CL2007002316A1 - Compuestos derivados de pirimidina, inhibidores de pi3k; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en enfermedades proliferativas como cancer. - Google Patents
Compuestos derivados de pirimidina, inhibidores de pi3k; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en enfermedades proliferativas como cancer.Info
- Publication number
- CL2007002316A1 CL2007002316A1 CL200702316A CL2007002316A CL2007002316A1 CL 2007002316 A1 CL2007002316 A1 CL 2007002316A1 CL 200702316 A CL200702316 A CL 200702316A CL 2007002316 A CL2007002316 A CL 2007002316A CL 2007002316 A1 CL2007002316 A1 CL 2007002316A1
- Authority
- CL
- Chile
- Prior art keywords
- compound
- pyrimidine
- cancer
- pharmaceutical composition
- proliferative diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006216108 | 2006-08-08 | ||
JP2007118631 | 2007-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2007002316A1 true CL2007002316A1 (es) | 2008-02-01 |
Family
ID=39032956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL200702316A CL2007002316A1 (es) | 2006-08-08 | 2007-08-08 | Compuestos derivados de pirimidina, inhibidores de pi3k; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en enfermedades proliferativas como cancer. |
Country Status (26)
Country | Link |
---|---|
US (1) | US8022205B2 (es) |
EP (1) | EP2050749B1 (es) |
JP (1) | JP4450857B2 (es) |
KR (1) | KR101435692B1 (es) |
AR (1) | AR062292A1 (es) |
AU (1) | AU2007282535B9 (es) |
BR (1) | BRPI0714908B8 (es) |
CA (1) | CA2659604C (es) |
CL (1) | CL2007002316A1 (es) |
CY (1) | CY1119882T1 (es) |
DK (1) | DK2050749T3 (es) |
ES (1) | ES2657635T3 (es) |
HU (1) | HUE035116T2 (es) |
IL (1) | IL196601A (es) |
LT (1) | LT2050749T (es) |
MX (1) | MX2009001451A (es) |
MY (1) | MY145385A (es) |
NO (1) | NO342978B1 (es) |
NZ (1) | NZ575274A (es) |
PE (1) | PE20080527A1 (es) |
PL (1) | PL2050749T3 (es) |
PT (1) | PT2050749T (es) |
RU (1) | RU2448109C2 (es) |
SI (1) | SI2050749T1 (es) |
TW (1) | TWI394758B (es) |
WO (1) | WO2008018426A1 (es) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
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DK2125822T3 (en) * | 2006-12-21 | 2015-01-12 | Nerviano Medical Sciences Srl | SUBSTITUTED PYRAZOLOQUINAZOLINDERIVATER, process for their preparation and their use as kinase inhibitors |
CL2009000241A1 (es) * | 2008-02-07 | 2010-09-03 | Chugai Pharmaceutical Co Ltd | Compuestos derivados de 5-(2-morfolin-4-il-7h-pirrolo[2,3-d]pirimidin-4-il)pirimidin-2-ilamina; proceso de preparacion; composicion farmaceutica; y uso de los compuestos para tratar o prevenir una enfermedad proliferativa tal como el cancer. |
PT2959900T (pt) * | 2008-06-16 | 2017-06-22 | Univ Tennessee Res Found | Composto para tratamento do cancro |
US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
US8822513B2 (en) | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
WO2010005558A2 (en) * | 2008-07-07 | 2010-01-14 | Xcovery, Inc. | Pi3k isoform selective inhibitors |
TWI378933B (en) | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
GB2465405A (en) | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
BRPI0921156A2 (pt) * | 2008-11-11 | 2016-02-23 | Xcovery Holding Co Llc | inibidores de pi3k/mtor quinase |
SG172266A1 (en) | 2008-12-19 | 2011-07-28 | Genentech Inc | Compounds and methods of use |
NZ595372A (en) | 2009-03-27 | 2013-11-29 | Vetdc Inc | Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy |
WO2010114494A1 (en) * | 2009-04-03 | 2010-10-07 | S*Bio Pte Ltd | 8-substituted-2-morpholino purines for use as pi3k and/or mtor inhibitors in the treatment of proliferative disorders |
RS57869B1 (sr) | 2009-06-17 | 2018-12-31 | Vertex Pharma | Inhibitori replikacije virusa gripa |
AR077280A1 (es) | 2009-06-29 | 2011-08-17 | Incyte Corp | Pirimidinonas como inhibidores de pi3k, y composiciones farmaceuticas que los comprenden |
EP2451802A1 (en) | 2009-07-07 | 2012-05-16 | Pathway Therapeutics, Inc. | Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy |
CA2773848A1 (en) * | 2009-09-09 | 2011-03-17 | Avila Therapeutics, Inc. | Pi3 kinase inhibitors and uses thereof |
WO2011075643A1 (en) | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
MX2012010115A (es) | 2010-03-01 | 2013-02-26 | Gtx Inc | Compuestos para el tratamiento de cancer. |
JP2013529212A (ja) * | 2010-05-19 | 2013-07-18 | エクスカバリー ホールディング カンパニー,エルエルシー | mTOR選択的キナーゼ阻害剤 |
TW201249844A (en) | 2010-12-20 | 2012-12-16 | Incyte Corp | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors |
BR112013020329A2 (pt) * | 2011-02-09 | 2016-08-02 | Hoffmann La Roche | compostos heterocíclicos como inibidores da pi3-quinase |
WO2012135160A1 (en) | 2011-03-28 | 2012-10-04 | Pathway Therapeutics Inc. | (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases |
CA2839937C (en) * | 2011-07-05 | 2020-11-03 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for producing azaindoles |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
SI2751109T1 (sl) | 2011-09-02 | 2017-03-31 | Incyte Holdings Corporation | Heterociklilamini kot inhibitorji pi3k |
US20130123255A1 (en) * | 2011-11-10 | 2013-05-16 | Chugai Seiyaku Kabushiki Kaisha | Combination of a pi3k inhibitor and a mek inhibitor |
WO2013083810A1 (en) | 2011-12-09 | 2013-06-13 | F. Hoffmann-La Roche Ag | Identification of non-responders to her2 inhibitors |
AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
JP6381523B2 (ja) | 2012-05-16 | 2018-08-29 | ノバルティス アーゲー | Pi−3キナーゼ阻害剤の投与レジメン |
CN103450204B (zh) * | 2012-05-31 | 2016-08-17 | 中国科学院上海药物研究所 | 吡咯[2,1-f][1,2,4]并三嗪类化合物,其制备方法及用途 |
NO2868660T3 (es) | 2012-07-02 | 2018-05-26 | ||
WO2014022728A1 (en) | 2012-08-02 | 2014-02-06 | Endo Pharmaceuticals, Inc | Substituted 5 - (quinazolin - 2 - yl) pyrimidin- 2 -amine derivatives useful as pi3k/mtor inhibitors for the treatment of cancer |
EP2914260A1 (en) | 2012-10-31 | 2015-09-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
PT2914296T (pt) * | 2012-11-01 | 2018-10-30 | Infinity Pharmaceuticals Inc | Tratamento de cancros utilizando moduladores de isoformas de pi3-quinase |
CN103588792B (zh) | 2013-03-04 | 2016-03-23 | 中国科学院上海药物研究所 | 吡啶并嘧啶或嘧啶并嘧啶类化合物、其制备方法、药物组合物及其用途 |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
US9296727B2 (en) | 2013-10-07 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines |
JP6139789B2 (ja) | 2013-10-16 | 2017-05-31 | シャンハイ インリ ファーマシューティカル カンパニー リミティド | 縮合複素環化合物、その調製方法、医薬組成物及びその使用 |
SI3068782T1 (sl) | 2013-11-13 | 2018-10-30 | Vertex Pharmaceuticals Incorporated | Postopki za pripravo inhibitorjev v replikacije virusov gripe |
CN111808957A (zh) | 2014-04-04 | 2020-10-23 | 中美冠科生物技术(太仓)有限公司 | 用于确定对mek/erk抑制剂的应答性的方法 |
WO2015155624A1 (en) | 2014-04-10 | 2015-10-15 | Pfizer Inc. | Dihydropyrrolopyrimidine derivatives |
WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
ES2772682T3 (es) | 2015-02-27 | 2020-07-08 | Taiho Pharmaceutical Co Ltd | Cristal de imidazooxazina, composición farmacéutica que contiene dicho cristal, y método de producción de dicho cristal |
CN117800973A (zh) | 2015-02-27 | 2024-04-02 | 因赛特控股公司 | Pi3k抑制剂的盐及其制备方法 |
US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
JP6857617B2 (ja) | 2015-05-13 | 2021-04-14 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤 |
EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
JP6616244B2 (ja) * | 2015-05-29 | 2019-12-04 | 北興化学工業株式会社 | 新規なヒドロキシフェニルボロン酸エステルとその製造方法、およびヒドロキシビフェニル化合物の製造法 |
US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
SG11201809792TA (en) * | 2016-05-18 | 2018-12-28 | Piqur Therapeutics Ag | Treatment of neurological disorders |
WO2018007331A1 (en) | 2016-07-08 | 2018-01-11 | F. Hoffmann-La Roche Ag | Fused pyrimidine derivatives |
JP6980751B2 (ja) | 2016-07-14 | 2021-12-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 縮合ピリミジン誘導体 |
IT201600092469A1 (it) * | 2016-09-14 | 2018-03-14 | Lundbeck Pharmaceuticals Italy S P A | Processo per la produzione di Blonanserina |
CN109476670B (zh) | 2016-10-04 | 2022-06-28 | 豪夫迈·罗氏有限公司 | 二环杂芳基衍生物 |
MX2019013862A (es) | 2017-05-23 | 2020-01-20 | Mei Pharma Inc | Terapia de combinacion. |
MX2020001727A (es) | 2017-08-14 | 2020-03-20 | Mei Pharma Inc | Terapia de combinacion. |
US11414420B2 (en) | 2017-11-27 | 2022-08-16 | Hoffmann-La Roche Inc. | Pyrimidine derivatives |
WO2021247862A1 (en) * | 2020-06-03 | 2021-12-09 | Yumanity Therapeutics, Inc. | Bicyclic heteroarenes and methods of their use |
TW202220661A (zh) | 2020-08-07 | 2022-06-01 | 德商柏林化學股份公司 | 包含pi3k抑制劑之經改良醫藥調配物 |
BR112023020806A2 (pt) | 2021-04-09 | 2023-12-12 | Immunic Ag | Inibidores de dhodh deuterados |
WO2023107603A1 (en) * | 2021-12-08 | 2023-06-15 | Kineta, Inc. | Pyrimidines and methods of their use |
WO2023107623A2 (en) * | 2021-12-08 | 2023-06-15 | Kineta, Inc. | Bicyclic heteroarenes and methods of their use |
WO2024023766A1 (en) | 2022-07-28 | 2024-02-01 | Berlin-Chemie Ag | P13k inhibitor combination therapy |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08325268A (ja) * | 1986-02-24 | 1996-12-10 | Mitsui Petrochem Ind Ltd | ピロロ〔3,4−d〕ピリミジン誘導体 |
EP0257102B1 (en) * | 1986-02-24 | 1997-11-19 | Mitsui Petrochemical Industries, Ltd. | Agents for treating neurophathy |
AU645504B2 (en) * | 1989-10-11 | 1994-01-20 | Teijin Limited | Bicyclic pyrimidine derivative, method of producing the same, and pharmaceutical preparation containing the same as active ingredient |
TW574214B (en) * | 1994-06-08 | 2004-02-01 | Pfizer | Corticotropin releasing factor antagonists |
CA2426654C (en) | 2000-10-23 | 2010-12-21 | Smithkline Beecham Corporation | 2,4,8-trisubstituted-8h-pyrido[2,3-d}pyrimidin-7-one compounds |
US7384937B2 (en) * | 2002-11-06 | 2008-06-10 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
AU2003295776B2 (en) * | 2002-11-21 | 2011-05-12 | Novartis Vaccines And Diagnostics, Inc. | 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (PI) 3-kinase inhibitors and their use in the treatment of cancer |
EP1622910A1 (en) | 2003-05-05 | 2006-02-08 | F. Hoffmann-La Roche Ag | Fused pyrimidine derivatives with crf activity |
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2007
- 2007-08-07 AU AU2007282535A patent/AU2007282535B9/en active Active
- 2007-08-07 PL PL07792065T patent/PL2050749T3/pl unknown
- 2007-08-07 ES ES07792065T patent/ES2657635T3/es active Active
- 2007-08-07 NZ NZ575274A patent/NZ575274A/en unknown
- 2007-08-07 PT PT77920650T patent/PT2050749T/pt unknown
- 2007-08-07 WO PCT/JP2007/065396 patent/WO2008018426A1/ja active Search and Examination
- 2007-08-07 MX MX2009001451A patent/MX2009001451A/es active IP Right Grant
- 2007-08-07 JP JP2008528817A patent/JP4450857B2/ja active Active
- 2007-08-07 KR KR1020097002650A patent/KR101435692B1/ko active IP Right Grant
- 2007-08-07 LT LTEP07792065.0T patent/LT2050749T/lt unknown
- 2007-08-07 US US12/376,039 patent/US8022205B2/en active Active
- 2007-08-07 SI SI200731994T patent/SI2050749T1/en unknown
- 2007-08-07 EP EP07792065.0A patent/EP2050749B1/en active Active
- 2007-08-07 HU HUE07792065A patent/HUE035116T2/hu unknown
- 2007-08-07 CA CA2659604A patent/CA2659604C/en active Active
- 2007-08-07 BR BRPI0714908A patent/BRPI0714908B8/pt active IP Right Grant
- 2007-08-07 MY MYPI20090459A patent/MY145385A/en unknown
- 2007-08-07 DK DK07792065.0T patent/DK2050749T3/en active
- 2007-08-07 RU RU2009108328/04A patent/RU2448109C2/ru active
- 2007-08-08 PE PE2007001059A patent/PE20080527A1/es active IP Right Grant
- 2007-08-08 CL CL200702316A patent/CL2007002316A1/es unknown
- 2007-08-08 TW TW096129165A patent/TWI394758B/zh active
- 2007-08-08 AR ARP070103510A patent/AR062292A1/es active IP Right Grant
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2008
- 2008-10-28 NO NO20084533A patent/NO342978B1/no unknown
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2009
- 2009-01-20 IL IL196601A patent/IL196601A/en active IP Right Grant
-
2017
- 2017-12-28 CY CY20171101353T patent/CY1119882T1/el unknown
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