CN100439336C - 制备环状苯甲脒衍生物的方法 - Google Patents
制备环状苯甲脒衍生物的方法 Download PDFInfo
- Publication number
- CN100439336C CN100439336C CNB2004800105008A CN200480010500A CN100439336C CN 100439336 C CN100439336 C CN 100439336C CN B2004800105008 A CNB2004800105008 A CN B2004800105008A CN 200480010500 A CN200480010500 A CN 200480010500A CN 100439336 C CN100439336 C CN 100439336C
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- CN
- China
- Prior art keywords
- compound
- expression
- salt
- formula
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
Abstract
Description
峰号 | X射线衍射数据2θ(°) | 强度 | 峰号 | X射线衍射数据2θ(°) | 强度 |
12345678910111213141516171819202122232425 | 9.9009.98010.54010.68012.16012.44013.56016.18016.24016.34018.08018.16019.04019.28019.72019.96020.04021.56021.94022.00022.32023.06023.52023.68023.780 | 2602082703483421288103826737224862356833538868511301140164391899745551785511951045 | 2627282930313233343536373839404142434445464748 | 24.20024.32024.58024.66025.10025.48025.60025.76025.82026.08026.94027.00027.14027.44027.92028.08028.40029.20029.40029.88030.06031.20031.600 | 367452520522493443460548590345615655492330312303290420397470387415270 |
Claims (6)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003040949 | 2003-02-19 | ||
JP040949/2003 | 2003-02-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1777583A CN1777583A (zh) | 2006-05-24 |
CN100439336C true CN100439336C (zh) | 2008-12-03 |
Family
ID=32958626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004800105008A Expired - Fee Related CN100439336C (zh) | 2003-02-19 | 2004-02-10 | 制备环状苯甲脒衍生物的方法 |
Country Status (11)
Country | Link |
---|---|
US (1) | US7375236B2 (zh) |
EP (2) | EP2444393A1 (zh) |
JP (1) | JP4549970B2 (zh) |
KR (1) | KR20050104376A (zh) |
CN (1) | CN100439336C (zh) |
AU (1) | AU2004218187C1 (zh) |
CA (1) | CA2515715C (zh) |
HK (1) | HK1091494A1 (zh) |
IL (1) | IL170175A (zh) |
TW (1) | TW200500340A (zh) |
WO (1) | WO2004078721A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106905388A (zh) * | 2017-02-16 | 2017-06-30 | 重庆西南制药二厂有限责任公司 | 一种天麻素的合成方法 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002088092A1 (fr) | 2001-04-19 | 2002-11-07 | Eisai Co., Ltd. | Derive de 2-imino-imidazole (2) |
CA2515715C (en) | 2003-02-19 | 2012-05-08 | Eisai Co., Ltd. | Methods for producing cyclic benzamidine derivatives |
WO2006018955A1 (ja) | 2004-08-16 | 2006-02-23 | Eisai R & D Management Co., Ltd. | イソインドール誘導体の製造方法 |
CN101811940B (zh) | 2004-08-17 | 2012-01-04 | 卫材R&D管理有限公司 | 用于制备二溴氟苯衍生物的中间体化合物 |
US7786330B2 (en) | 2005-02-28 | 2010-08-31 | Asahi Glass Company, Limited | Process for producing 1,2-dialkoxy-3-fluorobenzene |
DE102006036023A1 (de) | 2006-08-02 | 2008-02-07 | Sanofi-Aventis | Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität |
JPWO2008023438A1 (ja) | 2006-08-25 | 2010-01-07 | 旭硝子株式会社 | 1,2−ジアルコキシ−3−フルオロベンゼンの製造方法 |
JP5571389B2 (ja) | 2008-01-11 | 2014-08-13 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 医薬組成物、医薬組成物製造のための2−イミノピロリジン誘導体の使用および心疾患の治療用または改善用キット |
SI2242740T1 (sl) | 2008-02-05 | 2013-03-29 | Sanofi | SF5-derivati kot PAR1 inhibitorji, njihova priprava in uporaba kot zdravila |
WO2009097970A1 (de) | 2008-02-05 | 2009-08-13 | Sanofi-Aventis | Triazolopyridazine als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel |
KR20100120139A (ko) | 2008-02-05 | 2010-11-12 | 사노피-아벤티스 | Par1 억제제로서의 트리아졸륨 염, 이들의 제조방법, 및 약제로서의 용도 |
US20100056519A1 (en) * | 2008-07-15 | 2010-03-04 | Serebruany Victor L | Composition and method for reducing platelet activation and for the treatment of thrombotic events |
EP2427769A4 (en) | 2009-05-04 | 2016-08-03 | Univ Maryland | METHOD FOR MOLECULAR DYNAMIC SIMULATION BINDING SITE IDENTIFICATION (SILCS: COMPETITIVE SATURATION SITE IDENTIFICATION OF LIGAND) |
US8673890B2 (en) | 2009-10-29 | 2014-03-18 | Janssen Pharmaceutica Nv | 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist |
CN102757396B (zh) * | 2011-04-28 | 2014-10-15 | 天津药物研究院 | 含苯并五元杂环的环外亚胺化合物、其制备方法和用途 |
WO2013142630A1 (en) * | 2012-03-20 | 2013-09-26 | University Of Maryland, Baltimore | Site-specific fragment identification guided by single-step free energy perturbation calculations |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002085855A1 (fr) * | 2001-04-19 | 2002-10-31 | Eisai Co., Ltd. | Derives de 2-iminopyrrolidine |
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CN101811940B (zh) | 2004-08-17 | 2012-01-04 | 卫材R&D管理有限公司 | 用于制备二溴氟苯衍生物的中间体化合物 |
-
2004
- 2004-02-10 CA CA2515715A patent/CA2515715C/en not_active Expired - Fee Related
- 2004-02-10 EP EP12150545A patent/EP2444393A1/en not_active Withdrawn
- 2004-02-10 AU AU2004218187A patent/AU2004218187C1/en not_active Ceased
- 2004-02-10 CN CNB2004800105008A patent/CN100439336C/zh not_active Expired - Fee Related
- 2004-02-10 EP EP04709710A patent/EP1602646A4/en not_active Withdrawn
- 2004-02-10 WO PCT/JP2004/001396 patent/WO2004078721A1/ja active Application Filing
- 2004-02-10 KR KR1020057015182A patent/KR20050104376A/ko active IP Right Grant
- 2004-02-10 JP JP2005502995A patent/JP4549970B2/ja not_active Expired - Fee Related
- 2004-02-13 TW TW093103470A patent/TW200500340A/zh not_active IP Right Cessation
-
2005
- 2005-08-09 IL IL170175A patent/IL170175A/en not_active IP Right Cessation
- 2005-08-18 US US11/208,289 patent/US7375236B2/en not_active Expired - Fee Related
-
2006
- 2006-11-06 HK HK06112190.7A patent/HK1091494A1/xx not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002085855A1 (fr) * | 2001-04-19 | 2002-10-31 | Eisai Co., Ltd. | Derives de 2-iminopyrrolidine |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106905388A (zh) * | 2017-02-16 | 2017-06-30 | 重庆西南制药二厂有限责任公司 | 一种天麻素的合成方法 |
Also Published As
Publication number | Publication date |
---|---|
KR20050104376A (ko) | 2005-11-02 |
AU2004218187C1 (en) | 2011-04-07 |
CN1777583A (zh) | 2006-05-24 |
HK1091494A1 (en) | 2007-01-19 |
TWI305774B (zh) | 2009-02-01 |
US7375236B2 (en) | 2008-05-20 |
TW200500340A (en) | 2005-01-01 |
US20060058370A1 (en) | 2006-03-16 |
JP4549970B2 (ja) | 2010-09-22 |
JPWO2004078721A1 (ja) | 2006-06-08 |
EP1602646A4 (en) | 2010-07-28 |
EP2444393A1 (en) | 2012-04-25 |
EP1602646A1 (en) | 2005-12-07 |
AU2004218187A1 (en) | 2004-09-16 |
CA2515715C (en) | 2012-05-08 |
WO2004078721A1 (ja) | 2004-09-16 |
AU2004218187B2 (en) | 2010-09-30 |
CA2515715A1 (en) | 2004-09-16 |
IL170175A (en) | 2010-12-30 |
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