CL2019003095A1 - Anticuerpos anti-cd33 y métodos para utilizarlos. - Google Patents

Anticuerpos anti-cd33 y métodos para utilizarlos.

Info

Publication number
CL2019003095A1
CL2019003095A1 CL2019003095A CL2019003095A CL2019003095A1 CL 2019003095 A1 CL2019003095 A1 CL 2019003095A1 CL 2019003095 A CL2019003095 A CL 2019003095A CL 2019003095 A CL2019003095 A CL 2019003095A CL 2019003095 A1 CL2019003095 A1 CL 2019003095A1
Authority
CL
Chile
Prior art keywords
antibodies
compositions
methods
enhanced
project33
Prior art date
Application number
CL2019003095A
Other languages
English (en)
Inventor
Seung-Joo Lee
Arnon Rosenthal
Robert Pejchal
Nels P Nielson
Patricia Culp
Helen Lam
Original Assignee
Alector Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alector Llc filed Critical Alector Llc
Publication of CL2019003095A1 publication Critical patent/CL2019003095A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

LA PRESENTE DESCRIPCIÓN. HACE REFERENCIA, EN LÍNEAS GENERALES, A COMPOSICIONES QUE INCLUYEN ANTICUERPOS, POR EJEMPLO, ANTICUERPOS MONOCLONALES, QUIMÉRICOS, HUMANIZADOS, FRAGMENTOS DE ANTICUERPOS, ETC., QUE SE UNEN ESPECÍFICAMENTE A UNO O MÁS EPÍTOPOS DE UNA PROTEÍNA CD33, POR EJEMPLO, CD33 HUMANA O CD33 DE MAMÍFERO Y TIENEN CARACTERÍSTICAS FUNCIONALES MEJORADAS Y/O POTENCIADAS, Y AL USO DE DICHAS COMPOSICIONES PARA PREVENIR, REDUCIR EL RIESGO Y TRATAR A UN INDIVIDUO QUE LO NECESITE.
CL2019003095A 2017-08-03 2019-10-28 Anticuerpos anti-cd33 y métodos para utilizarlos. CL2019003095A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762541024P 2017-08-03 2017-08-03
US201862667388P 2018-05-04 2018-05-04

Publications (1)

Publication Number Publication Date
CL2019003095A1 true CL2019003095A1 (es) 2020-02-21

Family

ID=63245104

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2019003095A CL2019003095A1 (es) 2017-08-03 2019-10-28 Anticuerpos anti-cd33 y métodos para utilizarlos.
CL2020001619A CL2020001619A1 (es) 2017-08-03 2020-06-16 Anticuerpos anti-cd33 y métodos para utilizarlos. (divisional solicitud 201903095)
CL2021003535A CL2021003535A1 (es) 2017-08-03 2021-12-28 Anticuerpos anti-cd33 y métodos para utilizarlos. (divisional de solicitud 3095-2019)

Family Applications After (2)

Application Number Title Priority Date Filing Date
CL2020001619A CL2020001619A1 (es) 2017-08-03 2020-06-16 Anticuerpos anti-cd33 y métodos para utilizarlos. (divisional solicitud 201903095)
CL2021003535A CL2021003535A1 (es) 2017-08-03 2021-12-28 Anticuerpos anti-cd33 y métodos para utilizarlos. (divisional de solicitud 3095-2019)

Country Status (19)

Country Link
US (3) US10711062B2 (es)
EP (1) EP3589658A1 (es)
JP (2) JP7299160B2 (es)
KR (1) KR20200033798A (es)
CN (2) CN117700548A (es)
AU (1) AU2018310985A1 (es)
BR (1) BR112019023789A2 (es)
CA (1) CA3057447A1 (es)
CL (3) CL2019003095A1 (es)
CO (1) CO2019012200A2 (es)
CR (1) CR20190486A (es)
EC (1) ECSP19078414A (es)
IL (3) IL270238B (es)
MA (1) MA47691A (es)
PE (1) PE20200486A1 (es)
PH (1) PH12019502463A1 (es)
TW (1) TW201920268A (es)
WO (1) WO2019028283A1 (es)
ZA (1) ZA201906366B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11466082B2 (en) 2018-05-24 2022-10-11 Janssen Biotech, Inc. Anti-CD33 antibodies, anti-CD33/anti-CD3 bispecific antibodies and uses thereof

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7376977B2 (ja) 2015-06-12 2023-11-09 アレクトル エルエルシー 抗ｃｄ３３抗体及びその使用方法
EP3307779A2 (en) 2015-06-12 2018-04-18 Alector LLC Anti-cd33 antibodies and methods of use thereof
US20230121869A1 (en) * 2016-03-04 2023-04-20 Alector Llc Anti-TREM1 Antibodies and Methods of Use Thereof
JOP20190248A1 (ar) 2017-04-21 2019-10-20 Amgen Inc بروتينات ربط مولد ضد trem2 واستخداماته
CN117700548A (zh) 2017-08-03 2024-03-15 艾利妥 抗cd33抗体及其使用方法
ES2952982T3 (es) 2017-08-03 2023-11-07 Alector Llc Anticuerpos anti-TREM2 y métodos de uso de los mismos
WO2020068058A1 (en) * 2018-09-25 2020-04-02 Academia Sinica Anti-siglec antibody, pharmaceutical composition comprising the same, and uses thereof
WO2020239947A1 (en) * 2019-05-29 2020-12-03 Centre National De La Recherche Scientifique Prognosis method of leukemia
AU2020403021A1 (en) * 2019-12-12 2022-06-23 Alector Llc Methods of use of anti-CD33 antibodies
WO2023081898A1 (en) 2021-11-08 2023-05-11 Alector Llc Soluble cd33 as a biomarker for anti-cd33 efficacy
WO2023114499A1 (en) 2021-12-17 2023-06-22 Denali Therapeutics Inc. Polypeptide engineering, libraries, and engineered cd98 heavy chain and transferrin receptor binding polypeptides
CN117447594A (zh) * 2022-07-26 2024-01-26 北京东方百泰生物科技股份有限公司 一种抗Siglec-15单克隆抗体
CN116375874B (zh) * 2023-04-14 2023-12-26 上海精翰生物科技有限公司 一种cd33抗体及其应用

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