CL2021002521A1 - Compuestos heteocíclicos y sus usos. - Google Patents
Compuestos heteocíclicos y sus usos.Info
- Publication number
- CL2021002521A1 CL2021002521A1 CL2021002521A CL2021002521A CL2021002521A1 CL 2021002521 A1 CL2021002521 A1 CL 2021002521A1 CL 2021002521 A CL2021002521 A CL 2021002521A CL 2021002521 A CL2021002521 A CL 2021002521A CL 2021002521 A1 CL2021002521 A1 CL 2021002521A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- heteocyclic
- find
- oncology
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporcionan compuestos heterocíclicos como inhibidores de Wee1. Los compuestos pueden encontrar uso como agentes terapéuticos para el tratamiento de enfermedades y pueden encontrar un uso particular en oncología.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962831665P | 2019-04-09 | 2019-04-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021002521A1 true CL2021002521A1 (es) | 2022-04-29 |
Family
ID=72748693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021002521A CL2021002521A1 (es) | 2019-04-09 | 2021-09-28 | Compuestos heteocíclicos y sus usos. |
Country Status (14)
Country | Link |
---|---|
US (2) | US11332473B2 (es) |
EP (1) | EP3952877A4 (es) |
JP (1) | JP2022526831A (es) |
KR (1) | KR20210150476A (es) |
CN (1) | CN113939296A (es) |
AU (1) | AU2020271837A1 (es) |
BR (1) | BR112021019703A2 (es) |
CA (1) | CA3136492A1 (es) |
CL (1) | CL2021002521A1 (es) |
EA (1) | EA202192746A1 (es) |
IL (1) | IL287026A (es) |
MX (1) | MX2021012418A (es) |
SG (1) | SG11202110615TA (es) |
WO (1) | WO2020210375A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019074979A1 (en) | 2017-10-09 | 2019-04-18 | Girafpharma, Llc | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
WO2023280180A1 (zh) * | 2021-07-05 | 2023-01-12 | 微境生物医药科技(上海)有限公司 | 作为Wee-1抑制剂的稠环化合物 |
CN117751122A (zh) * | 2021-08-11 | 2024-03-22 | 微境生物医药科技(上海)有限公司 | 作为Wee-1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮化合物 |
CN117940430A (zh) * | 2021-09-22 | 2024-04-26 | 微境生物医药科技(上海)有限公司 | 作为Wee-1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮化合物 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1473295B1 (en) | 2002-01-18 | 2009-04-01 | Kyorin Pharmaceutical Co., Ltd. | Fused bicyclic pyrimidine derivatives |
ES2341545T3 (es) | 2003-06-06 | 2010-06-22 | Arexis Ab | Uso de compuestos heterociclicos condensados como inhibidores de scce para el tratamiento de enfermedades de la piel. |
WO2006039212A2 (en) | 2004-09-29 | 2006-04-13 | Portola Pharmaceuticals, Inc. | Substituted 2h-1,3-benzoxazin-4(3h)-ones |
AR060635A1 (es) | 2006-04-27 | 2008-07-02 | Banyu Pharma Co Ltd | Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer |
EP2168966B1 (en) | 2007-06-15 | 2016-09-28 | Msd K.K. | Bicycloaniline derivative |
AU2008315048A1 (en) | 2007-10-23 | 2009-04-30 | Msd K.K. | Pyridone-substituted-dihydropyrazolopyrimidinone derivative |
CA2745959A1 (en) | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivatives |
DK2477628T3 (en) | 2009-09-15 | 2014-11-24 | Merck Sharp & Dohme | Preparation of crystalline hemihydratformer of dihydropyrazolopyrimidinon |
US8796289B2 (en) | 2011-07-19 | 2014-08-05 | Abbvie Inc. | Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases |
WO2013059485A1 (en) | 2011-10-20 | 2013-04-25 | Abbvie Inc. | Pyridopyrimidinone inhibitors of kinases |
EP2817308B1 (en) | 2012-02-23 | 2016-09-07 | AbbVie Inc. | Pyridopyrimidinone inhibitors of kinases |
WO2014085216A1 (en) | 2012-11-28 | 2014-06-05 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer |
GB201306610D0 (en) | 2013-04-11 | 2013-05-29 | Almac Discovery Ltd | Pharmaceutical compounds |
WO2015019037A1 (en) | 2013-08-05 | 2015-02-12 | Almac Discovery Limited | Pharmaceutical compounds |
GB201322602D0 (en) | 2013-12-19 | 2014-02-05 | Almac Discovery Ltd | Pharmaceutical compounds |
JP6692423B2 (ja) | 2015-11-01 | 2020-05-13 | ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド,ア ボディ コーポレイト | Wee1キナーゼ阻害剤、並びにそれを作製及び使用する方法 |
GB201612095D0 (en) | 2016-07-12 | 2016-08-24 | Almac Discovery Ltd | Pharmaceutical compounds |
GB201612092D0 (en) | 2016-07-12 | 2016-08-24 | Almac Discovery Ltd | Pharmaceutical compounds |
KR102030886B1 (ko) | 2016-09-23 | 2019-10-10 | 재단법인 대구경북첨단의료산업진흥재단 | 신규한 이미다졸일 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
AU2017359844B2 (en) | 2016-11-16 | 2021-09-30 | Impact Therapeutics (Shanghai), Inc | 8,9-dihydroimidazole[1,2-a]pyrimido[5,4-e]pyrimidine-5(6H)-ketone compound |
ES2902050T3 (es) | 2017-01-23 | 2022-03-24 | Shijiazhuang Sagacity New Drug Dev Co Ltd | Derivado 1,2-dihidro-3H-pirazolo[3,4-D]pirimidin-3-ona como inhibidor de Wee1 |
GB201703881D0 (en) | 2017-03-10 | 2017-04-26 | Almac Discovery Ltd | Pharmaceutical compounds |
EP3604306B1 (en) * | 2017-03-23 | 2022-10-26 | Shanghai de Novo Pharmatech Co., Ltd. | Macrocyclic derivative of pyrazol[3,4-d]pyrimidin-3-one, pharmaceutical composition and use thereof |
KR20190130621A (ko) | 2017-03-31 | 2019-11-22 | 시애틀 지네틱스, 인크. | Chk1 저해제와 wee1 저해제의 조합물 |
CN110914277B (zh) | 2017-07-10 | 2022-08-09 | 上海瑛派药业有限公司 | 咪唑并[1,2-b]嘧啶并[4,5-d]哒嗪-5(6H)-酮类化合物及其应用 |
SG11202000789WA (en) * | 2017-08-01 | 2020-02-27 | Recurium Ip Holdings Llc | 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs |
WO2019037678A1 (zh) | 2017-08-24 | 2019-02-28 | 上海迪诺医药科技有限公司 | 吡唑并[3,4-d]嘧啶-3-酮衍生物、其药物组合物及应用 |
WO2019074979A1 (en) * | 2017-10-09 | 2019-04-18 | Girafpharma, Llc | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
CA3078945A1 (en) | 2017-10-09 | 2019-04-18 | Nuvation Bo Inc. | Heterocyclic compounds and uses thereof |
WO2019096322A1 (zh) | 2017-11-20 | 2019-05-23 | 上海医药集团股份有限公司 | 一种吡唑酮并嘧啶类化合物、其制备方法及应用 |
CN111315747B (zh) | 2018-01-05 | 2023-05-02 | 四川科伦博泰生物医药股份有限公司 | 二氢吡唑酮并嘧啶类化合物及其制备方法和用途 |
US11479555B2 (en) * | 2018-02-23 | 2022-10-25 | Newave Pharmaceutical Inc. | Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones as inhibitors of WEE-1 kinase |
AU2019227823A1 (en) | 2018-02-28 | 2020-08-06 | The Regents Of The University Of Colorado, A Body Corporate | WEE1 kinase inhibitors and methods of treating cancer using the same |
EP3762385A4 (en) * | 2018-03-09 | 2021-11-24 | Recurium IP Holdings, LLC | SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO [3,4-D] PYRIMIDINE-3-ONE |
WO2020210380A1 (en) | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
WO2020210377A1 (en) | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
WO2020210381A1 (en) | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
US20220168313A1 (en) | 2019-04-09 | 2022-06-02 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
-
2020
- 2020-04-08 CA CA3136492A patent/CA3136492A1/en active Pending
- 2020-04-08 JP JP2021559854A patent/JP2022526831A/ja active Pending
- 2020-04-08 EP EP20787951.1A patent/EP3952877A4/en not_active Withdrawn
- 2020-04-08 CN CN202080040846.1A patent/CN113939296A/zh active Pending
- 2020-04-08 US US16/843,713 patent/US11332473B2/en active Active
- 2020-04-08 SG SG11202110615TA patent/SG11202110615TA/en unknown
- 2020-04-08 WO PCT/US2020/027297 patent/WO2020210375A1/en unknown
- 2020-04-08 KR KR1020217036088A patent/KR20210150476A/ko unknown
- 2020-04-08 BR BR112021019703A patent/BR112021019703A2/pt not_active Application Discontinuation
- 2020-04-08 EA EA202192746A patent/EA202192746A1/ru unknown
- 2020-04-08 AU AU2020271837A patent/AU2020271837A1/en not_active Abandoned
- 2020-04-08 MX MX2021012418A patent/MX2021012418A/es unknown
-
2021
- 2021-09-28 CL CL2021002521A patent/CL2021002521A1/es unknown
- 2021-10-06 IL IL287026A patent/IL287026A/en unknown
-
2022
- 2022-05-12 US US17/743,061 patent/US20230118115A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112021019703A2 (pt) | 2021-12-14 |
WO2020210375A1 (en) | 2020-10-15 |
US20200325142A1 (en) | 2020-10-15 |
US11332473B2 (en) | 2022-05-17 |
AU2020271837A1 (en) | 2021-11-18 |
MX2021012418A (es) | 2021-11-12 |
EP3952877A4 (en) | 2022-12-14 |
JP2022526831A (ja) | 2022-05-26 |
EA202192746A1 (ru) | 2021-12-29 |
CA3136492A1 (en) | 2020-10-15 |
EP3952877A1 (en) | 2022-02-16 |
CN113939296A (zh) | 2022-01-14 |
SG11202110615TA (en) | 2021-10-28 |
US20230118115A1 (en) | 2023-04-20 |
IL287026A (en) | 2021-12-01 |
KR20210150476A (ko) | 2021-12-10 |
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