CN100347142C - 2,4,5-三氟苯乙酸的制备方法 - Google Patents
2,4,5-三氟苯乙酸的制备方法 Download PDFInfo
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- CN100347142C CN100347142C CNB2005100301620A CN200510030162A CN100347142C CN 100347142 C CN100347142 C CN 100347142C CN B2005100301620 A CNB2005100301620 A CN B2005100301620A CN 200510030162 A CN200510030162 A CN 200510030162A CN 100347142 C CN100347142 C CN 100347142C
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- trifluoro
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- acetic acid
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- benzene acetic
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CNB2005100301620A CN100347142C (zh) | 2005-09-29 | 2005-09-29 | 2,4,5-三氟苯乙酸的制备方法 |
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CNB2005100301620A CN100347142C (zh) | 2005-09-29 | 2005-09-29 | 2,4,5-三氟苯乙酸的制备方法 |
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CN1749232A CN1749232A (zh) | 2006-03-22 |
CN100347142C true CN100347142C (zh) | 2007-11-07 |
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Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101244994B (zh) * | 2007-02-14 | 2013-02-13 | 常州亚邦制药有限公司 | 制备2,4,5-三氟苯乙酸的方法 |
CN101367721B (zh) * | 2008-09-28 | 2011-07-20 | 浙江大学 | 含氨高温液态水介质中苯乙腈水解制备苯乙酸的方法 |
CN101429115B (zh) * | 2008-12-22 | 2012-06-13 | 浙江海翔药业股份有限公司 | 三氟苯乙酸和西他列汀的制备方法 |
CN101659630B (zh) * | 2009-09-28 | 2011-05-18 | 浙江永太科技股份有限公司 | 2,4,5-三氟苯乙腈的制备方法 |
CN101659611B (zh) * | 2009-09-28 | 2011-04-06 | 浙江永太科技股份有限公司 | 2,4,5-三氟苯乙酸的制备方法 |
CN101665407B (zh) * | 2009-09-28 | 2011-04-20 | 浙江永太科技股份有限公司 | 2,4,5-三氟苄氯的制备方法 |
EP2392575A1 (en) | 2010-06-04 | 2011-12-07 | LEK Pharmaceuticals d.d. | A novel synthetic approach to ß-aminobutyryl substituted compounds |
EP2576563B1 (en) | 2010-06-04 | 2016-05-11 | LEK Pharmaceuticals d.d. | A NOVEL SYNTHETIC APPROACH TO ß-AMINOBUTYRYL SUBSTITUTED COMPOUNDS |
CN102311351B (zh) * | 2011-07-11 | 2014-01-01 | 上海应用技术学院 | 一种2,4-二甲氧基苄胺的合成方法 |
CN102690166A (zh) * | 2012-06-12 | 2012-09-26 | 南通施美康药物化学有限公司 | 2,4,5-三氟苄氯和2,4,5-三氟苯乙酸的制备方法 |
CN104387259B (zh) * | 2014-11-05 | 2016-05-04 | 衢州学院 | 一种制备2,4,5-三氟苯乙酸的方法 |
CN107759459A (zh) * | 2017-04-18 | 2018-03-06 | 南京工业大学 | 一种2,5-二溴苯乙酸的合成方法 |
CN111454149A (zh) * | 2017-04-28 | 2020-07-28 | 浙江天宇药业股份有限公司 | 一种2,4,5-三氟苯乙酸的制备方法 |
ES2733477T3 (es) | 2017-07-04 | 2019-11-29 | Fis Fabbrica Italiana Sintetici Spa | Procedimiento eficaz para la preparación de sitagliptina a través de una preparación muy eficaz del intermedio ácido 2,4,5-trifluorofenilacético |
CN107383418B (zh) * | 2017-08-18 | 2019-05-17 | 广东宝利兴科技有限公司 | 一种抗紫外线塑料添加剂及其制备方法 |
ES2770143T3 (es) | 2018-02-13 | 2020-06-30 | Fis Fabbrica Italiana Sintetici Spa | Nuevo procedimiento eficiente para la preparación de sitagliptina |
CN110128258B (zh) * | 2019-04-24 | 2022-04-01 | 深圳市第二人民医院 | 西他列汀中间体2,4,5-三氟苯乙酸的合成方法 |
CN112457153B (zh) * | 2020-11-10 | 2022-09-09 | 台州臻挚生物科技有限公司 | 2,4,5-三氟苯乙酸的工业化制备方法 |
WO2022099439A1 (zh) * | 2020-11-10 | 2022-05-19 | 杭州臻挚生物科技有限公司 | 一种2,4,5-三氟苯乙酸的制备方法 |
CN112851493B (zh) * | 2020-11-10 | 2022-09-06 | 台州臻挚生物科技有限公司 | 一种2,4,5-三氟苯乙酸的制备方法 |
CN113278996A (zh) * | 2021-04-01 | 2021-08-20 | 安徽海康药业有限责任公司 | 一种2,4,5-三氟苯乙酸的制备方法 |
CN115246762A (zh) * | 2022-08-25 | 2022-10-28 | 上海朴颐化学科技有限公司 | 2,4,5-三氟苯乙酸的制备方法 |
CN115677477B (zh) * | 2022-09-26 | 2023-05-26 | 上海康鹏科技股份有限公司 | 一种2,4,5-三氟苯乙酸及其中间体的制备方法 |
CN117486706B (zh) * | 2024-01-02 | 2024-04-19 | 山东国邦药业有限公司 | 一种2,4,5-三氟苯乙酸的合成方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040068141A1 (en) * | 2002-10-08 | 2004-04-08 | Armstrong Joseph D. | Process for the synthesis of trifluorophenylacetic acids |
US6870067B2 (en) * | 2002-10-08 | 2005-03-22 | Merck & Co., Inc. | Process for the synthesis of trifluorophenylacetic acids |
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2005
- 2005-09-29 CN CNB2005100301620A patent/CN100347142C/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040068141A1 (en) * | 2002-10-08 | 2004-04-08 | Armstrong Joseph D. | Process for the synthesis of trifluorophenylacetic acids |
US6870067B2 (en) * | 2002-10-08 | 2005-03-22 | Merck & Co., Inc. | Process for the synthesis of trifluorophenylacetic acids |
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CN1749232A (zh) | 2006-03-22 |
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Address after: 2003 No. 3, Lane 1273, Tongpu Road, Shanghai Patentee after: SHANGHAI CHEMSPEC Corp. Address before: 2003 No. 3, Lane 1273, Tongpu Road, Shanghai Patentee before: Shanghai Kangpeng Chemical Co.,Ltd. |
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Address after: 2003-1 Building No. 200, 2891 Lane, Qilian Mountain South Road, Putuo District, Shanghai Patentee after: Shanghai Kangpeng Science and Technology Co.,Ltd. Address before: 2003 No. 3, Lane 1273, Tongpu Road, Shanghai Patentee before: SHANGHAI CHEMSPEC Corp. |