DE602005021379D1 - System und verfahren zur produktion von antikörpern in der pflanzenzellkultur - Google Patents

System und verfahren zur produktion von antikörpern in der pflanzenzellkultur

Info

Publication number
DE602005021379D1
DE602005021379D1 DE602005021379T DE602005021379T DE602005021379D1 DE 602005021379 D1 DE602005021379 D1 DE 602005021379D1 DE 602005021379 T DE602005021379 T DE 602005021379T DE 602005021379 T DE602005021379 T DE 602005021379T DE 602005021379 D1 DE602005021379 D1 DE 602005021379D1
Authority
DE
Germany
Prior art keywords
antibodies
production
cell culture
plant cell
vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005021379T
Other languages
English (en)
Inventor
Yoseph Shaaltiel
Sharon Hashmueli
Daniel Bartfeld
Gideon Baum
Tal Ratz
Einat Mizrachi
Yehava Forester
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Protalix Ltd
Original Assignee
Protalix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protalix Ltd filed Critical Protalix Ltd
Publication of DE602005021379D1 publication Critical patent/DE602005021379D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/13—Immunoglobulins specific features characterized by their source of isolation or production isolated from plants

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
DE602005021379T 2004-10-13 2005-10-11 System und verfahren zur produktion von antikörpern in der pflanzenzellkultur Active DE602005021379D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61764604P 2004-10-13 2004-10-13
PCT/IL2005/001075 WO2006040764A2 (en) 2004-10-13 2005-10-11 System and method for production of antibodies in plant cell culture

Publications (1)

Publication Number Publication Date
DE602005021379D1 true DE602005021379D1 (de) 2010-07-01

Family

ID=35462268

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005021379T Active DE602005021379D1 (de) 2004-10-13 2005-10-11 System und verfahren zur produktion von antikörpern in der pflanzenzellkultur

Country Status (12)

Country Link
US (1) US8119406B2 (de)
EP (1) EP1799813B1 (de)
JP (1) JP2008515454A (de)
KR (1) KR20070085291A (de)
AT (1) ATE468390T1 (de)
AU (1) AU2005293147A1 (de)
CA (1) CA2583691A1 (de)
DE (1) DE602005021379D1 (de)
IL (1) IL182517A (de)
MX (1) MX2007004414A (de)
WO (1) WO2006040764A2 (de)
ZA (1) ZA200703124B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL155588A0 (en) * 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
US20100196345A1 (en) * 2003-04-27 2010-08-05 Protalix Production of high mannose proteins in plant culture
US7951557B2 (en) * 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
EP1799813B1 (de) 2004-10-13 2010-05-19 Metabogal Ltd. System und verfahren zur produktion von antikörpern in der pflanzenzellkultur
JP2010517558A (ja) * 2007-02-09 2010-05-27 サントル ナショナル ドゥ ラ ルシェルシュ スィヤンティフィック（セーエヌエルエス） オストレオコッカス（Ｏｓｔｒｅｏｃｏｃｃｕｓ）種の核ゲノムからのポリペプチドの発現
BRPI0810343B1 (pt) 2007-05-07 2021-03-30 Protalix Ltd Dispositivo descartável para o cultivo e colheita de tecidos vegetais e/ou células, método de cultivo e colheita de um tecido vegetal e/ou células vegetais em um volume maior do que 400 litros e sistema de cultivo da célula vegetal
CA2787099A1 (en) 2009-03-30 2010-10-14 Anice C. Lowen Influenza virus hemagglutinin polypeptides containing stem domains, vaccines and uses thereof
KR20230164773A (ko) 2009-08-28 2023-12-04 이칸 스쿨 오브 메디슨 엣 마운트 시나이 산성 스핑고미엘리나제 결핍을 치료하기 위한 투여량 단계적 증가 효소 대체 요법
JP2013526849A (ja) 2010-03-30 2013-06-27 モウント シナイ スクール オフ メディシネ インフルエンザウイルスワクチン及びその使用
EP4241785A3 (de) 2011-09-20 2023-09-27 Icahn School of Medicine at Mount Sinai Influenzavirus-impfstoffe und verwendungen davon
NZ627796A (en) 2012-12-18 2017-07-28 Icahn School Med Mount Sinai Influenza virus vaccines and uses thereof
WO2014159960A1 (en) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
EP3092002B1 (de) * 2014-01-09 2019-09-25 Kentucky Bioprocessing, Inc. Verfahren zur reinigung monoklonaler antikörper
GB201411802D0 (en) 2014-07-02 2014-08-13 Univ Bradford Effervescent compositions
US9340604B1 (en) 2014-10-29 2016-05-17 Aridis Pharmaceuticals, Inc. Human monoclonal antibody specific for the F protein of respiratory syncytial virus (RSV)
US10736956B2 (en) 2015-01-23 2020-08-11 Icahn School Of Medicine At Mount Sinai Influenza virus vaccination regimens
CN109641041A (zh) 2016-06-15 2019-04-16 西奈山伊坎医学院 流感病毒血细胞凝集素蛋白及其用途
US20190352659A1 (en) 2016-11-30 2019-11-21 Kirin Company, Limited Method for Producing Useful Protein by Means of Plant
CA3058652A1 (en) 2017-04-07 2018-10-11 Icahn School Of Medicine At Mount Sinai Anti-influenza b virus neuraminidase antibodies and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080560A (en) * 1994-07-25 2000-06-27 Monsanto Company Method for producing antibodies in plant cells
AR020090A1 (es) 1998-06-15 2002-04-10 John Innes Ct Celula vegetal monocotiledonea o semilla de ella,planta o parte de una planta, metodo para hacer una celula vegetal monocotiledonea, metodo para hacer unaplanta, uso de una construccion de expresion para producir una celula de planta o semilla monocotiledonea, y uso de una construccion de expresion
AU6021699A (en) 1998-09-01 2000-03-21 Penn State Research Foundation Method and apparatus for aseptic growth or processing of biomass
US6528063B2 (en) 1999-01-04 2003-03-04 Rahan Meristem Recombinant vaccines against IBDV
US6962700B1 (en) 2000-09-13 2005-11-08 Atopix Pharmaceuticals Corporation Method of manufacturing immune globulin
WO2002101006A2 (en) * 2001-06-08 2002-12-19 Icon Genetics, Inc. Production of proteins in plants
WO2003013598A2 (en) 2001-08-09 2003-02-20 Lam Dominic M K Novel vaccine compositions and methods of vaccine preparation for veterinary and human diseases
CL2003002461A1 (es) 2002-11-27 2005-01-07 Dow Chemical Company Agroscien Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas.
PT1431394E (pt) 2002-12-20 2006-12-29 Greenovation Biotech Gmbh Metodo de produção de proteinas glicosiladas heterologas em celulas de briofitos
EP1799813B1 (de) 2004-10-13 2010-05-19 Metabogal Ltd. System und verfahren zur produktion von antikörpern in der pflanzenzellkultur

Also Published As

Publication number Publication date
EP1799813B1 (de) 2010-05-19
US20090082548A1 (en) 2009-03-26
MX2007004414A (es) 2007-09-25
ATE468390T1 (de) 2010-06-15
WO2006040764A3 (en) 2006-07-06
EP1799813A2 (de) 2007-06-27
CA2583691A1 (en) 2006-04-20
WO2006040764A2 (en) 2006-04-20
AU2005293147A1 (en) 2006-04-20
KR20070085291A (ko) 2007-08-27
IL182517A0 (en) 2007-09-20
US8119406B2 (en) 2012-02-21
IL182517A (en) 2012-06-28
JP2008515454A (ja) 2008-05-15
ZA200703124B (en) 2008-08-27

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