CL2003002461A1 - Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas. - Google Patents
Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas.Info
- Publication number
- CL2003002461A1 CL2003002461A1 CL200302461A CL2003002461A CL2003002461A1 CL 2003002461 A1 CL2003002461 A1 CL 2003002461A1 CL 200302461 A CL200302461 A CL 200302461A CL 2003002461 A CL2003002461 A CL 2003002461A CL 2003002461 A1 CL2003002461 A1 CL 2003002461A1
- Authority
- CL
- Chile
- Prior art keywords
- understands
- immunoglobulin
- glican
- afucosilated
- plants
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
- C07K16/087—Herpes simplex virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/13—Immunoglobulins specific features characterized by their source of isolation or production isolated from plants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42938502P | 2002-11-27 | 2002-11-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2003002461A1 true CL2003002461A1 (es) | 2005-01-07 |
Family
ID=32469313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL200302461A CL2003002461A1 (es) | 2002-11-27 | 2003-11-27 | Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas. |
Country Status (10)
Country | Link |
---|---|
US (1) | US8106169B2 (es) |
EP (1) | EP1606385A4 (es) |
JP (1) | JP2006517392A (es) |
CN (1) | CN1984993A (es) |
AR (1) | AR042145A1 (es) |
AU (1) | AU2003298727A1 (es) |
BR (1) | BR0316739A (es) |
CA (1) | CA2506744A1 (es) |
CL (1) | CL2003002461A1 (es) |
WO (1) | WO2004050838A2 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ512185A (en) | 1998-12-09 | 2004-02-27 | Dow Chemical Co | A method for manufacturing glycoproteins having human- type glycosylation in plant cells |
BRPI0015031B1 (pt) | 1999-10-26 | 2017-05-30 | Plant Res Int B V | método para prover uma planta transgênica capaz de expressar um anticorpo com galactosilação terminal e método para obtenção de uma glicoproteína desejada ou fragmento funcional da mesma |
IL156879A0 (en) | 2001-01-19 | 2004-02-08 | Dow Chemical Co | Method for secretory production of glycoprotein having human-type sugar chain using plant cell |
EP1367881A2 (en) * | 2001-03-06 | 2003-12-10 | The Dow Chemical Company | Plant cell having animal-type sugar chain adding function |
EP1485492B1 (en) | 2002-03-19 | 2011-12-21 | Stichting Dienst Landbouwkundig Onderzoek | Gntiii (udp-n-acetylglucosamine:beta-d mannoside beta(1,4)-n-acetylglucosaminyltransferase iii) expression in plants |
EP2339004B1 (en) | 2002-03-19 | 2015-02-25 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
CL2003002461A1 (es) | 2002-11-27 | 2005-01-07 | Dow Chemical Company Agroscien | Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas. |
AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
DE602005021379D1 (de) | 2004-10-13 | 2010-07-01 | Protalix Ltd | System und verfahren zur produktion von antikörpern in der pflanzenzellkultur |
AU2007205939B2 (en) | 2006-01-17 | 2012-12-13 | Synthon Biopharmaceuticals B.V. | Compositions and methods for humanization and optimization of N-glycans in plants |
EP1878747A1 (en) | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-engineered antibodies |
CA2684370C (en) * | 2007-04-17 | 2017-10-17 | Plant Research International B.V. | Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases |
WO2009062259A1 (en) * | 2007-11-15 | 2009-05-22 | International Flower Developments Pty Ltd | Genetically modified plants with altered inflorescence |
PT2248825E (pt) * | 2009-05-04 | 2013-01-07 | Ribovax Biotechnologies Sa | Fragmentos de antigénio ligantes a um anticorpo para uso no tratamento e diagnóstico de doenças oculares |
US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
ES2965212T3 (es) | 2009-07-08 | 2024-04-11 | Kymab Ltd | Modelos de animales y moléculas terapéuticas |
US9204599B2 (en) | 2009-08-19 | 2015-12-08 | Dow Agrosciences Llc | Detection of AAD1 event DAS-40278-9 |
US8598413B2 (en) | 2009-08-19 | 2013-12-03 | Dow AgroSciecnes, LLC. | AAD-1 event DAS-40278-9, related transgenic corn lines, event-specific identification thereof, and methods of weed control involving AAD-1 |
AU2010284286B2 (en) * | 2009-08-19 | 2015-08-20 | Dow Agrosciences Llc | Detection of AAD-1 event DAS-40278-9 |
JP2013526832A (ja) | 2009-08-19 | 2013-06-27 | ダウ アグロサイエンシィズ エルエルシー | Aad−1イベントdas−40278−9、関連するトランスジェニックトウモロコシ系統およびそのイベント特異的同定 |
CA2771543C (en) | 2009-08-19 | 2018-05-15 | Dow Agrosciences Llc | Control of aad-1 monocot volunteers in fields of dicot crops |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
TR201906650T4 (tr) | 2010-02-08 | 2019-05-21 | Regeneron Pharma | Ortak hafif zincirli fare. |
CN102234646B (zh) * | 2010-04-23 | 2014-10-22 | 深圳华大基因科技有限公司 | 一种启动子SbUbi1、其制备方法及用途 |
EP2686671A4 (en) | 2011-03-12 | 2015-06-24 | Momenta Pharmaceuticals Inc | N-GLYCANES CONTAINING N-ACETYLHEXOSAMINE IN GLYCOPROTEIN PRODUCTS |
ES2872081T3 (es) | 2011-08-05 | 2021-11-02 | Regeneron Pharma | Ratones con cadena ligera universal humanizada |
CA2846322A1 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
US10829543B2 (en) * | 2012-10-29 | 2020-11-10 | The University Of North Carolina At Chapel Hill | Compositions and methods for inhibiting pathogen infection |
US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
JP7133902B2 (ja) | 2013-10-01 | 2022-09-09 | カイマブ・リミテッド | 動物モデル及び治療用分子 |
KR20210088756A (ko) | 2014-03-21 | 2021-07-14 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
EP3221455B1 (en) | 2014-11-20 | 2020-08-12 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells |
AU2016232715A1 (en) | 2015-03-19 | 2017-09-28 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
CN111461239B (zh) * | 2020-04-03 | 2023-05-09 | 成都考拉悠然科技有限公司 | 基于白盒攻击的ctc场景文字识别模型优化方法 |
CN111551739A (zh) * | 2020-04-27 | 2020-08-18 | 杭州璞湃科技有限公司 | 一种免疫球蛋白a和免疫球蛋白a1的检测方法及其试剂盒 |
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FR2774379B1 (fr) | 1998-01-30 | 2002-03-29 | Groupe Limagrain Holding | Procede de production, par des cellules vegetales, d'alpha 1-antitrypsine et de ses variantes, et produits contenant l'alpha-antitrypsine ainsi obtenue |
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US20020174453A1 (en) * | 2001-04-18 | 2002-11-21 | Henry Daniell | Production of antibodies in transgenic plastids |
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WO2001082912A2 (en) | 2000-04-28 | 2001-11-08 | Gerolymatos P N Sa | TREATMENT OF PATHOLOGICAL CONDITIONS INFLUENCED BY THE ACTION OF MATRIX METALLOPROTEINASES (MMPs) USING PHANQUINONE |
DE60139720D1 (de) | 2000-06-28 | 2009-10-08 | Glycofi Inc | Verfahren für die Herstellung modifizierter Glykoproteine |
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IL156879A0 (en) * | 2001-01-19 | 2004-02-08 | Dow Chemical Co | Method for secretory production of glycoprotein having human-type sugar chain using plant cell |
EP1367881A2 (en) * | 2001-03-06 | 2003-12-10 | The Dow Chemical Company | Plant cell having animal-type sugar chain adding function |
CN1555411A (zh) | 2001-08-03 | 2004-12-15 | ���迨�����\���ɷݹ�˾ | 抗体-依赖性细胞毒性增大的抗体糖基化变体 |
US20030175755A1 (en) | 2002-03-05 | 2003-09-18 | Yoshihiro Abiko | Method of collecting data for estimation of susceptibility to periodontal disease |
EP2339004B1 (en) | 2002-03-19 | 2015-02-25 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
EP1485492B1 (en) * | 2002-03-19 | 2011-12-21 | Stichting Dienst Landbouwkundig Onderzoek | Gntiii (udp-n-acetylglucosamine:beta-d mannoside beta(1,4)-n-acetylglucosaminyltransferase iii) expression in plants |
US20040014174A1 (en) * | 2002-04-23 | 2004-01-22 | Mayfield Stephen P. | Expression of polypeptides in chloroplasts, and compositions and methods for expressing same |
CL2003002461A1 (es) | 2002-11-27 | 2005-01-07 | Dow Chemical Company Agroscien | Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas. |
-
2003
- 2003-11-27 CL CL200302461A patent/CL2003002461A1/es unknown
- 2003-11-27 AR ARP030104373A patent/AR042145A1/es unknown
- 2003-11-28 BR BR0316739-9A patent/BR0316739A/pt not_active IP Right Cessation
- 2003-11-28 US US10/536,875 patent/US8106169B2/en not_active Expired - Fee Related
- 2003-11-28 CN CNA2003801092320A patent/CN1984993A/zh active Pending
- 2003-11-28 JP JP2004557359A patent/JP2006517392A/ja active Pending
- 2003-11-28 AU AU2003298727A patent/AU2003298727A1/en not_active Abandoned
- 2003-11-28 EP EP03796484A patent/EP1606385A4/en not_active Withdrawn
- 2003-11-28 CA CA002506744A patent/CA2506744A1/en not_active Abandoned
- 2003-11-28 WO PCT/US2003/037905 patent/WO2004050838A2/en active Search and Examination
Also Published As
Publication number | Publication date |
---|---|
EP1606385A4 (en) | 2008-08-13 |
CN1984993A (zh) | 2007-06-20 |
JP2006517392A (ja) | 2006-07-27 |
AU2003298727A1 (en) | 2004-06-23 |
CA2506744A1 (en) | 2004-06-17 |
BR0316739A (pt) | 2005-10-18 |
AR042145A1 (es) | 2005-06-08 |
US20070089201A1 (en) | 2007-04-19 |
WO2004050838A3 (en) | 2006-08-03 |
US8106169B2 (en) | 2012-01-31 |
EP1606385A2 (en) | 2005-12-21 |
WO2004050838A2 (en) | 2004-06-17 |
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