CN100563635C - A kind of ageratum drop pill - Google Patents
A kind of ageratum drop pill Download PDFInfo
- Publication number
- CN100563635C CN100563635C CNB2003101072846A CN200310107284A CN100563635C CN 100563635 C CN100563635 C CN 100563635C CN B2003101072846 A CNB2003101072846 A CN B2003101072846A CN 200310107284 A CN200310107284 A CN 200310107284A CN 100563635 C CN100563635 C CN 100563635C
- Authority
- CN
- China
- Prior art keywords
- hours
- adjuvant
- drop pill
- oil
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000006187 pill Substances 0.000 title claims abstract description 171
- 240000003870 Ageratum houstonianum Species 0.000 title 1
- 239000002671 adjuvant Substances 0.000 claims abstract description 109
- 239000003814 drug Substances 0.000 claims abstract description 101
- 239000000463 material Substances 0.000 claims abstract description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 109
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 90
- 239000007788 liquid Substances 0.000 claims description 68
- 239000000203 mixture Substances 0.000 claims description 68
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 60
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 55
- 235000010447 xylitol Nutrition 0.000 claims description 55
- 239000000811 xylitol Substances 0.000 claims description 55
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 55
- 229960002675 xylitol Drugs 0.000 claims description 55
- 239000000758 substrate Substances 0.000 claims description 54
- 229920002472 Starch Polymers 0.000 claims description 53
- 239000008107 starch Substances 0.000 claims description 53
- 235000019698 starch Nutrition 0.000 claims description 53
- 239000003921 oil Substances 0.000 claims description 49
- 235000019198 oils Nutrition 0.000 claims description 49
- 239000001738 pogostemon cablin oil Substances 0.000 claims description 49
- 238000002156 mixing Methods 0.000 claims description 47
- 229940079593 drug Drugs 0.000 claims description 41
- 238000002360 preparation method Methods 0.000 claims description 41
- 241000544602 Ageratum Species 0.000 claims description 39
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 39
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 39
- 239000008101 lactose Substances 0.000 claims description 38
- 238000003756 stirring Methods 0.000 claims description 36
- 238000005325 percolation Methods 0.000 claims description 35
- 239000000284 extract Substances 0.000 claims description 33
- 238000010438 heat treatment Methods 0.000 claims description 28
- 238000009413 insulation Methods 0.000 claims description 28
- 238000002844 melting Methods 0.000 claims description 28
- 230000008018 melting Effects 0.000 claims description 28
- 239000002826 coolant Substances 0.000 claims description 26
- -1 hydroxypropyl Chemical group 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 26
- 235000010489 acacia gum Nutrition 0.000 claims description 25
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 25
- 241000196324 Embryophyta Species 0.000 claims description 24
- 238000009472 formulation Methods 0.000 claims description 23
- 229920002545 silicone oil Polymers 0.000 claims description 21
- 238000012856 packing Methods 0.000 claims description 19
- 239000012530 fluid Substances 0.000 claims description 17
- 229940057995 liquid paraffin Drugs 0.000 claims description 17
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 16
- 230000002879 macerating effect Effects 0.000 claims description 16
- 238000009738 saturating Methods 0.000 claims description 16
- 239000002904 solvent Substances 0.000 claims description 16
- 239000000706 filtrate Substances 0.000 claims description 14
- 241001597008 Nomeidae Species 0.000 claims description 11
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 9
- 229920001353 Dextrin Polymers 0.000 claims description 9
- 239000004375 Dextrin Substances 0.000 claims description 9
- 235000019425 dextrin Nutrition 0.000 claims description 9
- 239000000945 filler Substances 0.000 claims description 9
- 239000000600 sorbitol Substances 0.000 claims description 9
- 235000010443 alginic acid Nutrition 0.000 claims description 8
- 229920000615 alginic acid Polymers 0.000 claims description 8
- 239000000783 alginic acid Substances 0.000 claims description 8
- 229960001126 alginic acid Drugs 0.000 claims description 8
- 150000004781 alginic acids Chemical class 0.000 claims description 8
- 229920000609 methyl cellulose Polymers 0.000 claims description 8
- 239000001923 methylcellulose Substances 0.000 claims description 8
- 235000010981 methylcellulose Nutrition 0.000 claims description 8
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 7
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims description 6
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 6
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 6
- 235000010418 carrageenan Nutrition 0.000 claims description 6
- 229920001525 carrageenan Polymers 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000000905 isomalt Substances 0.000 claims description 6
- 235000010439 isomalt Nutrition 0.000 claims description 6
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 229940032147 starch Drugs 0.000 claims description 6
- 229920001817 Agar Polymers 0.000 claims description 5
- 229920000858 Cyclodextrin Polymers 0.000 claims description 5
- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 claims description 5
- 229920000881 Modified starch Polymers 0.000 claims description 5
- 239000008272 agar Substances 0.000 claims description 5
- 235000010419 agar Nutrition 0.000 claims description 5
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 5
- 239000000679 carrageenan Substances 0.000 claims description 5
- 229940113118 carrageenan Drugs 0.000 claims description 5
- 235000010980 cellulose Nutrition 0.000 claims description 5
- 229920002678 cellulose Polymers 0.000 claims description 5
- 239000001913 cellulose Substances 0.000 claims description 5
- 238000002425 crystallisation Methods 0.000 claims description 5
- 230000008025 crystallization Effects 0.000 claims description 5
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 5
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 5
- 239000008158 vegetable oil Substances 0.000 claims description 5
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 4
- 235000002639 sodium chloride Nutrition 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- 239000004386 Erythritol Substances 0.000 claims description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 2
- 235000019414 erythritol Nutrition 0.000 claims description 2
- 229940009714 erythritol Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 16
- 230000008673 vomiting Effects 0.000 abstract description 8
- 206010012735 Diarrhoea Diseases 0.000 abstract description 6
- 231100000331 toxic Toxicity 0.000 abstract description 6
- 230000002588 toxic effect Effects 0.000 abstract description 6
- 206010019345 Heat stroke Diseases 0.000 abstract description 5
- 210000004916 vomit Anatomy 0.000 abstract description 5
- 206010008631 Cholera Diseases 0.000 abstract description 4
- 235000013373 food additive Nutrition 0.000 abstract description 3
- 239000002778 food additive Substances 0.000 abstract description 3
- 206010022000 influenza Diseases 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 description 15
- 238000012360 testing method Methods 0.000 description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 13
- 239000002202 Polyethylene glycol Substances 0.000 description 12
- 229920001223 polyethylene glycol Polymers 0.000 description 12
- 201000010099 disease Diseases 0.000 description 10
- 238000009833 condensation Methods 0.000 description 9
- 230000005494 condensation Effects 0.000 description 9
- 238000011160 research Methods 0.000 description 9
- 230000004927 fusion Effects 0.000 description 7
- 230000008859 change Effects 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000000084 colloidal system Substances 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 210000000214 mouth Anatomy 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 150000005846 sugar alcohols Polymers 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000006225 natural substrate Substances 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 206010003757 Atypical pneumonia Diseases 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- 208000037319 Hepatitis infectious Diseases 0.000 description 3
- 239000009711 Huoxiang-zhengqi Substances 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- 208000037386 Typhoid Diseases 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 229920000591 gum Polymers 0.000 description 3
- 235000013402 health food Nutrition 0.000 description 3
- 208000005252 hepatitis A Diseases 0.000 description 3
- 239000002932 luster Substances 0.000 description 3
- 239000000594 mannitol Substances 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 231100000957 no side effect Toxicity 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 229920001277 pectin Polymers 0.000 description 3
- 239000001814 pectin Substances 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 150000004804 polysaccharides Chemical class 0.000 description 3
- 230000035943 smell Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 201000008297 typhoid fever Diseases 0.000 description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 244000286663 Ficus elastica Species 0.000 description 2
- 231100000111 LD50 Toxicity 0.000 description 2
- 235000004298 Tamarindus indica Nutrition 0.000 description 2
- 240000004584 Tamarindus indica Species 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- PYMYPHUHKUWMLA-LMVFSUKVSA-N aldehydo-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 229960001375 lactose Drugs 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 235000010987 pectin Nutrition 0.000 description 2
- 239000004334 sorbic acid Substances 0.000 description 2
- 229940075582 sorbic acid Drugs 0.000 description 2
- 235000010199 sorbic acid Nutrition 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229940098465 tincture Drugs 0.000 description 2
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 2
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 244000247812 Amorphophallus rivieri Species 0.000 description 1
- 235000001206 Amorphophallus rivieri Nutrition 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 208000012239 Developmental disease Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 241001411320 Eriogonum inflatum Species 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002581 Glucomannan Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 229920002752 Konjac Polymers 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- 244000275012 Sesbania cannabina Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 208000012873 acute gastroenteritis Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229940046240 glucomannan Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 239000001341 hydroxy propyl starch Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000013828 hydroxypropyl starch Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 235000010485 konjac Nutrition 0.000 description 1
- 239000000252 konjac Substances 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000021251 pulses Nutrition 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000003578 releasing effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007560 sedimentation technique Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000026676 system process Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229960001947 tripalmitin Drugs 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a kind ofly be used for the treatment of flu, vomit, have loose bowels, the medicine of heatstroke, cholera, the present invention overcome present drop pill adjuvant pure natural degree not high and at present the common chemical synthesis auxiliary material not in some national food additive catalogue, the relatively poor shortcoming of drop pill mouthfeel, be that a kind of natural degree is higher, the pharmaceutical preparation that safety is stronger, toxic and side effects is lower.
Description
Technical field
What the present invention relates to is the preparation that is prepared drop pill by the Chinese medicinal plant extract, specifically is the preparation method and its usage of ageratum dropping pill formulation.
Background technology
The ageratum prescription comes from " formulary of peaceful benevolent dispensary volume two " contained huoxiang zhengqi powder, main medicine is formed Herba Pogostemonis, Rhizoma Atractylodis, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Pericarpium Arecae, the Radix Angelicae Dahuricae, Folium Perillae, Poria, Pericarpium Citri Reticulatae, Radix Platycodonis, Radix Glycyrrhizae, we have in the harmony in the exterior of separating, the effect of eliminating turbid pathogen with aromatics is mainly used in affection of exogenous wind-cold, in humidity hysteresis is arranged or experiences heat-damp in summer, see exterior syndromes such as cold and heat headache outward, in have vexed, the indigestion and loss of appetite vomiting and nausea of breast abdominal distention, stomachache have loose bowels tastelessness greasy fur, the card of wet resistance such as relaxed and soft pulse.We are usually used in common cold of gastrointestinal type, acute gastroenteritis or dyspepsia etc. and have above-mentioned patient.In addition, the treatment that this prescription is used for pestilence (epidemic diseases) is offered promptly on the books at ancient Chinese prose, and " Wang Kentang is said, and epidemic disease person is that the air-flow that day row is ferocious and stern is capable as " Treatise on Febrile Diseases detailed outline volume seven ".The not positive person of all 4 o'clock orders is to have this gas also capable.If the people feels it, then long children is similar and sick, infects mutually again, and its work is similar to typhoid fever.Right typhoid fever gets because of cold, and this is a pestilential pathogen, can not discuss also together with cold, and method is when warding off diffusing pestilential pathogen, and it is main setting upright gas.Ruo Duori does not understand, and what disease of the pathogenic heat change of disease should become in the disease bar from typhoid fever and select for use.It is then different only to disperse medicine.All decoctions of dispersing, huoxiang zhengqi powder ...All available.”
At present, common clinically ageratum class preparation has pill (watered pill, water-honeyed pill, small honey pill, big honeyed pills, concentrated pill), tablet, mixture, oral liquid, tincture water preparation, bagged steeping drug, water preparation, electuary (granule), capsule (hard, soft capsule) etc., and is wherein more welcome with liquid dosage form.But the medicine of this class dosage form normally forms the blend decoction of crude drug through routine, and many effective armaticity volatile ingredient losses affect the treatment in the crude drug because of it can make, so should not adopt.Another kind is in the Pharmacopoeia of the People's Republic of China (1990 editions) the 534th page of records " HUOXIANG ZHENGQI SHUI ", its preparation method is after the raw material that will contain aromatic volatile component earlier is prepared into ethanol percolation liquid with alcohol percolation method, again with the decocting liquid that decocts gained by other raw material and patchouli oil and Folium perillae acutae oil merging, and the pure content that transfers in the finished product with ethanol is 40-50%, thereby this preparation is to contain the higher tincture of alcohol amount.The shortcoming that a large amount of ethanol exist is except that increasing product cost, main is big to GI irritation, the normal sense in clothes back is uncomfortable, even can cause vomiting, not easy for patients to accept, influenced the normal performance of curative effect, to ethanol allergy, or old man, child, and also all should not take the patient of alcohol prohibitions such as heating, vomiting, gastrointestinal ulceration, the scope of treatment target is restricted.Though pill is easy to carry, when taking, effective ingredient discharges slowly, and therapeutical effect is not obvious, is not suitable for being used to the patient who suffers heatstroke, vomits, has loose bowels.
The synthetic chemical substance that modern medicine is commonly used has spreaded all over each corner of human lives, chemical synthetic drug becomes the main flow of medicine, yet, appearance along with multiple difficult serious symptom miscellaneous diseases, western medical treatment presents imperfect, the human lives and the healthy reality and the up-to-date successes achieved in research have all proposed query to this situation, particularly along with the continuous appearance of chemical drugs toxic and side effects, the change of spectrum of disease and conversion of medical, make modern medicine be subjected to unprecedented challenge, and people also place hope in the application and development of traditional medicine on gradually.Advocate back to nature, pay attention to plant amedica use, hanker after traditional remedies, the trend of advocating natural drug forms, making full use of natural materials is human best selections.
At present, in the world, natural drug all has certain market, along with people increasing and the aging of population to the health requirements level of understanding, sub-health stateization, people thirst for back to nature more, the problem of utilize the high Drug therapy of pure natural degree, preventing some chemical synthetic drugs cann't be solved, so the background that exceeds its original traditional national culture has been expanded in the application of natural plant.From natural drug, seek the little and inexpensive medicine of side effect and become the target that countries in the world pharmaceutical manufacturer is chased.The European Community has carried out unified legislation to medical herbs, state medical herbs status such as Canada and Australia have legalized, U.S. government has also drafted the plant amedica management method, the compound recipe mix preparation that begins to accept natural drug is as curative, and these provide good international environment for Chinese medicine enters international medical market as curative.On the other hand, along with the quickening of global economic integration progress, particularly China becomes a full member of WTO, and Chinese Medicine market incorporates the breadth and depth of international medical big market and will further aggravate.Face the enormous impact of Asian countries's traditional medicine product such as the keen competition of powerful transnational medical group and Japan, Korea S, India, Thailand and European countries' plant amedica such as Germany, France, numerous products that China's Chinese medicine produces are owing to still can not meet the standard of international medical market and requirement and being kept outside of the door.
Expansion and human back to nature requirement along with the market global range, use the low medicine of toxic and side effects, especially pure natural medical more and more becomes people's first-selection, dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past, but present dropping pill formulation generally faces following problem: 1, drop pill adjuvant pure natural degree is not high: at present, drop pill substrate adjuvant mostly is synthetic, natural degree is lower, the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the drop pill outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, becomes the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of Chinese medicine or its preparation or abnormal smells from the patient and abandon the treatment of Chinese medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The purpose of this invention is to provide that a kind of treatment with new type natural substrate adjuvant preparation is caught a cold, vomits, had loose bowels, the medicine of heatstroke, cholera, infectious hepatitis, atypical pneumonia disease.
Another object of the present invention provides and a kind ofly treats flu, vomits, has loose bowels, the preparation method of heatstroke, cholera, infectious hepatitis, atypical pneumonia disease medicament preparation.
The selected substrate adjuvant of the present invention is resulting by a large amount of tests, it is little to have molecular weight, soluble in water, and molten diffusing speed is faster, pure natural degree height, toxic and side effects is lower, and can reduce the medicine irritation abnormal smells from the patient, has the oral cavity of improvement acid-base value during the buccal of oral cavity, improve the characteristics of oral cavity smell, the used substrate adjuvant of the present invention is the agent of food sedan-chair flavor, takes that mouthfeel is good, the acceptant characteristics of patient, is the direction of following substrate adjuvant development.
Drug component of the present invention, the selection of consumption and adjuvant thereof also gropes to sum up to draw through the inventor in a large number, each amounts of components all has curative effect preferably in following ranges: Rhizoma Atractylodis 80～240g, Pericarpium Citri Reticulatae 80～240g, Cortex Magnoliae Officinalis 80～240g, the Radix Angelicae Dahuricae 120～360g, Poria 120～360g, Pericarpium Arecae 120～360g, Rhizoma Pinelliae 80～240g, Radix Glycyrrhizae extractum 10～30g, patchouli oil 0.8～2.4ml, Folium perillae acutae oil 0.4～1.2ml, appropriate amount of auxiliary materials is made, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose; Preferred drug component consumption of the present invention and adjuvant thereof be chosen as Rhizoma Atractylodis 120～200g, Pericarpium Citri Reticulatae 120～200g, Cortex Magnoliae Officinalis 120～200g, the Radix Angelicae Dahuricae 180～300g, Poria 180～300g, Pericarpium Arecae 180～300g, Rhizoma Pinelliae 120～200g, Radix Glycyrrhizae extractum 15～25g, patchouli oil 1.2～2.0ml, Folium perillae acutae oil 0.6～1.0ml, appropriate amount of auxiliary materials is made, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose; Be chosen as the Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis 160g, Radix Angelicae Dahuricae 160g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml, appropriate amount of auxiliary materials of best drug component consumption of the present invention and adjuvant thereof make, and filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
Can also contain chemosynthesis adjuvant and animal origin adjuvant in the above-mentioned dressing, wherein filler comprises phenylglycol, hexadecanol, octadecanol, sodium stearate, tristerin, tripalmitin, carbamide, polyoxyethylene monostearate, polyoxyethylene alkyl ether; Wherein plasticity substrate comprises polyvinylpyrrolidone, crospolyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, gelatin.
In screening to above adjuvant, we find: plant colloid such as carrageenan, the tragakanta, pectin, agar, arabic gum, Ficus elastica, tamarind gum, locust bean gum, Pseudobulbus Bletillae (Rhizoma Bletillae) glue, guar gum, Konjac glucomannan, it is big that plant colloids such as POLY-karaya have viscosity, mobile poor, characteristics such as do not solidify after the condensation, and arabic gum has high dense low sticking character, can be mixed with the aqueous solution of 50% concentration and still have flowability, this is one of not available characteristics of other hydrophilic colloid, arabic gum has at high temperature, under the low concentration, can ooze, but not condensation, at low temperature, under the high concentration, be difficult for oozing, but characteristics such as energy condensation.Polysaccharide such as polysaccharide such as starch and derivant thereof (as gelling starch, carboxymethyl starch etc.), cellulose derivative (as methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose etc.), alginic acid, dextrin, cyclodextrin, lactose, in screening, find alginic acid have viscosity big, be the fruit jelly sample, dextrin has the colloid sample, characteristics such as lactose coagulability difference; And starch and derivant thereof are materials commonly used in the medical science adjuvant, thus in polysaccharide preferred starch and derivant thereof.Polyhydric alcohol such as sorbitol (88～102 ℃), xylitol (88～94.5 ℃), lactose (70～80 ℃), mannitol (166～169 ℃), maltose alcohol (135～140 ℃), isomalt polyhydric alcohol such as (98～103 ℃) screen, and find that it has following characteristics as drop pill substrate: sorbitol, lactose, isomalt are mobile poor; Mannitol, maltose alcohol fusing point are too high; The xylitol coagulability is poor slightly.After Preliminary screening, preferred xylitol, lactose, sorbitol in the selection of polyhydric alcohol, the best is an xylitol.Xylitol has following characteristics as drop pill substrate: in the time of 91 ℃, molten condition has appearred in xylitol, but not fusion fully, cooling rapidly, it separates out crystallization very soon, xylitol mixes the back good fluidity with extractum at certain proportion, can drip and can condensation, but be condensed into Powdered thing, loosely organized, the toughness extreme difference, that pinches is promptly broken.Organic acid and salt, alkali such as citric acid (100 ℃), sorbic acid (133 ℃), succinic acid (181～189 ℃), sodium acetate organic acid such as (58 ℃) and salt, alkali, its as drop pill substrate have fusing point too high, with Chinese medical concrete can't mixing etc. shortcoming.
Because of above single adjuvant existing shortcoming in as the drop pill preparation process, particularly we by above-mentioned Preliminary screening after, determine two kinds of adjuvants are used and screen: mainly be that above various adjuvants are carried out combined sorting, final determine following several: the plant colloid cooperates with the plant colloid, the cooperating of polyhydric alcohol and polyhydric alcohol, polyhydric alcohol and plant colloidally cooperate, the cooperating of the cooperating of xylitol and arabic gum, lactose and arabic gum, based on the composite auxiliary material of xylitol.Find preferred the cooperation to be xylitol, lactose and the compound use of other adjuvant, this kind combination has following characteristics: make up with mannitol: can drip not condensation; Make up with sorbic acid: both do not dissolve each other; Make up with lactose: can drip the energy condensation, but frangible; Make up with pomelo-pectin, tragakanta, sodium alginate: viscosity is big, can't drip; Make up with arabic gum: can drip, coagulability is poor slightly; Make up with dextrin: can drip, coagulability is poor slightly; Make up with starch: can drip, coagulability is also better.Determine that at last best of breed is that xylitol cooperates with arabic gum with starch, xylitol with starch, lactose.
At xylitol and starch, lactose and starch, in the research of xylitol and arabic gum combination, xylitol and starch Application of composite being prepared some required in the process of drop pill factors investigated, mainly is to the xylitol type, condensed fluid, condensate temperature influences the drop pill mouldability, xylitol and starch proportion influence mouldability, temperature is to the influence of drop pill mouldability, the extractum amount influences the drop pill mouldability, mixing time influences the drop pill mouldability, the dropper bore is to the influence of drop pill particle diameter, the formulation optimization of drop pill, the Preliminary Determination of drop pill, dissolve scattered time limit is investigated.Find that the solid xylitol has three types of powder, granular and crystallinity, and the easiest fusion of powder xylitol, again can fine dissolving be dispersed in the mixed liquor that starch, extractum forms, good fluidity, drippage is easy, and granular and crystalline xyhose alcohol is difficult for fusion, solubility property is also slightly poor, the mix flow that they and starch, extractum form is relatively poor, viscosity is very big, almost cannot drip, and therefore drips first-selected powder xylitol in the system process at drop pill.
At ratio of adjuvant molding is found in the sex research, in the combination of xylitol and starch, lactose and starch, xylitol and arabic gum, low melting point substrate adjuvant is 1: 0～1: 1.5 with the ratio of the weight of plasticity substrate adjuvant, be preferably 1: 0.1～1: 0.9, the best is 1: 0.1～1: 0.5.Low melting point substrate adjuvant of being formed within this scope and plasticity substrate adjuvant, the drug matrices fused solution all can ooze, and can condensation.Specific to each combination, xylitol is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and lactose is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and the ratio of the weight of xylitol and arabic gum is preferably 1: 0.2～and 1: 0.4.Find that in the research of temperature temperature is big especially to the influence of drop pill mouldability to the influence of drop pill mouldability, when temperature is too low, owing to the too big effect that oozes that influences drop pill of viscosity of substrate, when temperature is too high, not condensation of drop pill.Find that mixing time can have influence on the mouldability of drop pill in mixing time in to the sex research of drop pill molding, mixing time is too short, and mobile poor, influence oozes, and mixing time is oversize, influences the condensation of drop pill.Dripping under the system temperature, mixing time in 1～120 minute all can, suitable mixing time was at 10～30 minutes.Consider that mixing time can not be too short in the suitability for industrialized production, adopt the method that low temperature stirs for a long time, high temperature drips system.Find that in the research of dropper bore to the influence of drop pill particle diameter the dropper bore influences the size of drop pill and the flowability of fusion substrate, the system effect is dripped in influence.Drop pill diminishes and diminishes along with bore, but after 1.4 millimeters, along with the bore change of size that diminishes is not obvious, but the matrix flow reduction, system is dripped in influence.
So in the preparation method of preparation, medicine mixes mixing time with the substrate adjuvant be 10～30 minutes; The mixed heating and melting temperature of medicine and substrate adjuvant is 45～115 ℃, dripping the system temperature is 45～95 ℃, and liquid coolant is liquid paraffin, methyl-silicone oil or vegetable oil (Oleum Glycines, Semen Ricini wet goods), and the temperature of liquid coolant is-20～25 ℃, dropper mouth internal diameter is 1.0～4.0 millimeters; Preferred heating and melting temperature is 60～85 ℃, and dripping a system temperature is 60～85 ℃, and condensing agent is liquid paraffin, methyl-silicone oil, and the condensing agent temperature is 0～18 ℃, and the dropper bore is 1.1～3.5 millimeters, and the difference of dropper mouth external diameter and internal diameter is less for well; Best heating and melting temperature is that to make temperature be that 64 ℃, dropper bore are that 1.2～2.5 millimeters, condensing agent are 0 ℃ methyl-silicone oil to 64 ℃, droplet.
The substrate adjuvant of the best of the present invention is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
Xylitol is a kind of natural plant sweetening agent, approve through World Health Organization (WHO), xylitol is a kind of safest sweeting agent, countries in the world are extensive use of in fields such as food and oral-cavity articles, xylitol enters the help that need not insulin in the cell, when sugar utilizes obstacle, can not cause blood sugar increasing yet, can improve diabetics symptom, have the ketoplastic effect of powerful inhibition, can promote the generation of liver glycogen, directly infiltrate the Developmental and Metabolic Disorder that tissue is participated in metabolism, can be corrected protein, fat and steroid; Xylose is the internal metabolism intermediate product, and body has higher toleration to it.Clinical practice proves: the highest oral dosis tolerata can reach 220g every day, and intravenous drip every day can reach 100g.The oral 25700mg/Kg of median lethal dose(LD 50) (LD50) mice, quiet notes 6400mg/Kg, the quiet notes of rat 6200mg/Kg.
Medicine mesostroma adjuvant of the present invention and amount of drug are than can being the scope that allows on the galenic pharmacy, medicine described here can be that crude drug also can be the effective ingredient extract, in order to adapt to industrialized great production, the ratio range of mesostroma adjuvant of the present invention and medicine refers to the weight proportion of adjuvant and extract drugs extractum, and the substrate adjuvant is 1: 0.1～1: 1 with the ratio of the weight of drug extract; Preferred substrate adjuvant is 1: 0.1～1: 0.6 with the ratio of the weight of extract drugs extractum; Best substrate adjuvant is 1: 0.2～1: 0.4 with the ratio of the extraction extractum weight of medicine.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But, preferably adopt following technology to extract, but this can not limit protection scope of the present invention to raw material in order to make each crude drug of this medicine better bring into play drug effect.
The preparation method of medicine of the present invention is as follows:
(a) get Rhizoma Atractylodis 80～240g, Pericarpium Citri Reticulatae 80～240g, Cortex Magnoliae Officinalis 80～240g, the Radix Angelicae Dahuricae 120～360g, Poria 120～360g, Pericarpium Arecae 120～360g, Rhizoma Pinelliae 80～240g, Radix Glycyrrhizae extractum 10～30g, patchouli oil 0.8～2.4ml, Folium perillae acutae oil 0.4～1.2ml are standby;
(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 12～36 hours with 50～80% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 60～90 ℃ of warm macerating 2 times, 1.5～4.5 hours for the first time, 1～3 hour for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 8～20g, decoct with water 2 times, and 1.5～4.5 hours for the first time, 1～3 hour for the second time; Pericarpium Arecae decocts with water 1.5～4 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;
(c) in appropriate amount of auxiliary materials, add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil, fully mix, mixture stirs at 45～115 ℃ of heating and meltings, mixing time is 1～120 minute, insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
Preferred process for preparing medicine of the present invention comprises the following steps:
(a) get Rhizoma Atractylodis 120～200g, Pericarpium Citri Reticulatae 120～200g, Cortex Magnoliae Officinalis 120～200g, the Radix Angelicae Dahuricae 180～300g, Poria 180～300g, Pericarpium Arecae 180～300g, Rhizoma Pinelliae 120～200g, Radix Glycyrrhizae extractum 15～25g, patchouli oil 1.2～2.0ml, Folium perillae acutae oil 0.6～1.0ml are standby;
(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 20～30 hours with 55～65% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 75～85 ℃ of warm macerating 2 times, 2～4 hours for the first time, 1.5～2.5 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 10～15g, decoct with water 2 times, and 2.5～3.5 hours for the first time, 1.5～2.5 hours for the second time; Pericarpium Arecae decocts with water 2.5～3.5 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;
(c) in appropriate amount of auxiliary materials, add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil fully mixes, and mixture is at 60～85 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, in following system of 60～85 ℃ of temperature, the dropper bore is 1.1～3.5 millimeters, splashes in 0～18 ℃ the liquid paraffin, methyl-silicone oil, drip and make ball, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Best process for preparing medicine of the present invention comprises the following steps:
(a) get Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 160g, Radix Angelicae Dahuricae 240g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Rhizoma Zingiberis 13.5g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml are standby; Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 60% ethanol respectively according to the percolation under appendix I 0 fluid extract of Chinese Pharmacopoeia nineteen ninety-five version and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 80 ℃ of warm macerating 2 hours, 3 hours for the first time, 2 hours for the second time, extracting juice;
(b) Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 13.5g, decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;
(c) in appropriate amount of auxiliary materials, add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil fully mixes, and mixture is at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, make drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Best process for preparing medicine of the present invention comprises the following steps:
(a) get Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 160g, Radix Angelicae Dahuricae 240g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Rhizoma Zingiberis 13.5g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml are standby; Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 60% ethanol respectively according to the percolation under appendix I 0 fluid extract of Chinese Pharmacopoeia nineteen ninety-five version and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 80 ℃ of warm macerating 2 hours, 3 hours for the first time, 2 hours for the second time, extracting juice;
(b) Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 13.5g, decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;
(c): to ratio an amount of, weight is 1: 0.2～1: 0.3 xylitol and starch mixture; Or the ratio of weight is 1: 0.2～1: 0.3 lactose and starch mixture; Or the ratio of weight is to add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil in 1: 0.2～1: 0.4 xylitol and the arabic gum mixture, Folium perillae acutae oil fully mixes, and mixture is at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, make drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug, messenger drug or adjuvant drug and messenger drug in forming, can be replaced by suitable Chinese medicine individually or simultaneously with the identical property of medicine, effect, it is constant to replace back Chinese medicine preparation and drug effect thereof.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of dropping pill formulation taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, make drug effect faster, be that a kind of onset is treated flu faster, vomits, had loose bowels, the medicine of heatstroke, cholera, infectious hepatitis, atypical pneumonia disease.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill made from this adjuvant can reduce effective ingredient separating out in storage process, the sticking ball of drop pill, easy shortcomings such as moisture absorption deliquescing, but the big production of suitability for industrialized.
For a better understanding of the present invention, below routine by experiment beneficial effect of further setting forth the invention medicine, test explanation advantages of the present invention such as dissolve scattered time limit, the ball method of double differences of the ageratum drop pill that the new and old substrate adjuvant of experimental example is made is different, drop pill soft durometer, the sticking ball of drop pill, test is intended to further specify the effect of the ageratum drop pill that new substrate adjuvant makes below, but not limitation of the present invention.The invention medicine that this experimental example adopts is to be prepared from by embodiment 9.
Test example 1: dissolve scattered time limit, the different contrast experiment's example of the ball method of double differences
In vitro tests
The present invention be that the ageratum drop pill that adjuvant is made compares with the Polyethylene Glycol, by measuring dissolve scattered time limit, investigate its good releasing effect; By measuring indexs such as the ball method of double differences is different, whether ripe, whether be fit to suitability for industrialized production if investigating its preparation technology.
1. test medication: the new substrate ageratum of the present invention drop pill (newly) is the ageratum drop pill (old) that adjuvant is made with the Polyethylene Glycol.
2. method and result:
Dissolve scattered time limit: by " method is measured under this item of Chinese pharmacopoeia; The ball method of double differences is different: by " method is measured under this item of Chinese pharmacopoeia.Result of the test sees Table 1.
The ageratum drop pill (newly) that three batches in table 1 is made with the new medium adjuvant with the polyethylene glycol 6000 be ageratum drop pill (old) dissolve scattered time limit made of adjuvant, weight differential relatively
Test data shows, the dissolve scattered time limit of new substrate ageratum drop pill is that the ageratum drop pill made of adjuvant is few with the Polyethylene Glycol, and the ball method of double differences of the ageratum drop pill that new and old substrate is made is different all to be controlled in the pharmacopeia prescribed limit.Result of the test explanation, the molten diffusing speed of the ageratum drop pill made from novel adjuvant is faster, is more conducive to medicine and plays a role in the shortest time; The ball method of double differences is different all to be controlled in the pharmacopeia prescribed limit, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
Test example 2: the present invention with the Polyethylene Glycol be the sticking ball comparative observation of ageratum drop pill soft durometer, drop pill that adjuvant is made
The present invention be that the ageratum drop pill that adjuvant is made compares with the Polyethylene Glycol, by measuring indexs such as above-mentioned, investigate its effect.
1. test medication: the new substrate ageratum of the present invention drop pill (newly) is provided by the Jinshili Medicine Research ﹠. Development Co., Ltd., Tianjin; With the Polyethylene Glycol is the ageratum drop pill (old) that adjuvant is made, and is provided by the Jinshili Medicine Research ﹠. Development Co., Ltd., Tianjin.
2. method and result:
Get three batches of new, old substrate ageratum drop pill, be loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.1, table 2.2.
Three batches in table 2.1 is that the ageratum drop pill reserved sample observing that adjuvant is made compares with the Polyethylene Glycol
Table 2.2: the three batches of ageratum drop pill made from the new medium adjuvant (newly) with the Polyethylene Glycol be ageratum drop pill (old) character observation made of adjuvant relatively
Above test data shows, new substrate ageratum drop pill soft durometer changes and be that the ageratum drop pill made of adjuvant is similar, strong slightly with the Polyethylene Glycol; The sticking ball variation of new substrate ageratum drop pill, firmness change and be that the ageratum drop pill made of adjuvant is similar with the Polyethylene Glycol.The result of the test explanation, the sticking ball of the drop pill that new and old substrate adjuvant is made changes, firmness change is similar, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
The specific embodiment
Embodiment 1: the preparation of active constituents of medicine of the present invention
By the pharmacopeia specified volume get Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 160g, Radix Angelicae Dahuricae 240g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Rhizoma Zingiberis 13.5g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml are standby:
Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 60% ethanol respectively according to the percolation under appendix I 0 fluid extract of Chinese Pharmacopoeia nineteen ninety-five version and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 80 ℃ of warm macerating 2 hours, 3 hours for the first time, 2 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 13.5g, decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and considers the liquid concentrating under reduced pressure and becomes thick paste, adds Radix Glycyrrhizae extractum, patchouli oil, and Folium perillae acutae oil, mixing is made thing active component of the present invention.
Embodiment 2:
Get xylitol 833g and dextrin 167g mix homogeneously, add of the present invention thing active component of 50g according to the preparation of embodiment one method, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, make and drip the 1050g ball, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 3:
By the pharmacopeia specified volume get Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 160g, Radix Angelicae Dahuricae 240g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Rhizoma Zingiberis 13.5g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml are standby; Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 60% ethanol respectively according to the percolation under appendix I 0 fluid extract of Chinese Pharmacopoeia nineteen ninety-five version and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 80 ℃ of warm macerating 2 hours, 3 hours for the first time, 2 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 13.5g, decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and considers liquid and is concentrated into the thick paste shape, adds Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil, mixing;
With arabitol 800g, hydroxypropyl emthylcellulose 85g and the abundant mixing of xanthan gum 115g, put into drop pill and drip the system device, add and use the active component that legal system is equipped with gained, fully stir evenly, mixture is at 60～66 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 60～66 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, make the 1500g drop pill, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.The result shows, prepared drop pill rounding, even, consistent, the no adhesion phenomenon of color and luster of size.
Embodiment 4:
(a) it is standby to get Rhizoma Atractylodis 80g, Pericarpium Citri Reticulatae 80g, Cortex Magnoliae Officinalis 100g, Radix Angelicae Dahuricae 120g, Poria 120g, Pericarpium Arecae 140g, Rhizoma Pinelliae 80g, Radix Glycyrrhizae extractum 10g, patchouli oil 0.8ml, Folium perillae acutae oil 0.5ml, lactose 759g, starch 95g;
(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 20 hours with 70% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 70 ℃ of warm macerating 2 times, 4.5 hours for the first time, 3 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 15g, decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;
(c) in lactose, starch mixture, add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil fully mixes, and mixture is at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, make the 1025g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 5:
(a) it is standby to get Rhizoma Atractylodis 120g, Pericarpium Citri Reticulatae 200g, Cortex Magnoliae Officinalis 200g, Radix Angelicae Dahuricae 180g, Poria 160g, Pericarpium Arecae 180g, Rhizoma Pinelliae 120g, Radix Glycyrrhizae extractum 15g, patchouli oil 1.2ml, Folium perillae acutae oil 0.8ml, arabitol 400g, carboxymethyl starch 56g;
(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 55% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 80 ℃ of warm macerating 2 times, 4 hours for the first time, 2 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 14g, decoct with water 2 times, and 3.5 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;
(c) in arabitol and carboxymethyl starch mixture, add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil, fully mix, mixture is at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, and under 70 ℃ of insulations fused mass being splashed into temperature with 40 droplets/minute speed is in 4 ℃ the liquid paraffin liquid coolant, the dropper bore is 1.2～2.5 millimeters, make the 1025g drop pill, the liquid paraffin that goes to stick to the drop pill surface is inhaled with inhaling paper in back to be formed, and cold drying promptly.
Embodiment 6:
(a) it is standby to get Rhizoma Atractylodis 200g, Pericarpium Citri Reticulatae 180g, Cortex Magnoliae Officinalis 200g, Radix Angelicae Dahuricae 200g, Poria 300g, Pericarpium Arecae 180g, Rhizoma Pinelliae 200g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.2ml, Folium perillae acutae oil 1.0ml, xylitol 850g, starch 87g;
(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 30 hours with 65% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 85 ℃ of warm macerating 2 times, 3 hours for the first time, 2 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 13.5g, decoct with water 2 times, and 3.5 hours for the first time, 3 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;
(c) in xylitol and starch mixture, add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil fully mixes, and mixture is at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, moves in the drop pill machine, system is at the uniform velocity dripped in insulation from top to bottom under 64 ℃ of temperature, the dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, make the 1025g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 7:
(a) it is standby to get Rhizoma Atractylodis 240g, Pericarpium Citri Reticulatae 150g, Cortex Magnoliae Officinalis 240g, Radix Angelicae Dahuricae 360g, Poria 360g, Pericarpium Arecae 300g, Rhizoma Pinelliae 240g, Radix Glycyrrhizae extractum 30g, patchouli oil 2.4ml, Folium perillae acutae oil 1.2, xylitol 500g, methylcellulose 150g;
(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 60% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 80 ℃ of warm macerating 2 times, 4 hours for the first time, 3 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 18.5g, decoct with water 2 times, and 4 hours for the first time, 3 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;
(c) in xylitol and methylcellulose mixture, add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil fully mixes, and mixture is at 60～85 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 60～68 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splash in 0～10 ℃ the methyl-silicone oil, make the 1025g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 8:
(a) it is standby to get Rhizoma Atractylodis 240g, Pericarpium Citri Reticulatae 240g, Cortex Magnoliae Officinalis 240g, Radix Angelicae Dahuricae 300g, Poria 360g, Pericarpium Arecae 360g, Rhizoma Pinelliae 240g, Radix Glycyrrhizae extractum 25g, patchouli oil 1.6ml, Folium perillae acutae oil 1.2ml, sorbitol 550g, xanthan gum 75g;
(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 36 hours with 75% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 75 ℃ of warm macerating 2 times, 3.5 hours for the first time, 2.5 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 30g, decoct with water 2 times, and 4 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into thick
(c) in sorbitol and methylcellulose, add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil fully mixes, and mixture is at 85 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 80 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashing into temperature with 35 droplets/minute speed is in 5 ℃ the liquid paraffin liquid coolant, makes the 1000g drop pill, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried, promptly.The result shows, prepared drop pill rounding, even, consistent, the no adhesion phenomenon of color and luster of size.
Embodiment 9:
(a) it is standby to get Rhizoma Atractylodis 80g, Pericarpium Citri Reticulatae 240g, Cortex Magnoliae Officinalis 200g, Radix Angelicae Dahuricae 120g, Poria 120g, Pericarpium Arecae 360g, Rhizoma Pinelliae 180g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.4ml, Folium perillae acutae oil 1.2ml, xylitol 683g, starch 137g;
(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 55% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 85 ℃ of warm macerating 2 times, 4 hours for the first time, 3 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 16g, decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;
(c) in xylitol and starch mixture, add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil fully mixes, and mixture is at 65 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 65 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 4 ℃ the methyl-silicone oil, make drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 10:
(a) it is standby to get Rhizoma Atractylodis 110g, Pericarpium Citri Reticulatae 150g, Cortex Magnoliae Officinalis 200g, Radix Angelicae Dahuricae 180g, Poria 120g, Pericarpium Arecae 240g, Rhizoma Pinelliae 120g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.0ml, Folium perillae acutae oil 0.8ml, lactose 587g, starch 233g;
(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 20 hours with 80% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 60 ℃ of warm macerating 2 times, 3.5 hours for the first time, 2.5 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 15g, decoct with water 2 times, and 3.5 hours for the first time, 1 hour for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;
(c) in lactose and starch mixture, add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil fully mixes, and mixture is at 55 ℃ of heating and meltings, stir, mixing time is 10～20 minutes, insulation, in following system of 50 ℃ of temperature, the dropper bore is 1.7 millimeters, splashes into 35 droplets/minute speed in 0 ℃ the methyl-silicone oil, make the 1025g drop pill, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 11
With lactose 20g and the abundant mixing of arabic gum 5.8g, put into drop pill and drip the system device, the extract extractum 10.5 that adds embodiment 1 gained, Radix Glycyrrhizae extractum 6.5g, patchouli oil 1.6ml, Folium perillae acutae oil 1.3ml fully stir evenly, be heated to fusion at 80 ℃, under 60 ℃ of insulations fused mass being splashed into temperature with 35 droplets/minute speed is in 0 ℃ the liquid paraffin liquid coolant, makes 1000 drop pill, the liquid paraffin that goes to stick to the drop pill surface is inhaled with inhaling paper in back to be formed, and cold drying promptly.
Embodiment 12
With xylitol 13.5g and the abundant mixing of arabic gum 3.5g, put into drop pill and drip the system device, the extract extractum 5.5 that adds embodiment 1 gained, Radix Glycyrrhizae extractum 2.5g, patchouli oil 1.4ml, Folium perillae acutae oil 1.5ml fully stir evenly, be heated to fusion at 70 ℃, under 65 ℃ of insulations fused mass being splashed into temperature with 45 droplets/minute speed is in 0 ℃ the liquid vegetable oil, makes 1000 drop pill, the liquid that goes to stick to the drop pill surface is inhaled with inhaling paper in back to be formed, and cold drying promptly.
Embodiment 13
With lactose 20g, carrageenan 1g and the abundant mixing of starch 5g, put into drop pill and drip the system device, add the extract extractum 8.5g of embodiment 1 gained, Radix Glycyrrhizae extractum 1.5g, patchouli oil 2ml, Folium perillae acutae oil 0.4ml, fully stir evenly, mixture stirs at 45～115 ℃ of heating and meltings, mixing time is 1～120 minute, insulation is 1.80～3.0 millimeters at 45～95 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ the vegetable oil, make 1000 drop pill, promptly.
Embodiment 14
With lactose 12.3g, the abundant mixing of starch 3.7g, put into drop pill and drip the system device, the extract extractum 7.5g that adds embodiment 1 gained, Radix Glycyrrhizae extractum 2.5g, patchouli oil 0.4ml, Folium perillae acutae oil 0.6ml, fully stir evenly, mixture stirs at 60 ℃ of heating and meltings, and mixing time is 10 minutes, insulation, in following system of 60 ℃ of temperature, the dropper bore is 1.2 millimeters, splashes in 0～18 ℃ the methyl-silicone oil, drip and make 1000 balls, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 15
With isomalt 9g and the abundant mixing of alginic acid 8g, put into drop pill and drip the system device, the extract extractum 10.5g that adds embodiment 1 gained, Radix Glycyrrhizae extractum 5.5g, patchouli oil 2.4ml, Folium perillae acutae oil 1.2ml, fully stir evenly, mixture stirs at 85 ℃ of heating and meltings, and mixing time is 30 minutes, insulation, in following system of 85 ℃ of temperature, the dropper bore is 1.2 millimeters, splashes in 0 ℃ the liquid paraffin, drip and make 1000 balls, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 16
With isomalt 500g and the abundant mixing of carrageenan 200g, put into drop pill and drip the system device, the extract extractum 350g that adds embodiment 5 gained, Radix Glycyrrhizae extractum 150g, patchouli oil 30ml, Folium perillae acutae oil 18ml, fully stir evenly, under 65 ℃ of insulations fused mass being splashed into temperature with 35 droplets/minute speed is that back to be formed is with inhaling the liquid paraffin that the paper suction goes to stick to the drop pill surface in 0 ℃ the liquid paraffin liquid coolant, and cold drying promptly.
Embodiment 17
With lactose 15.5g and the abundant mixing of arabic gum 5.5g, put into drop pill and drip the system device, the extract extractum 2.5g that adds embodiment 9 gained, Radix Glycyrrhizae extractum 2.5g, patchouli oil 1ml, Folium perillae acutae oil 0.5ml, fully stir evenly, fully mix, mixture is at 70 ℃ of heating and meltings, stir, mixing time is 20 minutes, and insulation is in following system of 64 ℃ of temperature, the dropper bore is 2.0 millimeters, splash in 5 ℃ the methyl-silicone oil, make 1000 drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 18
With lactose 26.8g and the abundant mixing of dextrin 10.2g, put into drop pill and drip the system device, add the active component of embodiment 3 gained, fully stir evenly, mixture stirs at 75 ℃ of heating and meltings, mixing time is 15 minutes, and insulation is in following system of 66 ℃ of temperature, the dropper bore is 2.5 millimeters, splash in 10 ℃ the liquid paraffin, make 1000 drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 19
With xylitol 18g and the abundant mixing of hydroxypropyl emthylcellulose 3g, put into drop pill and drip the system device, the extract extractum 9.25g that adds embodiment 3 gained, Radix Glycyrrhizae extractum 3.5g, patchouli oil 1.8ml, Folium perillae acutae oil 0.8ml, fully stir evenly, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, in following system of 60～85 ℃ of temperature, the dropper bore is 1.1～3.5 millimeters, splashes into 35 droplets/minute speed in 5 ℃ the methyl-silicone oil, make 1000 drop pill, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 20
With lactose 750g and the abundant mixing of alginic acid 160g, put into drop pill and drip the system device, add the extract extractum 168.5g of embodiment 4 gained, Radix Glycyrrhizae extractum 78.5g, patchouli oil 18ml, Folium perillae acutae oil 9ml fully stir evenly heating in water bath, to fusion, bath temperature is 85 ℃.Under 65 ℃ of insulations fused mass being splashed into temperature with 35 droplets/minute speed is in 0 ℃ the liquid paraffin liquid coolant, makes 1000 drop pill, and back to be formed is with inhaling the liquid paraffin that the paper suction goes to stick to the drop pill surface, and cold drying promptly.The result shows, prepared drop pill rounding, even, consistent, the no adhesion phenomenon of color and luster of size.
Embodiment 21
With xylitol 15g and starch 4.5g mix homogeneously, get the extract extractum 12.5g of embodiment 9 gained, Radix Glycyrrhizae extractum 5.5g, patchouli oil 2.4ml, Folium perillae acutae oil 0.6ml, fully stir evenly, mixture is at 75 ℃ of heating and meltings, stir, mixing time is 15 minutes, and insulation is in following system of 65 ℃ of temperature, the dropper bore is 2.0 millimeters, splash into 45 droplets/minute speed in 5 ℃ the methyl-silicone oil, make 1000 drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Claims (12)
1, a kind of ageratum dropping pill formulation, it is characterized in that it is by Rhizoma Atractylodis 80～240g, Pericarpium Citri Reticulatae 80～240g, Cortex Magnoliae Officinalis 80～240g, the Radix Angelicae Dahuricae 120～360g, Poria 120～360g, Pericarpium Arecae 120～360g, Rhizoma Pinelliae 80～240g, Radix Glycyrrhizae extractum 10～30g, patchouli oil 0.8～2.4ml, Folium perillae acutae oil 0.4～1.2ml is that crude drug adds that appropriate amount of auxiliary materials makes, wherein adjuvant is made up of filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, arabitol, trehalose, xylitol, isomalt, lactose, maltose, and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, carrageenan, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof are pregelatinized Starch or carboxymethyl starch, and described cellulose and derivant thereof are methylcellulose or hydroxypropyl emthylcellulose.
2, ageratum dropping pill formulation as claimed in claim 1, it is characterized in that it is by Rhizoma Atractylodis 120～200g, Pericarpium Citri Reticulatae 120～200g, Cortex Magnoliae Officinalis 120～200g, the Radix Angelicae Dahuricae 180～300g, Poria 180～300g, Pericarpium Arecae 180～300g, Rhizoma Pinelliae 120～200g, Radix Glycyrrhizae extractum 15～25g, patchouli oil 1.2～2.0ml, Folium perillae acutae oil 0.6～1.0ml is that crude drug adds that appropriate amount of auxiliary materials makes, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose.
3, ageratum dropping pill formulation as claimed in claim 1, it is characterized in that it is is that crude drug adds that appropriate amount of auxiliary materials makes by Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis 160g, Radix Angelicae Dahuricae 160g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
4, ageratum dropping pill formulation as claimed in claim 3 is characterized in that described adjuvant is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
5, ageratum dropping pill formulation as claimed in claim 3 is characterized in that described adjuvant is lactose and starch, and lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
6, ageratum dropping pill formulation as claimed in claim 3 is characterized in that described adjuvant is xylitol and arabic gum, and the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
7,, it is characterized in that adjuvant and the ratio that raw material extracts the weight of extractum are 1: 0.1～1: 1 as claim 1,2 or 3 described ageratum dropping pill formulations.
8,, it is characterized in that adjuvant and the ratio that raw material extracts the weight of extractum are 1: 0.1～1: 0.6 as claim 1,2 or 3 described ageratum dropping pill formulations.
9,, it is characterized in that adjuvant and the ratio that raw material extracts the weight of extractum are 1: 0.2～1: 0.4 as claim 1,2 or 3 described ageratum dropping pill formulations.
10, the preparation method of claim 1,2 or 3 described ageratum drop pill is characterized in that this method comprises the following steps:
(a) get Rhizoma Atractylodis 80～240g, Pericarpium Citri Reticulatae 80～240g, Cortex Magnoliae Officinalis 80～240g, the Radix Angelicae Dahuricae 120～360g, Poria 120～360g, Pericarpium Arecae 120～360g, Rhizoma Pinelliae 80～240g, Radix Glycyrrhizae extractum 10～30g, patchouli oil 0.8～2.4ml, Folium perillae acutae oil 0.4～1.2ml are standby;
(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 12～36 hours with 50～80% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 60～90 ℃ of warm macerating 2 times, 1.5～4.5 hours for the first time, 1～3 hour for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 8～20g, decoct with water 2 times, and 1.5～4.5 hours for the first time, 1～3 hour for the second time; Pericarpium Arecae decocts with water 1.5～4 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;
(c) in appropriate amount of auxiliary materials, add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil, fully mix, mixture stirs at 45～115 ℃ of heating and meltings, mixing time is 1～120 minute, insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
11, the preparation method of ageratum drop pill as claimed in claim 10 is characterized in that this method comprises the following steps:
(a) get Rhizoma Atractylodis 120～200g, Pericarpium Citri Reticulatae 120～200g, Cortex Magnoliae Officinalis 120～200g, the Radix Angelicae Dahuricae 180～300g, Poria 180～300g, Pericarpium Arecae 180～300g, Rhizoma Pinelliae 120～200g, Radix Glycyrrhizae extractum 15～25g, patchouli oil 1.2～2.0ml, Folium perillae acutae oil 0.6～1.0ml are standby;
(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 20～30 hours with 55～65% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 75～85 ℃ of warm macerating 2 times, 2～4 hours for the first time, 1.5～2.5 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 10～15g, decoct with water 2 times, and 2.5～3.5 hours for the first time, 1.5～2.5 hours for the second time; Pericarpium Arecae decocts with water 2.5～3.5 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;
(c) in appropriate amount of auxiliary materials, add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil fully mixes, and mixture is at 60～85 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, in following system of 60～85 ℃ of temperature, the dropper bore is 1.1～3.5 millimeters, splashes in 0～18 ℃ the liquid paraffin, methyl-silicone oil, drip and make ball, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
12, the preparation method of ageratum drop pill as claimed in claim 10 is characterized in that this method comprises the following steps:
(a) it is standby to get Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis 160g, Radix Angelicae Dahuricae 240g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Rhizoma Zingiberis 13.5g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml; Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 60% ethanol respectively according to the percolation under Chinese Pharmacopoeia nineteen ninety-five version appendix I0 fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 80 ℃ of warm macerating 2 hours, 3 hours for the first time, 2 hours for the second time, extracting juice;
(b) Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 13.5g, decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;
(c) in appropriate amount of auxiliary materials, add above-mentioned thick paste, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil fully mixes, and mixture is at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, make drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101072846A CN100563635C (en) | 2003-12-11 | 2003-12-11 | A kind of ageratum drop pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101072846A CN100563635C (en) | 2003-12-11 | 2003-12-11 | A kind of ageratum drop pill |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1626126A CN1626126A (en) | 2005-06-15 |
| CN100563635C true CN100563635C (en) | 2009-12-02 |
Family
ID=34758093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003101072846A Expired - Fee Related CN100563635C (en) | 2003-12-11 | 2003-12-11 | A kind of ageratum drop pill |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100563635C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015003661A1 (en) | 2013-07-11 | 2015-01-15 | 天士力制药集团股份有限公司 | Preparation method for traditional chinese medicine micro drop pill and traditional chinese medicine micro drop pill prepared by using the method |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102998411B (en) * | 2011-09-13 | 2015-12-16 | 天士力制药集团股份有限公司 | A kind of detection method of ageratum dripping pill |
| CN103245733B (en) * | 2012-02-05 | 2016-03-02 | 天士力制药集团股份有限公司 | A kind of ageratum dripping pill authentication method |
| CN104225558B (en) * | 2014-09-29 | 2018-06-05 | 栗明峰 | A kind of pneumonia external patch and preparation method thereof |
| CN105079359A (en) * | 2015-09-09 | 2015-11-25 | 张士海 | Composition for treating heatstroke and preparation method thereof |
-
2003
- 2003-12-11 CN CNB2003101072846A patent/CN100563635C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 国家中成药标准汇编 肺系1分册. 国家药典委员会，480-481，国家药品监督管理局. 2002 |
| 国家中成药标准汇编 肺系1分册. 国家药典委员会，480-481，国家药品监督管理局. 2002 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015003661A1 (en) | 2013-07-11 | 2015-01-15 | 天士力制药集团股份有限公司 | Preparation method for traditional chinese medicine micro drop pill and traditional chinese medicine micro drop pill prepared by using the method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1626126A (en) | 2005-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100553615C (en) | A kind of medicine for the treatment of cardiovascular and cerebrovascular disease | |
| CN100563635C (en) | A kind of ageratum drop pill | |
| CN100421721C (en) | Medication for relieving cough and asthma | |
| CN100450504C (en) | Medication for treating pharyngitis | |
| CN100455314C (en) | Medication for treating cough | |
| CN100563634C (en) | A kind of Herba Sidae Rhombifoliae soup drop pill | |
| CN1872232B (en) | Composition of medication for curing cerebrovascular disease, and preparation method | |
| CN100421684C (en) | Medication for treating coronary heart disease and angina | |
| CN1872327B (en) | Composition of medicine for treating diarrhea | |
| CN100563673C (en) | Chinese medicine preparation of treatment angina pectoris and preparation method thereof | |
| CN100502840C (en) | Medication for treating chronic rhinitis and nasal sinusitis | |
| CN1872260B (en) | Method for preparing drop pills of ageratum vital qi | |
| CN100553617C (en) | A kind of medicine for the treatment of obstruction of qi in the chest and cardialgia | |
| CN100553620C (en) | A kind of medicine for the treatment of the thoracic obstruction | |
| CN100421658C (en) | Medication for treating coronary heart disease and angina | |
| CN100553652C (en) | A kind of medicine of Cure for insomnia | |
| CN100553618C (en) | A kind of medicine for the treatment of toothache | |
| CN1872230B (en) | A medication for treating coronary heart disease and preparation method | |
| CN1626133B (en) | Medication for treating coronary heart disease | |
| CN100536831C (en) | Medication for treating cardiovascular and cerebrovascular diseases | |
| CN100512833C (en) | Medication for treating cough | |
| CN100512832C (en) | Medication for treating ache | |
| CN100430070C (en) | Medication for treating coronary heart disease and angina | |
| CN100512824C (en) | Medication for treating headache | |
| CN100512841C (en) | Medication for treating bronchitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Tianjin Tasly Modern Chinese Medicine Resource Co., Ltd. Assignor: Tianjin Tianshili Pharmaceutical Co., Ltd. Contract record no.: 2011120000157 Denomination of invention: Quality detection method for Huoxiang Zhengqi dripping pills Granted publication date: 20091202 License type: Exclusive License Open date: 20050615 Record date: 20110824 |
|
| C56 | Change in the name or address of the patentee |
Owner name: TASLY PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: TIANJIN TASLY PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 300402 Tianjin Beichen Xinyi white road Liaohe Road No. 1 Patentee after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300402 Tianjin Beichen Xinyi white road Liaohe Road No. 1 Patentee before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
|
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 300402 Tianjin Beichen Xinyi white road Liaohe Road No. 1 Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300402 Tianjin Beichen Xinyi white road Liaohe Road No. 1 Patentee before: Tasly Pharmaceutical Group Co., Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20091202 Termination date: 20191211 |