CN102552295B - Medicine for treating internal and external hemorrhoids and preparation method thereof - Google Patents
Medicine for treating internal and external hemorrhoids and preparation method thereof Download PDFInfo
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- CN102552295B CN102552295B CN 201210055611 CN201210055611A CN102552295B CN 102552295 B CN102552295 B CN 102552295B CN 201210055611 CN201210055611 CN 201210055611 CN 201210055611 A CN201210055611 A CN 201210055611A CN 102552295 B CN102552295 B CN 102552295B
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Abstract
The invention relates to a medicine for treating internal and external hemorrhoids and a preparation method thereof. The existing operative therapy can cure various hemorrhoids, but has many shortcomings such as great pain, much bleeding, sequela and easy relapse, and is hard for the old and infirm people to bear. The currently acknowledged (PPH) anastomat resection is only superior to the traditional operation in smaller wound and faster healing, and also has shortcomings such as pain and bleeding. The medicine provided by the invention is prepared by mixing carbolic acid, quinine, tannic acid and sterile water. The invention provides a medicine for treating internal and external hemorrhoids and a preparation method thereof, wherein the medicine does not hurt normal tissue or require long-term treatment, takes effect after once injection, avoids pain and relapse, and has wide raw material source, low cost, wide clinical application and little side effect.
Description
Technical field
The present invention relates to a kind of medicine, relate in particular to a kind of medicine and manufacture method thereof for the treatment of mixed hemorrhoids.
Background technology
Hemorrhoid are a kind of chronic diseases of the vein group of the venous plexus generation varicose of anal orifice and rectal intestine bottom and anal mucosa and one or more softnesses of forming.Usually continue to exert oneself when defecation, cause herein that intravenous pressure raises repeatedly, vein will enlargement.If suffer from hemorrhoid, the wall of vein of anal enlargement distortion will become very thin, so very easily breaks during defecation.Internal hemorrhoid is long hemorrhoid at the anus catheter section start, if the vein that expands is positioned at more below, almost is on the anal canal mouth, and the vein of this varicose just is external hemorrhoid.External hemorrhoid is deviate from sometimes or is appeared suddenly outside the anal canal mouth.But this situation only just can occur when defecation, its original position of can retracting again behind the defecation.No matter thrombosis all may occur in internal hemorrhoid or external hemorrhoid.When thrombosis occurs, the blood clotting in bulk in the hemorrhoid, thus causing pain, hemorrhoid treating is generally, and the treatment phase is painful greatly, relapse rate is high.The sickness rate of hemorrhoid is very high, and existing sclerosing treatment hemorrhoid can only produce weak inflammatory reaction, and are better to slight internal hemorrhoid curative effect, to the Severe internal hemorrhoids weak curative effect, can not treat external hemorrhoid, because existing injection of sclerosing agent external hemorrhoid patient can produce severe pain, so existing sclerosing agent can not replace operative therapy.Though existing operative therapy can be cured various hemorrhoid, shortcoming is more, and is large such as misery, hemorrhage many, and sequela is arranged, and elderly and infirm's endurable easily recurs etc.(PPH) anastomat excision of generally acknowledging at present is just smaller than the wound of traditional operation, and healing hurry up.But still have pain, the shortcoming such as hemorrhage.
Summary of the invention
The object of the present invention is to provide a kind of is pathological changes local application, does not injure normal structure, no pain, need not long-term treatment, one pin takes effect, does not recur, raw material is wide, cost is low, clinical extensive utilization, medicine and the manufacture method thereof of the treatment mixed hemorrhoids that side effect is little.
In order to achieve the above object, the present invention adopts following technical proposal:
A kind of medicine for the treatment of mixed hemorrhoids, its raw material and weight proportion of making effective ingredient is:
Tannic acid 20-30 quinine 200-400
Carbolic acid 100-300 sterilized water 4000-6000.
For better effect, its raw material and weight proportion of making effective ingredient is:
Tannic acid 25-30 quinine 200-300
Carbolic acid 200-300 sterilized water 4000-5000
Optimum raw material and weight proportion are:
Tannic acid 25 quinines 230
Carbolic acid 220 sterilized water 5000.
The present invention treats the medicine of mixed hemorrhoids, and its manufacture method is:
A, be dissolved in respectively in the sterilized water of 1/5th weight by proportioning weighing carbolic acid, quinine, tannic acid, placed 10～14 hours;
B, again the lysate of A step and remaining sterilized water are mixed, stir, stirred once in per 3～5 hours, precipitate 10～14 hours, repeatedly stir and precipitate 2～4 times;
C, the medical filtration of B step is removed impurity, autoclaving is for subsequent use.
The function of this medicine be shrink vein, ease pain, impel the hemorrhoidal tissue proliferation of fibrous tissue mainly to be because:
Tannic acid can precipitating proteins, has astriction, can make the skin hardening, thereby the protection mucosa, prevents undue secretion and hemostasis; Can reduce local pain, the blood plasma that reduces injury oozes out, and the effect that prevents that antibacterial from infecting is arranged.Be mainly used in decubital ulcer, also can be used for eczema, hemorrhoid and newborn diapers rash etc.
Quinine has another name called quinine, heavy sulphuric acid quine, quinine dihydrochloride, quinin hydrochloride.Suppress or kill the erythrocytic stage of benign tertian malaria, quartan malaria and Plasmodium falciparum, can the malaria control symptom.In addition analgesic, uterine contraction effect.
Carbolic acid claims again phenol, can make disinfectant, and medicated soap commonly used just contains phenol, and bactericidal action is arranged, and can stimulate body to produce aseptic inflammation.
The present invention is reasonably combined, learning from other's strong points to offset one's weaknesses can vasoconstrictive, in the present invention is injected into hemorrhoid, make mastocyte and basophilic granulocyte take off granule and discharge histamine, the histamine that discharges, histamine is a kind of histamine receptor that stimulates vascular cell from the body active substance, make little vasodilation, endotheliocyte shrinks, and vascular permeability increases, cause the intravascular fluid body to leak, make the intravenous capacity reduce pressure decreased.And the liquid that spills enters into vein position, gap on every side, and its capacity is increased, and pressure raises.Observation hemorrhoid surfaces, injection of sclerosing agent after 10 minutes the hemorrhoid volume obviously swell, quality changes software strategy into software-hardware strategy, produce a kind of stronger aseptic inflammation reaction, comprise vein and arteriolar lasting leakage by blood vessel, the pressure of vein peripheral clearance constantly raises, and final pressure can be near arteriolar pressure.This pressure is apparently higher than intravenous pressure, and vein is under the poor effect of this external and internal pressure.This pressure-acting is in fact a kind of physical effect, and tube wall inwardly bounces back, and tube chamber diminishes.Make the ill vein that dilates return to normal state.After the hemorrhoidal tissue injection seven days, under the effect of medicine, proliferation of fibrous tissue, fibrosis gradually, this fiber holds and fixation vein, and the liquid that leaks into interstice is discharged by the hemorrhoid surface gradually, and the hemorrhoid body shrinks, and until complete obiteration, hemorrhoid are cured.The vein that this position is cured is owing to there be the holding and fixation of fibrous tissue of hypertrophy, makes that this vein no longer dilates, flexing, no longer forms hemorrhoid, reaches the radical cure effect.
The treatment internal hemorrhoid only needs a shot, external hemorrhoid then needs double injection, inject for the first time exactly after one hour again duplicate injection once, medicine is lengthened action time in hemorrhoid, and intensity is larger, can make the part venous occlusion, blood flow is cut off, cause hemorrhoidal tissue oxygen and nutrition supply to reduce, make the part apoptosis, external hemorrhoid is thoroughly cured.Be a kind of algogenic substance by the convention histamine, the inflammation that its caused inflammation and other pathology cause is the same can to make patient's feels pain.Why this medicine not only can not make the patient the pain increased when the injection pain external hemorrhoid, can original pain also disappear on the contrary? its reason is like this, the pressure that this medicine forms in hemorrhoid, vein is shunk, and can also constriction feel and the sensor of teleneuron its function is suppressed, thereby generation and the conduction of retardance nocuity neural impulse, present length than analgesic effect, so this medicine does not have pain until cure yet when the various hemorrhoid for the treatment of.
At present existing sclerosing agent has many kinds, and their action principle is roughly similar with therapeutic effect.When the treatment hemorrhoid, not to rely on its pharmacological action, present therapeutic effect but utilize injection of sclerosing agent to enter the slight aseptic inflammation that produces in the hemorrhoid.And this sclerosing agent is compared with existing sclerosing agent, has outstanding substantial characteristics: 1, existing injection of sclerosing agent enters to produce weak aseptic inflammation in the hemorrhoid, and this sclerosing agent can produce stronger aseptic inflammation, and action intensity is large.
2, the existing slight internal hemorrhoid curative effect of sclerosing treatment is better, to Severe internal hemorrhoids then weak curative effect, can not treat external hemorrhoid because the injection external hemorrhoid can cause the patient to have an intense pain, and this sclerosing agent can be treated weight degree internal hemorrhoid and can be treated all kinds of external hemorrhoids, wide accommodation.
3, this sclerosing agent has the long-acting analgesic function, and this existing sclerosing agent does not have.Because the sclerosing treatment hemorrhoid are to utilize its proinflammatory effect, be not to rely on its pharmacological action.
This Drug therapy mixed hemorrhoids is compared its advantage with conventional treatments; Need not perform the operation, need not anaesthetize, method is easy, with controlling with walking, can replace the existing various hemorrhoid technology of controlling, no pain, not hemorrhage, the elderly and infirm can both bear, no sequel does not recur, and can cure all kinds of hemorrhoid.
1, Chen Changlu, the clear small stream people of Dianjiang, the man, 45 years old, suffer from two of internal hemorrhoid in rectum the right, easily hemorrhage, prolapsus, each hemorrhoid is injected this medicine 0.6ml, stopped bleeding after 2 days, hemorrhoid contraction in 10 days is complete, the healing period no pain.
2, Zhuo Zhonghua, the Dianjiang people, the man, 32 years old, give birth to a thrombosed external hemorrhoid in the anus left side, 1.5 centimeters of diameters, distending pain is unbearably.Inject this liquid medicine 0.5ml, inject 0.5ml after one hour again, pain disappears after several minutes, cures in 20 days.
3, Jiang Zhonglan, the Dianjiang people, the woman, 30 years old, long two inflammatory external hemorrhoids in the anus left side, each hemorrhoid injection 0.3ml, each hemorrhoid injection 0.3ml again after a hour cured in 18 days afterwards.
I was engaged in hemorrhoid treatments for many years, 150 hemorrhoid patients was wherein followed up a case by regular visits to Severe internal hemorrhoids 35 people wherein, slight internal hemorrhoid 27 people by 3 years, go out internal hemorrhoid with bleeding 8 people, mixed hemorrhoid 7 people, severe external hemorrhoid 30 people, slight external hemorrhoid 28 people, thrombosed external hemorrhoid 10 people, rectal polyp 3 people, proctoptosis 2 people.Except 2 proctoptosis patients are twice healing, other hemorrhoid and rectal polyp patient once cure.No one's recurrence in 3 years, also no sequel occurs.
The specific embodiment
Embodiment one:
A, be dissolved in respectively in the 1000 gram sterilized water by proportioning weighing carbolic acid 100 gram, quinine 200 grams, tannic acid 20 grams, placed 10 hours;
B, again the lysate of A step and remaining 3000 gram sterilized water are mixed, stir, stirred once, and precipitated 10 hours in per 3 hours;
C, the medical filtration of B step is removed impurity, autoclaving is for subsequent use.
With the Drug therapy hemorrhoid of C step, routine disinfection enters the hemorrhoid center with drug injection, one centimetre of internal hemorrhoid diameter, 0.5 milliliter of medication, 0.8 milliliter of 1.5 centimetres of medication of diameter, 1.3 milliliters of 2 centimetres of medications of diameter.0.4 milliliter of one centimetre of medication of external hemorrhoid diameter, 0.6 milliliter of 1.5 centimetres of medication of diameter, 0.8 milliliter of 2 centimetres of medication of diameter.External hemorrhoid is after injection one hour, again with same area and identical dose duplicate injection once.The internal hemorrhoid part of mixed hemorrhoid is controlled by internal hemorrhoid, and external hemorrhoid section controls by external hemorrhoid and gets final product.Need fasting spicy food and wine at healing period, and prevention infection.
Embodiment two:
A, be dissolved in respectively in the 1000 gram sterilized water by proportioning weighing carbolic acid 300 gram, quinine 400 grams, tannic acid 30 grams, placed 14 hours;
B, again the lysate of A step and remaining 5000 gram sterilized water are mixed, stir, stirred once in per 5 hours, precipitate 14 hours, repeatedly stir and precipitate 4 times;
C, the medical filtration of B step is removed impurity, autoclaving is for subsequent use.
Embodiment three
A, be dissolved in respectively in the 100 gram sterilized water by proportioning weighing carbolic acid 22 gram, quinine 23 grams, tannic acid 2.5 grams, placed 12 hours;
B, again the lysate of A step and remaining 400 gram sterilized water are mixed, stir, stirred once in per 4 hours, precipitate 12 hours, repeatedly stir and precipitate 2 times;
C, the medical filtration of B step is removed impurity, autoclaving is for subsequent use.
Claims (4)
1. a medicine for the treatment of mixed hemorrhoids is characterized in that it is comprised of effective ingredient and adjuvant, and raw material and the weight proportion of wherein making medicine are:
Tannic acid 20-30 quinine 200-400
Carbolic acid 100-300 sterilized water 4000-6000.
2. a kind of medicine for the treatment of mixed hemorrhoids as claimed in claim 1, its raw material and weight proportion of making medicine is:
Tannic acid 25-30 quinine 200-300
Carbolic acid 200-300 sterilized water 4000-5000.
3. a kind of medicine for the treatment of mixed hemorrhoids as claimed in claim 1, its raw material and weight proportion of making medicine is:
Tannic acid 25 quinines 230
Carbolic acid 220 sterilized water 5000.
4. claim 1,2 or 3 described a kind of medicines for the treatment of mixed hemorrhoids, its manufacture method is:
A, be dissolved in respectively in the sterilized water of 1/5th weight by proportioning weighing carbolic acid, quinine, tannic acid, placed 10～14 hours;
B, again the lysate of A step and remaining sterilized water are mixed, stir, stirred once in per 3～5 hours, precipitate 10～14 hours, repeatedly stir and precipitate 2～4 times;
C, the medical filtration of B step is removed impurity, autoclaving is for subsequent use.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201210055611 CN102552295B (en) | 2012-03-05 | 2012-03-05 | Medicine for treating internal and external hemorrhoids and preparation method thereof |
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| CN 201210055611 CN102552295B (en) | 2012-03-05 | 2012-03-05 | Medicine for treating internal and external hemorrhoids and preparation method thereof |
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| CN102552295A CN102552295A (en) | 2012-07-11 |
| CN102552295B true CN102552295B (en) | 2013-04-24 |
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| CN104971200A (en) * | 2015-07-10 | 2015-10-14 | 浙江红雨医药用品有限公司 | Tannic acid pH-stable hemorrhoid gel and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927219A (en) * | 2005-09-06 | 2007-03-14 | 胡学勤 | Hemorrhoid injection |
| CN101485669A (en) * | 2009-02-13 | 2009-07-22 | 秦克骏 | Medicament for treating tumor and hemorrhoid and method for producing the same |
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2012
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927219A (en) * | 2005-09-06 | 2007-03-14 | 胡学勤 | Hemorrhoid injection |
| CN101485669A (en) * | 2009-02-13 | 2009-07-22 | 秦克骏 | Medicament for treating tumor and hemorrhoid and method for producing the same |
Non-Patent Citations (6)
| Title |
|---|
| 伍炳和.痔动脉周围硬化加痔核结扎法治疗内痔.《湖南医学》.1988,第5卷(第4期),236. |
| 内痔混合痔的枯痔油III号注射治疗;彭兵;《中国基层医学》;19950131;第2卷(第1期);61 * |
| 刘鹤松.消痔灵注射液治疗痔84例体会.《河北医药》.1987,第9卷(第2期),69. |
| 彭兵.内痔混合痔的枯痔油III号注射治疗.《中国基层医学》.1995,第2卷(第1期),61. |
| 消痔灵注射液治疗痔84例体会;刘鹤松;《河北医药》;19871231;第9卷(第2期);69 * |
| 痔动脉周围硬化加痔核结扎法治疗内痔;伍炳和;《湖南医学》;19881231;第5卷(第4期);236 * |
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