CL2018002347A1 - Nuevos derivados pirrolidina - Google Patents
Nuevos derivados pirrolidinaInfo
- Publication number
- CL2018002347A1 CL2018002347A1 CL2018002347A CL2018002347A CL2018002347A1 CL 2018002347 A1 CL2018002347 A1 CL 2018002347A1 CL 2018002347 A CL2018002347 A CL 2018002347A CL 2018002347 A CL2018002347 A CL 2018002347A CL 2018002347 A1 CL2018002347 A1 CL 2018002347A1
- Authority
- CL
- Chile
- Prior art keywords
- pyrrolidine derivatives
- new pyrrolidine
- new
- formula compound
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA INVENCIÓN SE REFIERE A UN COMPUESTO DE FÓRMULA (I), EN LA QUE R1 Y R2 SON TAL COMO SE DEFINE EN LA DESCRIPCIÓN Y EN LAS REIVINDICACIONES. EL COMPUESTO DE FÓRMULA (I) PUEDE UTILIZARSE COMO MEDICAMENTO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16157679 | 2016-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2018002347A1 true CL2018002347A1 (es) | 2018-11-30 |
Family
ID=55443159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2018002347A CL2018002347A1 (es) | 2016-02-26 | 2018-08-16 | Nuevos derivados pirrolidina |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US10689339B2 (es) |
| EP (1) | EP3419970B1 (es) |
| JP (1) | JP6952044B2 (es) |
| KR (1) | KR20180111862A (es) |
| CN (1) | CN108699044B (es) |
| AR (1) | AR107717A1 (es) |
| AU (1) | AU2017224343B2 (es) |
| CA (1) | CA3011652C (es) |
| CL (1) | CL2018002347A1 (es) |
| CO (1) | CO2018007756A2 (es) |
| CR (1) | CR20180404A (es) |
| DK (1) | DK3419970T3 (es) |
| ES (1) | ES2775781T3 (es) |
| HR (1) | HRP20200307T1 (es) |
| HU (1) | HUE047842T2 (es) |
| IL (1) | IL260130B (es) |
| LT (1) | LT3419970T (es) |
| MA (1) | MA43667B1 (es) |
| MX (1) | MX2018009638A (es) |
| MY (1) | MY196560A (es) |
| PH (1) | PH12018501585A1 (es) |
| PL (1) | PL3419970T3 (es) |
| PT (1) | PT3419970T (es) |
| RS (1) | RS59938B1 (es) |
| RU (1) | RU2736498C1 (es) |
| SG (1) | SG11201807074VA (es) |
| SI (1) | SI3419970T1 (es) |
| TW (1) | TWI740903B (es) |
| UA (1) | UA122084C2 (es) |
| WO (1) | WO2017144483A1 (es) |
| ZA (1) | ZA201804120B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS62477B1 (sr) | 2017-01-24 | 2021-11-30 | Astellas Pharma Inc | Fenildifluorometil - supstituisano jedinjenje prolinamida |
| AR114732A1 (es) * | 2018-09-18 | 2020-10-07 | Hoffmann La Roche | Utilización de un inhibidor de catepsina s contra la formación de anticuerpos antifármaco |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2421826T3 (pl) * | 2009-04-20 | 2014-03-31 | Hoffmann La Roche | Pochodne proliny jako inhibitory katepsyn |
| US8796471B2 (en) * | 2011-11-11 | 2014-08-05 | Hoffmann-La Roche Inc. | Process for the preparation of proline derivatives |
| CN103946213A (zh) * | 2011-11-25 | 2014-07-23 | 霍夫曼-拉罗奇有限公司 | 作为组织蛋白酶抑制剂的新吡咯烷衍生物 |
| US9427108B2 (en) * | 2011-12-09 | 2016-08-30 | W.C. Bradley Co. | Cooking grate with adjustable heating characteristics |
| US8802665B2 (en) * | 2012-02-17 | 2014-08-12 | Genentech, Inc. | Pyrrolidine derivatives |
| KR20150044947A (ko) * | 2012-08-21 | 2015-04-27 | 에프. 호프만-라 로슈 아게 | 신규한 피리딘 유도체 |
-
2017
- 2017-02-22 CA CA3011652A patent/CA3011652C/en active Active
- 2017-02-22 ES ES17705662T patent/ES2775781T3/es active Active
- 2017-02-22 JP JP2018541661A patent/JP6952044B2/ja active Active
- 2017-02-22 PT PT177056629T patent/PT3419970T/pt unknown
- 2017-02-22 CR CR20180404A patent/CR20180404A/es unknown
- 2017-02-22 LT LTEP17705662.9T patent/LT3419970T/lt unknown
- 2017-02-22 MX MX2018009638A patent/MX2018009638A/es unknown
- 2017-02-22 RS RS20200183A patent/RS59938B1/sr unknown
- 2017-02-22 SI SI201730195T patent/SI3419970T1/sl unknown
- 2017-02-22 SG SG11201807074VA patent/SG11201807074VA/en unknown
- 2017-02-22 RU RU2018133640A patent/RU2736498C1/ru active
- 2017-02-22 WO PCT/EP2017/053967 patent/WO2017144483A1/en active Application Filing
- 2017-02-22 MA MA43667A patent/MA43667B1/fr unknown
- 2017-02-22 KR KR1020187024347A patent/KR20180111862A/ko not_active Application Discontinuation
- 2017-02-22 HU HUE17705662A patent/HUE047842T2/hu unknown
- 2017-02-22 DK DK17705662.9T patent/DK3419970T3/da active
- 2017-02-22 PL PL17705662T patent/PL3419970T3/pl unknown
- 2017-02-22 MY MYPI2018001465A patent/MY196560A/en unknown
- 2017-02-22 CN CN201780013397.XA patent/CN108699044B/zh active Active
- 2017-02-22 UA UAA201809397A patent/UA122084C2/uk unknown
- 2017-02-22 AU AU2017224343A patent/AU2017224343B2/en active Active
- 2017-02-22 EP EP17705662.9A patent/EP3419970B1/en active Active
- 2017-02-24 TW TW106106388A patent/TWI740903B/zh active
- 2017-02-24 AR ARP170100467A patent/AR107717A1/es unknown
-
2018
- 2018-06-19 IL IL260130A patent/IL260130B/en active IP Right Grant
- 2018-06-20 ZA ZA2018/04120A patent/ZA201804120B/en unknown
- 2018-07-25 PH PH12018501585A patent/PH12018501585A1/en unknown
- 2018-07-26 CO CONC2018/0007756A patent/CO2018007756A2/es unknown
- 2018-08-16 CL CL2018002347A patent/CL2018002347A1/es unknown
- 2018-08-24 US US16/111,721 patent/US10689339B2/en active Active
-
2020
- 2020-02-24 HR HRP20200307TT patent/HRP20200307T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SV2018005792A (es) | Nuevos derivados piperidinilo sustituidos con hetero (arilo), un proceso para su preparacion y composiciones farmaceuticas que los contienen | |
| CL2023000198A1 (es) | Derivado de glucagón y una composición que comprende un conjugado de acción prolongada del mismo | |
| CL2018003474A1 (es) | Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen. | |
| CO2017013709A2 (es) | Lactamas bicíclicas. | |
| CO2017005790A2 (es) | Derivados heterocíclicos con sustituyentes que contienen azufre activos como plaguicidas | |
| CR20160503A (es) | Compuestos de [1,2,4] triazol e imidazol sustituidos, como fungicidas | |
| CR20160459A (es) | Nuevos derivados de piridina | |
| CL2017001100A1 (es) | Nuevas triazolo[4,5-d]pirimidinas | |
| CR20150250A (es) | Nuevos derivados de piridina | |
| CR20150440A (es) | Nuevos derivados de piridina | |
| CR20160448A (es) | Nuevos derivados de piridina | |
| CL2018001493A1 (es) | Nuevos derivados de fenilo | |
| CR20170008A (es) | Compuestos de [1,2,4] triazol e imidazol sustituidos | |
| UY35997A (es) | Derivados de isoquinoleína, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| CL2018003610A1 (es) | Nuevos derivados de [1,2,3]triazolo[4,5-d]pirimidina. | |
| CR20170090A (es) | Derivados de terahidroquinolina como inhibidores del bromodominio | |
| GT201600232A (es) | Derivados de diheterociclo enlazado a cicloalquilo | |
| CL2018002347A1 (es) | Nuevos derivados pirrolidina | |
| MX363458B (es) | Nuevos derivados de tetrazolona. | |
| CO7200259A2 (es) | Nuevos derivados de piridina | |
| CR20170183A (es) | Nuevas triazolo[4,5-d]pirimidinas |