PE20201499A1 - Oligonucleotidos para reducir la expresion de pd-l1 - Google Patents

Oligonucleotidos para reducir la expresion de pd-l1

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Publication number
PE20201499A1
PE20201499A1 PE2020000807A PE2020000807A PE20201499A1 PE 20201499 A1 PE20201499 A1 PE 20201499A1 PE 2020000807 A PE2020000807 A PE 2020000807A PE 2020000807 A PE2020000807 A PE 2020000807A PE 20201499 A1 PE20201499 A1 PE 20201499A1
Authority
PE
Peru
Prior art keywords
oligonucleotide
conjugate
expression
subsequence
refers
Prior art date
Application number
PE2020000807A
Other languages
English (en)
Inventor
Lykke Pedersen
Hassan Javanbakht
Malene Jackerott
Søren Ottosen
Souphalone Luangsay
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20201499A1 publication Critical patent/PE20201499A1/es

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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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Abstract

Se refiere a un conjugado de oligonucleotidos antisentido que comprende: a) un oligonucleotido que comprende una secuencia contigua de 10 a 30 nucleotidos de longitud con una complementariedad de al menos el 90% con un acido nucleico diana de ligando de muerte programada-1 (PD-L1); y b) al menos un resto conjugado que se dirige al receptor de asialoglucoproteina unido covalentemente al oligonucleotido en a), en donde la secuencia de nucleotidos contigua es complementaria a una subsecuencia del acido nucleico diana, en donde la subsecuencia esta en la posicion 5467-12107 en la SEQ ID NO: 1; en donde el oligonucleotido comprende la secuencia SEQ ID NO: 466. Dicho conjugado de oligonucleotidos antisentido reduce la expresion de PD-L1 en el higado, siendo util en el tratamiento de infecciones hepaticas viricas. Tambien se refiere a una composicion farmaceutica que comprende dicho conjugado.
PE2020000807A 2016-03-14 2017-03-14 Oligonucleotidos para reducir la expresion de pd-l1 PE20201499A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16160149 2016-03-14
PCT/EP2017/055925 WO2017157899A1 (en) 2016-03-14 2017-03-14 Oligonucleotides for reduction of pd-l1 expression

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PE20201499A1 true PE20201499A1 (es) 2020-12-29

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PE2022000852A PE20230157A1 (es) 2016-03-14 2017-03-14 Oligonucleotidos para reducir la expresion de pd-l1
PE2018001567A PE20181892A1 (es) 2016-03-14 2017-03-14 Oligonucleotidos para reducir la expresion de pd-l1

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PE2018001567A PE20181892A1 (es) 2016-03-14 2017-03-14 Oligonucleotidos para reducir la expresion de pd-l1

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US (5) US20170283496A1 (es)
EP (2) EP3430141B1 (es)
JP (4) JP6748219B2 (es)
KR (4) KR102580776B1 (es)
CN (4) CN114736900B (es)
AR (2) AR108038A1 (es)
AU (3) AU2017235278C1 (es)
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