CN101711770A - Fomitopsis officinalis (Vill. : Fr.) Bond. polysaccharide particle preparation and preparation method thereof - Google Patents
Fomitopsis officinalis (Vill. : Fr.) Bond. polysaccharide particle preparation and preparation method thereof Download PDFInfo
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- CN101711770A CN101711770A CN200910230080A CN200910230080A CN101711770A CN 101711770 A CN101711770 A CN 101711770A CN 200910230080 A CN200910230080 A CN 200910230080A CN 200910230080 A CN200910230080 A CN 200910230080A CN 101711770 A CN101711770 A CN 101711770A
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- fomitopsis officinalis
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Abstract
The invention belongs to the technical field of medicines, in particular to a Fomitopsis officinalis (Vill. : Fr.) Bond. polysaccharide particle preparation. The particle preparation is prepared by adopting Fomitopsis officinalis (Vill. : Fr.) Bond. polysaccharide as an active component and assisting by other pharmaceutical adjuvant materials which comprise a slow-release material, a filling agent, a bonding agent, a lubricating agent, and the like. The particle preparation solves the problems of low utilization ratio of traditional Chinese medicine effective components of Fomitopsis officinalis (Vill. : Fr.) Bond. and poor curing effect, has the effects of warming the lung, reducing phlegm, alleviating asthma and cough, dispelling wind, eliminating dampness and swelling, invigorating the blood circulation, micturating, and the like, and can reinforce the physical strength, prolong the fatigue resistant and anoxia resistant time and strengthen the stress capability of the human body.
Description
Technical field:
The present invention relates to a kind of Fructificatio Fomitopsis Officinalis polyoses grain preparation, it belongs to a kind of preparation made from Chinese crude drug extract and excipient substance.
Background technology:
Medicinal fungi (medicinal fungi) is meant to be had health-care effect, disease is had treatment and a class fungus of preventive effect human body.Be divided into two big classes: a class is a both for medicine and food, as Lentinus Edodes, Agaricus blazei Murrill, Auricularia, Hericium erinaceus (Bull. Ex Fr.) Pers., JINZHENGU, Caulis Bambusae In Taeniam etc.; Another kind of is medical tailored version, as Ganoderma, Coriolous Dersicolor (Fr.) Quel, Polyporus, Clavicipitaceae, Cordyceps etc.
Fructificatio Fomitopsis Officinalis belongs to the large-scale medical tailored version fungus that the Polyporaceae shelf fungus belongs to, at the Xinjiang aboundresources, it has effects such as warming the lung for resolving phlegm, lowering the adverse-rising QI to subdue asthma, expelling wind and removing dampness, promoting blood circulation and detumescence, diuresis, and energy physical strength reinforcing, prolong resisting fatigue and hypoxia endurance time, and the stress ability [Xinjiang Agricultural Univ's journal, 2002,1 (25): 40-41] of energy enhancing body.Fructificatio Fomitopsis Officinalis contains chemical constituents such as mushroom alkene class, Saponin class and polysaccharide.Wherein polysaccharide is its main effective ingredient [Xinjiang Medical College journal, 1998,2 (21): 158-159].In recent years, bibliographical information Fructificatio Fomitopsis Officinalis polysaccharide has immunological enhancement [Xinjiang Medicine University's journal, 2003,26 (6): 563-565], removes oxygen-derived free radicals effect [Xinjiang Medicine University's journal, 2006,29 (1): 15-17].
Fructificatio Fomitopsis Officinalis is the natural crude drugs in forest zone, Xinjiang, and is widely distributed, collects easily, and exploitation prospect is good.But existing Fructificatio Fomitopsis Officinalis has all adopted the mode of direct drug injection, and wherein the effective medicinal components utilization rate is low, can't reach the medicinal purpose of expection, in order to develop the Fructificatio Fomitopsis Officinalis medicine resource, be badly in need of a kind of can be with its mode of effectively utilizing.
Summary of the invention:
Go up the weak point that exists at existing Fructificatio Fomitopsis Officinalis exploitation, the present invention obtains the Fructificatio Fomitopsis Officinalis polysaccharide to the extraction purification that Fructificatio Fomitopsis Officinalis carries out active ingredient, and it is made Fructificatio Fomitopsis Officinalis polyoses grain preparation with excipient substance.Adopt that to have solved Fructificatio Fomitopsis Officinalis Chinese medicine utilization rate of active components after this mode low, the problem of weak curative effect has effects such as warming the lung for resolving phlegm, lowering the adverse-rising QI to subdue asthma, expelling wind and removing dampness, promoting blood circulation and detumescence, diuresis, and the energy physical strength reinforcing, prolong resisting fatigue and hypoxia endurance time, and the stress ability of energy enhancing body.
For achieving the above object, the technical scheme taked of the present invention is:
Fructificatio Fomitopsis Officinalis polyoses grain preparation of the present invention is made up of active component Fructificatio Fomitopsis Officinalis polysaccharide and pharmaceutically acceptable adjuvant.
Fructificatio Fomitopsis Officinalis polyoses grain preparation raw material component of the present invention is as follows, and each amounts of components is a weight portion:
Fructificatio Fomitopsis Officinalis polysaccharide 100-300 part
Slow-release material 150-300 part
Filler 100-250 part
Binding agent 10-50 part
Lubricant 1-5 part
Wherein the extracting method of Fructificatio Fomitopsis Officinalis polysaccharide is as follows:
Get the Fructificatio Fomitopsis Officinalis coarse powder, successively doubly with 5-15, preferred employing 6-12 doubly, the petroleum ether of weight, ether, each reflux, extract, 1-10 of 60-95% ethanol hour, preferred 4-8 hour, residue is after volatilizing solvent in the water-bath. and reuse 5-15 is doubly, 6-12 times of preferred employing, the water reflux, extract, of weight 1-6 time preferably adopts 3-5 time. and each 1-6 hour, the preferred employing 2-5 hour, merge all extracting solution, cooling, the 1/100-1/20. that is evaporated to original volume adds 95% ethanol, acetone is taken out repeatedly and is washed, the white Fructificatio Fomitopsis Officinalis polysaccharide goods that obtain loosening.Adopt this preparation technology the polysaccharide in the Fructificatio Fomitopsis Officinalis can be extracted, and the efficient of extracting is high, can further improve its utilization rate, and the solvent that is adopted can not influence the drug effect of Fructificatio Fomitopsis Officinalis polysaccharide, guarantee its application pharmaceutically.
Fructificatio Fomitopsis Officinalis polyoses grain preparation of the present invention, selected slow-release material are selected from one or more mixture in hydroxypropyl methylcellulose or ethyl cellulose or cellulose acetate or the Aquacoat.
Fructificatio Fomitopsis Officinalis polyoses grain preparation of the present invention, selected filler are selected from one or more mixture in microcrystalline Cellulose or sucrose or lactose or starch or mannitol or sorbitol or xylitol or dextrin or beta-schardinger dextrin-or calcium carbonate or calcium phosphate or the calcium hydrogen phosphate.
Fructificatio Fomitopsis Officinalis polyoses grain preparation of the present invention, selected binding agent are selected from the alcoholic solution of the polyvinylpyrrolidone of the alcoholic solution of ethyl cellulose of 1-5% or 5-15%.
Fructificatio Fomitopsis Officinalis polyoses grain preparation of the present invention, selected lubricant are selected from one or more mixture in the Polyethylene Glycol of micropowder silica gel or magnesium stearate or Pulvis Talci or micronizing.
Select above-mentioned various adjuvants for use, can be effectively and the Fructificatio Fomitopsis Officinalis polysaccharide be combined into granular preparation, and help to bring into play the drug effect of Fructificatio Fomitopsis Officinalis polysaccharide, make things convenient for the use of user simultaneously.
The preparation method of Fructificatio Fomitopsis Officinalis polyoses grain preparation of the present invention is as follows:
Get the Fructificatio Fomitopsis Officinalis polysaccharide, slow-release material, filler is crossed 100 sieves behind the mix homogeneously, add binding agent, 30-80 ℃ dry 1-10 hour, preferably adopted 4-8 hour, cross 20 mesh sieve granulate then, add lubricant, mixing, tabletting promptly gets Fructificatio Fomitopsis Officinalis polyoses grain preparation.
It is simple that the preparation method of Fructificatio Fomitopsis Officinalis polyoses grain preparation of the present invention has technology, and cost is low, is easy to the advantage of suitability for industrialized production.
It is low that Fructificatio Fomitopsis Officinalis polyoses grain preparation of the present invention has solved Fructificatio Fomitopsis Officinalis Chinese medicine utilization rate of active components, the problem of weak curative effect, have effects such as warming the lung for resolving phlegm, lowering the adverse-rising QI to subdue asthma, expelling wind and removing dampness, promoting blood circulation and detumescence, diuresis, and energy physical strength reinforcing, prolong resisting fatigue and hypoxia endurance time, and the stress ability of energy enhancing body.
The specific embodiment:
In order to understand technical scheme of the present invention better, below describe in further detail by specific embodiment.
Embodiment 1:
Get Fructificatio Fomitopsis Officinalis coarse powder 2kg, use the petroleum ether of 16kg successively, ether, each reflux, extract, of 80% ethanol 4 hours, residue is after volatilizing solvent in the water-bath. the water reflux, extract, of reuse 12kg 3 times. each 3 hours, merge all extracting solution, cooling, be evaporated to 300ml. and add 95% ethanol, acetone is taken out repeatedly and is washed, the white Fructificatio Fomitopsis Officinalis polysaccharide goods that obtain loosening.
Get the above-mentioned Fructificatio Fomitopsis Officinalis polysaccharide of 100g, the 200g hydroxypropyl methylcellulose, the 150g microcrystalline Cellulose is crossed 100 mesh sieves behind the mix homogeneously, add the alcoholic solution of the ethyl cellulose of 20g 1-5%, 60 ℃ of dryings 5 hours, cross 20 mesh sieve granulate then, add the 4g micropowder silica gel, mixing, tabletting promptly gets Fructificatio Fomitopsis Officinalis polyoses grain preparation.
Embodiment 2:
Get Fructificatio Fomitopsis Officinalis coarse powder 2kg, use the petroleum ether of 16kg successively, ether, each reflux, extract, of 80% ethanol 4 hours, residue is after volatilizing solvent in the water-bath. the water reflux, extract, of reuse 12kg 3 times. each 3 hours, merge all extracting solution, cooling, be evaporated to 300ml. and add 95% ethanol, acetone is taken out repeatedly and is washed, the white Fructificatio Fomitopsis Officinalis polysaccharide goods that obtain loosening.
Get the above-mentioned Fructificatio Fomitopsis Officinalis polysaccharide of 100g, the 200g ethyl cellulose, the 150g lactose is crossed 100 mesh sieves behind the mix homogeneously, add the alcoholic solution of the ethyl cellulose of 20g 1-5%, 60 ℃ of dryings 5 hours, cross 20 mesh sieve granulate then, add the 4g magnesium stearate, mixing, tabletting promptly gets Fructificatio Fomitopsis Officinalis polyoses grain preparation.
Embodiment 3:
Get Fructificatio Fomitopsis Officinalis coarse powder 2kg, use the petroleum ether of 16kg successively, ether, each reflux, extract, of 80% ethanol 4 hours, residue is after volatilizing solvent in the water-bath. the water reflux, extract, of reuse 12kg 3 times. each 3 hours, merge all extracting solution, cooling, be evaporated to 300ml. and add 95% ethanol, acetone is taken out repeatedly and is washed, the white Fructificatio Fomitopsis Officinalis polysaccharide goods that obtain loosening.
Get the above-mentioned Fructificatio Fomitopsis Officinalis polysaccharide of 100g, the 200g cellulose acetate, 150g mannitol is crossed 100 mesh sieves behind the mix homogeneously, add the alcoholic solution of the polyvinylpyrrolidone of 20g 5-15%, 60 ℃ of dryings 5 hours, cross 20 mesh sieve granulate then, add the 4g Pulvis Talci, mixing, tabletting promptly gets Fructificatio Fomitopsis Officinalis polyoses grain preparation.
Embodiment 4:
Get Fructificatio Fomitopsis Officinalis coarse powder 2kg, use the petroleum ether of 16kg successively, ether, each reflux, extract, of 80% ethanol 4 hours, residue is after volatilizing solvent in the water-bath. the water reflux, extract, of reuse 12kg 3 times. each 3 hours, merge all extracting solution, cooling, be evaporated to 300ml. and add 95% ethanol, acetone is taken out repeatedly and is washed, the white Fructificatio Fomitopsis Officinalis polysaccharide goods that obtain loosening.
Get the above-mentioned Fructificatio Fomitopsis Officinalis polysaccharide of 100g, the 200g Aquacoat, the 150g beta-schardinger dextrin-is crossed 100 mesh sieves behind the mix homogeneously, add the alcoholic solution of the polyvinylpyrrolidone of 20g 5-15%, 60 ℃ of dryings 5 hours, cross 20 mesh sieve granulate then, add the Polyethylene Glycol of 4g micronizing, mixing, tabletting promptly gets Fructificatio Fomitopsis Officinalis polyoses grain preparation.
Embodiment 5:
Get Fructificatio Fomitopsis Officinalis coarse powder 2kg, use the petroleum ether of 16kg successively, ether, each reflux, extract, of 80% ethanol 4 hours, residue is after volatilizing solvent in the water-bath. the water reflux, extract, of reuse 12kg 3 times. each 3 hours, merge all extracting solution, cooling, be evaporated to 300ml. and add 95% ethanol, acetone is taken out repeatedly and is washed, the white Fructificatio Fomitopsis Officinalis polysaccharide goods that obtain loosening.
Get the above-mentioned Fructificatio Fomitopsis Officinalis polysaccharide of 100g, 200g slow-release material (wherein from hydroxypropyl methylcellulose 100g, cellulose acetate 100g), 150g filler (wherein sucrose 100g, starch 50g) is crossed 100 mesh sieves behind the mix homogeneously, the alcoholic solution that adds the polyvinylpyrrolidone of 20g 5-15%, 60 ℃ of dryings 5 hours are crossed 20 mesh sieve granulate then, add 4g lubricant (micropowder silica gel 2g wherein, the Polyethylene Glycol 2g of micronizing), mixing, tabletting promptly gets Fructificatio Fomitopsis Officinalis polyoses grain preparation.
Claims (6)
1. Fructificatio Fomitopsis Officinalis polyoses grain preparation, it is characterized in that: the active component that is adopted is the Fructificatio Fomitopsis Officinalis polysaccharide, is aided with other pharmaceutic adjuvant, and its raw material components is as follows, and each amounts of components is a weight portion:
Fructificatio Fomitopsis Officinalis polysaccharide 100-300 part
Slow-release material 150-300 part
Filler 100-250 part
Binding agent 10-50 part
Lubricant 1-5 part
Wherein the extracting method of Fructificatio Fomitopsis Officinalis polysaccharide is as follows:
Get the Fructificatio Fomitopsis Officinalis coarse powder, successively with the petroleum ether of 5-15 times of weight, ether, each reflux, extract, 1-10 of 60-95% ethanol hour, residue was after volatilizing solvent in the water-bath. the water reflux, extract, of reuse 5-15 times weight 1-6 time. each 1-6 hour, merge all extracting solution, cooling, the 1/100-1/20. that is evaporated to original volume adds 95% ethanol, and acetone is taken out repeatedly and washed, the white Fructificatio Fomitopsis Officinalis polysaccharide goods that obtain loosening.
2. Fructificatio Fomitopsis Officinalis polyoses grain preparation as claimed in claim 1 is characterized in that: described slow-release material is selected from one or more mixture in hydroxypropyl methylcellulose or ethyl cellulose or cellulose acetate or the Aquacoat.
3. Fructificatio Fomitopsis Officinalis polyoses grain preparation as claimed in claim 1 is characterized in that: described filler is selected from one or more mixture in microcrystalline Cellulose or sucrose or lactose or starch or mannitol or sorbitol or xylitol or dextrin or beta-schardinger dextrin-or calcium carbonate or calcium phosphate or the calcium hydrogen phosphate.
4. Fructificatio Fomitopsis Officinalis polyoses grain preparation as claimed in claim 1 is characterized in that: described binding agent is selected from the alcoholic solution of the polyvinylpyrrolidone of the alcoholic solution of ethyl cellulose of 1-5% or 5-15%.
5. Fructificatio Fomitopsis Officinalis polyoses grain preparation as claimed in claim 1 is characterized in that: described lubricant is selected from one or more mixture in the Polyethylene Glycol of micropowder silica gel or magnesium stearate or Pulvis Talci or micronizing.
6. prepare Fructificatio Fomitopsis Officinalis polyoses grain preparation as claimed in claim 1, its preparation method is as follows:
Get the Fructificatio Fomitopsis Officinalis polysaccharide, slow-release material, filler is crossed 100 mesh sieves behind the mix homogeneously, add binding agent, 30-80 ℃ dry 1-10 hour, cross 20 mesh sieve granulate then, add lubricant, mixing, tabletting promptly gets Fructificatio Fomitopsis Officinalis polyoses grain preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910230080A CN101711770A (en) | 2009-11-13 | 2009-11-13 | Fomitopsis officinalis (Vill. : Fr.) Bond. polysaccharide particle preparation and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910230080A CN101711770A (en) | 2009-11-13 | 2009-11-13 | Fomitopsis officinalis (Vill. : Fr.) Bond. polysaccharide particle preparation and preparation method thereof |
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| CN101711770A true CN101711770A (en) | 2010-05-26 |
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| CN200910230080A Pending CN101711770A (en) | 2009-11-13 | 2009-11-13 | Fomitopsis officinalis (Vill. : Fr.) Bond. polysaccharide particle preparation and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878188A (en) * | 2014-11-06 | 2016-08-24 | 王辉 | Fermented cordyceps sinensis extracellular polysaccharide granules and preparation method thereof |
| CN108079011A (en) * | 2018-01-05 | 2018-05-29 | 新疆医科大学 | Application of the Ali red polysaccharide in prevention or/and treatment Alzheimer disease drug is prepared |
-
2009
- 2009-11-13 CN CN200910230080A patent/CN101711770A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 帕丽达等: "阿里红多糖的提取及含量测定", 《新疆医学院学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878188A (en) * | 2014-11-06 | 2016-08-24 | 王辉 | Fermented cordyceps sinensis extracellular polysaccharide granules and preparation method thereof |
| CN108079011A (en) * | 2018-01-05 | 2018-05-29 | 新疆医科大学 | Application of the Ali red polysaccharide in prevention or/and treatment Alzheimer disease drug is prepared |
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Application publication date: 20100526 |