CN105362225A - Propionic acid polyhexamethylene guanidine oral spray - Google Patents
Propionic acid polyhexamethylene guanidine oral spray Download PDFInfo
- Publication number
- CN105362225A CN105362225A CN201510745814.2A CN201510745814A CN105362225A CN 105362225 A CN105362225 A CN 105362225A CN 201510745814 A CN201510745814 A CN 201510745814A CN 105362225 A CN105362225 A CN 105362225A
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- CN
- China
- Prior art keywords
- polyhexamethylene guanidine
- solution
- propionic acid
- acid polyhexamethylene
- oral spray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a propionic acid polyhexamethylene guanidine oral spray and relates to the field of oral sprays. According to the formula, the oil spray is prepared from the following raw materials of 0.05%-0.5% of propionic acid polyhexamethylene guanidine, 1% of synergist, 20%-30% of glycerinum, 0.001%-0.5% of saccharin sodium, 0.05% of mint, 0.05% of solubilizer and 67.9%-79% of purified water. The production process comprises the following steps that the mint and the solubilizer are prepared according to the proportion and stirred for 15-20 minutes, and a water soluble mint solution A is obtained; the propionic acid polyhexamethylene guanidine and the synergist are added to the purified water sequentially according to the proportion and stirred for 5-10 minutes, and a solution B is obtained; the water soluble mint solution A, the glycerinum and the saccharin sodium are added to the solution B sequentially according to the proportion after the solution B is stirred uniformly, stirring is performed for 20-30 minutes, and the propionic acid polyhexamethylene guanidine oral spray is obtained. The propionic acid polyhexamethylene guanidine oral spray has the advantages that the oral spray is rapid to take effect, has no stimulation to mucosa, skin and the wound, no toxic or side effect or drug resistance, and has high cover protection capacity and the function of repairing and improving mucosa defense.
Description
Technical field:
The present invention relates to mouth sprays field, be specifically related to polyhexamethylene guanidine propionate mouth sprays.
Background technology:
Mouth sprays, heat-clearing and toxic substances removing, anti-inflammatory analgetic, is used for the treatment of stomatitis, oral ulcer, pharyngolaryngitis etc.
Existing mouth sprays, can produce certain stimulation to mucosa, skin, wound, have certain Drug resistance, permanence operation can reduce.
Summary of the invention:
The object of the invention is to the defect for prior art and deficiency; there is provided a kind of polyhexamethylene guanidine propionate mouth sprays reasonable in design, it is rapid-action, and sterilization rapidly; successful; mucosa, skin, wound are not stimulated, has no side effect, safe and reliable; unique pathogenic bacteria principle of killing makes it without Drug resistance; permanence operation does not subtract, and has very strong covering protection ability, repairs, improves the defense function of mucosa.
In order to solve the problem existing for background technology, the technical solution used in the present invention is: its formula is as follows:
Production technology is as follows:
1, Herba Menthae and solubilizing agent prepared according to aforementioned proportion and stir 15-20 minute, obtaining water-soluble Herba Menthae solution A;
2, according to aforementioned proportion, polyhexamethylene guanidine propionate, synergist are added in pure water successively, stir 5-10 minute, obtain solution B;
3, after stirring, more water-soluble Herba Menthae solution A, glycerol, saccharin sodium are added in solution B according to the above ratio, stir and namely obtain polyhexamethylene guanidine propionate mouth sprays in 20-30 minute.
Beneficial effect of the present invention is: it is rapid-action; sterilization rapidly; successful; mucosa, skin, wound are not stimulated, has no side effect, safe and reliable; unique pathogenic bacteria principle of killing makes it without Drug resistance; permanence operation does not subtract, and has very strong covering protection ability, repairs, improves the defense function of mucosa.
Detailed description of the invention:
Below in conjunction with detailed description of the invention, the present invention is further illustrated.
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with detailed description of the invention, the present invention is further elaborated.Should be appreciated that detailed description of the invention described herein only in order to explain the present invention, be not intended to limit the present invention.
This detailed description of the invention adopts following technical scheme: its formula is as follows:
Production technology is as follows:
1, the Herba Menthae of 0.05% and the solubilizing agent of 0.05% prepared and stir 15-20 minute, obtaining water-soluble Herba Menthae solution A;
2, by the polyhexamethylene guanidine propionate of 0.5%, 1% synergist add successively in the pure water of 77.9%, stir 5-10 minute, obtain solution B;
3, after stirring, more water-soluble Herba Menthae solution A, the glycerol of 20%, the saccharin sodium of 0.5% are added in solution B, stir and namely obtain polyhexamethylene guanidine propionate mouth sprays in 20-30 minute.
This product has anti-inflammatory analgetic effect, can be used as the medicine for treatment of the diseases such as the caused gingival hemorrhage such as acute and chronic gingivitis, pericoronitis, oral mucositis, periodontal turgescene and pyorrhea halitosis, oral ulcer, usage and dosage is: be sprayed directly on to affected part, oral cavity, under each 3-5, every day 1-3 time 5th ~ 10 is a course for the treatment of.
This product Main Ingredients and Appearance is polyhexamethylene guanidine propionate, has broad-spectrum bactericidal action to Grain-positive, gram-negative bacteria; To pathogenic bacterium such as staphylococcus, Streptococcus mutans, streptococcus salivarius, Candida albicans, escherichia coli, anaerobism bacterium acidi propionici, bloodthirsty streptococcus, Proteus, Rhodopseudomonas, Kleb, bacteroides fragilis genus and other Bacteroidess, fusiform bacilarmature, aerogenesis clostridium, Eubacterium, Wei Rong coccus, dyspepsiacoccus, peptostreptococcus, actinomyces, Lactobacillus, propionibacteriums, there is bactericidal action.Its mechanism of action is that active ingredient becomes electropositive, be easy to by electronegative each bacterioid, fungus, virus adsorb and be wound around, thus suppress the splitting function of pathogenic bacteria, make antibacterial lose fertility, add the respiration channel plugging microorganism, microorganism is choked to death rapidly.
Through mucous membrane stimulation, Skin Irritation Test, Eye irritation, repeatedly intact skin stimulate and a damaged skin experiment, belong to nonirritant; Through acute oral toxicity, acute inhalation toxicity, subacute toxicity test, micronucleus test, all belong to nontoxic.
This detailed description of the invention is rapid-action; sterilization rapidly; successful; mucosa, skin, wound are not stimulated, has no side effect, safe and reliable; unique pathogenic bacteria principle of killing makes it without Drug resistance; permanence operation does not subtract, and has very strong covering protection ability, repairs, improves the defense function of mucosa.
The above, only in order to technical scheme of the present invention to be described and unrestricted, other amendment that those of ordinary skill in the art make technical scheme of the present invention or equivalently to replace, only otherwise depart from the spirit and scope of technical solution of the present invention, all should be encompassed in the middle of right of the present invention.
Claims (2)
1. polyhexamethylene guanidine propionate mouth sprays, is characterized in that formula is as follows:
2. polyhexamethylene guanidine propionate mouth sprays according to claim 1, is characterized in that production technology is as follows:
One, Herba Menthae and solubilizing agent prepared according to aforementioned proportion and stir 15-20 minute, obtaining water-soluble Herba Menthae solution A;
Two, according to aforementioned proportion, polyhexamethylene guanidine propionate, synergist are added in pure water successively, stir 5-10 minute, obtain solution B;
Three, after stirring, more water-soluble Herba Menthae solution A, glycerol, saccharin sodium are added in solution B according to the above ratio, stir and namely obtain polyhexamethylene guanidine propionate mouth sprays in 20-30 minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510745814.2A CN105362225A (en) | 2015-11-06 | 2015-11-06 | Propionic acid polyhexamethylene guanidine oral spray |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510745814.2A CN105362225A (en) | 2015-11-06 | 2015-11-06 | Propionic acid polyhexamethylene guanidine oral spray |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105362225A true CN105362225A (en) | 2016-03-02 |
Family
ID=55365186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510745814.2A Pending CN105362225A (en) | 2015-11-06 | 2015-11-06 | Propionic acid polyhexamethylene guanidine oral spray |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105362225A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214926A (en) * | 2016-07-29 | 2016-12-14 | 腾科宝迪（厦门）生物科技有限公司 | A kind of nasal spray and preparation method thereof |
| CN115006348A (en) * | 2022-07-11 | 2022-09-06 | 振德医疗用品股份有限公司 | Long-acting spray for oral mucosa and nasal mucosa, preparation method and application |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101574087A (en) * | 2008-05-05 | 2009-11-11 | 铜陵高聚生物科技有限公司 | Polyhexamethylene guanidine propionate disinfectant and preparation method thereof |
| CN102870797A (en) * | 2011-07-15 | 2013-01-16 | 上海泽旭生物科技有限公司 | Sterilizing deodorant |
| CN104586767A (en) * | 2014-12-31 | 2015-05-06 | 卫国刚 | Polyhexamethylene guanidine oral spray |
-
2015
- 2015-11-06 CN CN201510745814.2A patent/CN105362225A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101574087A (en) * | 2008-05-05 | 2009-11-11 | 铜陵高聚生物科技有限公司 | Polyhexamethylene guanidine propionate disinfectant and preparation method thereof |
| CN102870797A (en) * | 2011-07-15 | 2013-01-16 | 上海泽旭生物科技有限公司 | Sterilizing deodorant |
| CN104586767A (en) * | 2014-12-31 | 2015-05-06 | 卫国刚 | Polyhexamethylene guanidine oral spray |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214926A (en) * | 2016-07-29 | 2016-12-14 | 腾科宝迪（厦门）生物科技有限公司 | A kind of nasal spray and preparation method thereof |
| CN115006348A (en) * | 2022-07-11 | 2022-09-06 | 振德医疗用品股份有限公司 | Long-acting spray for oral mucosa and nasal mucosa, preparation method and application |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160302 |