CL2020001264A1 - Compuestos y métodos sintéticos para la preparación de retinodes específicos del receptor x retinoide. - Google Patents
Compuestos y métodos sintéticos para la preparación de retinodes específicos del receptor x retinoide.Info
- Publication number
- CL2020001264A1 CL2020001264A1 CL2020001264A CL2020001264A CL2020001264A1 CL 2020001264 A1 CL2020001264 A1 CL 2020001264A1 CL 2020001264 A CL2020001264 A CL 2020001264A CL 2020001264 A CL2020001264 A CL 2020001264A CL 2020001264 A1 CL2020001264 A1 CL 2020001264A1
- Authority
- CL
- Chile
- Prior art keywords
- preparation
- retinodes
- methods
- specific
- synthetic compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 3
- 230000004071 biological effect Effects 0.000 abstract 4
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
- C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/32—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/44—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon double or triple bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
- C07C29/86—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by liquid-liquid treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/13—Monohydroxylic alcohols containing saturated rings
- C07C31/133—Monohydroxylic alcohols containing saturated rings monocyclic
- C07C31/1333—Monohydroxylic alcohols containing saturated rings monocyclic with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/13—Monohydroxylic alcohols containing saturated rings
- C07C31/137—Monohydroxylic alcohols containing saturated rings polycyclic with condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/38—Alcohols containing six-membered aromatic rings and other rings and having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
- C07C51/21—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen
- C07C51/255—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of compounds containing six-membered aromatic rings without ring-splitting
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporcionan en la presente compuestos útiles para la preparación de compuestos que tienen actividad biológica similar a retinoides. Asimismo, se proporcionan procesos para la preparación de compuestos que tienen actividad biológica similar a retinoides. se proporcionan en la presente compuestos útiles para la preparacion de compuestos que tienen actividad biológica similar a retinoides. Asimismo se proporcionan procesos para la preparacion de compuestos que tienen actividad biológica similar a retinoides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762588163P | 2017-11-17 | 2017-11-17 | |
US201862671137P | 2018-05-14 | 2018-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020001264A1 true CL2020001264A1 (es) | 2020-09-04 |
Family
ID=66534915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020001264A CL2020001264A1 (es) | 2017-11-17 | 2020-05-13 | Compuestos y métodos sintéticos para la preparación de retinodes específicos del receptor x retinoide. |
Country Status (16)
Country | Link |
---|---|
US (3) | US10590059B2 (es) |
EP (1) | EP3710027A4 (es) |
JP (2) | JP2021503464A (es) |
KR (1) | KR20200084350A (es) |
CN (2) | CN111465402B (es) |
AU (4) | AU2018367653B2 (es) |
CA (1) | CA3082485A1 (es) |
CL (1) | CL2020001264A1 (es) |
IL (5) | IL298073B2 (es) |
MX (1) | MX2020005027A (es) |
MY (1) | MY196734A (es) |
NZ (1) | NZ763866A (es) |
PH (1) | PH12020550613A1 (es) |
SG (1) | SG11202003733RA (es) |
WO (1) | WO2019099920A1 (es) |
ZA (3) | ZA202003475B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1937244T3 (pl) | 2005-09-30 | 2019-01-31 | Io Therapeutics, Llc | Leczenie nowotworu specyficznymi agonistami rxr |
CN110151745A (zh) | 2011-12-13 | 2019-08-23 | Io治疗公司 | 使用rxr激动剂的自身免疫紊乱的治疗 |
CN114904000A (zh) | 2016-03-10 | 2022-08-16 | Io治疗公司 | Rxr激动剂和甲状腺激素在制备用于治疗自身免疫疾病的药物中的用途 |
MX2020003223A (es) | 2017-09-20 | 2020-09-21 | Io Therapeutics Inc | Tratamiento de enfermedades con ésteres de agonistas de rxr selectivos. |
WO2019099920A1 (en) | 2017-11-17 | 2019-05-23 | Io Therapeutics, Inc. | Compounds and synthetic methods for the preparation of retinoid x receptor-specific retinoids |
WO2023108012A1 (en) * | 2021-12-07 | 2023-06-15 | Io Therapeutics, Inc. | Use of an rxr agonist and taxanes in treating her2+ cancers |
WO2023108015A1 (en) * | 2021-12-07 | 2023-06-15 | Io Therapeutics, Inc. | Use of an rxr agonist in treating drug resistant her2+ cancers |
TW202400548A (zh) * | 2022-03-15 | 2024-01-01 | 美商Io治療公司 | Rxr促效劑鹽形式、其多形體及其用途 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5917082A (en) * | 1995-06-06 | 1999-06-29 | Allergan Sales, Inc. | 2,4-pentadienoic acid derivatives having retinoid-like biological activity |
FR2752837B1 (fr) * | 1996-09-02 | 1999-11-12 | Cird Galderma | Nouveaux composes modulateurs des recepteurs hormonaux, les compositions les comprenant et leur utilisation en therapie |
US6048873A (en) | 1998-10-01 | 2000-04-11 | Allergan Sales, Inc. | Tetrahdroquinolin-2-one 6 or 7-yl, tetrahdroquinilin-2-thione 6 or 7-yl pentadienoic acid and related derivatives having retinoid-like biological activity |
US6147224A (en) * | 1998-10-01 | 2000-11-14 | Allergan Sales, Inc. | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors |
US6720423B2 (en) | 2002-04-30 | 2004-04-13 | Allergan, Inc. | Dihydrobenzofuran and dihydrobenzothiophene 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors |
US6936636B2 (en) * | 2003-06-26 | 2005-08-30 | Allergan, Inc. | 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity |
PL1937244T3 (pl) | 2005-09-30 | 2019-01-31 | Io Therapeutics, Llc | Leczenie nowotworu specyficznymi agonistami rxr |
EP1979347A2 (en) * | 2006-01-30 | 2008-10-15 | Irm Llc | Polycyclic 1,2,3,4-tetrahydro-isoquinoline derivatives and compositions comprising them as ppar modulators |
CN110151745A (zh) | 2011-12-13 | 2019-08-23 | Io治疗公司 | 使用rxr激动剂的自身免疫紊乱的治疗 |
US10653650B2 (en) | 2011-12-13 | 2020-05-19 | Io Therapeutics, Inc. | Treatment of diseases by concurrently eliciting remyelination effects and immunomodulatory effects using selective RXR agonists |
CN108289958A (zh) | 2015-10-31 | 2018-07-17 | Io治疗公司 | 使用rxr激动剂和甲状腺激素的组合治疗神经***紊乱 |
US20190365681A1 (en) | 2015-10-31 | 2019-12-05 | Io Therapeutics, Inc. | Treatment of cancer with combinations of rxr agonists and thyroid hormones |
US20180318241A1 (en) | 2015-10-31 | 2018-11-08 | Io Therapeutics, Inc. | Treatment of nervous system disorders using thyroid hormone neutral doses of rxr agonists |
CN114904000A (zh) | 2016-03-10 | 2022-08-16 | Io治疗公司 | Rxr激动剂和甲状腺激素在制备用于治疗自身免疫疾病的药物中的用途 |
CA3016878C (en) | 2016-03-10 | 2024-02-27 | Io Therapeutics, Inc. | Treatment of muscular disorders with combinations of rxr agonists and thyroid hormones |
WO2019099920A1 (en) | 2017-11-17 | 2019-05-23 | Io Therapeutics, Inc. | Compounds and synthetic methods for the preparation of retinoid x receptor-specific retinoids |
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2018
- 2018-11-16 WO PCT/US2018/061643 patent/WO2019099920A1/en active Application Filing
- 2018-11-16 EP EP18879593.4A patent/EP3710027A4/en active Pending
- 2018-11-16 JP JP2020526953A patent/JP2021503464A/ja active Pending
- 2018-11-16 IL IL298073A patent/IL298073B2/en unknown
- 2018-11-16 CN CN201880074452.0A patent/CN111465402B/zh active Active
- 2018-11-16 MX MX2020005027A patent/MX2020005027A/es unknown
- 2018-11-16 KR KR1020207017366A patent/KR20200084350A/ko not_active Application Discontinuation
- 2018-11-16 CA CA3082485A patent/CA3082485A1/en active Pending
- 2018-11-16 IL IL304970A patent/IL304970A/en unknown
- 2018-11-16 SG SG11202003733RA patent/SG11202003733RA/en unknown
- 2018-11-16 MY MYPI2020002033A patent/MY196734A/en unknown
- 2018-11-16 US US16/194,141 patent/US10590059B2/en active Active
- 2018-11-16 CN CN202210482327.1A patent/CN115010577A/zh active Pending
- 2018-11-16 IL IL289991A patent/IL289991B2/en unknown
- 2018-11-16 AU AU2018367653A patent/AU2018367653B2/en active Active
-
2020
- 2020-02-24 US US16/799,176 patent/US10919835B2/en active Active
- 2020-05-12 PH PH12020550613A patent/PH12020550613A1/en unknown
- 2020-05-13 CL CL2020001264A patent/CL2020001264A1/es unknown
- 2020-05-17 IL IL274729A patent/IL274729B/en active IP Right Grant
- 2020-05-18 NZ NZ763866A patent/NZ763866A/en unknown
- 2020-06-10 ZA ZA2020/03475A patent/ZA202003475B/en unknown
- 2020-10-07 AU AU2020250208A patent/AU2020250208B2/en active Active
-
2021
- 2021-01-13 US US17/147,732 patent/US20210139404A1/en not_active Abandoned
- 2021-04-19 AU AU2021202348A patent/AU2021202348B2/en active Active
- 2021-05-19 IL IL283282A patent/IL283282B/en unknown
- 2021-07-16 ZA ZA2021/05006A patent/ZA202105006B/en unknown
-
2023
- 2023-03-30 AU AU2023201963A patent/AU2023201963A1/en active Pending
- 2023-06-05 ZA ZA2023/05927A patent/ZA202305927B/en unknown
- 2023-11-27 JP JP2023199553A patent/JP2024028755A/ja active Pending
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