CN100409892C - Externally applied medicament for treating hyperplasia of mammary glands and preparation method thereof - Google Patents
Externally applied medicament for treating hyperplasia of mammary glands and preparation method thereof Download PDFInfo
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- CN100409892C CN100409892C CNB2006100512819A CN200610051281A CN100409892C CN 100409892 C CN100409892 C CN 100409892C CN B2006100512819 A CNB2006100512819 A CN B2006100512819A CN 200610051281 A CN200610051281 A CN 200610051281A CN 100409892 C CN100409892 C CN 100409892C
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Abstract
The invention discloses an externally used medicament for treating mammary gland hyperplasia which is prepared from the following raw materials: lycopus 330-660g, curcuma root 130-260g, cyperus rotundus 100-200g, curcuma zedoaria rose 130-260g, cassia twig 100-200g, ground beetle 170-340g, leech 170-340g, pinellia tuber 100-200g, bupleurum root 100-200g, licorice root 100-200g, burred tuber 130-260g and fritillary bulb 100-200g.
Description
Technical field
The present invention relates to a kind of medicine for external use that is used for the treatment of cyclomastopathy, belong to the field of Chinese medicines.
Background technology
Nodules of the breast is many because of feelings will internal injury, and the stagnation of liver-QI disease is coagulated, and the disease stasis of blood is tied due to the breast mutually, with breast shape lump not of uniform size is arranged, pain, relevant with menstrual cycle is the cystic hyperplasia of breast class disease of main performance, being equivalent to the said cystic cyclomastopathy of medical science, is commonly encountered disease and frequently-occurring disease.Doctor trained in Western medicine adopts operation or hormone symptomatic treatment more, its expense costliness, and side effect is bigger.The onset of traditional Chinese medical science oral medication is slow, and the course of treatment is long, and the intestines and stomach is also had certain stimulation.
Summary of the invention
The object of the present invention is to provide a kind of dispersing the stagnated live-QI to relieve the stagnation of QI, blood circulation promoting and blood stasis dispelling, removing obstruction for relieving pain can effectively be treated cyclomastopathy, and short term effect is remarkable, and late result is stable, safe without toxic side effect and the cheap medicine for external use that is used for the treatment of cyclomastopathy.
The consumption of external used medicine component of the present invention is groped to sum up to draw through the inventor in a large number, and each amounts of components is for all to have better curative effect in the following weight parts scope:
Herba Lycopi 330-660g Radix Curcumae 130-260g Rhizoma Cyperi 100-200g Rhizoma Curcumae 130-260g Ramulus Cinnamomi 100-200g Eupolyphaga Seu Steleophaga 170-340g Hirudo 170-340g Rhizoma Pinelliae 100-200g Radix Bupleuri 100-200g Radix Glycyrrhizae 100-200g rhizoma sparganic 130-260g Bulbus Fritillariae Thunbergii 100-200g.
Preferred each amounts of components is:
Herba Lycopi 500g Radix Curcumae 200g Rhizoma Cyperi 150g Rhizoma Curcumae 200g Ramulus Cinnamomi 150g Eupolyphaga Seu Steleophaga 250g Hirudo 250g Rhizoma Pinelliae 150g Radix Bupleuri 150g Radix Glycyrrhizae 150g rhizoma sparganic 200g Bulbus Fritillariae Thunbergii 150g.
The preparation method of external used medicine active ingredient of the present invention is:
Get the Herba Lycopi, Hirudo adds 75% ethanol extraction 2 times, each 2 hours, add for the first time 10 times of amounts, add 8 times of amounts for the second time; Filter, merging filtrate reclaims ethanol, and is condensed into thick paste, and is standby; Other gets Rhizoma Curcumae, Radix Curcumae, the Rhizoma Pinelliae, Radix Bupleuri, rhizoma sparganic, Ramulus Cinnamomi, Rhizoma Cyperi and is ground into coarse powder and Eupolyphaga Seu Steleophaga and adds 6 times of water gagings and extracted volatile oil 8 hours, collects volatile oil, and extracting solution filters, and is standby; Medicinal residues after getting Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae, alcohol extraction medicinal residues and extracting volatile oil add 6 times of water gagings respectively and extract three times, 2 hours for the first time, 1.5 hours, 1 hour for the third time for the second time, filter, merging filtrate and above-mentioned volatile oil extracting solution, being concentrated into relative density is 1.10-1.15 (60-70 ℃) extractum, gets alcohol-extracted extract; Add ethanol and make that to contain alcohol amount be 65%, left standstill 24 hours, filtering supernatant reclaims ethanol and also is condensed into extractum, precipitate with ethanol extractum.
The preparation method of the liniment of external used medicine of the present invention, also comprise the steps: to get 13% polyvinyl formal-acetal and be dissolved in an amount of ethanol, add precipitate with ethanol extractum, alcohol-extracted extract, the volatile oil that 3% dibutyl phthalate, 3% azone add successively again and stir, add ethanol to 670-1340ml.
Active ingredient of the present invention adds the required conventional adjuvant of medicine for external use, can be made into exterior-applied formulations such as unguentum, liniment, gel, Emulsion, patch, membrane, cataplasma.
Medicine of the present invention, compared with prior art, by above technical scheme as can be known, selecting natural plant for use is raw material, adopts the method for the Chinese medicine inner disease outer treat that occupies critical role in motherland's traditional medicine, pass through local topical, make medicine directly act on skin or mucosa, make it to absorb, can alleviate distending pain of the breast, tenderness, twinge rapidly to take stopgap measures on the one hand, also can eliminate the breast caking on the other hand to effect a permanent cure, reach the purpose for the treatment of both the principal and secondary aspects of a disease.It not only can cooperate treatment by oral administration of medicines to improve curative effect, can also alleviate patient's subjective symptoms rapidly, thereby reach the purpose of radical cure.Medicine of the present invention has dispersing the stagnated live-QI to relieve the stagnation of QI, blood circulation promoting and blood stasis dispelling, the characteristics of removing obstruction for relieving pain.Be used for nodules of the breast depression of liver-QI, syndrome of qi stagnation and blood stasis, disease is seen breast caking, distending pain, tenderness, twinge etc.Above-mentioned patient is seen in cystic hyperplasia of breast.
The specific embodiment
Below further set forth the beneficial effect of medicine of the present invention by the pharmacological testing of the medicine liniment of the present invention that obtains.
Trial drug: the embodiment of the invention 1 obtains the medicine liniment, the sepia membrane.Positive control drug-eliminating stagnation nodules of the breast plaster provides lot number by Qiqihar crane Xiang pharmaceutical Co. Ltd: 20050508.Estradiol benzoate injection, 1mg/ props up, lot number: 20050724, Tianjin gold credit aminoacid company limited provides.Progesterone injection, 10mg/ props up, lot number: 20050715, Zhejiang Province XianJu Pharmacy stock Co., Ltd provides.
Experimental animal: the SD rat is provided by the Guiyang Medical College Experimental Animal Center.Lot number is SCXK (Guizhou Province) 2002-0001.
Dosage is provided with: medicine liniment adult's 6 gram/days of consumption (being equivalent to 15 gram/days of crude drug) of the present invention, calculate 0.1 gram/kg/ day (being equivalent to 0.25 gram/kg/ day of crude drug) by adult 60kg, convert according to laboratory animal and the clinical consumption of people: the high low dosage of rat was respectively for 1 gram/kg/ day (being equivalent to 2.5 gram/kg/ days of crude drug) and 0.5 gram/kg/ day (being equivalent to 1.25 gram/kg/ days of crude drug).
Test method and result
Method: get 60 of female rats, body weight 213.2 ± 6.86g, divide 6 groups at random by body weight: normal control group, model group, positive controls, breast increase disappear liniment matrix group and breast and increase the liniment high and low dose group that disappears.Except normal control group (intramuscular injection normal saline 0.2ml/ time/day), all the other each group estradiol benzoate injection 0.5mg/kg/ day intramuscular injections, continuous 25 days; Intramuscular injection progesterone injection 5mg/kg/ day subsequently, continuous 5 days.Modeling was treated after 3 weeks, increased with breast respectively that the liniment substrate that disappears (1 gram/kg/ day), breast increase the liniment that disappears (1 gram/kg/ day, 0.5 gram/kg/ day) and eliminating stagnation nodules of the breast plaster (1 gram/kg/ day) is outer is applied to the 2nd pair, the 3rd pair mammary gland, continuous 5 weeks.After the last medication 24 hours, weigh and put to death animal, measure every rat the 2nd pair, the 3rd pair height of nipples and papilla diameter with vernier cursor; And get the uterus and ovary is weighed, and calculate its organ coefficient, experimental result sees the following form.
Medicine liniment of the present invention is to the outgrowth influence of rat mammary gland (x ± S)
| Group | Animal (only) | Dosage (g/kg/ day) | The 2nd pair of height of nipples (mm) | The 2nd pair of papilla diameter (mm) | The 3rd pair of height of nipples (mm) | The 3rd pair of papilla diameter (mm) | Uterus and ovary organ coefficient (body weight %) |
| Normally | 10 | - | 1.23±0.25 | 0.96±0.10 | 1.19±0.27 | 0.94±0.07 | 0.32±0.08 |
| Model | 10 | - | 1.74±0.47△ | 1.14±0.11△ | 1.78±0.37△ | 1.17±0.12△ | 0.22±0.06△ |
| Substrate | 10 | 1.0 | 1.67±0.31 | 1.13±0.11 | 1.61±0.49 | 1.16±0.15 | 0.23±0.11 |
| High dose | 10 | 1.0 | 1.23±0.21** | 1.02±0.13* | 1.19±0.17** | 1.01±0.14* | 0.28±0.07* |
| Low dosage | 10 | 0.5 | 1.33±0.18* | 1.03±0.13 | 1.20±0.20* | 1.01±0.14* | 0.23±0.03 |
| Positive | 10 | 1.0 | 1.34±0.11** | 1.05±0.16 | 1.32±0.21** | 1.06±0.14 | 0.23±0.05 |
Compare △ P＜0.01 with normal group; Compare * P＜0.05 * * P＜0.01 with model group.
Conclusion: respectively to rat intramuscular injection 25 days and 5 days, set up hyperplasia of mammary gland model with estradiol benzoate and Progesterone, modeling gives breast and increases the liniment that disappears and be applied to the 2nd pair, the 3rd pair mammary gland, continuous 5 weeks outward after 3 weeks.Result of the test shows: breast increases the liniment that disappears can significantly reduce experimental cyclomastopathy rat height of nipples and papilla diameter, suppresses cyclomastopathy.
Come further to set forth the preparation method of medicine of the present invention by the following examples.
Embodiment 1
Take by weighing raw material by following amount:
Herba Lycopi 500g Radix Curcumae 200g Rhizoma Cyperi 150g Rhizoma Curcumae 200g Ramulus Cinnamomi 150g
Eupolyphaga Seu Steleophaga 250g Hirudo 250g Rhizoma Pinelliae 150g Radix Bupleuri 150g Radix Glycyrrhizae 150g
Rhizoma sparganic 200g Bulbus Fritillariae Thunbergii 150g.
The preparation method of medicine of the present invention is:
Get the Herba Lycopi, Hirudo adds 75% ethanol extraction 2 times, each 2 hours, add for the first time 10 times of amounts, add 8 times of amounts for the second time; Filter, merging filtrate reclaims ethanol, and is condensed into thick paste, and is standby; Other gets Rhizoma Curcumae, Radix Curcumae, the Rhizoma Pinelliae, Radix Bupleuri, rhizoma sparganic, Ramulus Cinnamomi, Rhizoma Cyperi and is ground into coarse powder and Eupolyphaga Seu Steleophaga and adds 6 times of water gagings and extracted volatile oil 8 hours, collects volatile oil, and extracting solution filters, and is standby; Medicinal residues after getting Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae, alcohol extraction medicinal residues and extracting volatile oil add 6 times of water gagings respectively and extract three times, 2 hours for the first time, 1.5 hours, 1 hour for the third time for the second time, filter, merging filtrate and above-mentioned volatile oil extracting solution, being concentrated into relative density is 1.10-1.15 (60-70 ℃) extractum; Add ethanol and make that to contain alcohol amount be 65%, left standstill 24 hours, filtering supernatant reclaims ethanol and also is condensed into extractum, and is standby; Get 13% polyvinyl formal-acetal and be dissolved in an amount of ethanol, add 3% dibutyl phthalate, 3% azone and add precipitate with ethanol extractum, alcohol-extracted extract, volatile oil more successively and stir, add ethanol to 1000ml.
Embodiment 2
Take by weighing raw material by following amount:
Herba Lycopi 330g Radix Curcumae 130g Rhizoma Cyperi 100g Rhizoma Curcumae 130g Ramulus Cinnamomi 100g
Eupolyphaga Seu Steleophaga 170g Hirudo 170g Rhizoma Pinelliae 100g Radix Bupleuri 100g Radix Glycyrrhizae 100g
Rhizoma sparganic 130g Bulbus Fritillariae Thunbergii 100g.
The preparation method of medicine of the present invention is:
Get the Herba Lycopi, Hirudo adds 75% ethanol extraction 2 times, each 2 hours, add for the first time 10 times of amounts, add 8 times of amounts for the second time; Filter, merging filtrate reclaims ethanol, and is condensed into thick paste, and is standby; Other gets Rhizoma Curcumae, Radix Curcumae, the Rhizoma Pinelliae, Radix Bupleuri, rhizoma sparganic, Ramulus Cinnamomi, Rhizoma Cyperi and is ground into coarse powder and Eupolyphaga Seu Steleophaga and adds 6 times of water gagings and extracted volatile oil 8 hours, collects volatile oil, and extracting solution filters, and is standby; Medicinal residues after getting Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae, alcohol extraction medicinal residues and extracting volatile oil add 6 times of water gagings respectively and extract three times, 2 hours for the first time, 1.5 hours, 1 hour for the third time for the second time, filter, merging filtrate and above-mentioned volatile oil extracting solution, being concentrated into relative density is 1.10-1.15 (60-70 ℃) extractum; Add ethanol and make that to contain alcohol amount be 65%, left standstill 24 hours, filtering supernatant reclaims ethanol and also is condensed into extractum, and is standby; Get 13% polyvinyl formal-acetal and be dissolved in an amount of ethanol, add 3% dibutyl phthalate, 3% azone and add precipitate with ethanol extractum, alcohol-extracted extract, volatile oil more successively and stir, add ethanol to 670ml.
Embodiment 3
Take by weighing raw material by following amount:
Herba Lycopi 660g Radix Curcumae 260g Rhizoma Cyperi 200g Rhizoma Curcumae 260g Ramulus Cinnamomi 200g
Eupolyphaga Seu Steleophaga 340g Hirudo 340g Rhizoma Pinelliae 200g Radix Bupleuri 200g Radix Glycyrrhizae 200g
Rhizoma sparganic 260g Bulbus Fritillariae Thunbergii 200g.
The preparation method of medicine of the present invention is:
Get the Herba Lycopi, Hirudo adds 75% ethanol extraction 2 times, each 2 hours, add for the first time 10 times of amounts, add 8 times of amounts for the second time; Filter, merging filtrate reclaims ethanol, and is condensed into thick paste, and is standby; Other gets Rhizoma Curcumae, Radix Curcumae, the Rhizoma Pinelliae, Radix Bupleuri, rhizoma sparganic, Ramulus Cinnamomi, Rhizoma Cyperi and is ground into coarse powder and Eupolyphaga Seu Steleophaga and adds 6 times of water gagings and extracted volatile oil 8 hours, collects volatile oil, and extracting solution filters, and is standby; Medicinal residues after getting Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae, alcohol extraction medicinal residues and extracting volatile oil add 6 times of water gagings respectively and extract three times, 2 hours for the first time, 1.5 hours, 1 hour for the third time for the second time, filter, merging filtrate and above-mentioned volatile oil extracting solution, being concentrated into relative density is 1.10-1.15 (60-70 ℃) extractum; Add ethanol and make that to contain alcohol amount be 65%, left standstill 24 hours, filtering supernatant reclaims ethanol and also is condensed into extractum, and is standby; Get 13% polyvinyl formal-acetal and be dissolved in an amount of ethanol, add 3% dibutyl phthalate, 3% azone and add precipitate with ethanol extractum, alcohol-extracted extract, volatile oil more successively and stir, add ethanol to 1340ml.
The above, it only is preferred embodiment of the present invention, be not that the present invention is done any pro forma restriction, any technical solution of the present invention content that do not break away from,, all still belong in the scope of technical solution of the present invention any simple modification, equivalent variations and modification that above embodiment did according to technical spirit of the present invention.
Claims (5)
1. medicine for external use that is used for the treatment of cyclomastopathy is characterized in that it is made by following raw medicaments in portion by weight:
Herba Lycopi 330-660g Radix Curcumae 130-260g Rhizoma Cyperi 100-200g Rhizoma Curcumae 130-260g Ramulus Cinnamomi 100-200g Eupolyphaga Seu Steleophaga 170-340g Hirudo 170-340g Rhizoma Pinelliae 100-200g Radix Bupleuri 100-200g Radix Glycyrrhizae 100-200g rhizoma sparganic 130-260g Bulbus Fritillariae Thunbergii 100-200g.
2. the medicine for external use that is used for the treatment of cyclomastopathy as claimed in claim 1 is characterized in that the consumption of each crude drug is:
Herba Lycopi 500g Radix Curcumae 200g Rhizoma Cyperi 150g Rhizoma Curcumae 200g Ramulus Cinnamomi 150g Eupolyphaga Seu Steleophaga 250g Hirudo 250g Rhizoma Pinelliae 150g Radix Bupleuri 150g Radix Glycyrrhizae 150g rhizoma sparganic 200g Bulbus Fritillariae Thunbergii 150g.
3. the preparation method that is used for the treatment of the medicine for external use of cyclomastopathy as claimed in claim 1 or 2 is characterized in that:
Get the Herba Lycopi, Hirudo adds 75% ethanol extraction 2 times, each 2 hours, add for the first time 10 times of amounts, add 8 times of amounts for the second time; Filter, merging filtrate reclaims ethanol, and is condensed into thick paste, and is standby; Other gets Rhizoma Curcumae, Radix Curcumae, the Rhizoma Pinelliae, Radix Bupleuri, rhizoma sparganic, Ramulus Cinnamomi, Rhizoma Cyperi and is ground into coarse powder and Eupolyphaga Seu Steleophaga and adds 6 times of water gagings and extracted volatile oil 8 hours, collects volatile oil, and extracting solution filters, and is standby; Medicinal residues after getting Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae, alcohol extraction medicinal residues and extracting volatile oil add 6 times of water gagings respectively and extract three times, 2 hours for the first time, 1.5 hours, 1 hour for the third time for the second time, filter, merging filtrate and above-mentioned volatile oil extracting solution, being concentrated into 60-70 ℃ of survey relative density is 1.10-1.15 extractum, gets alcohol-extracted extract; Add ethanol and make that to contain alcohol amount be 65%, left standstill 24 hours, filtering supernatant reclaims ethanol and also is condensed into extractum, precipitate with ethanol extractum.
4. the preparation method that is used for the treatment of the medicine for external use of cyclomastopathy as claimed in claim 3 is characterized in that:
Get 13% polyvinyl formal-acetal and be dissolved in an amount of ethanol, add 3% dibutyl phthalate, 3% azone and add precipitate with ethanol extractum, alcohol-extracted extract, volatile oil more successively and stir, add ethanol to 670-1340ml, liniment.
5. the medicine for external use that is used for the treatment of cyclomastopathy as claimed in claim 1 or 2, wherein the dosage form of medicine for external use is unguentum, liniment, gel, Emulsion, patch, membrane, cataplasma.
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| CN104707105A (en) * | 2015-03-11 | 2015-06-17 | 范志民 | Traditional Chinese medicine preparation for treating mammary gland hyperplasia and preparation method thereof |
| CN105194271A (en) * | 2015-11-06 | 2015-12-30 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicine preparation for treating advanced breast cancer by virtue of combined chemotherapy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1416849A (en) * | 2001-11-05 | 2003-05-14 | 张高军 | Externally applied medicine for treating mastopathy and its prepn |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1416849A (en) * | 2001-11-05 | 2003-05-14 | 张高军 | Externally applied medicine for treating mastopathy and its prepn |
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