CN101269150A - Pharmaceutical composition for treating climacteric syndrome and preparation method thereof - Google Patents
Pharmaceutical composition for treating climacteric syndrome and preparation method thereof Download PDFInfo
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- CN101269150A CN101269150A CNA200810111632XA CN200810111632A CN101269150A CN 101269150 A CN101269150 A CN 101269150A CN A200810111632X A CNA200810111632X A CN A200810111632XA CN 200810111632 A CN200810111632 A CN 200810111632A CN 101269150 A CN101269150 A CN 101269150A
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Abstract
The invention provides a drug composition for curing climacteric syndrome and a preparation method thereof. The drug is made of raw medicines such as radix rehmanniae preparata, broomrape, milk veteh, epimedium and psoralea and can be processed into any one of clinically acceptable oral liquid, syrup, tablets, capsules, granular formulation and soft capsules. The drug composition can replenish vital essence to tonify the kidney, relieves liver qi stagnation, invigorate spleen and stomach, replenish qi and blood, activate blood and dissolve stasis, is used for curing the climacteric syndrome with the symptoms such as insomnia, amnesia, dizziness, tinnitus, inappetence, soreness-tired of waist and knee, depression, irritability, testiness and sexual function decrement and also can delay aging, enhance immunity and prevent osteoporosis.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, particularly relate to a kind of pharmaceutical composition for the treatment of climacteric syndrome and preparation method thereof, belong to the novel technique field.
Background technology
Climacteric syndrome be since climacteric a series of diseases that cause with the autonomic nervous system dysfunction that occur, principal element is that hormonal readiness reduces the symptom that takes place.Clinical difficulty falling asleep, insomnia, dizziness, headache, tinnitus, inappetence, asthenia, hypomnesis, absent minded, depressed, anxiety, anxiety, emotional lability, the irritated irritability of mainly showing as, hectic fever, night antiperspirant, suspicious, auditory hallucination, hallucination, the confusion of the menstrual cycle, sexual hypofunction etc.
Climacteric be human therefrom year transition until old year must through life stage, because the variation of spirit psychology, neuroendocrine and metabolic function, degeneration such as each organ dysfunction goes down, endocrine disturbance appear in body to be changed, therefore, climacteric syndrome is the climacteric syndrome greatly that changes of body function, easy concurrent cardiovascular system, skeletal musculature, urinary system, disease of immune system bring very big misery for the climacteric patient.
At present, clinical treatment for climacteric syndrome does not also have ideal treatment means, still based on symptomatic treatments such as gonadotherapy and alpha-2 receptor agonist, β adrenergic blocker, calmness-antianxiety drug and antidepressant, to alleviating clinical symptoms certain curative effect is arranged, but can't delay the speed of each organ dysfunction decline of body.
In recent years, motherland's medical science has treatment advantages such as the clinical symptoms of improvement, slow down aging having obtained certain progress aspect the dialectical opinion of climacteric syndrome is controlled, and is subjected to numerous doctors and patients' concern and approval.
Summary of the invention
One of the object of the invention is to provide a kind of pharmaceutical composition for the treatment of climacteric syndrome, this product has enriching yin and nourishing kidney, dispersing the stagnated live-QI to relieve the stagnation of QI, invigorating the spleen and regulating the stomach, benefiting QI and nourishing blood, the effect of blood circulation promoting and blood stasis dispelling, be used for the treatment of climacteric syndrome, disease is seen insomnia forgetfulness, dizziness and tinnitus, inappetence, soreness of the waist and knees, depression, anxiety, irritated irritability, sexual hypofunction etc., also has slow down aging, enhancing immunity, the effect of osteoporosis.
Two of the object of the invention is to provide this preparation of drug combination method.
Climacteric syndrome belongs to sick category such as motherland's medical science " asthenia ", " cardiopalmus ", " dizzy ", " suffering from a deficiency of the kidney ", it is all dirty to relate to the heart, liver, kidney, with deficiency of kidney-essence, it is main pathogenesis that deficiency of the liver and kindey causes yang blood and qi disorderly, so the present invention selects for use the product of enriching yin and nourishing kidney to consolidate it, is equipped with all medicines of depressed liver-energy dispersing and QI regulating, benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, invigorating the spleen and regulating the stomach, play invigorating the liver and kidney, bone and muscle strengthening altogether, the treatment climacteric syndrome, slow down aging, the effect of enhancing human body immunity power.
The pharmaceutical composition of treatment climacteric syndrome provided by the invention is to be made by following raw materials by weight proportions:
Radix Rehmanniae Preparata 10~60 weight portion Herba Cistanches 10~60 weight portions
The Radix Astragali 10~50 weight portion Herba Epimedii 5~40 weight portions
Fructus Psoraleae 5~40 weight portion Rhizoma Atractylodis Macrocephalaes 5~30 weight portions
Radix Angelicae Sinensis 5~40 weight portion Radix Achyranthis Bidentataes 5~40 weight portions
The Radix Paeoniae Alba 5~30 weight portion Radix Bupleuri 5~30 weight portions
Further, the pharmaceutical composition of treatment climacteric syndrome provided by the invention can be adopted as following raw materials by weight proportions especially and make:
Radix Rehmanniae Preparata 50 weight portion Herba Cistanches 50 weight portions
The Radix Astragali 40 weight portion Herba Epimedii 30 weight portions
The Fructus Psoraleae 30 weight portion Rhizoma Atractylodis Macrocephalaes 20 weight portions
Radix Angelicae Sinensis 30 weight portion Radix Achyranthis Bidentataes 20 weight portions
The Radix Paeoniae Alba 20 weight portion Radix Bupleuri 20 weight portions
The present invention adopts modern preparation technique, is processed into acceptable clinically oral liquid, syrup, tablet, capsule, granule, the arbitrary dosage form of soft capsule.
The preparation of drug combination method of treatment climacteric syndrome provided by the invention is as follows:
(1) gets Herba Cistanches, Herba Epimedii, Fructus Psoraleae, be ground into coarse powder, measure 50%~85% alcohol reflux 2~3 times with 6~10 times, the each extraction 2~3 hours, pure liquid filters, and filtrate merges, decompression recycling ethanol and to be concentrated into relative density be 1.05~1.35 clear paste, standby;
(2) get Radix Rehmanniae Preparata, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Achyranthis Bidentatae, the Radix Paeoniae Alba, Radix Bupleuri, be ground into coarse powder, decoct 2~3 times each 1~2 hour with 8~12 times of water gagings, decocting liquid filters, merging filtrate is evaporated to relative density and is 1.05~1.20 clear paste, adds ethanol and makes and contain the alcohol amount and reach 30%~75%, leave standstill, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.05~1.35 clear paste, standby;
(3) get above-mentioned clear paste, merge, formulation method adds pharmaceutical adjunct routinely, molding, and packing, check, promptly.
The specific embodiment
Embodiment 1
Prescription is formed:
Radix Rehmanniae Preparata 100g Herba Cistanches 100g Radix Astragali 80g Herba Epimedii 60g
Fructus Psoraleae 60g Rhizoma Atractylodis Macrocephalae 40g Radix Angelicae Sinensis 60g Radix Achyranthis Bidentatae 40g
Radix Paeoniae Alba 40g Radix Bupleuri 40g
Mel (refining) 100g sucrose 50g
Make 1000ml altogether
Preparation method:
(1) gets Herba Cistanches, Herba Epimedii, Fructus Psoraleae, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount 85% alcohol reflux 2 hours; Medicinal residues add 8 times of amount 85% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 85% alcohol reflux 2 hours again, extract pure liquid and filter, and filtrate merges, and decompression recycling ethanol and to be concentrated into relative density be 1.05 clear paste is standby;
(2) get Radix Rehmanniae Preparata, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Achyranthis Bidentatae, the Radix Paeoniae Alba, Radix Bupleuri, be ground into coarse powder, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1 hour, and decocting liquid filters; Medicinal residues add 8 times of water gagings again and decocted 1 hour, and decocting liquid filters; Merging filtrate is evaporated to relative density and is 1.10 clear paste, adds ethanol and makes and contain the alcohol amount and reach 60%, leaves standstill 24 hours, filter, and decompression filtrate recycling ethanol and to be concentrated into relative density be 1.05 clear paste, standby;
(3) get above-mentioned clear paste, merge, add Mel, sucrose, mix homogeneously adds water to ormal weight, sneak out, and fill, sterilization, packing, check, promptly.
Embodiment 2
Prescription is formed:
Radix Rehmanniae Preparata 200g Herba Cistanches 200g Radix Astragali 160g Herba Epimedii 120g
Fructus Psoraleae 120g Rhizoma Atractylodis Macrocephalae 80g Radix Angelicae Sinensis 120g Radix Achyranthis Bidentatae 80g
Radix Paeoniae Alba 80g Radix Bupleuri 80g
Starch 85g
Make 1000 altogether
Preparation method:
(1) gets Herba Cistanches, Herba Epimedii, Fructus Psoraleae, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount 85% alcohol reflux 2 hours; Medicinal residues add 8 times of amount 85% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 85% alcohol reflux 2 hours again, extract pure liquid and filter, and filtrate merges, and decompression recycling ethanol and to be concentrated into relative density be 1.25 clear paste is standby;
(2) get Radix Rehmanniae Preparata, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Achyranthis Bidentatae, the Radix Paeoniae Alba, Radix Bupleuri, be ground into coarse powder, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1 hour, and decocting liquid filters; Medicinal residues add 8 times of water gagings again and decocted 1 hour, and decocting liquid filters; Merging filtrate is evaporated to relative density and is 1.10 clear paste, adds ethanol and makes and contain the alcohol amount and reach 60%, leaves standstill 24 hours, filter, and decompression filtrate recycling ethanol and to be concentrated into relative density be 1.25 clear paste, standby;
(3) get above-mentioned clear paste, merge, add starch, mix homogeneously, drying is ground into fine powder, crosses 100 mesh sieves, gets dry extract, and sealing is standby;
(4) get dry extract, add 0.6% magnesium stearate, mix homogeneously, with capsule, packing, check, promptly.
Embodiment 3
Prescription is formed:
Radix Rehmanniae Preparata 100g Herba Cistanches 100g Radix Astragali 80g Herba Epimedii 60g
Fructus Psoraleae 60g Rhizoma Atractylodis Macrocephalae 40g Radix Angelicae Sinensis 60g Radix Achyranthis Bidentatae 40g
Radix Paeoniae Alba 40g Radix Bupleuri 40g
Make 1000 altogether
Preparation method:
(1) gets Herba Cistanches, Herba Epimedii, Fructus Psoraleae, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount 85% alcohol reflux 2 hours; Medicinal residues add 8 times of amount 85% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 85% alcohol reflux 2 hours again, extract pure liquid and filter, and filtrate merges, and decompression recycling ethanol and to be concentrated into relative density be 1.35 clear paste is standby;
(2) get Radix Rehmanniae Preparata, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Achyranthis Bidentatae, the Radix Paeoniae Alba, Radix Bupleuri, be ground into coarse powder, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1 hour, and decocting liquid filters; Medicinal residues add 8 times of water gagings again and decocted 1 hour, and decocting liquid filters; Merging filtrate is evaporated to relative density and is 1.10 clear paste, adds ethanol and makes and contain the alcohol amount and reach 60%, leaves standstill 24 hours, filter, and decompression filtrate recycling ethanol and to be concentrated into relative density be 1.35 clear paste, standby;
(3) get above-mentioned clear paste, merge, drying is ground into fine powder, crosses 120 mesh sieves, gets dry extract, and sealing is standby;
(4) get dry extract, soybean oil, Cera Flava, its weight ratio is 1: 1: 0.02;
(5) get soybean oil and be heated to 45 ℃, get Cera Flava, be dissolved in the part soybean oil, it is slowly joined be heated in the homothermic soybean oil stirring of limit edged again;
(6) get dry extract, join in the soybean oil that is preheated to 45 ℃, the peak wax mixture, fully mix homogeneously is crossed colloid mill, pelleting, and drying is washed ball, packing, check, promptly.
Claims (4)
1, the pharmaceutical composition of treatment climacteric syndrome is characterized in that this pharmaceutical composition is to be made by following raw materials by weight proportions:
Radix Rehmanniae Preparata 10~60 weight portion Herba Cistanches 10~60 weight portions
The Radix Astragali 10~50 weight portion Herba Epimedii 5~40 weight portions
Fructus Psoraleae 5~40 weight portion Rhizoma Atractylodis Macrocephalaes 5~30 weight portions
Radix Angelicae Sinensis 5~40 weight portion Radix Achyranthis Bidentataes 5~40 weight portions
The Radix Paeoniae Alba 5~30 weight portion Radix Bupleuri 5~30 weight portions.
2, the pharmaceutical composition of treatment climacteric syndrome as claimed in claim 1 is characterized in that this pharmaceutical composition is to be made by following raw materials by weight proportions:
Radix Rehmanniae Preparata 50 weight portion Herba Cistanches 50 weight portions
The Radix Astragali 40 weight portion Herba Epimedii 30 weight portions
The Fructus Psoraleae 30 weight portion Rhizoma Atractylodis Macrocephalaes 20 weight portions
Radix Angelicae Sinensis 30 weight portion Radix Achyranthis Bidentataes 20 weight portions
The Radix Paeoniae Alba 20 weight portion Radix Bupleuri 20 weight portions.
3, the pharmaceutical composition of treatment climacteric syndrome as claimed in claim 1 or 2 can be processed into oral liquid, syrup, tablet, capsule, granule, the arbitrary dosage form of soft capsule.
4, the preparation of drug combination method of treatment climacteric syndrome as claimed in claim 1 or 2 is as follows:
(1) gets Herba Cistanches, Herba Epimedii, Fructus Psoraleae, be ground into coarse powder, measure 50%~85% alcohol reflux 2~3 times with 6~10 times, the each extraction 2~3 hours, pure liquid filters, and filtrate merges, decompression recycling ethanol and to be concentrated into relative density be 1.05~1.35 clear paste, standby;
(2) get Radix Rehmanniae Preparata, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Achyranthis Bidentatae, the Radix Paeoniae Alba, Radix Bupleuri, be ground into coarse powder, decoct 2~3 times each 1~2 hour with 8~12 times of water gagings, decocting liquid filters, merging filtrate is evaporated to relative density and is 1.05~1.20 clear paste, adds ethanol and makes and contain the alcohol amount and reach 30%~75%, leave standstill, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.05~1.35 clear paste, standby;
(3) get above-mentioned clear paste, merge, formulation method adds pharmaceutical adjunct routinely, molding, and packing, check, promptly.
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CNA200810111632XA CN101269150A (en) | 2008-05-15 | 2008-05-15 | Pharmaceutical composition for treating climacteric syndrome and preparation method thereof |
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CNA200810111632XA CN101269150A (en) | 2008-05-15 | 2008-05-15 | Pharmaceutical composition for treating climacteric syndrome and preparation method thereof |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102233089A (en) * | 2010-05-08 | 2011-11-09 | 博安兄弟制药(中国)有限公司 | Traditional Chinese medicine composition and preparation method thereof |
CN104189693A (en) * | 2014-09-13 | 2014-12-10 | 陈远征 | Traditional Chinese medicine composition for treating posemenopausal osteoporosis |
CN104398656A (en) * | 2014-12-15 | 2015-03-11 | 周艳春 | Traditional Chinese medicine composition for treating post-menopause depression |
CN104873717A (en) * | 2015-06-30 | 2015-09-02 | 周冠旻 | Traditional Chinese medicine for treating climacteric syndromes |
-
2008
- 2008-05-15 CN CNA200810111632XA patent/CN101269150A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102233089A (en) * | 2010-05-08 | 2011-11-09 | 博安兄弟制药(中国)有限公司 | Traditional Chinese medicine composition and preparation method thereof |
CN102233089B (en) * | 2010-05-08 | 2013-02-13 | 博安兄弟制药(中国)有限公司 | Traditional Chinese medicine composition and preparation method thereof |
CN104189693A (en) * | 2014-09-13 | 2014-12-10 | 陈远征 | Traditional Chinese medicine composition for treating posemenopausal osteoporosis |
CN104189693B (en) * | 2014-09-13 | 2017-02-15 | 青岛辰达生物科技有限公司 | Traditional Chinese medicine composition for treating posemenopausal osteoporosis |
CN104398656A (en) * | 2014-12-15 | 2015-03-11 | 周艳春 | Traditional Chinese medicine composition for treating post-menopause depression |
CN104873717A (en) * | 2015-06-30 | 2015-09-02 | 周冠旻 | Traditional Chinese medicine for treating climacteric syndromes |
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Open date: 20080924 |