CL2021000873A1 - Proteínas de fusión de il-15/il-15ralfa-fc dirigidas a pd-1 y usos de las mismas en terapias combinadas. - Google Patents
Proteínas de fusión de il-15/il-15ralfa-fc dirigidas a pd-1 y usos de las mismas en terapias combinadas.Info
- Publication number
- CL2021000873A1 CL2021000873A1 CL2021000873A CL2021000873A CL2021000873A1 CL 2021000873 A1 CL2021000873 A1 CL 2021000873A1 CL 2021000873 A CL2021000873 A CL 2021000873A CL 2021000873 A CL2021000873 A CL 2021000873A CL 2021000873 A1 CL2021000873 A1 CL 2021000873A1
- Authority
- CL
- Chile
- Prior art keywords
- fusion proteins
- 15ralfa
- targeted
- combination therapies
- proteins targeting
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se dirige a proteínas de fusión a Fc heterodiméricas dirigidas a PD-1 novedosas que comprenden una proteína de fusión a Fc IL-15/IL-15Rα y una proteína de fusión a Fc de fragmento de anticuerpo contra PD-1. En algunas modalidades, las proteínas de fusión de IL-15/Rα-Fc dirigidas a PD-1 se administran a un paciente para tratar el cáncer. En algunas modalidades, las proteínas de fusión de IL-15/Rα-Fc dirigidas a PD-1 se administran en combinación con un anticuerpo de bloqueo a PD-1 tal como nivolumab y/o pembrolizumab. En algunas modalidades, las proteínas de fusión de IL-15/Rα-Fc dirigidas a PD-1 no compiten con un anticuerpo de bloqueo a PD-1 tal como nivolumab y/o pembrolizumab por la unión al antígeno.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862744946P | 2018-10-12 | 2018-10-12 | |
US201862784334P | 2018-12-21 | 2018-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021000873A1 true CL2021000873A1 (es) | 2021-12-10 |
Family
ID=68393093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021000873A CL2021000873A1 (es) | 2018-10-12 | 2021-04-09 | Proteínas de fusión de il-15/il-15ralfa-fc dirigidas a pd-1 y usos de las mismas en terapias combinadas. |
Country Status (17)
Country | Link |
---|---|
US (2) | US11377477B2 (es) |
EP (1) | EP3864047A2 (es) |
JP (1) | JP2022504550A (es) |
KR (1) | KR20210091710A (es) |
CN (1) | CN113423734A (es) |
AU (1) | AU2019359475A1 (es) |
BR (1) | BR112021006783A2 (es) |
CA (1) | CA3116188A1 (es) |
CL (1) | CL2021000873A1 (es) |
CO (1) | CO2021006092A2 (es) |
CR (1) | CR20210239A (es) |
IL (1) | IL282223A (es) |
MA (1) | MA53862A (es) |
MX (1) | MX2021004059A (es) |
PE (1) | PE20211055A1 (es) |
PH (1) | PH12021550802A1 (es) |
WO (1) | WO2020077276A2 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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KR102649972B1 (ko) | 2016-10-14 | 2024-03-22 | 젠코어 인코포레이티드 | IL15/IL15Rα 이종이량체 Fc-융합 단백질 |
AU2019256529A1 (en) | 2018-04-18 | 2020-11-26 | Xencor, Inc. | TIM-3 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and TIM-3 antigen binding domains |
WO2019204665A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof |
AU2019359475A1 (en) | 2018-10-12 | 2021-05-20 | Xencor, Inc. | PD-1 targeted IL-15/IL-15Ralpha Fc fusion proteins and uses in combination therapies thereof |
EP3897853A1 (en) | 2018-12-20 | 2021-10-27 | Xencor, Inc. | Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains |
TW202128757A (zh) * | 2019-10-11 | 2021-08-01 | 美商建南德克公司 | 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白 |
WO2022140797A1 (en) * | 2020-12-23 | 2022-06-30 | Immunowake Inc. | Immunocytokines and uses thereof |
US20220227867A1 (en) * | 2020-12-24 | 2022-07-21 | Xencor, Inc. | ICOS TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND ICOS ANTIGEN BINDING DOMAINS |
CN112851809A (zh) * | 2021-01-20 | 2021-05-28 | 上海交通大学 | 一种抗终末糖基化蛋白受体的抗体及其应用 |
KR20230148169A (ko) * | 2021-01-22 | 2023-10-24 | 엘피스 바이오파마슈티컬즈 | 항-pd-l1 모노클로날 항체 및 인터루킨-15 (il-15), 인터루킨-15 수용체 15 알파 또는 인터루킨-2와의 융합 단백질 |
TW202246357A (zh) * | 2021-03-09 | 2022-12-01 | 加拿大商康爾義明生物製藥公司 | 雙功能同源二聚體抗PD-1及IL-15/IL-15Rα融合蛋白及其用途 |
IL309533A (en) * | 2021-06-23 | 2024-02-01 | Cytune Pharma | Interleukin-15-based immunocytokines |
CN116023503B (zh) * | 2021-10-25 | 2024-05-31 | 上海交通大学 | 一种融合蛋白及其制备方法和用途 |
WO2023133424A2 (en) * | 2022-01-05 | 2023-07-13 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins and anti-pd-1 fusion peptides |
CN115806628A (zh) * | 2022-08-03 | 2023-03-17 | 深圳市先康达生命科学有限公司 | 一种自分泌IL-15与anti-TIGIT结合的融合蛋白及其应用 |
WO2024094119A1 (zh) * | 2022-11-02 | 2024-05-10 | 北京昌平实验室 | 融合蛋白及其应用 |
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-
2019
- 2019-10-11 AU AU2019359475A patent/AU2019359475A1/en not_active Abandoned
- 2019-10-11 CA CA3116188A patent/CA3116188A1/en active Pending
- 2019-10-11 MA MA053862A patent/MA53862A/fr unknown
- 2019-10-11 KR KR1020217014323A patent/KR20210091710A/ko unknown
- 2019-10-11 CN CN201980075190.4A patent/CN113423734A/zh active Pending
- 2019-10-11 CR CR20210239A patent/CR20210239A/es unknown
- 2019-10-11 WO PCT/US2019/055956 patent/WO2020077276A2/en active Application Filing
- 2019-10-11 PE PE2021000502A patent/PE20211055A1/es unknown
- 2019-10-11 MX MX2021004059A patent/MX2021004059A/es unknown
- 2019-10-11 JP JP2021519617A patent/JP2022504550A/ja active Pending
- 2019-10-11 US US16/600,236 patent/US11377477B2/en active Active
- 2019-10-11 BR BR112021006783-3A patent/BR112021006783A2/pt not_active Application Discontinuation
- 2019-10-11 EP EP19795737.6A patent/EP3864047A2/en active Pending
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2021
- 2021-04-09 CL CL2021000873A patent/CL2021000873A1/es unknown
- 2021-04-11 IL IL282223A patent/IL282223A/en unknown
- 2021-04-12 PH PH12021550802A patent/PH12021550802A1/en unknown
- 2021-05-11 CO CONC2021/0006092A patent/CO2021006092A2/es unknown
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2022
- 2022-06-02 US US17/831,197 patent/US20230055445A1/en active Pending
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US20200140512A1 (en) | 2020-05-07 |
IL282223A (en) | 2021-05-31 |
PE20211055A1 (es) | 2021-06-07 |
US20230055445A1 (en) | 2023-02-23 |
BR112021006783A2 (pt) | 2021-07-13 |
JP2022504550A (ja) | 2022-01-13 |
KR20210091710A (ko) | 2021-07-22 |
CO2021006092A2 (es) | 2021-08-09 |
US11377477B2 (en) | 2022-07-05 |
MX2021004059A (es) | 2021-09-23 |
CR20210239A (es) | 2021-12-15 |
PH12021550802A1 (en) | 2021-10-04 |
AU2019359475A1 (en) | 2021-05-20 |
CN113423734A (zh) | 2021-09-21 |
WO2020077276A3 (en) | 2020-05-14 |
CA3116188A1 (en) | 2020-04-16 |
WO2020077276A2 (en) | 2020-04-16 |
MA53862A (fr) | 2022-01-19 |
EP3864047A2 (en) | 2021-08-18 |
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