CL2019000512A1 - Nuevos compuestos sulfonimidoilpurinona 7-sustituidos y derivados para el tratamiento y la profilaxis de la infección vírica. - Google Patents

Nuevos compuestos sulfonimidoilpurinona 7-sustituidos y derivados para el tratamiento y la profilaxis de la infección vírica.

Info

Publication number
CL2019000512A1
CL2019000512A1 CL2019000512A CL2019000512A CL2019000512A1 CL 2019000512 A1 CL2019000512 A1 CL 2019000512A1 CL 2019000512 A CL2019000512 A CL 2019000512A CL 2019000512 A CL2019000512 A CL 2019000512A CL 2019000512 A1 CL2019000512 A1 CL 2019000512A1
Authority
CL
Chile
Prior art keywords
prophylaxis
derivatives
treatment
new
viral infection
Prior art date
Application number
CL2019000512A
Other languages
English (en)
Inventor
Lu Gao
Hongying Yun
Xiufang Zheng
Chungen Liang
Kun Miao
Jianping Wang
Bo Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2019000512A1 publication Critical patent/CL2019000512A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DE FÓRMULA (I), EN LA QUE R1, R2 Y R3 SON TAL COMO SE INDICA EN LA PRESENTE MEMORIA Y SUS PROFÁRMACOS O SAL, ENANTIÓMERO O DIASTEREÓMERO F ARMACÉUTICAMENTE ACEPTABLE DEL MISMO, Y COMPOSICIONES QUE INCLUYEN LOS COMPUESTOS Y MÉTODOS DE UTILIZACIÓN DE LOS COMPUESTOS.
CL2019000512A 2016-08-29 2019-02-26 Nuevos compuestos sulfonimidoilpurinona 7-sustituidos y derivados para el tratamiento y la profilaxis de la infección vírica. CL2019000512A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2016097140 2016-08-29
CN2017092653 2017-07-12

Publications (1)

Publication Number Publication Date
CL2019000512A1 true CL2019000512A1 (es) 2019-07-12

Family

ID=59738346

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019000512A CL2019000512A1 (es) 2016-08-29 2019-02-26 Nuevos compuestos sulfonimidoilpurinona 7-sustituidos y derivados para el tratamiento y la profilaxis de la infección vírica.

Country Status (31)

Country Link
US (3) US10233184B2 (es)
EP (2) EP3865482A1 (es)
JP (2) JP7013467B2 (es)
KR (2) KR20220147702A (es)
CN (1) CN109641904B (es)
AU (3) AU2017320742B2 (es)
BR (1) BR112019003519A2 (es)
CA (1) CA3034148A1 (es)
CL (1) CL2019000512A1 (es)
CO (1) CO2019000932A2 (es)
CR (1) CR20190087A (es)
DK (1) DK3504210T3 (es)
ES (1) ES2867849T3 (es)
HR (1) HRP20210621T1 (es)
HU (1) HUE053944T2 (es)
IL (3) IL293475A (es)
MA (1) MA46038B1 (es)
MX (2) MX2019002129A (es)
MY (1) MY197408A (es)
NZ (1) NZ750604A (es)
PE (1) PE20190476A1 (es)
PH (1) PH12019500432A1 (es)
PL (1) PL3504210T3 (es)
PT (1) PT3504210T (es)
RS (1) RS61752B1 (es)
RU (1) RU2751349C2 (es)
SG (2) SG11201901633WA (es)
SI (1) SI3504210T1 (es)
TW (1) TWI671300B (es)
UA (1) UA124270C2 (es)
WO (1) WO2018041763A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180003612A (ko) * 2015-05-08 2018-01-09 에프. 호프만-라 로슈 아게 바이러스 감염의 치료 및 예방을 위한 신규한 설폰이미도일푸린온 화합물 및 유도체
PT3504210T (pt) * 2016-08-29 2021-04-19 H Hoffnabb La Roche Ag Compostos de sulfonimidoílpurinona 7-substituídos para o tratamento e profilaxia de infeção por vírus
KR102497701B1 (ko) * 2016-09-13 2023-02-09 에프. 호프만-라 로슈 아게 Tlr7 작용제 및 hbv 캡시드 조립 억제제의 병용 치료
JP7328977B2 (ja) 2018-02-12 2023-08-17 エフ． ホフマン－ラ ロシュ アーゲー ウイルス感染の処置および予防のための新規のスルホン化合物および誘導体
AU2019228654A1 (en) * 2018-02-28 2020-09-03 F. Hoffmann-La Roche Ag 7-substituted sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of liver cancer
EP3849615A1 (en) 2018-09-12 2021-07-21 Silverback Therapeutics, Inc. Compositions for the treatment of disease with immune stimulatory conjugates
WO2020162705A1 (ko) 2019-02-08 2020-08-13 성균관대학교산학협력단 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도
WO2021067644A1 (en) 2019-10-01 2021-04-08 Silverback Therapeutics, Inc. Combination therapy with immune stimulatory conjugates
WO2021168274A1 (en) 2020-02-21 2021-08-26 Silverback Therapeutics, Inc. Nectin-4 antibody conjugates and uses thereof
CA3170551A1 (en) 2020-03-02 2021-09-10 Yong Taik Lim Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof
AU2021300362A1 (en) 2020-07-01 2023-02-23 ARS Pharmaceuticals, Inc. Anti-ASGR1 antibody conjugates and uses thereof
WO2022031057A1 (ko) 2020-08-04 2022-02-10 성균관대학교산학협력단 활성화 부위가 일시적으로 비활성화된 톨-유사 수용체 7 또는 8 작용자와 기능성 약물의 결합체 및 그 용도
JP2023536953A (ja) 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド 動力学的制御が可能なアジュバントを含むｍＲＮＡワクチン
EP4194008A1 (en) 2020-08-04 2023-06-14 Progeneer Inc. Kinetically acting adjuvant ensemble
WO2022063278A1 (zh) * 2020-09-27 2022-03-31 上海维申医药有限公司 大环tlr7激动剂、其制备方法、药物组合物及其用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
AU698419B2 (en) 1996-07-03 1998-10-29 Dainippon Sumitomo Pharma Co., Ltd. A novel purine derivative
AUPO912997A0 (en) * 1997-09-11 1997-10-02 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
NZ504800A (en) * 1997-11-28 2001-10-26 Sumitomo Pharma 6-Amino-9-benzyl-8-hydroxy-purine derivatives and interferon inducers, antiviral agents, anticancer agents and therapeutic agents for immunologic diseases thereof
JPH11180981A (ja) * 1997-12-19 1999-07-06 Sumitomo Pharmaceut Co Ltd 複素環誘導体
TW572758B (en) 1997-12-22 2004-01-21 Sumitomo Pharma Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives
JP4189048B2 (ja) 1997-12-26 2008-12-03 大日本住友製薬株式会社 複素環化合物
JP5420135B2 (ja) * 2002-03-15 2014-02-19 ウエイン・ステイト・ユニバーシテイ 抗ウイルス薬としての新規２−アミノ−９−［（２−ヒドロキシメチル）シクロプロピリデンメチル］プリン
US7754728B2 (en) * 2002-09-27 2010-07-13 Dainippon Sumitomo Pharma Co., Ltd. Adenine compound and use thereof
EP1888587A1 (en) 2005-05-04 2008-02-20 Pfizer Limited 2-amido-6-amino-8-oxopurine derivatives as toll-like receptor modulators for the treatment of cancer and viral infections, such as hepatitis c
DE102006053049A1 (de) 2006-11-10 2008-05-15 Daimler Ag Staufach mit einer Abdeckeinrichtung
MX2009013832A (es) * 2007-06-29 2010-03-10 Gilead Sciences Inc Derivados de purina y su uso como moduladores del receptor 7 similar a un puente.
CN101239980B (zh) 2008-02-18 2011-06-22 靳广毅 免疫受体调节剂偶联体前体和偶联体及其应用
EP2364314B1 (en) * 2008-12-09 2014-03-12 Gilead Sciences, Inc. Modulators of toll-like receptors
JP5694345B2 (ja) * 2009-10-22 2015-04-01 ギリアード サイエンシーズ， インコーポレイテッド Ｔｏｌｌ様受容体の調節因子
WO2011079016A1 (en) 2009-12-22 2011-06-30 Gilead Sciences, Inc. Methods of treating hbv and hcv infection
US8501724B1 (en) * 2012-01-31 2013-08-06 Pharmacyclics, Inc. Purinone compounds as kinase inhibitors
SG11201701169XA (en) 2014-08-15 2017-03-30 Chia Tai Tianqing Pharmaceutical Group Co Ltd Pyrrolopyrimidine compounds used as tlr7 agonist
KR20180003612A (ko) * 2015-05-08 2018-01-09 에프. 호프만-라 로슈 아게 바이러스 감염의 치료 및 예방을 위한 신규한 설폰이미도일푸린온 화합물 및 유도체
PT3504210T (pt) * 2016-08-29 2021-04-19 H Hoffnabb La Roche Ag Compostos de sulfonimidoílpurinona 7-substituídos para o tratamento e profilaxia de infeção por vírus

Also Published As

Publication number Publication date
MX2021006902A (es) 2021-07-07
RS61752B1 (sr) 2021-05-31
HUE053944T2 (hu) 2021-08-30
DK3504210T3 (da) 2021-04-26
CO2019000932A2 (es) 2019-02-08
IL284255B (en) 2022-07-01
US10233184B2 (en) 2019-03-19
AU2021204303B2 (en) 2022-05-12
AU2017320742B2 (en) 2021-08-05
JP7013467B2 (ja) 2022-01-31
BR112019003519A2 (pt) 2019-05-21
IL264710B (en) 2021-07-29
WO2018041763A1 (en) 2018-03-08
NZ750604A (en) 2024-02-23
JP7214900B2 (ja) 2023-01-30
US10752630B2 (en) 2020-08-25
RU2751349C2 (ru) 2021-07-13
CN109641904A (zh) 2019-04-16
JP2022050632A (ja) 2022-03-30
KR20190039829A (ko) 2019-04-15
US20200385387A1 (en) 2020-12-10
CA3034148A1 (en) 2018-03-08
TW201819382A (zh) 2018-06-01
AU2022204697A1 (en) 2022-07-21
RU2019107957A (ru) 2020-09-29
RU2019107957A3 (es) 2020-12-18
SI3504210T1 (sl) 2021-08-31
KR102459155B1 (ko) 2022-10-28
AU2017320742A1 (en) 2019-02-28
MY197408A (en) 2023-06-16
PH12019500432A1 (en) 2019-10-21
PE20190476A1 (es) 2019-04-04
MX2019002129A (es) 2019-06-20
IL284255A (en) 2021-07-29
HRP20210621T1 (hr) 2021-05-28
SG11201901633WA (en) 2019-03-28
EP3865482A1 (en) 2021-08-18
SG10202010520SA (en) 2020-11-27
CR20190087A (es) 2019-04-30
EP3504210A1 (en) 2019-07-03
MA46038A (fr) 2019-07-03
MA46038B1 (fr) 2021-05-31
US20180072730A1 (en) 2018-03-15
EP3504210B1 (en) 2021-02-24
KR20220147702A (ko) 2022-11-03
AU2021204303A1 (en) 2021-07-22
CN109641904B (zh) 2022-01-28
UA124270C2 (uk) 2021-08-18
PT3504210T (pt) 2021-04-19
IL293475A (en) 2022-08-01
JP2019526633A (ja) 2019-09-19
ES2867849T3 (es) 2021-10-21
PL3504210T3 (pl) 2021-07-05
TWI671300B (zh) 2019-09-11
US20190256515A1 (en) 2019-08-22

Similar Documents

Publication Publication Date Title
CL2019000512A1 (es) Nuevos compuestos sulfonimidoilpurinona 7-sustituidos y derivados para el tratamiento y la profilaxis de la infección vírica.
CR20170237A (es) Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones virales.
CR20160337A (es) Nuevas heteroarildihidropirimidinas 6-fusionadas para el tratamiento y la profilaxis de la infección por virus de la hepatitis b
SV2016005171A (es) Derivados de quinolizina sustituidos útiles como inhibidores de integrasa del vih
CO2017007355A2 (es) Compuestos derivados de pirazincarbozamida y de pirazincarboxilato para el tratamiento de la infección por el virus de hepatitis b
CU20170089A7 (es) Derivados de quinazolina utilizados para tratar el vih
SV2018005794A (es) Derivados de carbonucleósidos sustituidos útiles como agentes antineoplásicos
CO2018000589A2 (es) Oxiesteroles y composiciones farmacéuticas que los contienen
UY36564A (es) Derivados de nucleósidos sustituidos útiles como agentes antineoplásicos
CR20150183A (es) Derivados de 5-fenoxi-3h-pirimidin-4-ona y su uso como inhibidores de la transcriptasa inversa del vih
DOP2016000173A (es) Heteroarilos y usos de estos
UY35617A (es) Inhibidores de la fosfatidilinositol 3-quinasa
CO2017003838A2 (es) Compuestos de aminopurina sustituida, composiciones del mismo, y métodos de tratamiento con los mismos
CU24408B1 (es) Compuestos de dihidroisoquinolinona sustituida
CL2019001495A1 (es) Compuestos de heterociclo tetracíclicos útiles como inhibidores de la integrasa del vih.
CO2017009994A2 (es) Nuevos compuestos y derivados de sulfonimidoilpurinona para el tratamiento y profilaxis de infecciones víricas
DOP2016000115A (es) Derivados de purina
CL2019000476A1 (es) Compuestos de heteroarilcarboxamida como inhibidores de ripk2.
CU24608B1 (es) Compuestos de dihidrooxadiazinonas sustituidas útiles en el tratamiento de enfermedades hiperproliferativas y métodos para preparar dichos compuestos
SV2016005293A (es) Compuestos de azol amido-sustituidos como inhibidores de tnks1 y/o tnks2
CL2017000827A1 (es) Inhibidores de aldosterona sintasa
CO2020010306A2 (es) Compuestos de sulfonimidoilpurinona 7-sustituida y derivados para el tratamiento y profilaxis de cáncer de hígado.
NI201600163A (es) Derivados de diheterociclo enlazado a cicloalquilo
CR20180404A (es) Nuevos derivados pirrolidina
CO2017003225A2 (es) Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos