CN105362382A - Traditional Chinese medicine composition for treating recurrent oral ulcer and application thereof - Google Patents
Traditional Chinese medicine composition for treating recurrent oral ulcer and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
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Abstract
The invention relates to a traditional Chinese medicine composition for treating recurrent oral ulcer. The traditional Chinese medicine composition is prepared from raw rhubarb, Rhizoma coptidis, Radix aconiti carmichaeli, Cortex cinnamomi and Herba asari. The invention further provides application of the traditional Chinese medicine composition. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition meets theory, on 'monarch, minister, assistant and guide', of traditional Chinese medicine, various herbs cooperate with one another, and the traditional Chinese medicine composition can effectively treat the recurrent oral ulcer and is high in effective rate in clinical use.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically, is that one treats recurrent oral ulceration Chinese medicine composition and application thereof.
Background technology
Recurrent oral ulceration (RecurrentOralUlcer, ROU), also known as " recurrent aphtha ", " recurrent aphtha " (RecurrentAphthousUlcer, or " recurrent aphthous stomatitis " (RecurrentAphthousStomatitis RAU), RAS), refer to that a class is agnogenio, there is periodic flare but the damage of the limitation stomatocace of tool self limiting.This disease is modal ulcer diseases in oral mucosal disease, and prevalence, up to about 20%, occupies oral mucosal disease first place.During pathogenic process of re current, pathological changes tract pain is violent, causes material impact to patient work and life.
At present, pathogenic process of re current mechanism is still not clear.Research shows that immune factor, Nervous and Mental Factors, hormonal readiness all can induce recurrent oral ulceration to show effect, and systemic disease also plays an important role in the developing of recurrent oral ulceration.The pathological change of ulcer is its lamina propria neutrophilic granulocyte in various degree and monocyte infiltration, the infiltration such as multinuclear type leukocyte, plasma cell afterwards, the now easy diabrosis of mucosal epithelium, comes off, and forms ulcer.The pain of recurrent oral ulceration be because excessive inflammatory reaction and chemical factors stimulate propria lamina intersection afferent nerve endings caused by.Vital effect is played in inflammatory reaction in recurrent oral ulceration.
Because pathogenesis is still not clear, therefore, the treatment of current recurrent oral ulceration often for whole body therapeutic and topical therapeutic combine, Chinese traditional treatment and western medical treatment combine.The object of topical therapeutic is antiinflammatory, pain relieving, prevent secondary infection, Promotive union, and common drug comprises gargarism, gel, analgesic etc.; The object of systemic administration is etiological treatment, reduces recurrence, strives for alleviating, be expected to eliminating paathogenic factor, correcting on the basis of incitant, change the rule of onset of recurrent oral ulceration, extend the intermission, shorten ulcerative stage, the course of disease is eased, and anti-inflammatory drug, immunomodulator are the systemic drugs of modal treatment recurrent oral ulceration.
Have in technical paper, patent documentation much about the report of the Chinese medicine for the treatment of recurrent oral ulceration.Such as, Chinese patent literature CN1895573 discloses a kind of pharmaceutical composition for the treatment of oral ulcer, and it is the medicament be prepared from for raw material by Rhizoma Polygonati Odorati, Radix Adenophorae (Radix Glehniae), Radix Ophiopogonis, Herba Dendrobii, Folium Mori, Herba Lophatheri, Radix Asparagi, Pachyrhizua angulatus etc.Chinese patent literature CN102139081A discloses one and treats recurrent oral ulceration Chinese medicine composition, and described compositions is made up of the crude drug of following weight: Herba Hedyotidis Diffusae 10 ~ 50 weight portion, Herba Scutellariae Barbatae 5 ~ 30 weight portion, the Rhizoma Pinelliae 5 ~ 25 weight portion, Semen Coicis 10 ~ 50 weight portion, Rhizoma Curcumae 5 ~ 30 weight portion, Rabdosia rubescens 5 ~ 20 weight portion.Chinese patent literature CN102512611A discloses a kind of Chinese medicine and preparation method for the treatment of recurrent oral ulceration, Chinese medicine is prepared from, all with parts by weight by following component: Radix Scrophulariae 8 ~ 12 parts, Gypsum Fibrosum 2 ~ 5 parts, Herba Lophatheri 10 ~ 15 parts, Fructus Arctii 5 ~ 10 parts, Cortex Moutan 5 ~ 6 parts, 5 ~ 10 parts, Radix Glycyrrhizae, Flos Lonicerae 5 ~ 8 parts, 7 ~ 10 parts, the Radix Rehmanniae, Herba Asari 10 ~ 15 parts, 5 ~ 7 parts, Poria, the Radix Angelicae Dahuricae 4 ~ 7 parts, Fructus Forsythiae 5 ~ 8 parts, Herba Taraxaci 5 ~ 10 parts, Cortex Phellodendri 10 ~ 15 parts, Radix Platycodonis 10 ~ 15 parts, Borneolum Syntheticum 1 ~ 3 part.But about of the present invention a kind of treat recurrent oral ulceration Chinese medicine composition and application yet there are no report.
Summary of the invention
The object of the invention is for deficiency of the prior art, a kind of Chinese medicine composition for the treatment of recurrent oral ulceration is provided.
Of the present invention again one object be that a kind of application for the treatment of the Chinese medicine composition of recurrent oral ulceration is provided.
For achieving the above object, the technical scheme that the present invention takes is: a kind of Chinese medicine composition for the treatment of recurrent oral ulceration, and described Chinese medicine composition is made up of the component of following weight portion: Radix Et Rhizoma Rhei 4-8 part, Rhizoma Coptidis 4-8 part, Radix Aconiti Lateralis Preparata 2-4 part, Cortex Cinnamomi 4-8 part, Herba Asari 2-4 part.
Described Chinese medicine composition is made up of the component of following weight portion: Radix Et Rhizoma Rhei 5-7 part, Rhizoma Coptidis 5-7 part, Radix Aconiti Lateralis Preparata 2.5-3.5 part, Cortex Cinnamomi 5-7 part, Herba Asari 2.5-3.5 part.
Described Chinese medicine composition is made up of the component of following weight portion: Radix Et Rhizoma Rhei 6 parts, Rhizoma Coptidis 6 parts, Radix Aconiti Lateralis Preparata 3 parts, Cortex Cinnamomi 6 parts, Herba Asari 3 parts.
For realizing above-mentioned second object, the technical scheme that the present invention takes is: the application of described Chinese medicine composition in the medicine of preparation treatment recurrent oral ulceration.
Treat a Chinese medicine preparation for recurrent oral ulceration, described Chinese medicine preparation is made up of the arbitrary described Chinese medicine composition of claim 1-3 and pharmaceutically acceptable adjuvant.
The dosage form of described Chinese medicine preparation is oral formulations.
Described oral formulations is pill, powder, granule, tablet, capsule, drop pill or syrup.
The invention has the advantages that:
Chinese medicine composition of the present invention meets theory of Chinese medical science, " monarch ", and each herbal medicine cooperatively interacts, and effectively can treat recurrent oral ulceration, high through Clinical practice effective percentage.
Detailed description of the invention
Below in conjunction with embodiment, detailed description of the invention provided by the invention is elaborated.
A kind of Chinese medicine composition for the treatment of recurrent oral ulceration of the present invention, described Chinese medicine composition is made up of the component of following weight portion: Radix Et Rhizoma Rhei 4-8 part, Rhizoma Coptidis 4-8 part, Radix Aconiti Lateralis Preparata 2-4 part, Cortex Cinnamomi 4-8 part, Herba Asari 2-4 part.
Preferably, described Chinese medicine composition is made up of the component of following weight portion: Radix Et Rhizoma Rhei 5-7 part, Rhizoma Coptidis 5-7 part, Radix Aconiti Lateralis Preparata 2.5-3.5 part, Cortex Cinnamomi 5-7 part, Herba Asari 2.5-3.5 part.
Embodiment 1
Radix Et Rhizoma Rhei 6 parts, Rhizoma Coptidis 6 parts, Radix Aconiti Lateralis Preparata 3 parts, Cortex Cinnamomi 6 parts, Herba Asari 3 parts.
Embodiment 2
Radix Et Rhizoma Rhei 5 parts, Rhizoma Coptidis 7 parts, Radix Aconiti Lateralis Preparata 2.5 parts, Cortex Cinnamomi 7 parts, Herba Asari 2.5 parts.
Embodiment 3
Radix Et Rhizoma Rhei 7 parts, Rhizoma Coptidis 5 parts, Radix Aconiti Lateralis Preparata 3.5 parts, Cortex Cinnamomi 5 parts, Herba Asari 3.5 parts.
Embodiment 4
Radix Et Rhizoma Rhei 4 parts, Rhizoma Coptidis 8 parts, Radix Aconiti Lateralis Preparata 2 parts, Cortex Cinnamomi 8 parts, Herba Asari 2 parts.
Embodiment 5
Radix Et Rhizoma Rhei 8 parts, Rhizoma Coptidis 4 parts, Radix Aconiti Lateralis Preparata 4 parts, Cortex Cinnamomi 4 parts, Herba Asari 4 parts.
Embodiment 6
The pharmaceutical dosage form that the arbitrary described Chinese medicine composition of embodiment 1-5 is prepared by conventional formulation means, such as, make decoction by decocting method, pill, powder, granule, tablet, capsule, drop pill, syrup etc.
Embodiment 7
The arbitrary described Chinese medicine composition of Example 1-5, extracting in water twice, first time adds 12 times of water gagings, extracts 2.5 hours; Second time adds the water of 8 times amount, extracts 1.5 hours.Merge decocting liquid, filter, filtrate is condensed into clear paste, adds the ethanol equivalent of 95%, leaves standstill 24 hours, filter, filtrate is condensed into thick paste, adds the right amount of auxiliary materials such as starch, magnesium stearate, Pulvis Talci, dry, pulverize, granulate, be pressed into sheet, namely film coating or sugar-coat obtain tablet.
Embodiment 8
By the thick paste that embodiment 7 method is made, add right amount of auxiliary materials, pulverize granulation, dry, granulate, incapsulate and obtain capsule.
Embodiment 9
By the thick paste that embodiment 7 method is made, dry, to pulverize 160 mesh sieves fine powder.
Add filler, disintegrating agent mix homogeneously, granulate with wetting agent moistening, dry, granulate, then add disintegrating agent, lubricant, mix homogeneously, through tabletting machine, obtain dispersible tablet.
Embodiment 10
Thick paste is made by embodiment 7 method, for subsequent use; In thick paste, add Icing Sugar, right amount of auxiliary materials, make granule, dry, obtain granule.
Embodiment 11
1 data and method
1.1 physical data
Outpatient service Blood of Patients with Recurrent Oral 80 example in Shanghai Changhai Hospital traditional Chinese medical science clinic and Street Community, Xujiahui, Xuhui District of Shanghai Health Center in July, 2013 ~ 2015 year January.Wherein male 52 examples (accounting for 65%), female 28 example (accounting for 35%); Age >=60 years old 12 example (accounting for 15%), more than 25 years old less than 60 years old 68 examples (accounting for 85%); The course of disease is the shortest 3 months, the longest 6 years.
1.2 diagnostic criteria
Oral ulcer diagnostic criteria, with reference to " oral mucosal disease ", comprises light-duty oral ulcer, heavy oral ulcer and herpetiform ulceration.Clinical manifestation is that oral mucosa festers repeatedly, aphtha of the mouth and tongue, erosion and pain, thirsty flushed complexion, vexed insomnia, the few tongue of dimly red tongue, thready and rapid pulse without strength, prolongedly not heal, thus affect the function such as diet, language, and ulcer has periodicity, recurrent, self limiting and painful.
1.3 Therapeutic Method
The Chinese medicine composition of embodiment 1, adopts decocting method to make decoction, oral.
1.4 criterion of therapeutical effect
Cure: medication is transference cure after 7 days, and sign disappears substantially, ulcer disease damage all healed.
Effective: medication is transference cure after 7 days, and sign all has clear improvement, and ulcer healing reaches 2/3, or ulcer shoals and reduces.
Effective: medication is transference cure after 7 days, and sign all take a favorable turn, ulcer healing reach 1/3 or ulcer shoal and reduce.
Invalid: medication cardinal symptom after 7 days, sign are improved not obvious, and ulcer is substantially unchanged.
2 results
Major part patient pain relieving in 2 days, recovery from illness in 5 days, 3 days ~ 14 days treatment time, average out to 3.78 days.
Cure 71 examples, account for 88.75%; Effective 5 examples, account for 6.25%; Effective 2 examples, account for 2.5%; Invalid 2 examples, account for 2.5%; Total effective rate is 97.50%.Clinical efficacy result is as shown in table 1.
Table 1 clinical efficacy result
Embodiment 12
Animal is selected: 30 body weight are the purebred White Rabbit of 3kg-4kg New Zealand, male and female half and half.
Modeling method: 1. antigen preparation and emulsification method: young rabbit aseptically strips oral mucosa, liver, heart, shredded and ground to form pasty state, the phosphate buffer adding 0.1mol/L, pH=7.4 makes tissue homogenate, and it is anti-pollution to add 1:1000 ethyl sulfur hydrargyrum sodium solution.Be stored in-70 DEG C of cryogenic refrigerators for subsequent use.Add the Split completely of equivalent when immune animal, with syringe, the two is fully mixed, in emulsion.Drip on the water surface, do not scatter if still remain drop-wise, then can apply.2. inoculation: hair is picked at experimental rabbit back, routine disinfection, at the emulsion 1ml of the above-mentioned antigen plus adjuvant of spinal column both sides intradermal injection, every rabbit injects 20 points.Every injection in 2 weeks once, inject 4-5 time altogether.Experimental rabbit is caused to occur the oral ulcer with the feature basic simlarity of mankind's recurrent oral ulceration.
Grouping: the rabbit after modeling is divided into three groups at random: Chinese drug-treated group, Western medicine group and blank group, often organizes 10.Chinese drug-treated group: the decoction that the Chinese medicine composition adding embodiment 1 in feedstuff is obtained by decocting method, the consumption of Chinese medicine composition is 0.5g/kg/ day, and the course for the treatment of is 6 weeks.Western medicine group: mix levamisole, compound vitamin B in feedstuff
2and vitamin C, the course for the treatment of is 6 weeks.Blank group: only give feedstuff and distilled water.
Result: three treated animal ulcer healing situations are as shown in table 2, and Chinese drug-treated group healing days is minimum, and has statistical significance difference with blank group.
Table 2 three treated animal ulcer healing natural law
*compare with blank group, P < 0.05
Through animal acute toxicity experiment, Chinese medicine composition of the present invention meets safety criterion.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the inventive method; can also make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.
Claims (7)
1. treat a Chinese medicine composition for recurrent oral ulceration, it is characterized in that, described Chinese medicine composition is made up of the component of following weight portion: Radix Et Rhizoma Rhei 4-8 part, Rhizoma Coptidis 4-8 part, Radix Aconiti Lateralis Preparata 2-4 part, Cortex Cinnamomi 4-8 part, Herba Asari 2-4 part.
2. the Chinese medicine composition for the treatment of recurrent oral ulceration according to claim 1, it is characterized in that, described Chinese medicine composition is made up of the component of following weight portion: Radix Et Rhizoma Rhei 5-7 part, Rhizoma Coptidis 5-7 part, Radix Aconiti Lateralis Preparata 2.5-3.5 part, Cortex Cinnamomi 5-7 part, Herba Asari 2.5-3.5 part.
3. the Chinese medicine composition for the treatment of recurrent oral ulceration according to claim 1, is characterized in that, described Chinese medicine composition is made up of the component of following weight portion: Radix Et Rhizoma Rhei 6 parts, Rhizoma Coptidis 6 parts, Radix Aconiti Lateralis Preparata 3 parts, Cortex Cinnamomi 6 parts, Herba Asari 3 parts.
4. according to the application of the arbitrary described Chinese medicine composition of claim 1-3 in the medicine of preparation treatment recurrent oral ulceration.
5. treat a Chinese medicine preparation for recurrent oral ulceration, it is characterized in that, described Chinese medicine preparation is made up of the arbitrary described Chinese medicine composition of claim 1-3 and pharmaceutically acceptable adjuvant.
6. the Chinese medicine preparation for the treatment of recurrent oral ulceration according to claim 5, is characterized in that, the dosage form of described Chinese medicine preparation is oral formulations.
7. the Chinese medicine preparation for the treatment of recurrent oral ulceration according to claim 6, is characterized in that, described oral formulations is pill, powder, granule, tablet, capsule, drop pill or syrup.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998843A (en) * | 2016-07-09 | 2016-10-12 | 武善营 | Traditional Chinese medicine preparation for treating recurring type dental ulcers |
| CN109480278A (en) * | 2018-12-18 | 2019-03-19 | 漳州市吾梓贸易有限公司 | A kind of food and preparation method thereof for alleviating premenstrual canker sore and distending pain of the breast |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038916A (en) * | 2009-10-15 | 2011-05-04 | 张红旗 | Traditional Chinese medicine prescription for treating recurrent aphthae |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038916A (en) * | 2009-10-15 | 2011-05-04 | 张红旗 | Traditional Chinese medicine prescription for treating recurrent aphthae |
Non-Patent Citations (1)
| Title |
|---|
| 金采映: "蒋建运用经方治验四则", 《中国中医药报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998843A (en) * | 2016-07-09 | 2016-10-12 | 武善营 | Traditional Chinese medicine preparation for treating recurring type dental ulcers |
| CN109480278A (en) * | 2018-12-18 | 2019-03-19 | 漳州市吾梓贸易有限公司 | A kind of food and preparation method thereof for alleviating premenstrual canker sore and distending pain of the breast |
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