CL2021003027A1 - Moléculas de unión anti-tdp-43 y uso de las mismas. - Google Patents
Moléculas de unión anti-tdp-43 y uso de las mismas.Info
- Publication number
- CL2021003027A1 CL2021003027A1 CL2021003027A CL2021003027A CL2021003027A1 CL 2021003027 A1 CL2021003027 A1 CL 2021003027A1 CL 2021003027 A CL2021003027 A CL 2021003027A CL 2021003027 A CL2021003027 A CL 2021003027A CL 2021003027 A1 CL2021003027 A1 CL 2021003027A1
- Authority
- CL
- Chile
- Prior art keywords
- tdp
- disease
- encephalopathy
- binding molecules
- tardb
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2878—Muscular dystrophy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
Proteínas de unión a ADN de respuesta transactiva con un peso molecular de 43 kDa (TARDB o también TDP-43). Se describen moléculas de unión específicas de TDP-43, en particular con anticuerpos anti-TDP-43 o un fragmento de unión al antígeno o un derivado de los mismos y sus usos. Asimismo se proveen medios y métodos para diagnosticar, prevenir, aliviar y/o tratar una enfermedad, un trastorno y/o una anomalía asociada con agregados de TDP-43 que incluye, pero en un sentido no taxativo, demencia frontotemporal (FTD), esclerosis lateral amiotrófica (ALS), enfermedad de Alzheimer (AD), enfermedad de Parkinson (PD), encefalopatía traumática crónica, y encefalopatía TDP-43 con predominio límbico, relacionada con la edad (LATE).
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19176314 | 2019-05-23 | ||
EP19195916 | 2019-09-06 | ||
EP19207839 | 2019-11-07 | ||
EP20161060 | 2020-03-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021003027A1 true CL2021003027A1 (es) | 2022-06-24 |
Family
ID=70779783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021003027A CL2021003027A1 (es) | 2019-05-23 | 2021-11-16 | Moléculas de unión anti-tdp-43 y uso de las mismas. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20220315648A1 (es) |
EP (1) | EP3972692A1 (es) |
JP (1) | JP2022533432A (es) |
KR (1) | KR20220012270A (es) |
CN (1) | CN114008073A (es) |
AU (1) | AU2020278907A1 (es) |
BR (1) | BR112021023487A2 (es) |
CA (1) | CA3137882A1 (es) |
CL (1) | CL2021003027A1 (es) |
IL (1) | IL288314A (es) |
MX (1) | MX2021014274A (es) |
SG (1) | SG11202112453TA (es) |
TW (1) | TW202110879A (es) |
WO (1) | WO2020234473A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112920264B (zh) * | 2021-02-08 | 2022-07-05 | 武汉大学 | Tdp-43蛋白的o-糖基化突变体及其应用 |
US20240115736A1 (en) * | 2021-02-11 | 2024-04-11 | Mayo Foundation For Medical Education And Research | Methods and materials for treating tdp-43 proteinopathies |
TW202342519A (zh) | 2022-02-16 | 2023-11-01 | 瑞士商Ac 免疫有限公司 | 人源化抗tdp-43結合分子及其用途 |
WO2023194565A1 (en) | 2022-04-08 | 2023-10-12 | Ac Immune Sa | Anti-tdp-43 binding molecules |
CN117126269B (zh) * | 2023-10-25 | 2024-02-13 | 首都儿科研究所 | 一种1型人博卡病毒型别特异性抗体及其应用 |
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2020
- 2020-05-22 CN CN202080038441.4A patent/CN114008073A/zh active Pending
- 2020-05-22 US US17/613,444 patent/US20220315648A1/en active Pending
- 2020-05-22 KR KR1020217040767A patent/KR20220012270A/ko unknown
- 2020-05-22 AU AU2020278907A patent/AU2020278907A1/en active Pending
- 2020-05-22 WO PCT/EP2020/064335 patent/WO2020234473A1/en active Application Filing
- 2020-05-22 EP EP20727297.2A patent/EP3972692A1/en active Pending
- 2020-05-22 TW TW109117264A patent/TW202110879A/zh unknown
- 2020-05-22 BR BR112021023487A patent/BR112021023487A2/pt unknown
- 2020-05-22 CA CA3137882A patent/CA3137882A1/en active Pending
- 2020-05-22 JP JP2021569353A patent/JP2022533432A/ja active Pending
- 2020-05-22 SG SG11202112453TA patent/SG11202112453TA/en unknown
- 2020-05-22 MX MX2021014274A patent/MX2021014274A/es unknown
-
2021
- 2021-11-16 CL CL2021003027A patent/CL2021003027A1/es unknown
- 2021-11-22 IL IL288314A patent/IL288314A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3972692A1 (en) | 2022-03-30 |
JP2022533432A (ja) | 2022-07-22 |
TW202110879A (zh) | 2021-03-16 |
KR20220012270A (ko) | 2022-02-03 |
AU2020278907A1 (en) | 2022-01-20 |
WO2020234473A1 (en) | 2020-11-26 |
BR112021023487A2 (pt) | 2022-02-08 |
MX2021014274A (es) | 2022-01-06 |
CN114008073A (zh) | 2022-02-01 |
US20220315648A1 (en) | 2022-10-06 |
SG11202112453TA (en) | 2021-12-30 |
IL288314A (en) | 2022-01-01 |
CA3137882A1 (en) | 2020-11-26 |
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