CL2018002570A1 - Oligonucleótidos para reducir la expresión de pd-l1 - Google Patents

Oligonucleótidos para reducir la expresión de pd-l1

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Publication number
CL2018002570A1
CL2018002570A1 CL2018002570A CL2018002570A CL2018002570A1 CL 2018002570 A1 CL2018002570 A1 CL 2018002570A1 CL 2018002570 A CL2018002570 A CL 2018002570A CL 2018002570 A CL2018002570 A CL 2018002570A CL 2018002570 A1 CL2018002570 A1 CL 2018002570A1
Authority
CL
Chile
Prior art keywords
oligonucleotides
expression
reduce
infections
present
Prior art date
Application number
CL2018002570A
Other languages
English (en)
Inventor
Hassan Javanbakht
Søren Ottosen
Lykke Pedersen
Malene Jackerott
Souphalone Luangsay
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2018002570A1 publication Critical patent/CL2018002570A1/es
Priority to CL2020000865A priority Critical patent/CL2020000865A1/es
Priority to CL2020001127A priority patent/CL2020001127A1/es
Priority to CL2020001126A priority patent/CL2020001126A1/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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Abstract

LA PRESENTE INVENCIÓN SE REFIERE A OLIGONUCLEÓTIDOS ANTISENTIDO QUE SON CAPACES DE REDUCIR LA EXPRESIÓN DE PD-L1 EN UNA CÉLULA DIANA. LOS OLIGONUCLEÓTIDOS HIBRIDAN CON EL ARNM DE PD-L1. LA PRESENTE INVENCIÓN SE REFIERE ADEMÁS A CONJUGADOS DEL OLIGONUCLEÓTIDO Y COMPOSICIONES FARMACÉUTICAS Y MÉTODOS PARA EL TRATAMIENTO DE INFECCIONES HEPÁTICAS VÍRICAS, TALES COMO VHB, VHC Y VHD; INFECCIONES PARASITARIAS, TALES COMO MALARIA, TOXOPLASMOSIS, LEISHMANIOSIS Y TRIPANOSOMIASIS O CÁNCER HEPÁTICO O METÁSTASIS EN EL HÍGADO USANDO EL OLIGONUCLEÓTIDO.
CL2018002570A 2016-03-14 2018-09-07 Oligonucleótidos para reducir la expresión de pd-l1 CL2018002570A1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CL2020000865A CL2020000865A1 (es) 2016-03-14 2020-03-31 Oligonucleótidos para reducir la expresión de pd-l1 (divisional solicitud 201802570)
CL2020001127A CL2020001127A1 (es) 2016-03-14 2020-04-28 Oligonucleótidos para reducir la expresión de pd-l1 (divisional solicitud 202000865)
CL2020001126A CL2020001126A1 (es) 2016-03-14 2020-04-28 Oligonucleótidos para reducir la expresión de pd-l1. (divisional solicitud 202000865)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16160149 2016-03-14

Publications (1)

Publication Number Publication Date
CL2018002570A1 true CL2018002570A1 (es) 2018-12-28

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ID=58314191

Family Applications (4)

Application Number Title Priority Date Filing Date
CL2018002570A CL2018002570A1 (es) 2016-03-14 2018-09-07 Oligonucleótidos para reducir la expresión de pd-l1
CL2020000865A CL2020000865A1 (es) 2016-03-14 2020-03-31 Oligonucleótidos para reducir la expresión de pd-l1 (divisional solicitud 201802570)
CL2020001126A CL2020001126A1 (es) 2016-03-14 2020-04-28 Oligonucleótidos para reducir la expresión de pd-l1. (divisional solicitud 202000865)
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CN108779465A (zh) 2018-11-09
US20210147535A1 (en) 2021-05-20
MX2018010830A (es) 2019-02-07
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PL3430141T3 (pl) 2022-02-28
IL290294B (en) 2022-10-01
CL2020000865A1 (es) 2020-08-28
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KR102306797B1 (ko) 2021-10-05
TWI721128B (zh) 2021-03-11
JP2020172488A (ja) 2020-10-22
JP2019512498A (ja) 2019-05-16
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HRP20210315T1 (hr) 2021-04-16
EP3430141B1 (en) 2020-12-30
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TW202128997A (zh) 2021-08-01
IL296483B1 (en) 2023-06-01
AU2021236439B2 (en) 2022-06-16
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US20200048344A1 (en) 2020-02-13
PE20181892A1 (es) 2018-12-11

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