CL2020002573A1 - Inhibidores atf6 y sus usos. - Google Patents

Inhibidores atf6 y sus usos.

Info

Publication number
CL2020002573A1
CL2020002573A1 CL2020002573A CL2020002573A CL2020002573A1 CL 2020002573 A1 CL2020002573 A1 CL 2020002573A1 CL 2020002573 A CL2020002573 A CL 2020002573A CL 2020002573 A CL2020002573 A CL 2020002573A CL 2020002573 A1 CL2020002573 A1 CL 2020002573A1
Authority
CL
Chile
Prior art keywords
atf6
inhibitors
compounds
diseases
treating
Prior art date
Application number
CL2020002573A
Other languages
English (en)
Inventor
Jennifer Alfaro
Sebastian Belmar
Vasquez Gonzalo Esteban Núñez
Brahmam Pujala
Sebastian Bernales
Sarvajit Chakravarty
Pooja Thakral
Rajesh Kumar Patidar
Balaji Dashrath Sathe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of CL2020002573A1 publication Critical patent/CL2020002573A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Se proporcionan compuestos como inhibidores del factor de transcripción activador 6 (ATF6). Los compuestos pueden ser útiles como agentes terapéuticos para tratar enfermedades o trastornos mediados por ATF6 y pueden ser particularmente útiles para tratar infecciones virales, enfermedades neurodegenerativas, enfermedades vasculares o cáncer.
CL2020002573A 2018-04-06 2020-10-05 Inhibidores atf6 y sus usos. CL2020002573A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862654263P 2018-04-06 2018-04-06

Publications (1)

Publication Number Publication Date
CL2020002573A1 true CL2020002573A1 (es) 2021-03-05

Family

ID=66248737

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020002573A CL2020002573A1 (es) 2018-04-06 2020-10-05 Inhibidores atf6 y sus usos.

Country Status (14)

Country Link
US (3) US10829485B2 (es)
EP (1) EP3774782A2 (es)
JP (1) JP7476167B2 (es)
KR (1) KR20210028144A (es)
CN (1) CN112313224A (es)
AU (1) AU2019247533B2 (es)
BR (1) BR112020020181A2 (es)
CA (1) CA3096139A1 (es)
CL (1) CL2020002573A1 (es)
IL (1) IL277794B2 (es)
MX (1) MX2020010469A (es)
RU (1) RU2020136310A (es)
SG (1) SG11202009570SA (es)
WO (1) WO2019195810A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021069721A1 (en) * 2019-10-09 2021-04-15 Black Belt Tx Ltd Atf6 modulators and uses thereof
BR112022006734A2 (pt) * 2019-10-09 2022-09-06 Praxis Biotech LLC Moduladores atf6 e usos dos mesmos
EP4001917A1 (en) 2020-11-12 2022-05-25 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts Inhibitors for use in treating liver disorders
KR102644194B1 (ko) * 2021-02-22 2024-03-08 주식회사 이노셀젠헬스케어 종양의 진단 및 치료를 위한 표적단백질로서의 atf6
WO2022266232A1 (en) * 2021-06-16 2022-12-22 Sanford Burnham Prebys Medical Discovery Institute Methods and compositions for treating chronic liver disease and hepatocellular carcinoma
CN113501787A (zh) * 2021-08-20 2021-10-15 黑龙江省科学院石油化学研究院 一种合成6-三氟甲基-3-甲基吲唑的方法
WO2024015425A1 (en) 2022-07-14 2024-01-18 Fmc Corporation Herbicidal benzoxazines
KR20240030727A (ko) * 2022-08-31 2024-03-07 단국대학교 천안캠퍼스 산학협력단 퓨릴티아졸계 화합물 및 이를 유효성분으로 포함하는 근감소증 예방 또는 치료용 조성물

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1073658B1 (en) * 1998-04-20 2003-08-13 Pfizer Inc. Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction
GEP20074236B (en) * 2003-05-01 2007-11-12 Bristol Myers Squibb Co Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
JP2009521430A (ja) 2005-12-23 2009-06-04 アストラゼネカ・アクチエボラーグ Ｇａｂａ−ｂ受容体モジュレーター
AR069650A1 (es) * 2007-12-14 2010-02-10 Actelion Pharmaceuticals Ltd Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2010101964A2 (en) * 2009-03-02 2010-09-10 Stemsynergy Therapeutics, Inc Methods and compositions useful in treating cancer and reducing wnt mediated effects in a cell
EP2516417B1 (en) 2009-12-22 2017-10-11 Vertex Pharmaceuticals Incorporated Isoindolinone inhibitors of phosphatidylinositol 3-kinase
MX2015001864A (es) 2012-08-10 2015-05-15 Hoffmann La Roche Compuestos de pirazol-carboxamida, composiciones y metodos de uso.
EP2903611A4 (en) * 2012-10-04 2016-11-16 Oyagen Inc SMALL MOLECULES AS ANTI-HIV AGENTS FOR INTERRUPTING THE VIF SELF-ASSOCIATION AND METHOD FOR USE THEREOF
LT3286181T (lt) * 2015-04-22 2021-04-26 Rigel Pharmaceuticals, Inc. Pirazolo junginiai ir junginių gamybos bei naudojimo būdas
AU2016284398C1 (en) 2015-06-22 2021-01-07 Sumitomo Dainippon Pharma Co., Ltd. 1,4-disubstituted imidazole derivative
SI3390395T1 (sl) 2015-12-16 2020-11-30 Loxo Oncology, Inc. Spojine uporabne kot inhibitorji kinaz
US10898469B2 (en) 2016-02-26 2021-01-26 Sumitomo Dainippon Pharma Co., Ltd. Imidazolylamide derivative
US10357477B2 (en) 2016-09-13 2019-07-23 Regents Of The University Of Minnesota Anticancer compounds

Also Published As

Publication number Publication date
IL277794B1 (en) 2023-10-01
CA3096139A1 (en) 2019-10-10
US20190367497A1 (en) 2019-12-05
RU2020136310A (ru) 2022-05-06
AU2019247533B2 (en) 2023-09-28
MX2020010469A (es) 2021-04-19
SG11202009570SA (en) 2020-10-29
JP7476167B2 (ja) 2024-04-30
CN112313224A (zh) 2021-02-02
US20210221803A1 (en) 2021-07-22
JP2021521271A (ja) 2021-08-26
IL277794B2 (en) 2024-02-01
KR20210028144A (ko) 2021-03-11
IL277794A (en) 2020-11-30
RU2020136310A3 (es) 2022-05-06
WO2019195810A3 (en) 2019-11-21
EP3774782A2 (en) 2021-02-17
WO2019195810A2 (en) 2019-10-10
US10829485B2 (en) 2020-11-10
AU2019247533A1 (en) 2020-10-15
BR112020020181A2 (pt) 2021-01-19
US20240124434A1 (en) 2024-04-18

Similar Documents

Publication Publication Date Title
CL2020002573A1 (es) Inhibidores atf6 y sus usos.
NI201900070A (es) Compuestos heterocíclicos como inmunomoduladores
CO2021000151A2 (es) Inhibidores de pd-1/pd-l1
CL2018001685A1 (es) Compuestos heterociclicos como inmuno moduladores.
CL2018003701A1 (es) Compuestos heterocíclicos como inmunomoduladores.
CL2018001152A1 (es) Composiciones y métodos para el tratamiento del cáncer
ECSP18073726A (es) Inhibidores del enlace proteína-proteína de wdr5
SV2017005557A (es) Derivados de indol mono o disustituidos como inhibidores de la replicacion viral del dengue
BR112017012342A2 (pt) compostos inibitórios de bcl-xl e conjugados de anticorpo-fármaco incluindo os mesmos
MX2018013472A (es) Tratamiento de combinacion de trastornos y enfermedades inflamatorios oculares.
CL2019000304A1 (es) Fracciones de plasma en sangre como tratamiento para tratamientos cognitivos relacionados con el envejecimiento.
CL2019002368A1 (es) Composiciones y métodos para el tratamiento de cáncer.
ECSP20046463A (es) Compuestos, composiciones y métodos para tratar enfermedades que involucren tejidos con enfermedades ácidas o hipóxicas
CR20180493A (es) Derivados de indolina sustituidos como inhibidores de la replicación viral del dengue
UY37466A (es) N-hidroxiamidinheterociclos sustituidos como moduladores de la indolamina 2,3-dioxigenasa
PL410665A1 (pl) Inhibitory arginazy oraz ich zastosowania terapeutyczne
CL2019001330A1 (es) Inhibidores de la tirosina quinasa de bruton.
DOP2016000308A (es) Compuestos de 1, 3, 4-tiadiazol y uso de los mismos para el tratamiento del cáncer
ECSP21026485A (es) Piridazinonas y sus métodos de uso
EA201990400A1 (ru) Соединения и композиции и их применение
BR112017024908A2 (pt) usos terapêuticos da 4-cloroquinurenina
UY37729A (es) NUEVOS COMPUESTOS QUE INHIBEN LA ACTIVIDAD DE Nav1.7
CL2018003109A1 (es) Formas polimorficas de 3-[2-butil-1-(2-dietilamino-etil-1h-benzoimidazol-5-yl]-n-hidroxi-acrilamida y sus usos.
UY38352A (es) Inhibidores de integrina alfavbeta6
CL2019000702A1 (es) Anticuerpos anti-gm-csf y usos de los mismos.