bacteria of gonorrhea, non-pouring to be hidden growing of living in be difficult for executing control, as cause gonorrhea by gonococcus, generally be present in the multinuclear leucocyte; The mycoplasma, the chlamydia that cause non-pouring then are the microorganisms that parasitizes human body, main parasitic is in the cell of vagina, urethral mucosa, and Candida albicans belongs to a kind of of fungus, colonizes in human body cell gap or pore, the pore, outer rule of treatment difficulty reaches focus, and treatment by oral administration of medicines also is difficult for gathering effect.The 2nd, antibiotics is adopted in conventional treatment more, many again with transfusion or intramuscular injection, circulate kill pathogens by the body inner blood, have only a spot of medicine to reach lesions position by blood capillary, and that the medicine 80% that is used for kill pathogens is discharged to by Liver and kidney is external, so form obstinate.The 3rd, for oral administration or injecting drug use measure and then is not enough to kill pathogens for a short time, also long-term prescription cause variability of pathogenic bacteria self and drug resistance to strengthen again, and the medication metering is excessive, easily causes lesions of liver and kidney again, though so sterilization good medicine is arranged, and the doctor is at a loss to know how to conduct.The 4th, the present method of controlling of executing is difficult to change the environment that pathogenic bacteria grows, brings back to life, and can not thoroughly cure so can only change its surface symptoms, and cause more and regenerate, and gives birth to and the morbid state circulation controlled again.
Based on above-mentioned, the approach of controlling of executing of the present invention is: carry out exterior washings by the strong dose thing, directly be sprinkled upon around the pathogenic bacteria, make it infiltrate lesions position, kill pathogens lentamente.Vagina, urethral mucosa can absorb a part of medicine simultaneously, and this part medicine can kill the pathogenic bacteria that does not contact medicine by blood circulation.Its sterilization mechanism is because pathogenic bacteria also has the skin care film of self; the protection external environment is to its adverse effect, and in the application of soda and the sour environment of the existence of pathogenic bacteria, can tear the protecting film of pathogenic bacteria; it is proteinic synthetic to make bactericide can thoroughly block pathogenic bacteria, can make pathogenic bacteria death rapidly.Acorn nut can make normal human body cell fine and close rapidly, but can not normal contraction by the cell of mycoplasma, chlamydia infection, thereby make it isolated, help the strong dose thing pathogenic bacteria is is thoroughly catched and killed, and remove dead pathogenic bacteria and downright bad slough, keep vagina, urethra cleaning by dodecylbenzene sodium sulfonate, promote the recovery of vagina, urethral mucosa, change pathogenic bacteria and bring back to life, grow environment, sick portion can thoroughly effect a radical cure naturally, and can avoid recurrence effectively.The concrete function of each component drug is respectively in the prescription of the present invention:
Acorn nut: can strengthen immune function of human body, promote growth promoter, cellular metabolism is used for removing the necrotic tissue and promoting granulation, repairs vagina, urethral mucosa.
Rhizoma Osmundae: have heat-clearing and toxic substances removing, cooling blood for hemostasis, the parasite killing anthelmintic, effect such as antibacterial grade is used for sterilization, sterilization, protection vagina, urethral mucosa.
Tetracycline: gram positive bacteria, negative bacterium, rickettsia, filterable virus, Spirochaetes and even former insects are all had the good restraining effect, to the certain antibacterial activity of gonococcus tool, be used for the treatment of tetanus, gas gangrene, syphilis, gonorrhea and the leptospirosis etc. of penicillin anaphylaxis.
Soda: can in and the sour environment around the pathogenic bacteria, and can make the film rupture of pathogenic bacteria epidermis protected acidic.
Dodecylbenzene sodium sulfonate: be used to remove dead pathogenic bacteria and downright bad slough, keep vagina, urethra cleaning, promote the recovery of vagina, urethral mucosa.
Compound external-use preparation of the present invention adopts Chinese medicine and western medicine to cooperate at the pathological characters of various gonorrheas, non-pouring, and its prescription compatibility is proper, and preparation method is simple, and respectively executes its length by each component drug, and synergism comprehensively effects a radical cure disease.Compared with prior art, said preparation can be eradicated property diseases such as the gonorrhea that various infection such as the various male urethra inflammation that have gonorrhea diplococcus, Candida albicans, mycoplasma, chlamydia, infusorian etc. to cause, prostatitis, women vaginitis, cervical erosion cause, non-pouring effectively, and have instant effect, cure rate height, relapse rate low, portably use advantages such as convenient.
The specific embodiment
Compound external-use preparation of the present invention is by the long-pending ten several years convection potential gonorrheas of inventor, non-pouring pathogenesis and executes the concentrated research of administering opinion and medical record at all times, and by a large amount of clinical practices and test gained, each component of its medicine all has curative effect preferably in the following weight parts ratio range: 100～200 parts of acorn nuts, 30～50 parts of Rhizoma Osmundae, 10～20 parts of tetracyclines, 70～80 parts of soda, 10～20 parts of dodecylbenzene sodium sulfonate.
Embodiment 1
The weight portion proportioning of each component drug of externally used compound pharmaceutical preparation of the present invention can be: 100 parts of acorn nuts, 30 parts of Rhizoma Osmundae, 10 parts of tetracyclines, 70 parts of soda, 10 parts in the basic sour sodium of dodecane.
Embodiment 2
The weight portion proportioning of each component drug of externally used compound pharmaceutical preparation of the present invention also can be: 150 parts of acorn nuts, 40 parts of Rhizoma Osmundae, 15 parts of tetracyclines, 75 parts of soda, 15 parts in the basic sour sodium of dodecane.
Embodiment 3
The weight portion proportioning of each component drug of externally used compound pharmaceutical preparation of the present invention can also be: 200 parts of acorn nuts, 50 parts of Rhizoma Osmundae, 20 parts of tetracyclines, 80 parts of soda, 20 parts in the basic sour sodium of dodecane.
The preparation method of medicine of the present invention is:
Get acorn nut (shelling), Rhizoma Osmundae, removal of contamination, and pulverize and to make powder then, takes by weighing tetracycline, soda, the basic sour sodium of dodecane and acorn nut and Cyrtomium Rhizome respectively by described proportional quantity and mixes and mill evenly, crosses 280 mesh sieves, promptly makes the compound external-use powder.Its amount by every bag 5 gram is encapsulated in the bag, during use, adds in the entry, stir or rock even, medicated powder is all dissolved, promptly make the compound external-use lotion by the proportioning of medicated powder and water: 5g: 1～2kg.Clean affected part repeatedly with this lotion, according to state of an illness weight is for 20 times a course of treatment, clean 1 first every day course of treatment, clean once second per 3～5 days of course of treatment, each wash number successive doubling blanking time prolongation course of treatment later on, 1～2 course of treatment of general treatment, severe patient uses just can fully recover 3～4 courses of treatment.Use pharmaceutical treatment gonorrhea of the present invention and non-gonorrhea, can be after the recovery from illness generally not in recurrence.
External preparation of the present invention uses for many years patient Shi Zhi through the inventor, case 1286 examples are followed up a case by regular visits in tracking, therapeutic effect is obvious, the obvious alleviator of clinical symptoms reaches 1272 examples, obvious effective rate reaches 98.9%, 1222 examples of thoroughly fully recovering, cure rate reaches more than 95%, has followed up a case by regular visits to recidivist's 11 examples, and relapse rate is just controlled the patient and gasp in admirationd gratitude invariably less than 1%.
Experiment case 1
Mr. Xia infected gonorrhea in 18 years old, because the shy psychology of sufferer fails in time to cure, caused bacterial resistance, formed chronicly, and medical history more than 11 year is cured for a long time in many ways, and effect is all undesirable, once repeatedly want to remove to commit suiside misery.Seek medical advice to this clinic in March, 2003, and clinical symptoms is: the urine mouth is suppurated, and is yellow green, and abnormal flavour is arranged, very itch unbearably, and the urine twinge, urine once urine is exactly once painful, unbearably puzzlement.Through using external preparation of the present invention, only itched in 4 days every day 1 time, clean 20 days table diseases and disappear substantially, cleaned medication once in per 3 days the 2nd, 3 courses of treatment, recovery from illness after 3 months, disease is all eliminated, and follows up a case by regular visits to and does not have recurrence more so far.
Experiment case 2
Lee XX, male, 42 years old, the worker of Henan Province Affiliated Hospital of the college of traditional Chinese medicine, suffer from mycoplasma, chlamydia infection more than 8 years, the multi-treatment poor effect, seek medical advice to this clinic in March, 1998, clinical examination, the urine mouth drips white, red and swollen, and urethra is very itched, the concomitant infections prostatitis, clean through using externally-applied powder water distribution of the present invention, the same day can be antipruritic, cleaned 1 time in later per three days, and 20 times is a course of treatment, the 2nd course of treatment, jede Woche cleans medication once, and the 3rd, 4 course of treatment, every fortnight cleans medication once, thoroughly recovery from illness after 4 courses of treatment is followed up a case by regular visits to and is not had recurrence more so far.
Experiment case 3
Mr. Wang, 44 years old, Nanyang Wancheng District basin kiln village people, infection by Candida albicans is for 7 years, and is bad during fashion, never radical cure.Ill existing 12 years history is repeatedly cured through province, city-level hospital, and effect is undesirable.Cure to this clinic February calendar year 2001, and through valuing, glans penis turns white, dirty sample is arranged, and it is hard to bear very to itch, cleans through using externally-applied powder water distribution of the present invention, after medication in first day is cleaned, can be antipruritic, the 1st, 2 course of treatment, medication every day is cleaned once, the 3rd course of treatment, medication in per three days is cleaned once, after the recovery from illness, follows up a case by regular visits to and does not have recurrence more so far.
Claims (2)
1. compound external-use preparation that is used for the treatment of gonorrhea and non-pouring, it is characterized in that: it is to be made by the following medicaments in part by weight raw material: 100～200 parts of acorn nuts, 30～50 parts of Rhizoma Osmundae, 10～20 parts of tetracyclines, 70～80 parts of soda, 10～20 parts of dodecylbenzene sodium sulfonate.
2. the preparation method of the compound external-use preparation of described treatment gonorrhea of claim 1 and non-pouring, it is characterized in that: it is to be undertaken by following step:
(1) gets acorn nut and clean, dry, shell, get Rhizoma Osmundae and mix clearly, clean, dry, the two pulverize separately is made Powdered standby;
(2) get the acorn nut and the Cyrtomium Rhizome of tetracycline, soda, dodecylbenzene sodium sulfonate and preparation respectively by described prescription proportioning, mixing is milled, and crosses 280 mesh sieves, promptly makes the compound external-use powder;
When (3) using, with mixed powder by medicated powder: the weight portion proportioning of water=5: 1000～2000 adds water, rocks or stirs, and mixed powder is all dissolved, and promptly makes the compound external-use lotion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101408987A CN101327233B (en) | 2008-08-04 | 2008-08-04 | Compound external-use formulation for treating gonorrhoea and nongonococcal urethritis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101408987A CN101327233B (en) | 2008-08-04 | 2008-08-04 | Compound external-use formulation for treating gonorrhoea and nongonococcal urethritis |
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| Publication Number | Publication Date |
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| CN101327233A CN101327233A (en) | 2008-12-24 |
| CN101327233B true CN101327233B (en) | 2010-08-25 |
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| CN2008101408987A Expired - Fee Related CN101327233B (en) | 2008-08-04 | 2008-08-04 | Compound external-use formulation for treating gonorrhoea and nongonococcal urethritis |
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Non-Patent Citations (4)
| Title |
|---|
| 姚五原.四种常见性病简介.医药养生保健报.2006,第013版. * |
| 张运昌.非淋菌性***炎如何治.家庭医药.2004,48. * |
| 钱桐荪.***的治疗.中国中西医结合肾病杂志.2001,2(4),187-189. * |
| 陈伯崇.急性淋病性尿道炎98例诊治.华西医讯.1989,4(4),457-458. * |
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