CN107582947A - A kind of Chinese medicine composition of intelligence development cerebrum tonifying and preparation method thereof - Google Patents
A kind of Chinese medicine composition of intelligence development cerebrum tonifying and preparation method thereof Download PDFInfo
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Abstract
The invention provides a kind of Chinese medicine composition of intelligence development cerebrum tonifying, include the bulk drug of following parts by weight：3 10 parts of 15 parts of ginseng, 3 10 parts of mulberry fruit, 3 10 parts of Poria cocos, 15 parts of Chinese cassia tree, 15 parts of fructus alpiniae oxyphyllae, 15 parts of the sophora bud, 38 parts of the root of kudzu vine, 15 parts of cape jasmine, 38 parts of sea-buckthorn, 38 parts of matrimony vine, 15 parts of rose and hawthorn.By zoopery and the checking of clinical trial; it was found that the Chinese medicine composition of the intelligence development cerebrum tonifying can maintain the balance between patient's body oxidative and anti-oxidative really; nerve cell is protected, delays the development of senile dementia symptom, significantly improves the cognition dysfunction of old dementia patients.In addition, present invention also offers the preparation method of the Chinese medicine composition of intelligence development cerebrum tonifying, the product of a variety of formulations is prepared, facilitates patient to take.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition of intelligence development cerebrum tonifying and preparation method thereof,
To prevent or treat senile dementia.
Background technology
One of senile dementia disease high as the incidence of disease in old group, seriously endangers the normal life of the elderly.
Epidemiology survey result shows that over-65s crowd, senile dementia incidence is between 4%~8%, according to the cause of disease not
Together, senile dementia includes the several types such as Alzheimer disease, vascular dementia and mixed dementia.In recent years investigation knot
Fruit shows, increasingly serious with China human mortality Aging Problem, the incidence of disease of senile dementia raises year by year.Therefore, how to have
The prophylactic treatment senile dementia of effect, the quality of the life of the elderly is improved, mitigate the mental burden of society, turn into more next in recent years
More how medical scholar increasingly concern.
Modern medicine is not yet illustrated the pathogenesis of senile dementia, does not also find effective treatment method, mesh so far
Preceding treatment method is mainly that drug application acts on different neurotransmitter transmission systems, strengthens the advanced of central nervous system
Activity, mitigate the various symptoms appeared in lysis, delay the further development of dementia.At present, it is clinically silly to old age
Slow-witted disease, which implements the conventional medicine for the treatment of, to be had：Anticholinesterase, NMDA receptor antagonist, calcium ion
Antagonist etc., takes that the therapeutic effect of these medicines is bad, and cure rate is almost nil, and early stage patient passes through its symptom of drug administration
Improvement rate is only 12%.
The content of the invention
For the senile dementia problem of getting worse, the present invention provides a kind of Chinese medicine composition and its system of intelligence development cerebrum tonifying
Preparation Method.
In a first aspect, a kind of Chinese medicine composition of intelligence development cerebrum tonifying provided by the invention, include the raw material of following parts by weight
Medicine：Ginseng 1-5 parts, mulberry fruit 3-10 parts, Poria cocos 3-10 parts, Chinese cassia tree 1-5 parts, fructus alpiniae oxyphyllae 1-5 parts, sophora bud 1-5 parts, root of kudzu vine 3-8 parts,
Cape jasmine 1-5 parts, sea-buckthorn 3-8 parts, matrimony vine 3-8 parts, rose 1-5 parts and hawthorn 3-10 parts.
Alternatively, the parts by weight of each bulk drug are：3 parts of ginseng, 6 parts of mulberry fruit, 6 parts of Poria cocos, 3 parts of Chinese cassia tree, fructus alpiniae oxyphyllae 3
6 parts of part, 3 parts of the sophora bud, 5 parts of the root of kudzu vine, 3 parts of cape jasmine, 5 parts of sea-buckthorn, 5 parts of matrimony vine, 2 parts of rose and hawthorn.
Alternatively, the Chinese medicine composition is following formulation：Medicinal tea, granule, oral liquid, tablet or capsule.
Second aspect, the invention provides a kind of preparation method of above-mentioned Chinese medicine composition, comprise the following steps：
According to corresponding parts by weight, dry each bulk drug is weighed, co-grinding, No. two sieves is crossed, is well mixed, packing, be made
Tea bag, sterilization treatment, obtain medicinal tea.
The third aspect, the invention provides the preparation method of another above-mentioned Chinese medicine composition, comprise the following steps：
（1）Take Chinese cassia tree and fructus alpiniae oxyphyllae to mix, after soaking, heat and extract volatile oil, obtain decoction, the dregs of a decoction and volatile oil；
（2）The dregs of a decoction are mixed with the sophora bud, the root of kudzu vine, cape jasmine, mulberry fruit, matrimony vine, rose, hawthorn, adds water to cook, obtains decoction liquor；
（3）Decoction liquor and decoction are merged into concentration, concentrate is obtained, ethanol is added in concentrate, filters, is filtered after refrigeration
Liquid；
（4）Sea-buckthorn, ginseng and Poria cocos mixing are taken, adds ethanol to extract, filters, obtain alcohol precipitation filtrate；
（5）Filtrate and alcohol precipitation filtrate are merged, ethanol is reclaimed, concentration, is dried under reduced pressure, obtains dry extract；
（6）By volatile oil beta-schardinger dextrin inclusion, refrigeration filtering, dry, obtain beta-cyclo dextrin included compound；
（7）By dry extract and beta-cyclo dextrin included compound co-grinding, the auxiliary material of survival dose is added, obtains granule.
Alternatively, step（3）Middle concentrate is 1.14-1.18 in 60 DEG C of relative density.
Alternatively, step（5）Middle dry extract is 1.35-1.40 in 50 DEG C of relative density
Fourth aspect, the invention provides the preparation method of another above-mentioned Chinese medicine composition, comprise the following steps：
（1）Sea-buckthorn, ginseng and Poria cocos mixing are taken, adds ethanol to extract, ethanol is reclaimed and is concentrated under reduced pressure, obtain alcohol extracting take cream；
（2）Take Chinese cassia tree and fructus alpiniae oxyphyllae to mix, soak, heat distilled, obtain decoction and the dregs of a decoction, collect distillate；
（3）The dregs of a decoction are mixed with the sophora bud, the root of kudzu vine, cape jasmine, mulberry fruit, matrimony vine, rose, hawthorn, adds water to cook, obtains decoction liquor；
（4）Decoction liquor and decoction are merged into concentration, concentrate is obtained, ethanol is added in concentrate, stratification, filters out supernatant
Liquid, reclaim ethanol and concentrate, obtain water decoction-alcohol sedimentation cream；
（5）Alcohol extracting take cream and water decoction-alcohol sedimentation cream are merged, the auxiliary material of survival dose is added, obtains intelligence development cerebrum tonifying oral liquid.
Alternatively, step（1）Middle alcohol extracting take cream is 1.12-1.14 in 60 DEG C of relative density.
Alternatively, step（4）Middle concentrate is 1.08-1.10 in 60 DEG C of relative density, and water decoction-alcohol sedimentation cream is at 60 DEG C
Relative density is 1.14-1.16.
Traditional Chinese medicine has abundant theory and practice experience in terms of disease preventing and treating, also has to the etiology and pathogenesis of senile dementia
Uniqueness understanding, many prescriptions confirm that they are curative for effect in improvement cognitive disorder etc. through zoopery and clinical research.
The traditional Chinese medical science thinks that " damage of kidney-essence " caused by the void of the five internal organs, " spiritually barren " are the dull-witted Basic disease cause interpretation of the cause, onset and process of an illness occurred, and treatment adopts
Take qi-restoratives medicine Zhi Qiben, dredging collateral awaking drug to control its mark, using with tonify the liver and kidney, the Chinese medicine of consciousness regaining, effect of benefiting intelligence, deeply
The mechanism of action of Chinese medicine shield brain is probed into, can not only promote the innovation and development of traditional Chinese medicine, can also be nervous system disease agent
Research and development and clinical practice provide foundation and laid the foundation.The medicine and health products of preventing and treating senile dementia are developed, plays the traditional Chinese medical science
Medicine characteristic has broad prospect of application.
The invention provides the Chinese medicine composition of intelligence development cerebrum tonifying, with nourishing YIN for benefiting the kidney, based on beneficial to spirit and marrow, meet senile dementia
Chinese traditional treatment it is theoretical, cerebrum tonifying, strong kidney, QI invigorating can be played, liver-kidney tonifying, inducing resuscitation intelligence development, the powdered medicine ' Tongluosan ' stasis of blood, brain tonic benefit god, prolonged
Slow aging of brain, strengthens memory, effect of promoting longevity.By zoopery and the checking of clinical trial, it is found that the intelligence development is mended
The Chinese medicine composition of brain can maintain the balance between patient's body oxidative and anti-oxidative really, protect nerve cell, delay old age
The development of dementia symptom, significantly improve the cognition dysfunction of old dementia patients.In addition, present invention also offers intelligence development cerebrum tonifying
Chinese medicine composition preparation method, prepare the product of a variety of formulations, facilitate patient to take.
Embodiment
With reference to embodiment, the present invention will be further described, but the present invention is not limited by following embodiments.
Embodiment one
A kind of intelligence development cerebrum tonifying medicinal tea, preparation method are as follows：
（1）Weigh dry bulk drug respectively according to following mass fraction, it is standby.1 part of ginseng, 3 parts of mulberry fruit, 3 parts of Poria cocos, Chinese cassia tree
3 parts of 1 part, 1 part of fructus alpiniae oxyphyllae, 1 part of the sophora bud, 3 parts of the root of kudzu vine, 1 part of cape jasmine, 3 parts of sea-buckthorn, 3 parts of matrimony vine, 1 part of rose and hawthorn.
（2）By each bulk drug, co-grinding, No. two sieves are crossed, are well mixed, packing, tea bag, every bag of 5g, sterilizing is made
Processing, obtains intelligence development cerebrum tonifying medicinal tea.
With tonifying Qi of the kidney, promoting blood circulation and removing blood stasis, clearing and activating the channels and collaterals effect.For prevent and treat dizziness caused by obstruction of collaterals by blood stasis,
Apoplexy, symptoms include limbs do not have to, aphasia and have a dizzy spell；Cerebral arteriovenous malformation, ishemic stroke and cerebral hemorrhage sequelae person.Mouthful
Clothes.Once a bag, 2-3 times on the one, the water after being boiled with 200mL is brewed, i.e. drinkable after about 5min, and repeatable brew is drunk.
Embodiment two
A kind of intelligence development cerebrum tonifying granule, preparation method are as follows：
（1）Ginseng 50g, mulberry fruit 100g, Poria cocos 100g, Chinese cassia tree 50g, fructus alpiniae oxyphyllae 50g, sophora bud 50g, root of kudzu vine 80g, Cape jasmine are weighed respectively
Sub- 50g, sea-buckthorn 80g, matrimony vine 80g, rose 50g and hawthorn 100g, it is standby.Take Chinese cassia tree and fructus alpiniae oxyphyllae to mix, add 8 times of amount water loggings
Bubble heats after 1 hour and extracts volatile oil, extracts 5 hours, obtains decoction, the dregs of a decoction and volatile oil.
（2）The dregs of a decoction are mixed with the sophora bud, the root of kudzu vine, cape jasmine, mulberry fruit, matrimony vine, rose, hawthorn, add water to cook 2 times, every time
Add 8 times of amount water, decoct 1 hour every time, obtain decoction liquor.
（3）It is that relative density is 1.14-1.18 that decoction liquor and decoction are merged into concentration（60 DEG C of surveys）Concentrate, concentrating
Ethanol is added in liquid, alcohol content is reached 60%, refrigeration is filtered after 24 hours, obtains filtrate.
（4）Sea-buckthorn, ginseng and Poria cocos mixing are taken, adds 5 times of 70% ethanol of amount extractions three times, extraction 3 hours, filtering, are obtained every time
To alcohol precipitation filtrate.
（5）Filtrate and alcohol precipitation filtrate are merged, ethanol is reclaimed, is concentrated into relative density about 1.35-1.40（50 DEG C of surveys）, in
Less than 70 DEG C are dried under reduced pressure, and obtain dry extract.
（6）By volatile oil beta-schardinger dextrin according to mass ratio 1:10 carry out inclusion, refrigeration filtering, less than 40 DEG C dryings, obtain
To beta-cyclo dextrin included compound.
（7）By dry extract and beta-cyclo dextrin included compound co-grinding, it is 1 to add mass ratio:1 auxiliary material (sucrose-dextrin 1:
1) in right amount, it is well mixed, particle 1000g is made with 70% ethanol, less than 60 DEG C dryings, packing, every bag of 10g, produces intelligence development cerebrum tonifying
Granule.
With tonifying Qi of the kidney, promoting blood circulation and removing blood stasis, clearing and activating the channels and collaterals effect.For prevent and treat dizziness caused by hemostasis ancestral's network,
Apoplexy, symptoms include limbs do not have to, aphasia and have a dizzy spell；Cerebral arteriovenous malformation, ishemic stroke and cerebral hemorrhage sequelae person.Mouthful
Clothes.Once a bag, hot water is taken after mixing it with water, 2-3 times on the one.
Embodiment three
A kind of intelligence development cerebrum tonifying oral liquid, preparation method are as follows：
（1）Ginseng 30g, mulberry fruit 60g, Poria cocos 60g, Chinese cassia tree 30g, fructus alpiniae oxyphyllae 30g, sophora bud 30g, root of kudzu vine 50g, cape jasmine are weighed respectively
30g, sea-buckthorn 50g, matrimony vine 50g, rose 20g and hawthorn 60g, it is standby.Sea-buckthorn, ginseng and Poria cocos mixing are taken, adds 5 times of amounts 70%
Ethanol extracts three times, every time extraction 3 hours, merges 3 alcohol extracts, reclaims ethanol and is concentrated under reduced pressure into relative density and is
1.12-1.14（60 DEG C of surveys）Stream cream, obtain alcohol extracting take cream.
（2）Take Chinese cassia tree and fructus alpiniae oxyphyllae to mix, add 10 times of water to soak 1 hour, heat distilled, obtain decoction and the dregs of a decoction, collect
Distillate.
（3）The dregs of a decoction are mixed with the sophora bud, the root of kudzu vine, cape jasmine, mulberry fruit, matrimony vine, rose, hawthorn, soaks 1 hour, adds decocting
Boil 2 times, 2 hours every time, filtering, obtain decoction liquor；
（4）It is 1.08-1.10 that decoction liquor and decoction merging are concentrated under reduced pressure into relative density（60 DEG C of surveys）, concentrate is obtained,
Ethanol is added in concentrate makes alcohol content be 70%, stands 48 hours at 0-4 DEG C, is layered, filters out supernatant, second is recovered under reduced pressure
Alcohol and to be concentrated into relative density be 1.14-1.16（60 DEG C of surveys）, obtain water decoction-alcohol sedimentation cream；
（5）Alcohol extracting take cream and water decoction-alcohol sedimentation cream are merged, add ethyl hydroxy benzoate 1.2g, adds distillate and pure water makes the cumulative volume be
950ml, stir evenly, adjust pH to 6.0, be heated to seething with excitement, it is cold heavy 72 hours at -4 DEG C to set to 0, and filters out supernatant, adds flavouring, uses
Pure water adjustment cumulative volume is 1000ml, is heated to reflux to boiling, stands 24 hours, filter, dispense, sterilizing, every bottle of 10ml, obtains benefit
Intelligence cerebrum tonifying oral liquid.
With tonifying Qi of the kidney, promoting blood circulation and removing blood stasis, clearing and activating the channels and collaterals effect.For prevent and treat dizziness caused by hemostasis ancestral's network,
Apoplexy, symptoms include limbs do not have to, aphasia and have a dizzy spell；Cerebral arteriovenous malformation, ishemic stroke and cerebral hemorrhage sequelae person.Mouthful
Clothes.One time 1 bottle, 2-3 times on the one.
Example IV
Influence research of the intelligence development cerebrum tonifying oral liquid to Senile Dementia Model Rats ability of learning and memory and hippocampus LTP
This experiment is oral by observing intelligence development cerebrum tonifying with bilateral hippocampus injection A β 25-35 method structure senile dementia rat models
Influence of the liquid to rat model ability of learning and memory and hippocampus LTP, and then its mechanism of action is inquired into, it is clinical treatment senile dementia
Certain theoretical foundation is provided.
1 materials and methods
1.1 clinical data
1.1.1 experimental animal healthy adult SD rat 40, SPF levels, body weight（220±20）G, male and female half and half, Shandong University are real
Animal center offer, credit number are provided：SCXK（Shandong）20090001.
1.1.2 key instrument and reagent
Rat diving tower instrument, institute of Materia Medica,Chinese Academy of Medical Sciences；RM6240 biochips diagnosis analysis systems, Chengdu
Instrument plant；Stereotaxic apparatus, Chengdu Instruement Factory；A β 25-35, Sigma Reagent Companies of the U.S., lot number A4559；Piracetam（Pyrrole
La Xitan pieces）, Hubei Huahzong Medicine Co., Ltd, lot number 20160810.
Intelligence development cerebrum tonifying side oral liquid（Prepared by Medicine Institute, Shandong Province centers for making of pharmaceutical preparations, the side provided by embodiment three
Method is prepared）10mL/ branch.
1.2 research method
1.2.1 model is prepared and is administered
Experimental animal is randomly divided into control group, model group, piracetam group and intelligence development and mended after standard environment adaptability is raised 1 week
Brain oral liquid group, every group 10.Each group rat is through being injected intraperitoneally 10% chloraldurate（0.3 ml/100g）After anesthesia, it is fixed on
On stereotaxic apparatus, with reference to Paxinos rat brain stereotaxic atlases, by Bergam points 3.2mm backward, by center line
2.2mm, bilateral skull is drilled through with bone drill, under stereotaxic apparatus guiding, the vertical inserting needle 4mm of micro syringe, model group, brain
The A β 25-35 solution that multiple health group and intelligence development cerebrum tonifying oral liquid group are slowly injected into 4 μ L in bilateral hippocampus tissue is slow（Per the μ L of side 2）,
Control group injects isometric sterile saline.Postoperative next day piracetam group, intelligence development cerebrum tonifying oral liquid group give piracetam respectively
（40 mg/ml）And intelligence development cerebrum tonifying oral liquid gavage, each group animal are administered by 2ml/100g, control group and model group are given daily
2ml/100g physiological saline gavage, 1 time/d, continuous 20d.Each group animal records weekly a body weight, adjusts injection dosage.
1.2.2 rat learning and memory performances is tested
After medication terminates, rat jumps onto the time of platform after being powered using step dow n test record（The reaction phase）With in 5min by electricity
The number hit（Errors number）As school grade.The time that record rat is jumped to from platform on copper grid（Incubation period）In 5min
By the number to shock by electricity（Errors number）As Memory result.
1.2.3 electrophysiology detection
After Behaviors survey terminates, colony's spike potential of single Induced by Stimulation is recorded first（PS）30min is as base value, so
After carry out high frequency stimulation（HFS）PS after induction LTP, record HFS in 60min.With the mean of 30min PS values before HFS
For baseline value, i.e., 100.0%, each PS values produce the PS amplitude relative values of each point by comparison in experiment, and PS average amplitudes are higher than
Baseline value at least more than 20.0% and the person that continues more than 30min, which can be considered, generates LTP, Continuous Observation record 60min.Experiment knot
Shu Hou, makees localization examination to stimulating electrode and recording electrode, and position inaccurate person gives rejecting.
1.2.4 statistical procedures
Data Management Analysis is carried out using SPSS18.0 software kits, data represent that multigroup is compared and use X with x ± s2Analyze, between group
Compare two-by-two and examined with LST-t, P ＜ 0.05 have significant difference.
2 results
The comparison of 2.1 each group learning and memory in rats abilities（Jumping test method）Compared with control group, the reaction phase of model group prolongs
It is long, shorter latencies, errors number increase（P ＜ 0.01）；Compared with model group, piracetam group and intelligence development cerebrum tonifying oral liquid group are anti-
Should substantially it shorten the phase, incubation period is obviously prolonged, and errors number significantly reduces（P ＜ 0.01）, 1 is shown in Table, shows that intelligence development cerebrum tonifying is oral
Liquid can improve the ability of learning and memory of senile dementia rat.
Influence of the intelligence development cerebrum tonifying oral liquid of table 1 to senile dementia learning and memory in rats ability（x±s）
Note：aThe vs control groups of P ＜ 0.01,bThe vs model groups of P ＜ 0.01,cThe vs piracetam groups of P ＞ 0.05
2.2 electrophysiology detection results
After HFS, each group P of Rats S amplitude shows that each group rat hippocampus have LTP shape compared with increasing by more than 20.0% before HFS
Into.Model group PS amplitudes have a certain degree of enhancing after HFS, but are significantly lower than control group（P ＜ 0.01）；Piracetam group and intelligence development
PS amplitudes are significantly greater than model group after cerebrum tonifying oral liquid group HFS（P ＜ 0.01）；PS changes in amplitude can be seen that after HFS, mould
Type group PS amplitudes in 60min are below control group, piracetam group and intelligence development cerebrum tonifying oral liquid group（P ＜ 0.01）.Control group, brain
Multiple health group and intelligence development cerebrum tonifying oral liquid group the PS changes in amplitude unobvious in the 60min recorded, there was no significant difference（P ＞
0.05）.
3 discuss
The traditional Chinese medical science thinks that the generation of senile dementia is mainly foster with brain mistake, spleen kidney two is thanks to relevant.Therefore in senile dementia Chinese traditional treatment
It is upper more based on beneficial to spirit and marrow, invigorating spleen and kidney.This experiment is with nourishing YIN for benefiting the kidney, beneficial to spirit and marrow with the Chinese medicine composition of intelligence development cerebrum tonifying
It is main, meet the therapy theory of senile dementia.In the diagnosis and treatment evaluation of senile dementia, learning and memory level is most important finger
Mark.Jumping test result finds that Senile Dementia Model Rats ability of learning and memory is decreased obviously, and its reaction time is obviously prolonged,
Incubation period substantially shortens, and errors number substantially increases；After intelligence development cerebrum tonifying oral liquid treatment, the rat reaction time substantially contracts
Short, incubation period is obviously prolonged, and errors number substantially reduces, and illustrates that the Chinese medicine composition of intelligence development cerebrum tonifying provided by the invention can be notable
Improve senile dementia Cognition Function in Rats obstacle.
Long term potentiation（LTP）Refer to nerve pathway after tetanic stimulation or the effect of other specific stimulations, its nerve synapse
Transmit the phenomenon of efficiency enhancing for a long time.Numerous studies show that LTP and learning and memory process are closely related, it is considered to be research
The best model of the neuron plasticity related to learning and memory.LTP reflects the neuroelectricity life in synaptic plasticity change
Change in terms of reason activity, and as a main physiologic index of Neuscience measurement synaptic plasticity.This research is tied
Fruit shows, compared with control group, model group rats Hippocampal CA 1 LTP amplitudes significantly reduce, and the oral liquid energy of intelligence development cerebrum tonifying subtracts
Inhibitory action of the light A β 25-35 to Hippocampal CA 1 LTP, hence it is evident that improve the plasticity of synaptic function.Illustrate benefit provided by the invention
The Chinese medicine composition of intelligence cerebrum tonifying has some improvement for the plasticity tool of cynapse.
In summary, the Chinese medicine composition of intelligence development cerebrum tonifying provided by the invention can significantly improve senile dementia rat cognition work(
Energy obstacle, its mechanism of action may be with the LTP in raising rat hippocampus CA1 areas, hence it is evident that the plasticity for improving cynapse is relevant.
Embodiment five
1 clinical data
1.1 general information
118 are Laiwu Fang Gan convalescent homes inpatient in June, -2015 in April, 2013, are diagnosed as senile dementia, according to
Medical order is randomly divided into two groups.Treatment group 59, wherein man 28, female 31；Age 60-79 year, average age
(70.31 ± 2.18) year；Course of disease 3-14, average course of disease (7.01 ± 2.64) year；Wherein illiteracy 7, it is small to learn to read and write 14,
Middle school and above culture 38.Control group 59, wherein man 29, female 30；Age 62-81 year, average age
(71.04 ± 3.24) year；Course of disease 2-15, average course of disease (7.25 ± 2.43) year；Wherein illiteracy 8, it is small to learn to read and write 15,
Middle school and above culture 36.Two groups of patients are at age, sex, the course of disease etc., through statistical analysis there are no significant difference
(P ＞ 0.05), there is comparativity.
1.2 diagnostic criteria
Meet nineteen ninety Aged in China medical association《Diagnosis of dementia, medicine typing and efficacy assessment standard》The diagnosis of formulation
Standard:Intelligence detection confirms dull-witted；At least 2 identification function obstacles；Memory and cognitive disorders progressive aggravate；It is unconscious
Obstacle；40-90 year onset；The above-mentioned state of an illness can be explained without other bodies or brain diseases.
1.3 inclusive criteria
(1) the disconnected standard of senile dementia is met；(2) patient's informed consent, and informed consent form is signed, being capable of periodic review；(3)
Age is between 55-75 year.
1.4 exclusion standard
(1) unconsciousness, can not partner treatment, the past spiritedness patients with history；(2) it is associated with the great device such as heart, kidney
Official's insufficiency and tumor patient；(3) take used anti senile dementia drug orally within nearly 1 month or participate in the clinical examination of other drugs
The person of testing；(4) Dementia patients caused by disease such as wound, brain lesionses, dialysis, anoxic (respiratory is cardiogenic).
2 treatment methods
2.1 control group
Primary Care:(1) health propaganda and education, including knowledge on drug abuse, coherence check purpose, reasonable diet (less salt, low fat) etc.；
(2) drug therapy:Two groups are both needed to improve Brain circlulation, trophic nerve etc. according to the actual conditions of patient；Cure the Primary Disease,
Blood pressure, blood glucose, blood fat are controlled, such as slight Hypertension person, giving nifedipine, (Diao Group Chengdu Pharmaceutical Co., Ltd. gives birth to
Production) 10-20mg is oral, one time a day；Cholesterol increased perosn, giving Lovastatin, (Yangzijiang Pharmaceutical Group Co., Ltd gives birth to
Production) 10-20mg is oral, takes one time a day, during dinner；Hyperlipidemia person, give fenofibrate (the limited public affairs of Anhui pioneer's pharmacy
Department's production) 0.2g is oral, one time a day.The stable normal condition of the holdings such as blood sample of patient, blood glucose, blood platelet is controlled as far as possible.
2.2 treatment group
On the basis of control group treatment, intelligence development cerebrum tonifying side oral liquid is given（Prepared by Medicine Institute, Shandong Province centers for making of pharmaceutical preparations, lead to
The method for crossing the offer of embodiment three is prepared）10mL/ branch, orally, 3 times a day.90d is 1 course for the treatment of, treats 2 treatments altogether
Journey.
3 treatment results
3.1 curative effect determinate standards are effective:Patient clinical symptom, sign disappear substantially；Mind returns to waking state, Neng Gouqing
Oneself wish is expressed by Chu；With higher respond, stronger initiative；Self-care ability is strong, can carry out in general society
Activity.Effectively:Patient clinical sign, symptom has weakened or partial disappearance；Active force strengthens before relatively treating, but reacts still
It is more blunt, it there are dysnoesia；It is basic that there is self-care ability, but also still some are difficult with people's progress social interaction.It is good
Turn:Clinical main physical signs, symptom partial disappearance；Can speech, but can not understand express oneself wish；Thinking understandability,
Judgment is poor；Unstable condition is easily repeatedly；It can't take care of oneself.It is invalid:Clinical sign, symptom do not have to change even substantially
Deteriorate；Mental dementia, language ability is lost, can't take care of oneself.
3.2 result
3.2.1 two groups of Clinical efficacy comparisons:It is shown in Table 2.
2 two groups of clinical treatments of table compare (example)
Compared with control group,**P ＜ 0.01.
3.2.2 in two groups of pretherapy and post-treatment serum SOD contents comparison:It is shown in Table 3.
The comparison (U/mL, x ± s) of SOD contents in 3 two groups of pretherapy and post-treatment serum of table
With this group before treatment,**P ＜ 0.01；Compared with after control group treatment,##P ＜ 0.01.
4 discuss
At present, some scholars think that the dynamic equilibrium of the normal oxidation/reduction reaction of brain is destroyed, and can induce brain tissue generation
Substantial amounts of cell factor and growth factor, promote the generation and development of dementia, therefore, response to oxidative stress is recognized by clinical workers
To be one of dull-witted important pathogenesis, and SOD vigor reflects the ability of body scavenging activated oxygen, and its level can
Reflect disease severity and evaluation patient's prognosis.Response to oxidative stress promotes A β neurotoxic effects, and SOD is as anti-oxidant
Agent, its vigor is stronger, and it is stronger to remove the ability of free radical, can play and suppress A β neurotoxic effects, protects neuronal cell,
Ensure human body metabolic balance.Doctor trained in Western medicine in addition to the health propaganda and educations such as reasonable diet, gives reduction blood more for old dementia patients
Pressure, the Primary Cares such as blood fat are reduced, it is unsatisfactory to improving patient's dementia symptom, to preventing the development impact of senile dementia not
It is good.And there are some researches prove Chinese medicine is with a wide range of applications in prevention and treatment senile dementia.Traditional Chinese medicine thinks that liver kidney is not
Foot, deficiency of qi and blood, caused brain do not fill, the mind lose support be senile dementia main pathogenesis, therefore, the such disease of Chinese medicine
Disease, kidney-nourishing enriching yin is commonly used, Tianjing Busuiye medicinal, is subject to good recipe promoting blood circulation and removing blood stasis, eliminating the phlegm resolving sputum and inducing resuscitation are had one's ideas straightened out.
This result of study shows that intelligence development cerebrum tonifying side oral liquid treatment senile dementia is evident in efficacy to be higher than control group (P ＜
0.01), and SOD content it is higher (P ＜ 0.01).Show that intelligence development cerebrum tonifying oral liquid by antiopxidant effect, improves SOD in serum
Content, occupy certain advantage for treatment senile dementia, represent the enhancing of patient's body Antioxidant Enzyme Systems defencive function, i.e.,
SOD contents increase, and maintain the balance between patient's body oxidative and anti-oxidative, protect nerve cell, delay senile dementia symptom
Development, be worth of widely use.
Claims (9)
1. a kind of Chinese medicine composition of intelligence development cerebrum tonifying, it is characterised in that include the bulk drug of following parts by weight：Ginseng 1-5 parts,
Mulberry fruit 3-10 parts, Poria cocos 3-10 parts, Chinese cassia tree 1-5 parts, fructus alpiniae oxyphyllae 1-5 parts, sophora bud 1-5 parts, root of kudzu vine 3-8 parts, cape jasmine 1-5 parts, sand
Spine 3-8 parts, matrimony vine 3-8 parts, rose 1-5 parts and hawthorn 3-10 parts.
2. the Chinese medicine composition of intelligence development cerebrum tonifying according to claim 1, it is characterised in that the parts by weight of each bulk drug
For：3 parts of ginseng, 6 parts of mulberry fruit, 6 parts of Poria cocos, 3 parts of Chinese cassia tree, 3 parts of fructus alpiniae oxyphyllae, 3 parts of the sophora bud, 5 parts of the root of kudzu vine, 3 parts of cape jasmine, 5 parts of sea-buckthorn,
6 parts of 5 parts of matrimony vine, 2 parts of rose and hawthorn.
3. the Chinese medicine composition of intelligence development cerebrum tonifying according to claim 1 or 2, it is characterised in that the Chinese medicine composition is
Following formulation：Medicinal tea, granule, oral liquid, tablet or capsule.
4. a kind of preparation method of Chinese medicine composition as claimed in claim 3, it is characterised in that comprise the following steps：
According to corresponding parts by weight, dry each bulk drug is weighed, co-grinding, No. two sieves is crossed, is well mixed, packing, be made
Tea bag, sterilization treatment, obtain medicinal tea.
5. a kind of preparation method of Chinese medicine composition as claimed in claim 3, it is characterised in that comprise the following steps：
（1）Take Chinese cassia tree and fructus alpiniae oxyphyllae to mix, after soaking, heat and extract volatile oil, obtain decoction, the dregs of a decoction and volatile oil；
（2）The dregs of a decoction are mixed with the sophora bud, the root of kudzu vine, cape jasmine, mulberry fruit, matrimony vine, rose, hawthorn, adds water to cook, obtains decoction liquor；
（3）Decoction liquor and decoction are merged into concentration, concentrate is obtained, ethanol is added in concentrate, filters, is filtered after refrigeration
Liquid；
（4）Sea-buckthorn, ginseng and Poria cocos mixing are taken, adds ethanol to extract, filters, obtain alcohol precipitation filtrate；
（5）Filtrate and alcohol precipitation filtrate are merged, ethanol is reclaimed, concentration, is dried under reduced pressure, obtains dry extract；
（6）By volatile oil beta-schardinger dextrin inclusion, refrigeration filtering, dry, obtain beta-cyclo dextrin included compound；
（7）By dry extract and beta-cyclo dextrin included compound co-grinding, the auxiliary material of survival dose is added, obtains granule.
6. preparation method according to claim 5, it is characterised in that step（3）Relative density of the middle concentrate at 60 DEG C
For 1.14-1.18.
7. preparation method according to claim 5, it is characterised in that step（5）Relative density of the middle dry extract at 50 DEG C
For 1.35-1.40
A kind of preparation method of Chinese medicine composition as claimed in claim 3, it is characterised in that comprise the following steps：
（1）Sea-buckthorn, ginseng and Poria cocos mixing are taken, adds ethanol to extract, ethanol is reclaimed and is concentrated under reduced pressure, obtain alcohol extracting take cream；
（2）Take Chinese cassia tree and fructus alpiniae oxyphyllae to mix, soak, heat distilled, obtain decoction and the dregs of a decoction, collect distillate；
（3）The dregs of a decoction are mixed with the sophora bud, the root of kudzu vine, cape jasmine, mulberry fruit, matrimony vine, rose, hawthorn, adds water to cook, obtains decoction liquor；
（4）Decoction liquor and decoction are merged into concentration, concentrate is obtained, ethanol is added in concentrate, stratification, filters out supernatant
Liquid, reclaim ethanol and concentrate, obtain water decoction-alcohol sedimentation cream；
（5）Alcohol extracting take cream and water decoction-alcohol sedimentation cream are merged, the auxiliary material of survival dose is added, obtains oral liquid.
8. preparation method according to claim 8, it is characterised in that step（1）Middle alcohol extracting take cream is relatively close at 60 DEG C
Spend for 1.12-1.14.
9. preparation method according to claim 8, it is characterised in that step（4）Relative density of the middle concentrate at 60 DEG C
For 1.08-1.10, water decoction-alcohol sedimentation cream is 1.14-1.16 in 60 DEG C of relative density.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1341432A (en) * | 2001-06-15 | 2002-03-27 | 薛志祥 | Brain-tonifying intelligence-raising granules |
| CN1954880A (en) * | 2005-10-28 | 2007-05-02 | 黄金秀 | Anshenbunao granule and its preparation method |
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2017
- 2017-09-30 CN CN201710917142.8A patent/CN107582947A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1341432A (en) * | 2001-06-15 | 2002-03-27 | 薛志祥 | Brain-tonifying intelligence-raising granules |
| CN1954880A (en) * | 2005-10-28 | 2007-05-02 | 黄金秀 | Anshenbunao granule and its preparation method |
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