CL2015000787A1 - Derivados de 1,2,4-triazina para el tratamiento de infecciones virales. - Google Patents

Derivados de 1,2,4-triazina para el tratamiento de infecciones virales.

Info

Publication number
CL2015000787A1
CL2015000787A1 CL2015000787A CL2015000787A CL2015000787A1 CL 2015000787 A1 CL2015000787 A1 CL 2015000787A1 CL 2015000787 A CL2015000787 A CL 2015000787A CL 2015000787 A CL2015000787 A CL 2015000787A CL 2015000787 A1 CL2015000787 A1 CL 2015000787A1
Authority
CL
Chile
Prior art keywords
treatment
viral infections
triazine derivatives
triazine
tlr8
Prior art date
Application number
CL2015000787A
Other languages
English (en)
Inventor
Vincent Gembus
Philippe Jubault
Christophe Hoarau
Vincent Levacher
Gowan David Graig Mc
Jerome Emile Georges Guillemont
Jean-Francois Bonfanti
Original Assignee
Univ Rouen
Inst Nat Sciences Appliq
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rouen, Inst Nat Sciences Appliq, Centre Nat Rech Scient filed Critical Univ Rouen
Publication of CL2015000787A1 publication Critical patent/CL2015000787A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPUESTOS DERIVADOS DE 1,2,4-TRIAZINA; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE; Y SU USO PARA EL TRATAMIENTO DE UN TRASTORNO EN EL CUAL LA MODULACION DE TLR7 Y/O TLR8 ESTA IMPLICADA, TAL COMO INFECCIONES VIRALES Y TRASTORNOS INMUNES O INFLAMATORIOS.
CL2015000787A 2012-10-01 2015-03-30 Derivados de 1,2,4-triazina para el tratamiento de infecciones virales. CL2015000787A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12306196.2A EP2712866A1 (en) 2012-10-01 2012-10-01 1,2,4-triazine derivatives for the treatment of viral infections

Publications (1)

Publication Number Publication Date
CL2015000787A1 true CL2015000787A1 (es) 2015-10-02

Family

ID=46982496

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015000787A CL2015000787A1 (es) 2012-10-01 2015-03-30 Derivados de 1,2,4-triazina para el tratamiento de infecciones virales.

Country Status (22)

Country Link
US (1) US9416114B2 (es)
EP (2) EP2712866A1 (es)
JP (1) JP6298998B2 (es)
KR (1) KR102138393B1 (es)
CN (1) CN104812747B (es)
AU (1) AU2013326579B2 (es)
BR (1) BR112015007310B1 (es)
CA (1) CA2886630C (es)
CL (1) CL2015000787A1 (es)
EA (1) EA026236B1 (es)
ES (1) ES2616496T3 (es)
HK (1) HK1208223A1 (es)
IL (1) IL237871A (es)
IN (1) IN2015DN03327A (es)
MX (1) MX348229B (es)
MY (1) MY182558A (es)
NZ (1) NZ706354A (es)
PH (1) PH12015500724A1 (es)
SG (1) SG11201502522WA (es)
UA (1) UA114644C2 (es)
WO (1) WO2014053516A1 (es)
ZA (1) ZA201502240B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME03782B (me) 2011-04-08 2021-04-20 Janssen Sciences Ireland Unlimited Co Derivati pirimidina za tretman virusnih infekcija
LT2776439T (lt) 2011-11-09 2018-10-10 Janssen Sciences Ireland Uc Purino dariniai, skirti virusinų infekcijų gydymui
WO2014009509A1 (en) 2012-07-13 2014-01-16 Janssen R&D Ireland Macrocyclic purines for the treatment of viral infections
ES2670513T3 (es) 2012-10-10 2018-05-30 Janssen Sciences Ireland Uc Derivados pirrolo[3,2-d]pirimidínicos para el tratamiento de infecciones víricas y otras enfermedades
MX361585B (es) 2012-11-16 2018-12-11 Janssen Sciences Ireland Uc Derivados 2-aminoquinazolínicos sustituidos heterocíclicos para el tratamiento de infecciones víricas.
UA118751C2 (uk) 2013-02-21 2019-03-11 ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі Похідні 2-амінопіримідину для лікування вірусних інфекцій
EA202090547A3 (ru) 2013-03-29 2020-12-30 Янссен Сайенсиз Айрлэнд Юси Макроциклические деаза-оксипурины для лечения вирусных инфекций
EP3004074B1 (en) 2013-05-24 2017-10-25 Janssen Sciences Ireland UC Pyridone derivatives for the treatment of viral infections and further diseases
DK3030563T3 (da) 2013-06-27 2017-11-20 Janssen Sciences Ireland Uc Pyrrolo-[3,2-d]-pyrimidin-derivater til behandling af virale infektioner og andre sygdomme
MX368625B (es) 2013-07-30 2019-10-08 Janssen Sciences Ireland Uc Derivados de tieno[3,2-d]pirimidinas para el tratamiento de infecciones virales.
US11053256B2 (en) 2016-07-01 2021-07-06 Janssen Sciences Ireland Unlimited Company Dihydropyranopyrimidines for the treatment of viral infections
CA3037989A1 (en) * 2016-09-29 2018-04-05 Janssen Sciences Ireland Unlimited Company Pyrimidine prodrugs for the treatment of viral infections and further diseases
TW201945003A (zh) 2018-03-01 2019-12-01 愛爾蘭商健生科學愛爾蘭無限公司 ２，４－二胺基喹唑啉衍生物及其醫學用途
WO2020162705A1 (ko) 2019-02-08 2020-08-13 성균관대학교산학협력단 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도
WO2021177679A1 (ko) 2020-03-02 2021-09-10 성균관대학교산학협력단 병원균 외벽 성분 기반 생병원체 모방 나노 입자 및 그 제조 방법
EP4194006A1 (en) 2020-08-04 2023-06-14 Progeneer Inc. Mrna vaccine comprising adjuvant capable of kinetic control
WO2022031011A1 (ko) 2020-08-04 2022-02-10 성균관대학교산학협력단 동력학적으로 작용하는 아주번트 앙상블
US20230277525A1 (en) 2020-08-04 2023-09-07 Progeneer Inc Conjugate of functional drug and toll-like receptor 7 or 8 agonist of which active site is temporarily inactivated and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485531A1 (fr) * 1980-06-25 1981-12-31 Fabre Sa Pierre Nouveaux n-oxydes de diaryl-5,6 as triazines 1-2-4, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
ES2232871T3 (es) 1996-07-03 2005-06-01 Sumitomo Pharmaceuticals Company, Limited Nuevos derivados de purina.
KR100613634B1 (ko) 1997-11-28 2006-08-18 다이닛본 스미토모 세이야꾸 가부시끼가이샤 신규한 복소환 화합물
CN101035773B (zh) * 2004-08-10 2012-06-06 詹森药业有限公司 抑制hiv的1,2,4-三嗪-6-酮衍生物
MX2007013780A (es) 2005-05-04 2008-02-05 Pfizer Ltd Derivados 2 amido-6-amino-8-oxo purina como moduladores del receptor como tipo peaje (toll) para el tratamiento del cancer y las infecciones virales tal como la hepatitis c.
CN101296907B (zh) * 2005-09-01 2013-03-27 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3调节剂的二氨基嘧啶类
RU2352565C1 (ru) * 2007-10-08 2009-04-20 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" 3-амино-6-ароилметил-5-гидрокси-1,2,4-триазины и способ их получения
PE20091236A1 (es) 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
WO2012067269A1 (en) * 2010-11-19 2012-05-24 Dainippon Sumitomo Pharma Co., Ltd. Aminoalkoxyphenyl compounds and their use in the treatment of disease

Also Published As

Publication number Publication date
PH12015500724B1 (en) 2015-06-01
MY182558A (en) 2021-01-25
MX2015004160A (es) 2016-02-05
ES2616496T3 (es) 2017-06-13
WO2014053516A1 (en) 2014-04-10
JP2015535839A (ja) 2015-12-17
JP6298998B2 (ja) 2018-03-28
CA2886630A1 (en) 2014-04-10
EP2903976A1 (en) 2015-08-12
IL237871A (en) 2017-04-30
AU2013326579B2 (en) 2017-04-27
PH12015500724A1 (en) 2015-06-01
CA2886630C (en) 2021-01-26
MX348229B (es) 2017-05-31
NZ706354A (en) 2018-08-31
SG11201502522WA (en) 2015-05-28
EP2903976B1 (en) 2016-12-07
US20150336907A1 (en) 2015-11-26
US9416114B2 (en) 2016-08-16
CN104812747A (zh) 2015-07-29
KR102138393B1 (ko) 2020-08-14
ZA201502240B (en) 2016-05-25
BR112015007310A2 (pt) 2017-08-08
EP2712866A1 (en) 2014-04-02
AU2013326579A1 (en) 2015-04-09
CN104812747B (zh) 2017-03-08
KR20150084791A (ko) 2015-07-22
UA114644C2 (uk) 2017-07-10
HK1208223A1 (en) 2016-02-26
IN2015DN03327A (es) 2015-10-09
EA201500383A1 (ru) 2015-07-30
BR112015007310B1 (pt) 2022-07-19
EA026236B1 (ru) 2017-03-31

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