CN101688205B - 抗肿瘤药物、药剂、组合物及其用途 - Google Patents
抗肿瘤药物、药剂、组合物及其用途 Download PDFInfo
- Publication number
- CN101688205B CN101688205B CN2008800159044A CN200880015904A CN101688205B CN 101688205 B CN101688205 B CN 101688205B CN 2008800159044 A CN2008800159044 A CN 2008800159044A CN 200880015904 A CN200880015904 A CN 200880015904A CN 101688205 B CN101688205 B CN 101688205B
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- CN
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- Prior art keywords
- seq
- polypeptide
- cell
- tumour
- protein
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Abstract
Description
引物 | SEQ ID NO | 序列 |
168A-cds-5 | 19 | GACGACGACAAGATGGCCTTTGATGTGTCCTGGTTTG |
168A-cds-4 | 20 | GAGGAGAAGCCCGGTTCAGGGATACTTGAAGGCGTTCAGCACA |
组 | 测试物质 | 处理剂量(mg/kg) | 第12天的MBW(g) | 第28天的MBW(g) | 第12-28天的MBWC(g) |
1 | 载体 | 0 | 22.35±1.17 | 24.40±1.19 | +2.36(±0.59) |
2 | 顺铂 | 5.00 | 21.40±0.85 | 18.69±1.97 | -2.70(±1.57) |
3 | 168A-T2 | 15.0 | 21.74±0.89 | 24.20±1.37 | +2.45(±0.65) |
4 | 168A-T2+顺铂 | 15.0+5.00 | 20.74±1.41 | 18.39±0.74 | -2.35(±1.99) |
Claims (15)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/798,685 | 2007-05-16 | ||
EP07108349.7 | 2007-05-16 | ||
US11/798,685 US7906621B2 (en) | 2007-05-16 | 2007-05-16 | Anti-tumor drug, medicament, composition, and use thereof |
EP20070108349 EP1992694A1 (en) | 2007-05-16 | 2007-05-16 | Anti-tumor drug, medicament, composition, and use thereof |
PCT/EP2008/056075 WO2008138994A1 (en) | 2007-05-16 | 2008-05-16 | Anti-tumor drug, medicament, composition, and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101688205A CN101688205A (zh) | 2010-03-31 |
CN101688205B true CN101688205B (zh) | 2013-07-24 |
Family
ID=39734168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008800159044A Expired - Fee Related CN101688205B (zh) | 2007-05-16 | 2008-05-16 | 抗肿瘤药物、药剂、组合物及其用途 |
Country Status (9)
Country | Link |
---|---|
US (2) | US8742067B2 (zh) |
EP (1) | EP2158317B1 (zh) |
JP (1) | JP5597534B2 (zh) |
CN (1) | CN101688205B (zh) |
AU (1) | AU2008249961B2 (zh) |
CA (1) | CA2685551C (zh) |
ES (1) | ES2674710T3 (zh) |
HK (1) | HK1142631A1 (zh) |
WO (1) | WO2008138994A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2907823A1 (en) * | 2014-02-14 | 2015-08-19 | Gene Signal International SA | Polypeptide fragments of 168A-T2 and compositions comprising them for use in treating cancer |
US9539305B1 (en) | 2014-03-14 | 2017-01-10 | Fleurir Abx Llc | Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002081731A2 (en) * | 2001-01-30 | 2002-10-17 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
WO2006029183A2 (en) * | 2004-09-08 | 2006-03-16 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004031211A2 (en) * | 2002-10-03 | 2004-04-15 | Epimmune Inc. | Hla binding peptides and their uses |
US5747660A (en) | 1995-11-06 | 1998-05-05 | The University Of Colorado | Nucleic acid encoding prostaglandin F2α receptor regulatory protein |
AU7180298A (en) | 1996-11-15 | 1998-06-03 | Cedars-Sinai Medical Center | Nucleic acid encoding schwannominbinding-proteins and products related th ereto |
EP0996725A1 (en) | 1997-06-27 | 2000-05-03 | Human Genome Sciences, Inc. | Human nk-3 related prostate specific gene-1 |
US7034132B2 (en) * | 2001-06-04 | 2006-04-25 | Anderson David W | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
FR2798674B1 (fr) | 1999-09-21 | 2004-01-30 | Mahmood Salman Al | Procede d'identification de nouveaux genes impliques dans la regulation de l'angiogenese, etude de ces genes et leur utilisation a des fins therapeutiques |
WO2001060860A2 (en) | 2000-02-17 | 2001-08-23 | Millennium Predictive Medicine, Inc. | Genes differentially expressed in human prostate cancer and their use |
US7092985B2 (en) * | 2000-03-30 | 2006-08-15 | United Devices, Inc. | Method of managing workloads and associated distributed processing system |
AU2001274888A1 (en) * | 2000-05-19 | 2001-12-03 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
WO2002034783A2 (en) | 2000-10-27 | 2002-05-02 | Incyte Genomics, Inc. | Transmembrane proteins |
US20020137081A1 (en) | 2001-01-08 | 2002-09-26 | Olga Bandman | Genes differentially expressed in vascular tissue activation |
EP1401858A4 (en) | 2001-06-04 | 2005-12-21 | Curagen Corp | THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS COATING THEREOF AND METHOD OF USE |
EP1992643A3 (en) * | 2001-06-20 | 2008-12-10 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
FR2836687A1 (fr) | 2002-03-04 | 2003-09-05 | Gene Signal | Genes impliques dans la regulation de l'angiogenese, preparations pharmaceutiques les contenant et leurs applications |
FR2837391B1 (fr) | 2002-03-22 | 2007-04-20 | Gene Signal | Genes regulateurs de l'angiogenese, preparations pharmaceutiques les contenant et leurs applications |
US7803906B2 (en) * | 2002-03-22 | 2010-09-28 | Gene Signal International Sa | Composition comprising an angiogenesis related protein |
EP1585482A4 (en) | 2002-09-25 | 2009-09-09 | Genentech Inc | NEW COMPOSITIONS AND METHODS FOR TREATING PSORIASIS |
-
2008
- 2008-05-16 JP JP2010507938A patent/JP5597534B2/ja not_active Expired - Fee Related
- 2008-05-16 ES ES08759707.6T patent/ES2674710T3/es active Active
- 2008-05-16 EP EP08759707.6A patent/EP2158317B1/en not_active Not-in-force
- 2008-05-16 CN CN2008800159044A patent/CN101688205B/zh not_active Expired - Fee Related
- 2008-05-16 CA CA2685551A patent/CA2685551C/en not_active Expired - Fee Related
- 2008-05-16 AU AU2008249961A patent/AU2008249961B2/en not_active Ceased
- 2008-05-16 WO PCT/EP2008/056075 patent/WO2008138994A1/en active Application Filing
- 2008-05-16 US US12/600,329 patent/US8742067B2/en not_active Expired - Fee Related
-
2010
- 2010-09-24 HK HK10109169.4A patent/HK1142631A1/xx not_active IP Right Cessation
-
2014
- 2014-01-17 US US14/157,753 patent/US9539306B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002081731A2 (en) * | 2001-01-30 | 2002-10-17 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
WO2006029183A2 (en) * | 2004-09-08 | 2006-03-16 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
Also Published As
Publication number | Publication date |
---|---|
AU2008249961A1 (en) | 2008-11-20 |
CN101688205A (zh) | 2010-03-31 |
US20100151051A1 (en) | 2010-06-17 |
EP2158317B1 (en) | 2018-03-28 |
US20140134276A1 (en) | 2014-05-15 |
EP2158317A1 (en) | 2010-03-03 |
JP2010526549A (ja) | 2010-08-05 |
AU2008249961B2 (en) | 2017-02-02 |
CA2685551C (en) | 2016-11-29 |
ES2674710T3 (es) | 2018-07-03 |
HK1142631A1 (en) | 2010-12-10 |
WO2008138994A1 (en) | 2008-11-20 |
US8742067B2 (en) | 2014-06-03 |
JP5597534B2 (ja) | 2014-10-01 |
US9539306B2 (en) | 2017-01-10 |
CA2685551A1 (en) | 2008-11-20 |
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