CN101152246B - 一种用于心脑血管疾病的药物组合物及其制备方法 - Google Patents
一种用于心脑血管疾病的药物组合物及其制备方法 Download PDFInfo
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Non-Patent Citations (6)
Title |
---|
吴德康.丹参和丹参注射液.上海医药23 2.2002,23(2),80. |
吴德康.丹参和丹参注射液.上海医药23 2.2002,23(2),80. * |
沈爱宗等.瓜蒌研究进展.中医药信息 6.1997,(6),14-16. |
沈爱宗等.瓜蒌研究进展.中医药信息 6.1997,(6),14-16. * |
陈容.自拟丹参瓜蒌饮治疗心绞痛30 例临床分析.现代医药卫生20 23.2004,20(23),2548. |
陈容.自拟丹参瓜蒌饮治疗心绞痛30 例临床分析.现代医药卫生20 23.2004,20(23),2548. * |
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