CN104707105A - Traditional Chinese medicine preparation for treating mammary gland hyperplasia and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating mammary gland hyperplasia and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine preparation for treating mammary gland hyperplasia. The traditional Chinese medicine preparation is prepared from antlers, rhizoma cyperi, rhizoma sparganii, curcuma zedoary, ground beeltles, leeches, prepared rehmannia roots, liquorice and radix paeoniae alba, and prepared into capsules, tablets, particles, pills and the like. The traditional Chinese medicine preparation has effects of relieving pain, promoting the circulation of qi, removing stagnation, reducing phlegm, resolving masses and regulating thoroughfare and conception vessels, is obvious in curative effect, significantly improves clinical symptoms, and has no toxic or side effects. The mammary gland hyperplasia is unlikely recur after being cured.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of mastopathy, particularly relate to a kind of Chinese medicine preparation for the treatment of cyclomastopathy, also disclose preparation method and the pentazocine purposes thereof of this medicine simultaneously, belong to Chinese medicine field of medical technology.
Background technology
Cyclomastopathy (cyclomastopathy) is one of common cystic hyperplasia of breast of Breast Surgery, be mammary gland parenchyma and interstitial to some extent hypertrophy and the breast structure caused by subinvolution in quantity and modal exception, belong to the hyperplasia of prostate of mammary gland essence, there is the features such as the course of disease is long, slow, the easy recurrence of development, be most commonly in the young women of 25 ~ 40 years old.Motherland's medical science is thought, disease of hyperplasia of mammary glands glands belongs to " nodules of the breast " category, mostly is Chong and Ren channel disorder, and the stagnation of QI, blood stasis, expectorant knot hinders caused by the newborn network.Therefore, treatment should be the main rule for the treatment of with warming and recuperating the kidney-YANG, blood circulation promoting and blood stasis dispelling, dissipating phlegm and resolving masses, in order to Chong and Ren Meridians regulating, regulate Female Genital Endocrine, weaken receptor sensitivity, slow down and copy hypertrophy.Modern medicine study shows, and this disease can cause female incretion dysfunction by bad direct stimulation etc., estrogen, progestogen proportional imbalance, stimulates mammary gland tissue hyperplasia to cause.The clinical hormone that adopts of doctor trained in Western medicine is treated it more, though there is certain curative effect, untoward reaction is more, and easily recurrence after treatment, and compound Chinese medicinal preparation can regulate organism endocrine, treatment cyclomastopathy is evident in efficacy, gradually by clinical accreditation.
A kind of Chinese medicine preparation for the treatment of hyperplasia of mammary glands and preparation method thereof (ZL 201010117336.8), a kind of Chinese medicine preparation for the treatment of cyclomastopathy is provided, there is activating QI to alleviate the depression, dissipating phlegm and resolving masses, Chong and Ren Meridians regulating effect, determined curative effect, clinical symptoms is improved obviously, not easily recurs after healing.There is mechanism of action indefinite in therapeutic process and have the side effect of diarrhoea.
To sum up, current home and abroad still lacks a kind of determined curative effect, the Therapeutic Method that safe and effective, mechanism of action is clear and definite and medicine.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of cyclomastopathy, and have paroxysmal pain and activating QI to alleviate the depression, dissipating phlegm and resolving masses, Chong and Ren Meridians regulating effect, determined curative effect, clinical symptoms is improved obviously, without toxicity, not easily recurs after healing.
The invention also discloses the preparation method of this medicine, be applicable to suitability for industrialized production.
The present invention is according to China's Chinese medicine to hyperplasia of mammary glands pathogeny and Therapeutic Principle, and selected following pure Chinese crude drug, through scientific composition compatibility, makes Chinese medicine preparation: (by weight)
Cornu Cervi 20-200 part, Rhizoma Cyperi 15-150 part, Rhizoma Sparganii 10-100 part, Rhizoma Curcumae 10-100 part, Eupolyphaga Seu Steleophaga 10-100 part, Hirudo 3-30 part, Radix Rehmanniae Preparata 5-50 part, Radix Glycyrrhizae 5-50 part, Radix Paeoniae Alba 10-100 part.
The raw material of the preferred following weight proportion of Chinese medicine composition of the present invention is prepared from:
Cornu Cervi 40-160 part, Rhizoma Cyperi 30-120 part, Rhizoma Sparganii 20-80 part, Rhizoma Curcumae 20-80 part, Eupolyphaga Seu Steleophaga 20-80 part, Hirudo 6-24 part, Radix Rehmanniae Preparata 10-40 part, Radix Glycyrrhizae 10-40 part, Radix Paeoniae Alba 20-80 part.
The raw material of the preferred following weight proportion of Chinese medicine composition of the present invention is prepared from:
120 parts, Cornu Cervi, Rhizoma Cyperi 80 parts, Rhizoma Sparganii 40 parts, Rhizoma Curcumae 40 parts of, Eupolyphaga Seu Steleophaga 40 parts, Hirudo 20 parts, Radix Rehmanniae Preparata 20 parts, 20 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 40 parts.
Chinese medicine composition object space solution of the present invention is as follows:
Cyclomastopathy, how the traditional Chinese medical science nodules of the breast, form because feelings will internal injury, liver energy depression and phlegm stagnation, worry impairing spleen, depressed rage impairing the liver, Chong and Ren channel disorder, the stagnation of QI, expectorant are solidifying etc.Method is with depressed liver-energy dispersing and QI regulating, promoting blood circulation and breaking stagnation, and the hard eliminating stagnation that disappears, regulating thoroughfare and controlling vessel are main.In side Cornu Cervi salty in the mouth warm in nature, return Liver and kidney, life heat radiation promoting the circulation of blood, detumescence to exorcise evil spirits, specially control distending pain of the breast, breast lumps, and " herbal classic " is said: " be usually used in acute mastitis sore swollen toxin blood stasis to have a pain and levy." Rhizoma Cyperi acrid in the mouth hardship, Gan Ping, depressed liver-energy dispersing and QI regulating, eliminating stagnationization are hard, circulation of qi promoting and battalion." book on Chinese herbal medicine justice " is said: " specially control depressed for sick." more than two medicines share, altogether long memorial liver and qi, heat radiation promoting the circulation of blood, dispersing swelling and dissipating binds, be monarch drug altogether.Rhizoma Sparganii acrid in the mouth bitterness temperature in side, removing blood stasis, circulation of qi promoting stop-pass." property of medicine book on Chinese herbal medicine " is said: " cure painful abdominal mass addiction cold air." Rhizoma Curcumae acrid in the mouth hardship, removing blood stasis, promoting the circulation of QI to relieve pain." Bencao Jingshu " is said: " coalescent piece of the punish-old hypochondriac lump." " book on Chinese herbal medicine justice " say: " can control all condensations stop tangible heavily fortified point long-pending ".Eupolyphaga Seu Steleophaga salty in the mouth is slightly cold, removing blood stasis, and " warp dredged by book on Chinese herbal medicine " is said: " Zhuan Zhi WEIJIA mass in the abdomen." Hirudo salty in the mouth hardship is flat, removing blood stasis, Zhuan Zhi WEIJIA is gathered, and " property of medicine opinion " is said: " row blood-retention, blood stasis gathers." more than the same use of four medicines, play removing blood stasis altogether, promoting the circulation of QI to relieve pain, eliminating stagnation disappears effect of block, is ministerial drug altogether.Radix Rehmanniae Preparata sweet in the mouth in side, micro-hardship, warm in nature, nourishing the blood and yin, vital essence replenishing and marrow benifiting, is the key medicine of strong water, specially controls hepatic and renal YIN deficiency, deficient all kinds of diseases and ailments." this thick grass is new " is said: " sharp blood vessels, tonification is Kidney-Yin." acid of Radix Paeoniae Alba bitter in the mouth is slightly cold, nourish blood yin fluid astringing, this pain of easing the affected liver, with Radix Rehmanniae Preparata share invigorating middle warmer have loose, loose in have receipts, regulating thoroughfare and controlling vessel, use same with Radix Glycyrrhizae, benefiting QI and nourishing blood, relieving spasm to stop pain, two tastes share, and the healthy energy damage preventing excessive removing blood stasis from bringing is adjuvant drug altogether.In side, Radix Glycyrrhizae sweet in the mouth is put down, invigorating the spleen and replenishing QI, relieving spasm to stop pain, specially controlling carbuncle chancre and swells, can also being in harmonious proportion hundred medicines for making medicine.Above monarch medicine share, altogether long memorial liver and qi, and removing blood stasis, disappear hard eliminating stagnation, relieving spasm to stop pain, effect of regulating thoroughfare and controlling vessel, therefore can control nodules of the breast also.
Chinese medicine composition of the present invention can make various dosage form by this area customary preparation methods, as capsule, tablet, granule, pill etc.
The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:
Above nine tastes, Cornu Cervi, Rhizoma Cyperi, Rhizoma Curcumae, the Radix Paeoniae Alba, Hirudo powder are broken into 80 ~ 120 order fine powders, mixing; Rhizoma Sparganii, Eupolyphaga Seu Steleophaga, Radix Rehmanniae Preparata, Radix Glycyrrhizae four taste decoct with water 3 times, and amount of water is respectively 10,8,6 times, and decocting time is 3,2,1 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.25-1.30(80 DEG C) thick paste; Mix with the powder of Cornu Cervi, Rhizoma Cyperi, Rhizoma Curcumae, Hirudo, the Radix Paeoniae Alba, less than 85 DEG C temperature dry, pulverize, and sieve, and then make Chinese medicine preparation according to Chinese medicine customary preparation methods.As capsule, tablet, granule, pill etc.
[indication]: soothing the liver, circulation of qi promoting, resolving depression, reduce phlegm, eliminating stagnation, Chong and Ren Meridians regulating.Be used for the treatment of adenosis of breast, vexed, irritability, insomnia, forgetful, menoxenia etc.
[usage and consumption]: oral meal, each 1.2 grams-2.5 grams, every day 3 times.Within 28 days, be a course for the treatment of, interval 5-7 days, can continue second course for the treatment of.Also can take continuously.
[function with cure mainly]: lump in breast, with susceptible to anger growth and decline, generally premenstrually to increase the weight of, through after alleviation of pain, with feeling of oppression over the chest and distention of hypochondrium, be apt to strongly fragrant irritability, the soreness of waist is weak, tired, menoxenia, stringy and thready pulse.Be used for the treatment of adenosis of breast, vexed, irritability, insomnia, forgetful, menoxenia etc.
For showing resisting hyperplasia of mammary glands effect and the analgesia therapy Function and its mechanisms of Chinese medicine composition of the present invention, carry out comparative study with Chinese medicine composition of the present invention and " a kind of Chinese medicine preparation for the treatment of hyperplasia of mammary glands and preparation method thereof (ZL 201010117336.8) " 14 taste Chinese medicine compositions by multiple hypertrophy, pain model, statistical analysis is summarized as follows:
One,
resisting hyperplasia of mammary glands effect
(1) zoopery grouping
Healthy female Wistar rats 100, is divided into 5 groups at random: Normal group, model control group, tamoxifen group, 14 taste medicine groups, pharmaceutical quantities groups of the present invention, often organizes 20.
animal model replication
To the rat of model control group, tamoxifen, ten four Chinese medicine groups, pharmaceutical quantities group of the present invention, every rat femoribus internus intramuscular injection estradiol benzoate injection, 0.5mg/kg/d, continuous 25 days.Test and start to inject progesterone injection for the 26th day, 5mg/kg/d, continuous 5 days, to set up rat mammary gland model of hyperplasia.All laboratory animals are 10 cages and raise, and freely drink water, take body weight weekly.
tamoxifen medicine, ten four Chinese medicine things, medicine treatment of the present invention
After rat mammary gland model of hyperplasia is set up, start with tamoxifen (tamoxifen) (1.8 mg/kg), ten four Chinese medicine things (140 mg/kg) and nine taste pharmaceutical quantities (140 mg/kg) give tamoxifen medicine group respectively, the rat oral gavage of ten four Chinese medicine thing groups and pharmaceutical quantities group of the present invention, every day 1 time, continuous 30 days.
result
the comparison of each group rat papilla diameter change in a experiment
the comparison (unit: mm) (± s) of rat papilla diameter respectively organized by table 1
Note: compared with normal control medicine group: * p<0.05, * * p < 0.01; Compared with model comparison medicine group: #p<0.05, ##p<0.01; Compared with tamoxifen group: △ p<0.05, △ △ p < 0.01.
hormonal readiness measurement result in each group of rat blood
the comparison of hormonal readiness measurement result in rat blood respectively organized by table 2(
± s, n=10)
Note: compared with normal control medicine group: * p<0.05, * * p < 0.01; Compared with model comparison medicine group: #p<0.05, ##p<0.01.
rat the 2nd pair of mammary gland tissue morphology pathological section result
Microscopic observation is shown in that rats in normal control group corpus mamma is undeveloped, and only have lobule little on a small quantity, acinus and conduit to be dispersed in and be distributed in fat and connective tissue, conduit and alveolar lumen are showed no expansion, ductal epithelial cell queueing discipline; Model group animal's mammary gland is diffusivity hypertrophy, and acinus and lobule significantly increase, rarely seen a small amount of fat and connective tissue in interstitial, alveolar lumen is expanded, intracavity and the interior visible a large amount of secretions of catheter lumen, Epithelial hyperplasia, cell is irregular alignment, and what have dashes forward to tube chamber in mamillary.
table 3 is on the impact (± s, n=10) of rat mammary gland lobule, acinus and conduit
Note: compared with normal control medicine group: * p<0.05, * * p < 0.01; Compared with model comparison medicine group: #p<0.05, ##p<0.01; Compared with tamoxifen group: △ p<0.05, △ △ p < 0.01.
on the impact of rat mammary gland hypertrophy pathological model mammary gland tissue ER, PR content of Estrogen and progestin induction
table 4 ER, PR quantitative expression in each group of specimen (%) (± s, n=10)
Note: compared with normal control medicine group: * p<0.05, * * p < 0.01; Compared with model comparison medicine group: #p<0.05, ##p<0.01; Compared with tamoxifen group: △ p<0.05, △ △ p < 0.01.
table 4 ER, PR quantitative expression in each group of specimen (%) (± s, n=10)
two, analgesic activity
(1) mice acetic acid twisting experiment
Female ICR mice 40,18 ~ 25g.4 groups are divided at random according to body weight, be respectively blank group (0.9% sodium chloride injection), positive control drug group aspirin (250mg/kg body weight), ten four Chinese medicine groups (98mg/kg body weight), nine taste medicines (98mg/kg body weight) group, often organizes 10.Gavage is carried out to aspirin group and each group of mice, every day 1 time, continuous 7 days.Test the 8th day, every mouse peritoneal injects 1% glacial acetic acid 0.1ml/10g induced pain, and writhing number of times in time and 15 minutes that record starts to occur writhing, compares group difference.Whole experimental temperature should be controlled in (20 ± 1) DEG C.
mouse hot-plate is tested
Female KM mice, 18 ~ 25g(primary dcreening operation, threshold of pain < 30s is qualified mice).Sift out qualified mice 40, according to body weight, it is divided into 4 groups at random, be respectively blank group (0.9% sodium chloride injection), nine taste medicines (98mg/kg body weight) group, ten four Chinese medicine groups (98mg/kg body weight), positive control drug group aspirin (250mg/kg body weight), often organizes 10.Pain threshold (survey and get its meansigma methods for twice, measure time interval > 5min twice) before measuring each raticide with intelligent hot-plate instrument.Gavage is carried out to matched group and each group of mice, every day 1 time, continuous 7 days.Test and measured pain threshold before each raticide respectively at after medicine 30 minutes, 60 minutes with intelligent hot-plate instrument on the 7th day.If pain threshold is more than 60s, stop test by 60s.And calculate threshold of pain raising percentage rate according to the following formula, compare group difference.
(3) Mus photo-thermal induced pain tail-flick test
Female Wistar rats 40,200 ~ 250g(carries out primary dcreening operation, and 5s < whipping time < 30s is qualified rat).Get qualified rat 40, be divided into 6 groups at random according to body weight, be respectively blank group (0.9% sodium chloride injection), nine taste medicine (140mg/kg) groups, ten four Chinese medicine groups, positive control drug group aspirin (175mg/kg), often organize 10.Measure the whipping time of rat with photo-thermal tail pain tester, survey and get its meansigma methods for twice as the front threshold of pain of medicine.Blank group, positive drug control group and respectively organize rat oral gavage, every day 1 time, continuous 7 days.After testing administration in the 8th day, 1h, 2h, 3h, 4h, 5h, 6h measure the threshold of pain of each rat respectively, and calculate response inhabitation percentage rate according to the following formula, the difference between more each group.
statistical method
Experimental data employing means standard deviation (
± s) mode represent, use group difference compare t inspection carry out statistical analysis.
p﹤ 0.05 has statistical significance for difference,
p﹤ 0.01 has significance statistical significance for difference.
experimental result
a Dichlorodiphenyl Acetate causes the impact of mouse writhing
Compared with blank group, nine taste medicines can extend the threshold of pain time of mice and suppress mouse writhing number of times, wherein with nine taste medicine group effects the most obviously (p < 0.01).Compared with positive control drug aspirin group, in nine taste medicines, dosage group still obviously can suppress mouse writhing number of times (p < 0.05).Ten four Chinese medicines significantly do not affect (p>0.05) to the threshold of pain time of mice and writhing number of times.
table 5 Dichlorodiphenyl Acetate causes the impact of mouse writhing(
± s, n=6)
Note: compared with normal control medicine group: * p<0.05, * * p < 0.01; Compared with aspirin group: #p<0.05, ##p<0.01.
table 5 Dichlorodiphenyl Acetate causes the impact of mouse writhing(
± s, n=6)
Note: compared with normal control medicine group: * p<0.05, * * p < 0.01; Compared with aspirin group: #p<0.05, ##p<0.01.
b is on the impact of mouse hot-plate induced pain
Compared with blank group, nine taste medicine groups can improve the 30min hot plate method in mice threshold of pain (p<0.05) after medicine, can improve 30min, 60min hot plate method in mice threshold of pain (p<0.05) after medicine.Compared with aspirin group, each group has no significant effect (p>0.05) the hot plate method in mice threshold of pain.
table 6 capsule is on the impact of mouse hot-plate induced pain(%) (
± s, n=8)
Note: compared with normal control medicine group: * p<0.05, * * p < 0.01; Compared with model comparison medicine group: #p<0.05, ##p<0.01.
table 6 is on the impact of mouse hot-plate induced pain(%) (
± s, n=8)
| Group | 30min | 60min |
| Blank group | -19.79±40.25 | 49.89±76.16 |
| Aspirin group | 28.86±65.86 | 160.43±146.09 * |
| Ten four Chinese medicine groups | 27.95±50.58 * | 86.38±79.03 |
| Medicine group of the present invention | 104.34±128.44 * | 151.11±92.78 * |
Note: compared with normal control medicine group: * p<0.05, * * p < 0.01; Compared with model comparison medicine group: #p<0.05, ##p<0.01.
c is on the impact of mice photo-thermal induced pain
Compared with blank group, each dosage group all can significantly improve 2h, 3h, 4h, 5h rat photo-thermal induced pain method threshold of pain (p<0.05 or <0.01) after medicine.Compared with positive control drug group, ten four Chinese medicines can significantly improve 2h, 4h, 5h, 6h rat photo-thermal induced pain method threshold of pain (P<0.05 or <0.01) after medicine, and in medicine of the present invention, dosage group can significantly improve 2h, 3h, 4h, 5h, 6h rat photo-thermal induced pain method threshold of pain (P<0.05 or <0.01) after medicine.
table 7 is on the impact (%) of mouse hot-plate induced pain(
± s, n=10)
Note: compared with normal control medicine group: * p<0.05, * * p < 0.01; Compared with aspirin group: #p<0.05, ##p<0.01.
By multiple hypertrophy, pain model, illustrate the present invention to the therapeutical effect of cyclomastopathy and mechanism thereof: the 2nd pair of papilla diameter that can reduce hyperplasia of mammary gland model rat; Can make cyclomastopathy rat mammary gland acinus decreased number, acinus starts atrophy, volume-diminished, and some can close to rats in normal control group breast structure state; Obviously can reduce hyperplasia of mammary gland model rat breast tissue estrogen receptor (ER), progesterone receptor (PR).In adjustable cyclomastopathy pathology rat model body, the hormone secretion of hypophysis-gonad is movable, adjustment cyclomastopathy pathology rat model hormone in vivo metabolism disorder level, reduce hypophysis prolactin antagonist (PRL), FSH (FSH) and estradiol (E2) in rat blood, raise the content of lutropin (LH), progesterone (PGN).Thus reach therapeutic purposes.Significantly can reduce the mouse writhing number of times that acetic acid causes, improve the hot plate method in mice threshold of pain, the prolong rats whipping time, show there is certain analgesic activity.Through 1000 many cases clinical verifications, turn out to be safety, effective, curative effect Chinese medicine preparation rapidly, effective percentage is more than 95%, and remission rate is more than 85%.
good effect of the present invention is:
Selected Cornu Cervi, Rhizoma Cyperi, the Radix Paeoniae Alba etc. nine taste Chinese medicine composition, for pure Chinese medicinal preparation, person caused by mainly for treating mammary gland hypertrophy cause of disease stagnation of liver-QI stagnation of QI and blood, can resolving depression eliminating stagnation, again can regulating menstruation and activating blood pain relieving, curative effect is obvious, treating both the principal and secondary aspects of a disease, optimization formulation also rejects the five tastes such as bitterness Chinese herb rhubarb, Radix Scutellariae, Semen Armeniacae Amarum, Semen Persicae, Rhizoma Paridis in original prescription, clinical application range is wider, strengthens compliance, reduces costs and reduce the toxic and side effects such as soft stool, diarrhoea clinically, treating both the principal and secondary aspects of a disease simultaneously, therapeutic effect is obvious, without bounce-back after curing.
Detailed description of the invention
Technical solution of the present invention is further illustrated below by specific embodiment
embodiment 1
Take Cornu Cervi 120g, Rhizoma Cyperi 100g respectively, Rhizoma Curcumae 40g, Radix Paeoniae Alba 40g, Hirudo 20g be ground into 80 ~ 120 order fine powders, mixing; Rhizoma Sparganii 40g, Eupolyphaga Seu Steleophaga 40g, Radix Rehmanniae Preparata 20g, Radix Glycyrrhizae 20g tetra-taste decoct with water 3 times, and amount of water is respectively 10,8,6 times, and decocting time is 3,2,1 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.25-1.30(80 DEG C) thick paste; Mix with the powder of Cornu Cervi, Rhizoma Cyperi, Rhizoma Curcumae, Hirudo, the Radix Paeoniae Alba, less than 85 DEG C temperature dry, pulverize, and sieve, and add Mel furnishing pill, and other should meet People's Republic of China's version pharmacopeia pill item in 2010.
embodiment 2
Take Cornu Cervi 120g, Rhizoma Cyperi 80g respectively, Rhizoma Curcumae 40g, Radix Paeoniae Alba 40g, Hirudo 20g be ground into 80 ~ 120 order fine powders, mixing; Rhizoma Sparganii 40 g, Eupolyphaga Seu Steleophaga 4 0g, Radix Rehmanniae Preparata 20 g, Radix Glycyrrhizae 40 g decoct with water 3 times, and amount of water is respectively 10,8,6 times, and decocting time is 3,2,1 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.25-1.30(80 DEG C) thick paste.Mix with the powder of Cornu Cervi, Rhizoma Cyperi, Rhizoma Curcumae, Hirudo, the Radix Paeoniae Alba, less than 85 DEG C temperature dry, pulverize, and sieve, and then make various dosage form according to Chinese medicine customary preparation methods, as capsule, tablet, granule, pill etc.
embodiment 3
Get Cornu Cervi 160 g, Rhizoma Cyperi 120 g, Rhizoma Curcumae 80 g, Hirudo 24 g, Radix Paeoniae Alba 80g be ground into 80 ~ 120 order fine powders, mixing; Rhizoma Sparganii 80 g, Eupolyphaga Seu Steleophaga 80 g, Radix Rehmanniae Preparata 40g, Radix Glycyrrhizae 40g decoct with water 3 times, and amount of water is respectively 10,8,6 times, and decocting time is 3,2,1 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.25-1.30(80 DEG C) thick paste.Mix with the powder of Cornu Cervi, Rhizoma Cyperi, Rhizoma Curcumae, Hirudo, the Radix Paeoniae Alba, less than 85 DEG C temperature dry, pulverize, and sieve, fill becomes capsule, and other should meet People's Republic of China's version pharmacopeia capsule item in 2010.
embodiment 4
Take Cornu Cervi 200g, Rhizoma Cyperi 150g respectively, Rhizoma Curcumae 100g, Hirudo 30g, Radix Paeoniae Alba 100g be ground into 80 ~ 120 order fine powders, mixing; Rhizoma Sparganii 100g, Eupolyphaga Seu Steleophaga 100g, Radix Rehmanniae Preparata 50g, Radix Glycyrrhizae 50g decoct with water 3 times, and amount of water is respectively 10,8,6 times, and decocting time is 3,2,1 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.25-1.30(80 DEG C) thick paste.Mix with the powder of Cornu Cervi, Rhizoma Cyperi, Rhizoma Curcumae, Hirudo, the Radix Paeoniae Alba, less than 85 DEG C temperature dry, pulverize, and sieve, and then make capsule according to Chinese medicine customary preparation methods.
embodiment 5
Take Cornu Cervi 20g, Rhizoma Cyperi 15g respectively, Rhizoma Curcumae 10g, Hirudo 3g, Radix Paeoniae Alba 10g be ground into 80 ~ 120 order fine powders, mixing; Rhizoma Sparganii 10g, Eupolyphaga Seu Steleophaga 10g, Radix Rehmanniae Preparata 5g, Radix Glycyrrhizae 5g decoct with water 3 times, and amount of water is respectively 10,8,6 times, and decocting time is 3,2,1 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.25-1.30(80 DEG C) thick paste.Mix with the powder of Cornu Cervi, Rhizoma Cyperi, Rhizoma Curcumae, Hirudo, the Radix Paeoniae Alba, less than 85 DEG C temperature dry, pulverize, and sieve, and then make capsule according to Chinese medicine customary preparation methods.
following selection portion divides healing case history so that the curative effect of medicine of the present invention to be described.
model case:
case 1:lee, female, 35 years old, because two swelling of the breast block accompanies premenstrual pain two months, carry out my institute's first visit on June 10th, 2010, quarter examined: two swelling of the breast block pain, and companion is depressed joyless, and spiritlessness and weakness, tongue fur BOHUANG, arteries and veins is carefully profound, weakness of the spleen and stomach.Last menstrual period on April 20th, 2009, have a medical check-up: the outside upper quadrant of two breast, right newborn LOQ has the block lumps of three sheets, in matter, and tenderness, about 1 × 1cm size.B surpasses inspection and shows: two cyclomastopathy, diagnosis: cyclomastopathy.After giving 2 courses for the treatment of of medicine of the embodiment of the present invention 1, after JIUYUE in 2010 treatment on the 30th, check was followed up a case by regular visits to through half a year: two breast is without pain, and without lump, sick announcement is fully recovered.
case 2:wang, female, 33 years old, because two swelling of the breast block accompanies pain 14 months, carry out my Out-patient Department first visit on May 21st, 2010, quarter examined: two swelling of the breast block pain, companion's sternal rib pain, and susceptible to lose temper due to restlessness, depressed, thin white fur of tongue, arteries and veins is carefully profound, loose stool.Have a medical check-up: two breast is outside upper, lower quadrant has four block lamellar lumps, and matter is soft, tenderness, about 1.5 × 1.5cm size, and ultrasound diagnosis is shown: two cyclomastopathy, diagnosis: cyclomastopathy.Give 1 course for the treatment of of medicine of the embodiment of the present invention 2, menstrual period withdraw, and on July 11st, 2010 follows up a case by regular visits to and checks after treatment: without mastalgia, and two swelling of the breast block disappears, and sick announcement is fully recovered.
case 3:leaf, female, 42 years old.Main suit suffers from cyclomastopathy medical history more than 20 year, intermittent treatment.Within nearly 1 week, because of the tired induced insomnia that works, delayed menstruaion, extremely two swelling of the breast block did not increase hardening twinge, suffers from indiestion.Check: facial pigmentation is obvious, two breast outside and directly over all lay one's hand on and lump, Huang Zhongjie is still clear, and light tenderness, mobility still can.Molybdenum target X-ray shows: two breast is dispersed in lamellar ghost, has no calcification point, examines as " bilateral breast hypertrophy is sick ".Give 2 courses for the treatment of of medicine of the embodiment of the present invention 3, lump is deliquescing gradually, hyper-menorrhea.Continuously again take menstruation in 2 months and rise all on time, lump disappears substantially, and pigmented spots disappear on the face, sickly accuses recovery from illness.
case 4:gold certain, female, 38 years old.First visit on February 15 in 2011.Bimastism distending pain 2 years.Patient's disposition is depressed, and bimastism inspection can touch multiple lesser tubercle, obscure boundary, and matter is more tough, has tenderness, and tongue is dark red, white and thin fur, stringy and thready pulse, incoordination between the spleen and stomach.B ultrasonic and the prompting of x-ray mammography in nonpalpable breast: two cyclomastopathy.Give 3 courses for the treatment of of medicine of the embodiment of the present invention 4, menstrual period withdraw, and after 3 months, patient tells symptom and substantially disappears, and two newborn lesser tubercle deliquescing, reduces, treat after 3 months, and B ultrasonic shows, and lump in breast disappears.Recovery from illness.
case 5:beam, female, 39 years old.December in 2012 first visit on the 15th.Bimastism distending pain 2 years.Depression in patients is inclined to, and bimastism inspection can touch multiple lesser tubercle, obscure boundary, and matter is more tough, has tenderness, and tongue is dark red, white and thin fur, stringy and thready pulse, weakness of the spleen and stomach.B ultrasonic and the prompting of x-ray mammography in nonpalpable breast: two cyclomastopathy.Give 3 courses for the treatment of of medicine of the embodiment of the present invention 5, menstrual period withdraw, and menstrual period withdraw, and after 2 months, patient tells symptom and substantially disappears, and two newborn lesser tubercle deliquescing, reduces, treat after 1 month, and B ultrasonic shows, and lump in breast disappears, recovery from illness.
Claims (5)
1. treating a Chinese medicine preparation for cyclomastopathy, it is characterized in that primarily of following raw materials by weight portion than making:
Cornu Cervi 20-200 part, Rhizoma Cyperi 15-150 part, Rhizoma Sparganii 10-100 part, Rhizoma Curcumae 10-100 part, Eupolyphaga Seu Steleophaga 10-100 part, Hirudo 3-30 part, Radix Rehmanniae Preparata 5-50 part, Radix Glycyrrhizae 5-50 part, Radix Paeoniae Alba 10-100 part.
2. Chinese medicine composition according to claim 1, the raw material of preferred following weight proportion is prepared from:
Cornu Cervi 40-160 part, Rhizoma Cyperi 30-120 part, Rhizoma Sparganii 20-80 part, Rhizoma Curcumae 20-80 part, Eupolyphaga Seu Steleophaga 20-80 part, Hirudo 6-24 part, Radix Rehmanniae Preparata 10-40 part, Radix Glycyrrhizae 10-40 part, Radix Paeoniae Alba 20-80 part.
3. Chinese medicine composition according to claim 1, the raw material of preferred following weight proportion is prepared from:
120 parts, Cornu Cervi, Rhizoma Cyperi 80 parts, Rhizoma Sparganii 40 parts, Rhizoma Curcumae 40 parts of, Eupolyphaga Seu Steleophaga 40 parts, Hirudo 20 parts, Radix Rehmanniae Preparata 20 parts, 20 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 40 parts.
4., according to the preparation method of the Chinese medicine composition described in claim 1 ~ 3, comprise the following steps:
Above nine tastes, Cornu Cervi, Rhizoma Cyperi, Rhizoma Curcumae, the Radix Paeoniae Alba, Hirudo powder are broken into 80 ~ 120 order fine powders, mixing; Rhizoma Sparganii, Eupolyphaga Seu Steleophaga, Radix Rehmanniae Preparata, Radix Glycyrrhizae four taste decoct with water 3 times, and amount of water is respectively 10,8,6 times, and decocting time is 3,2,1 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.25-1.30(80 DEG C) thick paste; Mix with the powder of Cornu Cervi, Rhizoma Cyperi, Rhizoma Curcumae, Hirudo, the Radix Paeoniae Alba, less than 85 DEG C temperature dry, pulverize, and sieve, and then make Chinese medicine preparation according to Chinese medicine customary preparation methods.
5. can be made into the pharmaceutical dosage forms such as capsule, tablet, granule, pill according to the Chinese medicine composition described in claim 1 ~ 3.
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| CN101773643A (en) * | 2010-03-04 | 2010-07-14 | 刘国津 | Chinese medicine preparation for treating mammary gland proliferation diseases and preparation method thereof |
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| WO2004087182A1 (en) * | 2003-04-02 | 2004-10-14 | Bioplanta Arzneimittel Gmbh | Active ingredient combinations of plant oils containing $g(v)3-fatty acids and plant extracts containing isoprenoids and the use thereof |
| CN1966043A (en) * | 2006-11-17 | 2007-05-23 | 贵阳新天药业股份有限公司 | Externally applied medicament for treating hyperplasia of mammary glands and preparation method thereof |
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Application publication date: 20150617 |