CN101366727B - 一种小牛血去蛋白提取物的制备方法及其产品 - Google Patents
一种小牛血去蛋白提取物的制备方法及其产品 Download PDFInfo
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- CN101366727B CN101366727B CN2008101488411A CN200810148841A CN101366727B CN 101366727 B CN101366727 B CN 101366727B CN 2008101488411 A CN2008101488411 A CN 2008101488411A CN 200810148841 A CN200810148841 A CN 200810148841A CN 101366727 B CN101366727 B CN 101366727B
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- hydrochloric acid
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- 210000004369 blood Anatomy 0.000 title claims abstract description 35
- 239000008280 blood Substances 0.000 title claims abstract description 35
- 244000309466 calf Species 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title abstract description 15
- 239000006228 supernatant Substances 0.000 claims abstract description 37
- 238000000605 extraction Methods 0.000 claims abstract description 16
- 230000008014 freezing Effects 0.000 claims abstract description 13
- 238000007710 freezing Methods 0.000 claims abstract description 13
- 238000003916 acid precipitation Methods 0.000 claims abstract description 12
- 239000003513 alkali Substances 0.000 claims abstract description 9
- 239000000047 product Substances 0.000 claims abstract description 9
- 238000001223 reverse osmosis Methods 0.000 claims abstract description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 40
- 238000002360 preparation method Methods 0.000 claims description 25
- 238000000108 ultra-filtration Methods 0.000 claims description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000012510 hollow fiber Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 238000010257 thawing Methods 0.000 claims description 7
- 230000004071 biological effect Effects 0.000 abstract description 4
- 239000012535 impurity Substances 0.000 abstract description 3
- 238000005119 centrifugation Methods 0.000 abstract 3
- 230000008018 melting Effects 0.000 abstract 2
- 238000002844 melting Methods 0.000 abstract 2
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 17
- 239000008213 purified water Substances 0.000 description 5
- 238000004587 chromatography analysis Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000003544 deproteinization Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
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Abstract
Description
Claims (12)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2008101488411A CN101366727B (zh) | 2008-09-27 | 2008-09-27 | 一种小牛血去蛋白提取物的制备方法及其产品 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN2008101488411A CN101366727B (zh) | 2008-09-27 | 2008-09-27 | 一种小牛血去蛋白提取物的制备方法及其产品 |
Publications (2)
Publication Number | Publication Date |
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CN101366727A CN101366727A (zh) | 2009-02-18 |
CN101366727B true CN101366727B (zh) | 2010-11-03 |
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CN2008101488411A Active CN101366727B (zh) | 2008-09-27 | 2008-09-27 | 一种小牛血去蛋白提取物的制备方法及其产品 |
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CN (1) | CN101366727B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101947242B (zh) * | 2010-09-26 | 2012-05-23 | 武汉华龙生物制药有限公司 | 小牛血去蛋白提取物的制备方法 |
CN104147047B (zh) * | 2014-07-30 | 2017-10-20 | 哈尔滨圣泰生物制药有限公司 | 一种小牛血去蛋白提取物组合物及其注射剂和制法 |
CN105561346B (zh) * | 2015-12-31 | 2018-05-18 | 李彬 | 一种超声造影剂的制备方法 |
CN111265935A (zh) * | 2020-02-27 | 2020-06-12 | 安徽华金味食品有限公司 | 一种酵母提取物的浓缩方法 |
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2008
- 2008-09-27 CN CN2008101488411A patent/CN101366727B/zh active Active
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CN101366727A (zh) | 2009-02-18 |
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EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Shengtai Pharmaceutical Co., Ltd., Harbin Assignor: Gao Xiang Contract record no.: 2011230000046 Denomination of invention: Method for preparing calf blood protein-removed extract and products thereby Granted publication date: 20101103 License type: Exclusive License Open date: 20090218 Record date: 20110727 |
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EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Shengtai Pharmaceutical Co., Ltd., Harbin Assignor: Gao Xiang Contract record no.: 2011230000046 Date of cancellation: 20111020 |
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EE01 | Entry into force of recordation of patent licensing contract |
Assignee: HARBIN SANCTITY BIOLOGICAL PHARMACEUTICAL CO., LTD. Assignor: Gao Xiang Contract record no.: 2011230000300 Denomination of invention: Method for preparing calf blood protein-removed extract and products thereby Granted publication date: 20101103 License type: Exclusive License Open date: 20090218 Record date: 20111027 |
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EC01 | Cancellation of recordation of patent licensing contract |
Assignee: HARBIN SANCTITY BIOLOGICAL PHARMACEUTICAL CO., LTD. Assignor: Gao Xiang Contract record no.: 2011230000300 Date of cancellation: 20120330 |
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Owner name: HARBIN SANCTITY BIOPHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: GAO XIANG Effective date: 20120419 |
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C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20120419 Address after: 150025 No. 99 Beijing Road, Limin Development Zone, Heilongjiang, Harbin Patentee after: HARBIN SANCTITY BIOLOGICAL PHARMACEUTICAL CO., LTD. Address before: 150025 Heilongjiang province Harbin Limin Development Zone Beijing Road No. 99 Harbin Shengtai pharmaceutical Limited by Share Ltd Patentee before: Gao Xiang |