CN1762236A - Health-caring product capable of increasing human immunity and its preparation method - Google Patents
Health-caring product capable of increasing human immunity and its preparation method Download PDFInfo
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Abstract
The invention provides a health-caring product capable of increasing human immunity and its preparation method, which is prepared mainly from Lentinan 10-100 weight parts, Ganoderma lucidum polysaccharide 10-100 weight parts, Hericium erinaceus polysaccharide 10-100 weight parts, Cordyceps polysaccharide 10-100 weight parts, Polysaccharoses 10-100 weight parts, Polysaccharide of Lycium barbarum 10-100 weight parts, medicinal calcium 50-250 weight parts, vitamin A 0.015-0.075 weight part, vitamin C 10-50 weight parts, vitamin D 0.015-0.075 wt part, vitamin E 1.25-10.0 weight parts, zinc gluconate 8-17 weight parts, carotene-beta 0.015-0.075 weight part, vitamin B1 0.125-0.50 weight part, vitamin B2 0.125-0.50 weight part, vitamin B6 0.125-0.50 weight part, folic acid 0.025-0.050 weight part, and sodium selenite 0.015-0.025 weight part. The invention also provides the process for preparing the health food product.
Description
Technical field
The present invention relates to a kind of health food, particularly a kind of health food of forming by complex polysaccharide that can strengthen immunity; The invention still further relates to the preparation method of this health food.
Background technology
Inside of human body not only has the complete protection immune system of a cover, as lymphoid tissue under thymus gland, spleen, lymph node, the enteron aisle respiratory mucosa etc., can produce the immunocompetent cell of carrying out immunologic function but also have, as T cell, bone-marrow-derived lymphocyte, macrophage etc., these immunocompetent cells, under nerve, body fluid and immune self adjusting, coordinate to carry out the function of oneself mutually, be in a homeostatic normal condition to guarantee human body.Modern immunology is thought; the immunologic function of human body has defence infection, homeostasis and immunosurveillance three to act on greatly; under normal circumstances; body keeps poised state; and the dependence immunologic function, resist various infection, remove harmful substance in the body; promptly " oneself's identification ", " pushing aside or excluding persons of different views " reach homeostatic physiology protective effect.But when immunologic dysfunction, the stable state of self will be broken, and cause the various autoimmune disease, as the generation of rheumatoid arthritis, lupus erythematosus, chorionitis, Behcet, AIDS and other disease, and close ties are all arranged with the generation of the aging of human body and tumour, hypertension, diabetes etc.
Polysaccharide is a kind of baroque macromolecular compound; in the polysaccharide component based on glucan; to have β-1; the straight chain of 3 glucoside bond combinations and β-1; the side chain of 6 glucoside bond combinations constitutes special space structure; has good physiologically active; human health there is important role; as improve immunity of organism; strengthen lymphocytic vigor; strengthen the body defence capability; promote leucocyte to viral bacterium and abnormal cell phagocytic function; eliminate the generation of free radical in the body fluid; prevent the oxidation of cellulose; the protection normal cell reduces cholesterol and hypotensive and blood fat in the blood, can produce multiple antibiotic to virus; bacterium has good inhibition effect etc.Because of it has multiple biologically active and has no side effect, more and more cause people's attention.Facts have proved that complex polysaccharide has sure immunoloregulation function, its effect is multipath, too many levels and many target spots, and complex polysaccharide can produce stronger immune strength.Complex polysaccharide is than the fungi polysaccharide of single type human activin immune system more comprehensively, different fungi polysaccharide molecules is different with structure because of its chemical composition, the approach of its activating immune system is also different, and there is self limitation inevitably in the immunization of the fungi polysaccharide of single kind; And the contained different types of polysaccharide molecule group of complex polysaccharide can activate the immune system of different aspects by the different mechanism of action, produces stronger immunization.
GL-B: glossy ganoderma (Ganoderma luciclum) have the title of " celestial grass in thousand ", record in " Compendium of Materia Medica ", and glossy ganoderma eats for a long time, and it is old to make light of one's life by commiting suicide, and promotes longevity.Studies have shown that, be rich in β-D glucan in the glossy ganoderma, and it is main, and side chain is β-1-6D glucan in conjunction with being β-1-3D glucan that main chain and side chain (branch) are than being 1: this combination of 2.5-3.1 is absorbed by the body its immunocompetence by force and easily.Has multiple efficacies such as improving immunity, suppress tumour, suppress hepatitis viruse, be hypoglycemic, hypotensive.GL-B is extracted by ganoderma lucidum fruitbody, and GL-B mainly shows following several aspects to immune effect: (1) activating macrophage Lee next spring etc. is with regard to GL-B (GLB
7) influence of Turnover of Mouse Peritoneal Macrophages signal transcription process is furtherd investigate, confirm that GL-B can strengthen the phagocytic function of mouse macrophage, causes mouse macrophage [Ca
2+] i and [pH] i rising, increase InsP3 (IP in the macrophage
3) and the generation of DG (DAG) and cAMP and cGMP, promote the mouse macrophage secrete cytokines and influence its protein kinase activity at transcriptional level.(2) activated T cell and B cell GL-B can obviously strengthen mixed lymphocyte culture reaction (MLR), increase total cell yield, obviously enhanced CT L function.(3) influence of the pair cell factor promotes the generation of interleukins (IL): GL-B can increase IL-2 and IL-3 activity in the mixed lymphocytes nutrient solution supernatant, the external expression that can promote mouse boosting cell IL-2 and IL-3 mRNA.
Hericium erinaceum polysaccharide: Hericium erinaceus (Hericium erinaceus) is one of China's famous " eight big mountains delicacy ", and the flat flavor of property is sweet, favourable the five internal organs, aid digestion, the effect that nourishes the body.Hericium erinaceum polysaccharide based on β-1-6D glucan, also contains protein, skin propylhomoserin and several mineral materials by proposing in the hericium mycelium in the polysaccharide composition; The main health-care effect of Hericium erinaceus is to prevent and treat gastrointestinal disease, improves immunocompetence and the effect that suppresses three aspects such as tumour.Total effective rate to treatment cancer of the esophagus, cancer of the stomach reaches 63.8%, at aspects such as anti-ageing, hypoglycemic, blood pressure, blood fat good effect is arranged also.Xu Hangmin reports such as [6], hericium erinaceum polysaccharide has stronger promotion proliferation function to the mouse chest cell with canavaline (ConA) activation.Hericium erinaceus also can significantly promote the propagation of the SPL cultivated, thinks that thus hericium erinaceum polysaccharide has immunoregulation effect.Yu Li equality test hericium erinaceum polysaccharide is given the S180 knurl strain effect that obvious inhibition inoculation is arranged in 1 week of mouse, and is activated the NK cells in mice activity by 50 ~ 200mg/kg dosage, thinks that thus hericium erinaceum polysaccharide has tumor-inhibiting action.
Lentinan: mushroom (Lentinula edodes Pegler) is the traditional famous medicine-food two-purpose fungi of China, and the traditional Chinese medical science is thought mushroom " beneficial gas, not hungry, control the broken blood of wind ".Lentinan based on β-1-3D glucan, contains a spot of wood sugar and mannose by extracting in the mushroom fruiting body in the polysaccharide composition, contains the nutriment to the human body beneficial such as amino acid, protein, trace element in addition.Have antiviral, antitumor, regulate immunologic function and stimulate functions such as interferon formation.Lentinan mainly shows following several aspects to immune effect: (1) activating macrophage lentinan energy activating macrophage, can selectivity improve the activity of Turnover of Mouse Peritoneal Macrophages, and increase its absolute quantity; (2) activated T cell and B cell lentinan are typical T cell reinforcing agents, and it all can promote the generation of specific cytotoxic T lymphocyte (CTL) in vivo and in vitro, and improve the killing activity of CTL.(3) influence of cell factor promotes the generation of interleukins (IL): lentinan can promote that spleen t-cell release IL-burst size is 5 times of blank cell.Promote the generation of interferon (IFN): the lentinan vivo medicine-feeding can induce IF N-γ, behind the administration 12h in the blood plasma concentration of IFN peak, but in vitro test does not have this effect, this may be a kind of mechanism of lentinan viral infection resisting function.(4) there is anticomplementary action activating complement system lentinan inside and outside.Lentinan is by classical path activating complement, and experiment shows that the ACA polysaccharide mostly is acid heteroglycan greatly, and its acidic moiety mainly is galacturonic acid and glucuronic acid.The Radix Astragali is many
Astragalus polyose: the Radix Astragali is the dry root of legume astragalus mongolicus Astragalus membranaceus (Fisch.) Bge.Var.mongholicus (Bge.) Hsiao or Astragalus membranacus Astragalus membranaceus (Fisch.) Bge., contains active stronger triterpenoid saponin (as astragalus saponin 1, second, third), flavonoids, polysaccharide, amino acid and trace element.The Radix Astragali is a traditional Chinese medical science tonifying Qi key medicine, modern study finds that this " tonifying Qi " effect of the Radix Astragali mainly shows enhancing immunity, improves aspects such as heart function and blood microcirculation, can treat coronary heart disease, in heart failure, ICVD, anti-curing cold, treatment children's bronchus asthma, the treatment chronic hepatitis B, chronic nephritis, vital myocarditis, Hemorrhagic fever and peptic ulcer etc.Astragalus polyose mainly shows following several aspects to immune effect: (1) activating macrophage astragalus polyose not only can strengthen the phagocytic function and the quantity of Turnover of Mouse Peritoneal Macrophages, and can resist the inhibitory action of prednisolone (25mg/kg) to phagocytic function fully; (2) activated T cell and B cytoflav astragalus polysaccharides are the T cellular immunity adjuvants based on enhancing T cell function, have the immunoregulation effect of similar thymosin extrasin sample, and the Astragalus membranacus polysaccharide can make the immune system of cancer patient and T cell function recover normal level; (3) activating NK cytoflav astragalus polysaccharides can stimulate NK cell proliferation, improves its activity; (4) influence of the pair cell factor promotes the generation of interleukins (IL): the model of spleen deficiency mouse IL-2 level that astragalus polyose can raise and set up with rheum officinale; Promote the generation of interferon (IFN), astragalus polyose can inducement interferon.
LBP-X: matrimony vine is the ripening fruits of matrimony vine of solanaceae plant; contain LBP-X, several amino acids, trace element, vitamin, taurine, alkaloid, volatilization wet goods chemical composition; have nourishing liver and kidney; the effect of benefiting shrewd head, modern clinical be widely used in reduce blood-fat and blood sugar, protect the liver, antitumor, anti-ageing waiting for a long time.It is generally acknowledged that its main active ingredient is LBP-X (LBP), separation and purification obtains 5 Lycium chinense glycopeptides (being called for short LbGp) that immunocompetence is stronger from LBP in recent years.LBP-X has immune effect:
(1) activated T cell and B cell LBP-X are to strengthen the T cellular immunity adjuvant of T cell function, to have the immunoregulation effect of similar thymosin extrasin sample; (2). activate NK cell mouse lumbar injection LBP-X 5g/L (7d) and can significantly strengthen the killing ability of NK cell, and can partly resist the inhibitory action of endoxan NK cells in mice; (3) influence of the pair cell factor promotes the generation LBP-X of interleukins (IL) can significantly increase the secretion of old-age group or adult mice cell IL-2, also can promote the secretion of IL-3 during low concentration.
Cordyceps sinensis polysaccharide: Cordyceps sinensis (Cordyceps sinensis): be a kind of famous and precious strong tonic Chinese herbal medicine, have cough-relieving, reduce phlegm, tonifying kidney and strengthening yang and moistening lung effect; Cordyceps sinensis polysaccharide is the main active ingredient of artificial aweto, is to extract (peacilomyce hepiahi bacterium strain) by the solid mycelium, and biologically active is strong, adapts to wide.Have the immunity regulated, hypoglycemic, reducing blood lipid, antiatherosclerosis, anti-anoxic, calmness, antiviral, effect such as protect the liver.Can be used for treating toxic and side effect behind hyperlipidemia, atherosclerotic, diabetes, chronic fatigue syndrome, chronic hepatitis, cirrhosis, malignant tumour and the ameliorate tumor radiation and chemotherapy etc.The immunoregulation effect of Cordyceps sinensis polysaccharide mainly shows as Cordyceps sinensis polysaccharide has the T lymphocyte of stimulation and B cell to produce proliferation function, mononuclear macrophage, T lymphocyte, bone-marrow-derived lymphocyte and NK cell all there is effect, it is the wider immunopotentiator of a kind of acting surface, can strengthen Abwehrkraft des Koepers, improve body function, help to delay senility.
Calcium is strengthening aspect the immunity of organisms, and calcium is the opsonic stimulus of serum, can quicken the synthetic of human body complement, induces and strengthens the phagocytosis of macrophage to pathogen, and the pathogenic microorganism that intrudes in the body is had killing action.
Zinc is a kind of important element that participates in immunologic function, and immunologic function is had nutrition and regulating action, and additional zinc can increase the function of spleen, improves the serum antibody level, strengthens the NK cytoactive, improves the ability of body anti-tumor factor, improves anti-infectious ability.
Selenium is polyphenoils, can guarantee that the immune system of human body is not encroached on by eliminating free radical, thereby improve the immunity of human body; But some enzyme of selenium activated lymphocyte, thereby strengthen lymphocytic antitumaous effect.Selenium energy immune stimulatory globulin and production of antibodies strengthen the resistance of body to disease.
Vitamin A has the title of " anti-infection vitamin ", has immunization.Vitamin A can influence the sterilizing ability of engulfing of macrophage (M φ); Vitamin A can strengthen NK (NK cell) activity, blocking-up stress due to atrophy of thymus gland, eliminate the immunosupress that causes by steroid hormone, can also strengthen graft rejection (DCH), eliminate immune tolerance.
Vitamin D (D2 or D3) itself there is no biologically active, and only being converted into could be to internal system, immune system performance regulating action behind the metabolite calcium two pure and mild calcitriol of vitamin D.
Vitamin C can stimulate health to make interferon (a kind of anti-cancer active matter), can encroach on white blood cell by viral interference, activates the leucocyte of whole body, strengthen the phagocytic activity of leucocyte to virus, killing pathogenic bacteria, thus the immunity of enhancing human body makes human body avoid virus infraction.
Vitamin E can strengthen lymphocyte to the IR of mitogen and antigen, antibody response, promotes to engulf.Vitamin E may directly stimulate the B cell to make its propagation, and certain immunosuppressive factor is not activated in the serum and make.
The strengthened immunity medicine and the health food kind of being sold in the market are numerous, the present invention is according to the mechanism and the balanced nutritious principle of the enhancing immunity of various polysaccharide, the various nutrients of polysaccharide such as lentinan, GL-B, hericium erinaceum polysaccharide, Cordyceps sinensis polysaccharide, astragalus polyose, LBP-X and needed by human body such as calcium, zinc, selenium, vitamin A, vitamin D, vitamin C, vitamin E are combined, be intended to improve better the immunocompetence of human body.
Through patent retrieval, adopted matrimony vine water extract in its prescription of the patent report of publication number CN1124627 A " a kind of oral liquid that strengthens immunologic function " by name; Raw materials such as vitamin A, vitamin C, zinc sulfate, mushroom, the Radix Astragali, carrot have been adopted in the patent of publication number CN1034859 A " strengthening the preparation and the production method of immunity nutrient " by name; The patent of publication number CN1135887 A " a kind of Western medicine compound of novel enhanced immunity function " by name is reported in its prescription and has been adopted Cobastab
2, Cobastab
6Deng raw material; The patent of publication number CN1426787 A " health care mixture of antifatigne and enhancing immunity " by name is reported the extract that contains Chinese medicine matrimony vine, mushroom, the Radix Astragali in its prescription; The patent of publication number CN1644095 A " have and strengthen immunity and radiation hazradial bundle is had health products of defencive function and preparation method thereof " by name is reported in its prescription and has been adopted Chinese medicine matrimony vine, the Radix Astragali; Publication number CN1099993, the patent of " biological immunopotentiator " Kangaiping " " by name, the prescription of report is made up of lentinan, licorice polysaccharide, pollen polysaccharide, panaxan and 13 flavor Chinese medicines; Publication number CN1110901, the patent of by name " brain health oral liquor and manufacture craft " has been reported a kind of oral liquid that is made of fish oil micelle and the multiple liquid of lentinan liquid such as (or) fruit juice; The patent of publication number CN1620920 " a kind of composite fungi amylose nutrient " by name has been reported a kind of nutritional agents that contains lentinan, grifolan, Morchella esculenta (L.) Pers polysaccharide, LBP-X powder, PURE WHEY, vinegar, honey, haw berry powder, fructus hordei germinatus powder, vitamin B compound, zinc lactate, calcium carbonate, xylo-oligosaccharide; Publication number CN1252280, the patent of " a kind of biological health-care product with immunoloregulation function " by name has been reported a kind of biological health-care product that contains frozen dry powder of sheep placenta, gynostemma pentaphyllum total saponin, GL-B; Publication number CN1634122 is called the patent of " a kind of pharmaceutical composition and preparation and application that contains panaxan, astragalus polyose ", has reported the pharmaceutical composition of a kind of panaxan of containing, astragalus polyose; Publication number CN1669558 is called the patent of " a kind of Pharmaceutical composition that contains the panaxan ", has reported the Pharmaceutical composition of a kind of panaxan of containing, astragalus polyose, Radix Et Caulis Acanthopanacis Senticosi polysaccharide.And through non-patent retrieval, also not seeing has the report of these 6 kinds of polysaccharide prescriptions being made the health food that strengthens immunity.
Summary of the invention
The present invention will provide a kind of safely, have no side effect, and can systematically strengthen the health food of body immunity comprehensively, the present invention also will provide the preparation method of this health food.
The present invention is to provide a kind of health food that contains the enhancing immunity of complex polysaccharide, the formulation of this health food is a tablet.
Technical scheme of the present invention:
Mainly make by raw material lentinan 10-100 weight portion, GL-B 10-100 weight portion, hericium erinaceum polysaccharide 10-100 weight portion, Cordyceps sinensis polysaccharide 10-100 weight portion, astragalus polyose 10-100 weight portion, LBP-X 10-100 weight portion.
Technical scheme of the present invention can be lentinan 20-60 weight portion, GL-B 20-60 weight portion, hericium erinaceum polysaccharide 20-60 weight portion, Cordyceps sinensis polysaccharide 20-60 weight portion, astragalus polyose 20-60 weight portion, the LBP-X 20-60 weight portion that comprises following weight parts.
Optimized technical scheme can be:
Also can add medicinal calcium 50-250 weight portion, vitamin A 0.015-0.075 weight portion, vitamin C 10-50 weight portion, vitamin D 0.015-0.075 weight portion vitamin E 1.25-10.0 weight portion, zinc gluconate 8-17 weight portion.
The preferred technical scheme of the present invention can also be:
Beta carotene 0.015-0.075 weight portion, the Cobastab that also can comprise following weight parts in its raw material
10.125-0.50 weight portion, Cobastab
20.125-0.50 weight portion, Cobastab
60.125-0.50 weight portion, folic acid 0.025-0.050 weight portion, sodium selenite 0.015-0.025 weight portion.
The preferred technical scheme of the present invention can also be:
Lentinan 40 weight portions, GL-B 40 weight portions, hericium erinaceum polysaccharide 30 weight portions, Cordyceps sinensis polysaccharide 30 weight portions, astragalus polyose 30 weight portions, LBP-X 30 weight portions, calcium carbonate 250 weight portions, vitamin A 0.05 weight portion, vitamin C 25 weight portions, vitamin D 0.05 weight portion, vitamin E 3.75 weight portions, zinc gluconate 8.75 weight portions, beta carotene 0.05 weight portion, Cobastab
10.25 weight portion, Cobastab
20.25 weight portion, Cobastab
60.25 weight portion, folic acid 0.0375 weight portion, sodium selenite 0.0166 weight portion is made.
The health food that can strengthen immunity provided by the present invention, the parts by weight that it also contains auxiliary material are: disintegrant 10-200 weight portion, lubricant 2-12 weight portion.
The said disintegrant of the present invention is microcrystalline cellulose, sodium carboxymethyl starch, PVPP, the mixture of any in the sodium carboxymethylcellulose or two kinds; Lubricant is the mixture of any or two kinds in dolomol, talcum powder and the lauryl sodium sulfate.
The health food that can strengthen immunity provided by the present invention, pharmaceutically acceptable calcium is meant one or more the combination in calcium gluconae, calcium lactate, calcium acetate, calcium citrate, calcium levulinate, Calcium Ascorbate, calcium malate, Aminoacid sequestration calcium, the calcium carbonate in the raw material.
The health food that can strengthen immunity provided by the present invention, vitamin D is meant calciferol, cholecalciferol, 25-(OH) cholecalciferol, 1, the combination of one or more in 25-(OH) 2 cholecalciferols in the raw material.
The health food tablet that can strengthen immunity provided by the present invention, its weight ratio is:
Lentinan 40 weight portions, GL-B 40 weight portions, hericium erinaceum polysaccharide 30 weight portions, Cordyceps sinensis polysaccharide 30 weight portions, astragalus polyose 30 weight portions, LBP-X 30 weight portions, calcium carbonate 250 weight portions, vitamin A 0.05 weight portion, vitamin C 25 weight portions, vitamin D 0.05 weight portion, vitamin E 3.75 weight portions, zinc gluconate 8.75 weight portions, beta carotene 0.05 weight portion, Cobastab
10.25 weight portion, Cobastab
20.25 weight portion, Cobastab
60.25 weight portion, folic acid 0.0375 weight portion, sodium selenite 0.0166 weight portion, microcrystalline cellulose 40 weight portions, sodium carboxymethyl starch 48 weight portions; Dolomol 6 weight portions are formed.
The preparation method that can strengthen the health food of immunity provided by the present invention is: take by weighing the supplementary material mixing by above-mentioned weight ratio, and dry granulation, adding lubricant, compress tablet coating is promptly.
The health food that the present invention can strengthen immunity is by polysaccharide such as lentinan, GL-B, hericium erinaceum polysaccharide, Cordyceps sinensis polysaccharide, astragalus polyose, LBP-Xs, the nutrient that can strengthen immunocompetence with calcium, zinc, selenium, vitamin A, vitamin D, vitamin C, vitamin E etc. combines, reach and strengthen the immunity of organisms effect comprehensively and systematically, taking total amount every day is 2.4 grams.
So health food of the present invention is a kind of safe, without any side effects fully, the natural health care that can take for a long time.
The present invention adopts the dry granulation tablet forming technique, and technology is not only simple, and has avoided the interaction between each raw material, makes product quality more stable, is fit to industrialized production.
The specific embodiment
Embodiment 1
Prescription:
Lentinan 40 weight portions, GL-B 40 weight portions, hericium erinaceum polysaccharide 30 weight portions, LBP-X 30 weight portions, Cordyceps sinensis polysaccharide 30 weight portions, astragalus polyose 30 weight portions, calcium carbonate 250 weight portions, vitamin(e) A acetate (10%) micro-capsule 0.50 weight portion, vitamin D
2(100,000 units/gram) 0.5 weight portion, vitamin C 25 weight portions, Vitwas E (50%) micro-capsule 7.5 weight portions, zinc gluconate 8.75 weight portions, Cobastab
10.25 weight portion, Cobastab
20.25 weight portion, Cobastab
60.25 weight portion, beta carotene (10%) micro-capsule 0.50 weight portion, folic acid 0.0375 weight portion, sodium selenite 0.0166 weight portion, sodium carboxymethyl starch 48 weight portions, microcrystalline cellulose 40.5 weight portions, dolomol 6 weight portions, hydroxypropyl methylcellulose 12 weight portions are made 1000.
Method for making:
Other supplementary materials except that micro-capsule are all crossed 100 mesh sieves; Take by weighing microcrystalline cellulose, sodium carboxymethyl starch, lentinan, GL-B, hericium erinaceum polysaccharide, Cordyceps sinensis polysaccharide, astragalus polyose, LBP-X, calcium carbonate, vitamin(e) A acetate, beta carotene, the Cobastab of recipe quantity
1, Cobastab
2, Cobastab
6, vitamin C, vitamin D
2, Vitwas E, folic acid, zinc gluconate, sodium selenite put in the mixer-granulator and mix, and carries out dry granulation, whole grain, compressing tablet, dressing are promptly.
Embodiment 2
Prescription:
Lentinan 40 weight portions, GL-B 40 weight portions, hericium erinaceum polysaccharide 100 weight portions, Cordyceps sinensis polysaccharide 40 weight portions, astragalus polyose 50 weight portions, LBP-X 40 weight portions, calcium carbonate 200 weight portions, vitamin(e) A acetate (10%) micro-capsule 0.50 weight portion, vitamin D
30.75 weight portion, vitamin C 10 weight portions, Vitwas E (50%) micro-capsule 5 weight portions, zinc gluconate 8.75 weight portions, Cobastab
10.5 weight portion, Cobastab
20.5 weight portion, Cobastab
60.5 weight portion, beta carotene (10%) micro-capsule 0.50 weight portion, folic acid 0.025 weight portion, sodium selenite 0.025 weight portion, PVPP 12 weight portions, microcrystalline cellulose 33 weight portions, dolomol 6 weight portions, hydroxypropyl methylcellulose 12 weight portions are made 1000; Method for making is with embodiment 1.
Embodiment 3
Prescription:
Lentinan 30 weight portions, GL-B 30 weight portions, hericium erinaceum polysaccharide 20 weight portions, Cordyceps sinensis polysaccharide 20 weight portions, astragalus polyose 30 weight portions, LBP-X 100 weight portions, calcium lactate 200 weight portions, vitamin(e) A acetate (10%) micro-capsule 0.50 weight portion, vitamin D
20.50 weight portion, vitamin C 50 weight portions, Vitwas E (50%) micro-capsule 7.5 weight portions, zinc gluconate 17 weight portions, Cobastab
10.25 weight portion, Cobastab
20.25 weight portion, Cobastab
60.25 weight portion, beta carotene (10%) micro-capsule 0.15 weight portion, folic acid 0.035 weight portion, sodium selenite 0.018 weight portion, sodium carboxymethylcellulose 60 weight portions, microcrystalline cellulose 54.5 weight portions, dolomol 2 weight portions, hydroxypropyl methylcellulose 12 weight portions are made 1000; Method for making is with embodiment 1.
Embodiment 4
Prescription:
Lentinan 10 weight portions, GL-B 100 weight portions, hericium erinaceum polysaccharide 20 weight portions, Cordyceps sinensis polysaccharide 10 weight portions, astragalus polyose 100 weight portions, LBP-X 50 weight portions, calcium citrate 50 weight portions, vitamin(e) A acetate (10%) micro-capsule 0.50 weight portion, vitamin D
20.50 weight portion, vitamin C 50 weight portions, Vitwas E (50%) micro-capsule 10 weight portions, zinc gluconate 17 weight portions, Cobastab
10.25 weight portion, Cobastab
20.25 weight portion, Cobastab
60.25 weight portion, beta carotene (10%) micro-capsule 0.50 weight portion, folic acid 0.03 weight portion, sodium selenite 0.02 weight portion, sodium carboxymethylcellulose 36 weight portions, microcrystalline cellulose 126.7 weight portions, dolomol 6 weight portions, hydroxypropyl methylcellulose 12 weight portions, make 1000, method for making is with embodiment 1.
Embodiment 5
Prescription:
Lentinan 100 weight portions, GL-B 10 weight portions, hericium erinaceum polysaccharide 20 weight portions, Cordyceps sinensis polysaccharide 100 weight portions, astragalus polyose 10 weight portions, LBP-X 20 weight portions, calcium gluconae 100 weight portions, vitamin(e) A acetate (10%) micro-capsule 0.75 weight portion, vitamin D
20.15 weight portion, vitamin C 50 weight portions, Vitwas E (50%) micro-capsule 20 weight portions, zinc gluconate 17 weight portions, Cobastab
10.5 weight portion, Cobastab
20.5 weight portion, Cobastab
60.5 weight portion, beta carotene (10%) micro-capsule 0.75 weight portion, folic acid 0.05 weight portion, sodium selenite 0.018 weight portion, sodium carboxymethylcellulose 48 weight portions, microcrystalline cellulose 77.8 weight portions, lauryl sodium sulfate 12 weight portions, hydroxypropyl methylcellulose 12 weight portions, make 1000, method for making is with embodiment 1.
Embodiment 6
Prescription:
Lentinan 60 weight portions, GL-B 50 weight portions, hericium erinaceum polysaccharide 10 weight portions, Cordyceps sinensis polysaccharide 60 weight portions, astragalus polyose 50 weight portions, LBP-X 10 weight portions, amino acid chelated calcium 150 weight portions, vitamin(e) A acetate (10%) micro-capsule 0.50 weight portion, vitamin D
2(100,000 units/gram) 0.50 weight portion, vitamin C 50 weight portions, Vitwas E (50%) micro-capsule 2.5 weight portions, zinc gluconate 17 weight portions, Cobastab
10.125 weight portion, Cobastab
20.125 weight portion, Cobastab
60.125 weight portion, beta carotene (10%) micro-capsule 0.50 weight portion, folic acid 0.035 weight portion, sodium selenite 0.025 weight portion, sodium carboxymethylcellulose 48 weight portions, microcrystalline cellulose 71.6 weight portions, talcum powder 8 weight portions, hydroxypropyl methylcellulose 12 weight portions, make 1000, method for making is with embodiment 1.
Claims (11)
1. health food that can strengthen immunity, it is characterized in that: it is to be made by raw material lentinan 10-100 weight portion, GL-B 10-100 weight portion, hericium erinaceum polysaccharide 10-100 weight portion, Cordyceps sinensis polysaccharide 10-100 weight portion, astragalus polyose 10-100 weight portion, LBP-X 10-100 weight portion basically.
2. the health food of enhancing immunity according to claim 1 is characterized in that the weight ratio of raw material is: lentinan 20-60 part, GL-B 20-60 part, hericium erinaceum polysaccharide 20-60 part, Cordyceps sinensis polysaccharide 20-60 part, astragalus polyose 20-60 part, LBP-X 20-60 part.
3. the health food of enhancing immunity according to claim 2 is characterized in that the weight ratio of raw material is: 40 parts of lentinans, 40 parts of GL-Bs, 30 parts of hericium erinaceum polysaccharides, 30 parts of Cordyceps sinensis polysaccharides, 30 parts of astragalus polyoses, 30 parts of LBP-Xs.
4. according to the health food of the arbitrary described enhancing immunity of claim 1-3, it is characterized in that: pharmaceutically acceptable calcium 50-250 part, vitamin A 0.015-0.075 part, vitamin C 10-50 part, vitamin D 0.015-0.075 part vitamin E 1.25-10.0 part, zinc gluconate 8-17 part of also comprising following weight parts in its raw material.
5. according to the health food of the described enhancing immunity of claim 1-4, it is characterized in that: the beta carotene 0.015-0.075 part, the Cobastab that also comprise following weight parts in its raw material
10.125-0.50 part, Cobastab
20.125-0.50 part, Cobastab
60.125-0.50 part, folic acid 0.025-0.050 part, sodium selenite 0.015-0.025 part.
6. the health food of enhancing immunity according to claim 5 is characterized in that: it is 0.05 part of 8.75 parts of 3.75 parts of 0.05 part of 25 parts of 0.05 part of 250 parts in 30 parts of 30 parts of 30 parts of 30 parts of 40 parts of 40 parts of lentinans, GL-Bs, hericium erinaceum polysaccharides, Cordyceps sinensis polysaccharides, astragalus polyoses, LBP-Xs, calcium carbonate, vitamin A, vitamin Cs, vitamin D, vitamin Es, zinc gluconates, beta carotene, Cobastab by following weight parts
10.25 part, Cobastab
20.25 part, Cobastab
60.25 part, 0.0375 part in folic acid, sodium selenite are made for 0.0166 part.
7. according to the health food of the arbitrary described enhancing immunity of claim 1-6, it is characterized in that: it also contains auxiliary material disintegrant 10-200 weight portion, lubricant 2-12 weight portion; Disintegrant wherein is microcrystalline cellulose, sodium carboxymethyl starch, PVPP, the mixture of any in the sodium carboxymethylcellulose or two kinds; Lubricant is the mixture of any or two kinds in dolomol, talcum powder and the lauryl sodium sulfate.
8. the health food of enhancing immunity according to claim 7 is characterized in that: 40 parts of disintegrant microcrystalline celluloses, 48 parts of sodium carboxymethyl starches, 6 parts of magnesium stearate lubricants.
9. the health food of enhancing immunity according to claim 4 is characterized in that: pharmaceutically acceptable calcium is meant one or more the combination in calcium gluconae, calcium lactate, calcium acetate, calcium citrate, calcium levulinate, Calcium Ascorbate, calcium malate, Aminoacid sequestration calcium, the calcium carbonate in the raw material.
10 health foods according to claim 4 or 6 arbitrary described enhancing immunity, it is characterized in that: vitamin D is meant one or more the combination in vitamin D Z, cholecalciferol, 25 1 (OH) cholecalciferol, 1,25 one (OH), 2 cholecalciferols in the raw material.
11. the preparation method according to the health food of the arbitrary described enhancing immunity of claim 1-10 is characterized in that comprising the steps: taking by weighing by weight the supplementary material mixing, dry granulation, adds lubricant, compress tablet coating promptly.
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