SG10202010520SA - 7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection - Google Patents

7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection

Info

Publication number: SG10202010520SA
Authority: SG; Singapore
Prior art keywords: prophylaxis; treatment; virus infection; substituted; compounds
Prior art date: 2016-08-29

Application number

SG10202010520SA

Inventor

Lu Gao

Chungen Liang

Hongying Yun

Xiufang Zheng

Jianping Wang

Kun Miao

Bo Zhang

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-08-29

Filing date

2017-08-28

Publication date

2020-11-27

2017-08-28 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2020-11-27 Publication of SG10202010520SA publication Critical patent/SG10202010520SA/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

SG10202010520SA 2016-08-29 2017-08-28 7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection SG10202010520SA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CN2016097140		2016-08-29
CN2017092653		2017-07-12

Publications (1)

Publication Number	Publication Date
SG10202010520SA true SG10202010520SA (en)	2020-11-27

Family

ID=59738346

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SG10202010520SA SG10202010520SA (en)	2016-08-29	2017-08-28	7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection
SG11201901633WA SG11201901633WA (en)	2016-08-29	2017-08-28	7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SG11201901633WA SG11201901633WA (en)	2016-08-29	2017-08-28	7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection

Country Status (31)

Country	Link
US (3)	US10233184B2 (en)
EP (2)	EP3504210B1 (en)
JP (2)	JP7013467B2 (en)
KR (2)	KR102459155B1 (en)
CN (1)	CN109641904B (en)
AU (3)	AU2017320742B2 (en)
BR (1)	BR112019003519A2 (en)
CA (1)	CA3034148A1 (en)
CL (1)	CL2019000512A1 (en)
CO (1)	CO2019000932A2 (en)
CR (1)	CR20190087A (en)
DK (1)	DK3504210T3 (en)
ES (1)	ES2867849T3 (en)
HR (1)	HRP20210621T1 (en)
HU (1)	HUE053944T2 (en)
IL (3)	IL293475A (en)
MA (1)	MA46038B1 (en)
MX (2)	MX2019002129A (en)
MY (1)	MY197408A (en)
NZ (1)	NZ750604A (en)
PE (1)	PE20190476A1 (en)
PH (1)	PH12019500432A1 (en)
PL (1)	PL3504210T3 (en)
PT (1)	PT3504210T (en)
RS (1)	RS61752B1 (en)
RU (1)	RU2751349C2 (en)
SG (2)	SG10202010520SA (en)
SI (1)	SI3504210T1 (en)
TW (1)	TWI671300B (en)
UA (1)	UA124270C2 (en)
WO (1)	WO2018041763A1 (en)

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MY182353A (en) *	2015-05-08	2021-01-20	Hoffmann La Roche	Novel sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection
CA3034148A1 (en) *	2016-08-29	2018-03-08	F. Hoffmann-La Roche Ag	7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection
BR112019004560A2 (en) *	2016-09-13	2019-07-02	Hoffmann La Roche	combination treatment with tlr7 agonist and a hbv capsid formation inhibitor
WO2019155042A1 (en)	2018-02-12	2019-08-15	F. Hoffmann-La Roche Ag	Novel sulfone compounds and derivatives for the treatment and prophylaxis of virus infection
MA52412A (en) *	2018-02-28	2021-06-02	Hoffmann La Roche	NEW SULFONIMIDOYLPURINONE COMPOUNDS SUBSTITUTED IN POSITION 7 AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF LIVER CANCER
SG11202101980VA (en)	2018-09-12	2021-03-30	Silverback Therapeutics Inc	Methods and composition for the treatment of disease with immune stimulatory conjugates
WO2020162705A1 (en)	2019-02-08	2020-08-13	성균관대학교산학협력단	Toll-like receptor 7 or 8 agonist-cholesterol complex, and use of same
AU2020358726A1 (en)	2019-10-01	2022-04-07	Silverback Therapeutics, Inc.	Combination therapy with immune stimulatory conjugates
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CA3170551A1 (en)	2020-03-02	2021-09-10	Yong Taik Lim	Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof
AU2021300362A1 (en)	2020-07-01	2023-02-23	ARS Pharmaceuticals, Inc.	Anti-ASGR1 antibody conjugates and uses thereof
EP4194008A1 (en)	2020-08-04	2023-06-14	Progeneer Inc.	Kinetically acting adjuvant ensemble
EP4194006A1 (en)	2020-08-04	2023-06-14	Progeneer Inc.	Mrna vaccine comprising adjuvant capable of kinetic control
JP2023536954A (en)	2020-08-04	2023-08-30	プロジェニアインコーポレイテッド	Conjugate of Toll-like Receptor 7 or 8 Agonist with Temporarily Inactivated Activation Site and Functional Drug, and Use of the Same
CN114315861A (en) *	2020-09-27	2022-04-12	上海维申医药有限公司	Macrocyclic TLR7 agonist, preparation method thereof, pharmaceutical composition and application thereof

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ES2232871T3 (en)	1996-07-03	2005-06-01	Sumitomo Pharmaceuticals Company, Limited	NEW DERIVATIVES OF PURINA.
AUPO912997A0 (en) *	1997-09-11	1997-10-02	Commonwealth Scientific And Industrial Research Organisation	Antiviral agents
US6329381B1 (en) *	1997-11-28	2001-12-11	Sumitomo Pharmaceuticals Company, Limited	Heterocyclic compounds
JPH11180981A (en) *	1997-12-19	1999-07-06	Sumitomo Pharmaceut Co Ltd	Heterocyclic derivative
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JP4189048B2 (en) *	1997-12-26	2008-12-03	大日本住友製薬株式会社	Heterocyclic compounds
ATE443507T1 (en) *	2002-03-15	2009-10-15	Univ Wayne State	NEW 2-AMINO-9-((2-HYDROXYMETHYL)CYCLOPROPYLIDENMETHYL)-PURINES AS ANTIVIRAL AGENTS
BR0314761A (en) *	2002-09-27	2005-07-26	Sumitomo Pharma	Adenine Compound and its Use
JP2008540396A (en)	2005-05-04	2008-11-20	ファイザー・リミテッド	2-Amido-6-amino-8-oxopurine derivatives as toll-like receptor modulators for treating viral infections such as cancer and hepatitis C
DE102006053049A1 (en)	2006-11-10	2008-05-15	Daimler Ag	Storage compartment with a cover
TWI434849B (en) *	2007-06-29	2014-04-21	Gilead Sciences Inc	Modulators of toll-like receptor 7
CN101239980B (en)	2008-02-18	2011-06-22	靳广毅	Immune receptor regulator couplet precursor, couplet and application thereof
KR101787309B1 (en) *	2008-12-09	2017-10-18	길리애드 사이언시즈, 인코포레이티드	Modulators of toll-like receptors
NZ598933A (en) *	2009-10-22	2013-04-26	Gilead Sciences Inc	Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections
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MY182353A (en) *	2015-05-08	2021-01-20	Hoffmann La Roche	Novel sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection
CA3034148A1 (en) *	2016-08-29	2018-03-08	F. Hoffmann-La Roche Ag	7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection

2017
- 2017-08-28 CA CA3034148A patent/CA3034148A1/en active Pending
- 2017-08-28 RU RU2019107957A patent/RU2751349C2/en active
- 2017-08-28 KR KR1020197008982A patent/KR102459155B1/en active Application Filing
- 2017-08-28 PT PT177585270T patent/PT3504210T/en unknown
- 2017-08-28 JP JP2019532184A patent/JP7013467B2/en active Active
- 2017-08-28 SI SI201730728T patent/SI3504210T1/en unknown
- 2017-08-28 CN CN201780052692.6A patent/CN109641904B/en active Active
- 2017-08-28 MA MA46038A patent/MA46038B1/en unknown
- 2017-08-28 EP EP17758527.0A patent/EP3504210B1/en active Active
- 2017-08-28 MY MYPI2019001082A patent/MY197408A/en unknown
- 2017-08-28 AU AU2017320742A patent/AU2017320742B2/en active Active
- 2017-08-28 NZ NZ750604A patent/NZ750604A/en unknown
- 2017-08-28 UA UAA201903059A patent/UA124270C2/en unknown
- 2017-08-28 PE PE2019000346A patent/PE20190476A1/en unknown
- 2017-08-28 EP EP20207475.3A patent/EP3865482A1/en not_active Withdrawn
- 2017-08-28 IL IL293475A patent/IL293475A/en unknown
- 2017-08-28 IL IL284255A patent/IL284255B/en unknown
- 2017-08-28 WO PCT/EP2017/071514 patent/WO2018041763A1/en active Application Filing
- 2017-08-28 MX MX2019002129A patent/MX2019002129A/en unknown
- 2017-08-28 TW TW106129087A patent/TWI671300B/en active
- 2017-08-28 CR CR20190087A patent/CR20190087A/en unknown
- 2017-08-28 KR KR1020227036198A patent/KR20220147702A/en not_active Application Discontinuation
- 2017-08-28 HU HUE17758527A patent/HUE053944T2/en unknown
- 2017-08-28 BR BR112019003519-2A patent/BR112019003519A2/en unknown
- 2017-08-28 DK DK17758527.0T patent/DK3504210T3/en active
- 2017-08-28 PL PL17758527T patent/PL3504210T3/en unknown
- 2017-08-28 SG SG10202010520SA patent/SG10202010520SA/en unknown
- 2017-08-28 RS RS20210489A patent/RS61752B1/en unknown
- 2017-08-28 SG SG11201901633WA patent/SG11201901633WA/en unknown
- 2017-08-28 ES ES17758527T patent/ES2867849T3/en active Active
- 2017-08-29 US US15/689,136 patent/US10233184B2/en active Active
2019
- 2019-01-29 US US16/260,744 patent/US10752630B2/en active Active
- 2019-01-30 CO CONC2019/0000932A patent/CO2019000932A2/en unknown
- 2019-02-07 IL IL264710A patent/IL264710B/en unknown
- 2019-02-21 MX MX2021006902A patent/MX2021006902A/en unknown
- 2019-02-26 CL CL2019000512A patent/CL2019000512A1/en unknown
- 2019-02-27 PH PH12019500432A patent/PH12019500432A1/en unknown
2020
- 2020-08-24 US US17/001,572 patent/US20200385387A1/en not_active Abandoned
2021
- 2021-04-19 HR HRP20210621TT patent/HRP20210621T1/en unknown
- 2021-06-24 AU AU2021204303A patent/AU2021204303B2/en active Active
2022
- 2022-01-17 JP JP2022004832A patent/JP7214900B2/en active Active
- 2022-06-30 AU AU2022204697A patent/AU2022204697A1/en active Pending

Also Published As

Publication number	Publication date
KR20220147702A (en)	2022-11-03
SI3504210T1 (en)	2021-08-31
TW201819382A (en)	2018-06-01
MA46038B1 (en)	2021-05-31
JP7013467B2 (en)	2022-01-31
SG11201901633WA (en)	2019-03-28
AU2017320742A1 (en)	2019-02-28
JP2019526633A (en)	2019-09-19
CL2019000512A1 (en)	2019-07-12
IL264710B (en)	2021-07-29
US20190256515A1 (en)	2019-08-22
IL284255A (en)	2021-07-29
JP7214900B2 (en)	2023-01-30
AU2021204303B2 (en)	2022-05-12
US20200385387A1 (en)	2020-12-10
AU2022204697A1 (en)	2022-07-21
PL3504210T3 (en)	2021-07-05
RU2019107957A3 (en)	2020-12-18
EP3504210A1 (en)	2019-07-03
RS61752B1 (en)	2021-05-31
US10233184B2 (en)	2019-03-19
ES2867849T3 (en)	2021-10-21
HUE053944T2 (en)	2021-08-30
HRP20210621T1 (en)	2021-05-28
MX2019002129A (en)	2019-06-20
CR20190087A (en)	2019-04-30
RU2019107957A (en)	2020-09-29
PH12019500432A1 (en)	2019-10-21
TWI671300B (en)	2019-09-11
AU2021204303A1 (en)	2021-07-22
AU2017320742B2 (en)	2021-08-05
UA124270C2 (en)	2021-08-18
EP3504210B1 (en)	2021-02-24
WO2018041763A1 (en)	2018-03-08
EP3865482A1 (en)	2021-08-18
CO2019000932A2 (en)	2019-02-08
CN109641904A (en)	2019-04-16
RU2751349C2 (en)	2021-07-13
DK3504210T3 (en)	2021-04-26
KR20190039829A (en)	2019-04-15
CN109641904B (en)	2022-01-28
NZ750604A (en)	2024-02-23
PE20190476A1 (en)	2019-04-04
JP2022050632A (en)	2022-03-30
KR102459155B1 (en)	2022-10-28
US10752630B2 (en)	2020-08-25
IL293475A (en)	2022-08-01
US20180072730A1 (en)	2018-03-15
MY197408A (en)	2023-06-16
IL284255B (en)	2022-07-01
BR112019003519A2 (en)	2019-05-21
CA3034148A1 (en)	2018-03-08
MA46038A (en)	2019-07-03
MX2021006902A (en)	2021-07-07
PT3504210T (en)	2021-04-19

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IL284255A (en)	2021-07-29	7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection
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ZA201900770B (en)	2019-12-18	7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection
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ZA201604784B (en)	2019-12-18	Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection