CN101574087A - Polyhexamethylene guanidine propionate disinfectant and preparation method thereof - Google Patents
Polyhexamethylene guanidine propionate disinfectant and preparation method thereof Download PDFInfo
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- CN101574087A CN101574087A CNA2008100968411A CN200810096841A CN101574087A CN 101574087 A CN101574087 A CN 101574087A CN A2008100968411 A CNA2008100968411 A CN A2008100968411A CN 200810096841 A CN200810096841 A CN 200810096841A CN 101574087 A CN101574087 A CN 101574087A
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- disinfectant
- polyhexamethylene guanidine
- guanidine propionate
- propionate
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Abstract
The invention provides a polyhexamethylene guanidine propionate disinfectant and a preparation method thereof. The polyhexamethylene guanidine propionate disinfectant is a hydrophilic solution prepared by the following steps: adding polyhexamethylene guanidine propionate, citric acid and surfactant to water and uniformly stirring the mixture at normal temperature. The polyhexamethylene guanidine propionate disinfectant has the advantages of broad spectrum of disinfection, quick results, long-time disinfection capability, high safety, non-toxicity, environmental protection, high stability, easy application, quick infiltration and volatilization, no coloration, easy cleaning, and the like. The polyhexamethylene guanidine propionate disinfectant has strong sterilization functions for colon bacillus, staphylococcus aureus, candida albicans, and the like with two-year effective periods. The polyhexamethylene guanidine propionate disinfectant can be used for disinfection of skins, wound surfaces, hands, air, departments of gynecology and urology, drinking water, and the like, thereby being a novel and ideal disinfectant.
Description
Technical field
The present invention relates to a kind of disinfectant and preparation method thereof, specifically a kind of polyhexamethylene guanidine propionate class disinfectant and preparation method thereof.
Background technology
Detrimental microorganisms can be brought a lot of diseases to the mankind, serious harm people's life security.So for people's health, sterilizing becomes safeguards the requisite important step of human life's safety.And the most convenient, commonly used be various disinfectants.As everyone knows, disinfectant generally all has bigger penetrating odor and stronger corrosiveness, and most bactericide has bigger toxicity, can cause environmental pollution, and some disinfectant has carcinogenesis.The sterilization expert proposes the requirement to best disinfectant: fungicidal spectrum is wide; Valid density is low; Speed of action is fast; Stable in properties; Soluble in water; Can use at normal temperatures; Antibacterial for a long time, have no side effect; Non-corrosiveness; Colourless, tasteless, nothing is smelt; Toxicity is low; Do not fire, not quick-fried, safe in utilization; Cheap; Convenient transportation.According to expert's investigation for many years, the disinfectant of Shi Yonging all can not satisfy above requirement fully in the market.
And guanidine class disinfectant disinfectant belong to that safety is the highest, effect is best one of, wherein Polyhaxemethylenguanidine Hydrochloride has begun to be applied as a kind of raw material of disinfectant, but, therefore limited it and used in sterilization such as aspects such as medicine equipment, pipeline, precision instrument, electronic circuits because Polyhaxemethylenguanidine Hydrochloride has certain corrosivity to aluminium, copper.And polyhexamethylene guanidine propionate just has been developed as a kind of novel guanidine like polymer, and it is compared with Polyhaxemethylenguanidine Hydrochloride, also has complete free from corrosion performance, therefore it is prepared disinfectant as the primary raw material of disinfectant, so just overcome the weakness of original Polyhaxemethylenguanidine Hydrochloride, the present invention is that primary raw material is prepared a kind of new disinfectant with the polyhexamethylene guanidine propionate exactly.
Summary of the invention
The objective of the invention is to develop safety non-toxic, environmental protection, the free from corrosion disinfectant that a kind of polyhexamethylene guanidine propionate is a main component.
The hydrophilic solution that polyhexamethylene guanidine propionate disinfectant of the present invention is made up of polyhexamethylene guanidine propionate, citric acid, surfactant and water.This disinfectant has the performance of broad-spectrum antiseptic, long-acting bacteriostatic, and has totally nontoxic, non-stimulated, no burn into degradable environmental protection characteristic, therefore it is used the disinfection of each environment aspects such as hand, body surface, water, air.
The concrete technical scheme that realizes the object of the invention is: by weight forming, polyhexamethylene guanidine propionate accounts for 0.1%～0.5% to polyhexamethylene guanidine propionate disinfectant by following each component, citric acid accounts for 0.01%～0.04%, surfactant comprise 1%～2%, water account for 97.5%～98%; The pH value of solution value is 5.0～8.0.
With content polyhexamethylene guanidine propionate, citric acid, surfactant are mixed with water by said components, stir at normal temperatures, PH to adjust to 5.0～8.0 afterwards disinfectant.
Citric acid is used for regulating the pH value.
Surfactant is to be used for acting synergistically with polyhexamethylene guanidine propionate, increase effect, it can make this disinfectant products have easy to use, be easy to smear, moulding property preferably can be arranged after the drying, can reach long-term antibiotic effect, according to the actual conditions reaction, use the metope after this disinfectant is sterilized to keep trimestral antibacterial effect.Polyhexamethylene guanidine propionate is a bactericidal component, its sterilization mechanism is the acting in conjunction of chemistry and physics, at first it can be elecrtonegativity cells of microorganisms film strong effect usually, destroy microorganisms storage power and nutrient are carried necessary ion gradient, even cause the endochylema seepage; Polymer becomes electropositive simultaneously, be easy to be usually electronegative each bacterioid, viral adsorbed and winding, thereby the splitting function that has suppressed bacterium, virus, make bacterium, virus lose fecundity, add that the film of polymer formation has stopped up the respiration channel of microorganism, is choked to death microorganism rapidly.Thereby its has a broad antifungal spectrum, and microorganism is difficult for developing immunity to drugs.
This disinfectant uses the New-type wide-spectrum antimicrobial-polyhexamethylene guanidine propionate of up-to-date research and development to be primary raw material, cooperate suitable surfactant, its sterilizing, long-term antibacterial effect have been strengthened, this product has powerful killing action to bacterial viruses such as Escherichia coli, staphylococcus aureus, Candida albicans, influenza viruses, and has long antibacterial action.It can be applied in fields such as skin and surface of a wound sterilization, hand sterilization, air sterillization, gynaecology and urological department sterilization, drinking water disinfection, is new disinfectant widely applicable, safety and environmental protection.
Embodiment
Among the embodiment of the following stated, except that specializing, inventory all is meant weight.
Embodiment
0.5 part of polyhexamethylene guanidine propionate, 0.1 part of citric acid, 1 part of propane diols and 98.4 parts of water mixing and stirring are promptly got disinfectant, and the pH value is 7.0.
Claims (3)
1, a kind of polyhexamethylene guanidine propionate disinfectant, it is characterized in that this disinfectant by following component by weight forming: polyhexamethylene guanidine propionate accounts for 0.1%～0.5%, citric acid accounts for 0.01%～0.04%, surfactant comprise 1%～2%, water account for 97.5%～98%; The pH value of solution value is 5.0～8.0.
2, disinfectant described in a kind of claim 1, wherein said surfactant is propane diols, polyethylene glycol or fatty alcohol-polyoxyethylene ether.
3, the preparation method of disinfectant described in a kind of claim 1 or 2, it is characterized in that with content polyhexamethylene guanidine propionate, citric acid, surfactant being mixed with water by component described in 1 or 2 in claims, stir at normal temperatures, pH is to adjusting to 5.0～8.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100968411A CN101574087A (en) | 2008-05-05 | 2008-05-05 | Polyhexamethylene guanidine propionate disinfectant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100968411A CN101574087A (en) | 2008-05-05 | 2008-05-05 | Polyhexamethylene guanidine propionate disinfectant and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101574087A true CN101574087A (en) | 2009-11-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100968411A Pending CN101574087A (en) | 2008-05-05 | 2008-05-05 | Polyhexamethylene guanidine propionate disinfectant and preparation method thereof |
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| CN (1) | CN101574087A (en) |
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102138567A (en) * | 2011-02-22 | 2011-08-03 | 刘俊阁 | Composite preparation for killing bacteria and removing algae under water environment |
| CN102217588A (en) * | 2010-04-15 | 2011-10-19 | 上海于泽生物科技有限公司 | Tissue specimen preserving fluid and application of water-soluble polyhexamethylene guanidine derivative |
| CN102835924A (en) * | 2012-08-29 | 2012-12-26 | 苏州宝丽洁日化有限公司 | Wet cloth for kitchen cleaning |
| CN103070798A (en) * | 2012-09-14 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Soft skin cleaning wet tissue |
| CN103070793A (en) * | 2012-09-14 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Health sterilization wet tissue |
| CN103070629A (en) * | 2012-09-14 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Care sanitary wet tissue |
| CN103070794A (en) * | 2012-09-14 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Health sterilization emulsion and preparation method thereof |
| CN103070796A (en) * | 2012-09-14 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Care health emulsion and preparation method thereof |
| CN103070797A (en) * | 2012-09-14 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Skin cleaning emulsion and preparation method thereof |
| CN103141469A (en) * | 2013-03-18 | 2013-06-12 | 广东海洋大学 | Use of polyhexamethylene guanidine as animal specimen mildew preventive |
| CN103202785A (en) * | 2012-09-14 | 2013-07-17 | 苏州宝丽洁日化有限公司 | Emulsion for preventing baby's red butt and preparation method thereof |
| CN103202670A (en) * | 2012-09-14 | 2013-07-17 | 苏州宝丽洁日化有限公司 | Wet tissue for preventing buttocks of infant from becoming red |
| CN103600726A (en) * | 2013-10-31 | 2014-02-26 | 苏州宝丽洁日化有限公司 | Anti-fog wet tissue of automotive glass |
| CN105213312A (en) * | 2015-10-30 | 2016-01-06 | 卫国刚 | Polyhexamethylene guanidine propionate cream for treating dexmatosis and spray |
| CN105232456A (en) * | 2015-11-06 | 2016-01-13 | 卫国刚 | Polyhexamethylene guanidine propionate eye drop |
| CN105232455A (en) * | 2015-11-06 | 2016-01-13 | 卫国刚 | Polyhexamethylene guanidine propionate auristilla |
| CN105343165A (en) * | 2015-10-30 | 2016-02-24 | 卫国刚 | Polyhexamethylene guanidine propionate lotion, gel and suppository for department of gynecology |
| CN105362225A (en) * | 2015-11-06 | 2016-03-02 | 卫国刚 | Propionic acid polyhexamethylene guanidine oral spray |
| CN107047602A (en) * | 2016-12-08 | 2017-08-18 | 雅克维生物药业（江苏）有限公司 | A kind of polyhexamethylene guanide effervescent tablet and preparation method thereof |
| CN107788013A (en) * | 2017-11-17 | 2018-03-13 | 侯英 | Drink water purifying disinfectant and preparation method thereof |
| CN110339089A (en) * | 2019-08-22 | 2019-10-18 | 上海奇良生物科技有限公司 | Lotion is smeared in a kind of external application of the antibacterial smelly anti-drying peeling of dispelling of strength hidroschesis |
| CN111759805A (en) * | 2020-08-03 | 2020-10-13 | 山东莱博生物科技有限公司 | Oral and facial sterilizing and antiviral spray and preparation method and application thereof |
| CN113303330A (en) * | 2021-05-12 | 2021-08-27 | 开贝纳米科技(苏州)有限公司 | Composite disinfectant and preparation process thereof |
-
2008
- 2008-05-05 CN CNA2008100968411A patent/CN101574087A/en active Pending
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102217588B (en) * | 2010-04-15 | 2014-07-16 | 上海于泽生物科技有限公司 | Tissue specimen preserving fluid and application of water-soluble polyhexamethylene guanidine derivative |
| CN102217588A (en) * | 2010-04-15 | 2011-10-19 | 上海于泽生物科技有限公司 | Tissue specimen preserving fluid and application of water-soluble polyhexamethylene guanidine derivative |
| CN102138567A (en) * | 2011-02-22 | 2011-08-03 | 刘俊阁 | Composite preparation for killing bacteria and removing algae under water environment |
| CN102835924A (en) * | 2012-08-29 | 2012-12-26 | 苏州宝丽洁日化有限公司 | Wet cloth for kitchen cleaning |
| CN103070794A (en) * | 2012-09-14 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Health sterilization emulsion and preparation method thereof |
| CN103070629A (en) * | 2012-09-14 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Care sanitary wet tissue |
| CN103070793A (en) * | 2012-09-14 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Health sterilization wet tissue |
| CN103070796A (en) * | 2012-09-14 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Care health emulsion and preparation method thereof |
| CN103070797A (en) * | 2012-09-14 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Skin cleaning emulsion and preparation method thereof |
| CN103202785A (en) * | 2012-09-14 | 2013-07-17 | 苏州宝丽洁日化有限公司 | Emulsion for preventing baby's red butt and preparation method thereof |
| CN103202670A (en) * | 2012-09-14 | 2013-07-17 | 苏州宝丽洁日化有限公司 | Wet tissue for preventing buttocks of infant from becoming red |
| CN103070798A (en) * | 2012-09-14 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Soft skin cleaning wet tissue |
| CN103141469A (en) * | 2013-03-18 | 2013-06-12 | 广东海洋大学 | Use of polyhexamethylene guanidine as animal specimen mildew preventive |
| CN103600726A (en) * | 2013-10-31 | 2014-02-26 | 苏州宝丽洁日化有限公司 | Anti-fog wet tissue of automotive glass |
| CN105213312A (en) * | 2015-10-30 | 2016-01-06 | 卫国刚 | Polyhexamethylene guanidine propionate cream for treating dexmatosis and spray |
| CN105343165A (en) * | 2015-10-30 | 2016-02-24 | 卫国刚 | Polyhexamethylene guanidine propionate lotion, gel and suppository for department of gynecology |
| CN105232456A (en) * | 2015-11-06 | 2016-01-13 | 卫国刚 | Polyhexamethylene guanidine propionate eye drop |
| CN105232455A (en) * | 2015-11-06 | 2016-01-13 | 卫国刚 | Polyhexamethylene guanidine propionate auristilla |
| CN105362225A (en) * | 2015-11-06 | 2016-03-02 | 卫国刚 | Propionic acid polyhexamethylene guanidine oral spray |
| CN107047602A (en) * | 2016-12-08 | 2017-08-18 | 雅克维生物药业（江苏）有限公司 | A kind of polyhexamethylene guanide effervescent tablet and preparation method thereof |
| CN107788013A (en) * | 2017-11-17 | 2018-03-13 | 侯英 | Drink water purifying disinfectant and preparation method thereof |
| CN110339089A (en) * | 2019-08-22 | 2019-10-18 | 上海奇良生物科技有限公司 | Lotion is smeared in a kind of external application of the antibacterial smelly anti-drying peeling of dispelling of strength hidroschesis |
| CN111759805A (en) * | 2020-08-03 | 2020-10-13 | 山东莱博生物科技有限公司 | Oral and facial sterilizing and antiviral spray and preparation method and application thereof |
| CN113303330A (en) * | 2021-05-12 | 2021-08-27 | 开贝纳米科技(苏州)有限公司 | Composite disinfectant and preparation process thereof |
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Application publication date: 20091111 |