CA3101270A1 - Anticorps anti-cd33, anticorps bispecifiques anti-cd33/anti-cd3 et leurs utilisations - Google Patents
Anticorps anti-cd33, anticorps bispecifiques anti-cd33/anti-cd3 et leurs utilisations Download PDFInfo
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- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
L'invention concerne des anticorps anti-CD33 et des fragments associés de liaison à l'antigène et des anticorps bispécifiques anti-CD33/anti-CD3 ou des fragments associés de liaison à l'antigène. L'invention concerne également des acides nucléiques codant pour les anticorps, des compositions comprenant les anticorps, et des procédés de production des anticorps et des méthodes d'utilisation des anticorps pour traiter ou prévenir des maladies telles que le cancer.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US201862676123P | 2018-05-24 | 2018-05-24 | |
US62/676,123 | 2018-05-24 | ||
US201962825846P | 2019-03-29 | 2019-03-29 | |
US62/825,846 | 2019-03-29 | ||
PCT/IB2019/054182 WO2019224711A2 (fr) | 2018-05-24 | 2019-05-21 | Anticorps anti-cd33, anticorps bispécifiques anti-cd33/anti-cd3 et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
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CA3101270A1 true CA3101270A1 (fr) | 2019-11-28 |
Family
ID=67211770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA3101270A Pending CA3101270A1 (fr) | 2018-05-24 | 2019-05-21 | Anticorps anti-cd33, anticorps bispecifiques anti-cd33/anti-cd3 et leurs utilisations |
Country Status (23)
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US (1) | US11466082B2 (fr) |
EP (1) | EP3802606A2 (fr) |
JP (1) | JP2021524244A (fr) |
KR (1) | KR20210013156A (fr) |
CN (1) | CN112189022A (fr) |
AU (1) | AU2019274229A1 (fr) |
BR (1) | BR112020023357A2 (fr) |
CA (1) | CA3101270A1 (fr) |
CL (1) | CL2020003028A1 (fr) |
CO (1) | CO2020014575A2 (fr) |
CR (1) | CR20200567A (fr) |
EC (1) | ECSP20075198A (fr) |
IL (1) | IL278844A (fr) |
JO (1) | JOP20190116A1 (fr) |
MA (1) | MA52771A (fr) |
MX (1) | MX2020012588A (fr) |
NI (1) | NI202000088A (fr) |
PE (1) | PE20210180A1 (fr) |
PH (1) | PH12020552010A1 (fr) |
SG (1) | SG11202011210TA (fr) |
TW (1) | TW202033551A (fr) |
UY (1) | UY38242A (fr) |
WO (1) | WO2019224711A2 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
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KR102537102B1 (ko) | 2015-05-29 | 2023-05-25 | 엠피베나 테라퓨틱스, 인크. | 이중특이적 cd33 및 cd3 결합 단백질을 사용하는 방법 |
EP3802608A2 (fr) | 2018-05-24 | 2021-04-14 | Janssen Biotech, Inc. | Anticorps anti-cd3 et leurs utilisations |
DE102018127845A1 (de) | 2018-11-07 | 2020-05-07 | Grimme Landmaschinenfabrik Gmbh & Co. Kg | Verfahren zur Regelung des Betriebs einer Maschine zum Ernten von Hackfrüchten |
CN114502584A (zh) * | 2019-02-22 | 2022-05-13 | 纪念斯隆凯特琳癌症中心 | Cd33抗体和使用所述抗体治疗癌症的方法 |
US20210179724A1 (en) * | 2019-12-09 | 2021-06-17 | Twist Bioscience Corporation | Variant nucleic acid libraries for adenosine receptors |
EP4233895A3 (fr) * | 2020-03-13 | 2023-09-27 | Janssen Biotech, Inc. | Matériaux et procédés de liaison de siglec-3/cd33 |
JP2023519932A (ja) * | 2020-03-31 | 2023-05-15 | フレッド ハッチンソン キャンサー センター | 抗cd33抗体及びその使用 |
WO2021231237A2 (fr) * | 2020-05-11 | 2021-11-18 | Augmenta Bioworks, Inc. | Anticorps anti sras-cov-2 et leurs utilisations |
JP2023542257A (ja) | 2020-09-16 | 2023-10-05 | アムジェン インコーポレイテッド | 癌の治療のために二重特異性t細胞誘導分子の治療用量を投与する方法 |
US20220259319A1 (en) * | 2021-01-21 | 2022-08-18 | Twist Bioscience Corporation | Methods and compositions relating to adenosine receptors |
CA3211163A1 (fr) | 2021-02-16 | 2022-08-25 | Janssen Pharmaceutica Nv | Anticorps trispecifique ciblant bcma, gprc5d et cd3 |
KR20230160874A (ko) | 2021-03-24 | 2023-11-24 | 얀센 바이오테크 인코포레이티드 | CD79b, CD20 및 CD3을 표적으로 하는 삼중특이적 항체 |
WO2022228471A1 (fr) * | 2021-04-27 | 2022-11-03 | 上海驯鹿生物技术有限公司 | Cellule souche hématopoïétique génétiquement modifiée et son utilisation en combinaison avec lymphocyte car-t |
EP4377354A1 (fr) * | 2021-07-30 | 2024-06-05 | Nanjing Legend Biotech Co., Ltd. | Anticorps anti-cd33 et leurs utilisations |
WO2023034564A2 (fr) * | 2021-09-02 | 2023-03-09 | Memorial Sloan-Kettering Cancer Center | Anticorps anti-cd33 et leurs utilisations |
KR20240055002A (ko) * | 2021-09-13 | 2024-04-26 | 얀센 바이오테크 인코포레이티드 | 암 치료를 위한 CD33 x Vδ2 다중특이성 항체 |
WO2023081898A1 (fr) * | 2021-11-08 | 2023-05-11 | Alector Llc | Cd33 soluble en tant que biomarqueur pour une efficacité anti-cd33 |
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US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
US20020142000A1 (en) | 1999-01-15 | 2002-10-03 | Digan Mary Ellen | Anti-CD3 immunotoxins and therapeutic uses therefor |
CN102875680B (zh) | 2002-11-07 | 2015-04-22 | 伊谬诺金公司 | 抗-cd33抗体和使用其治疗急性髓性白血病的方法 |
AU2005282700A1 (en) | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Heteromultimeric molecules |
ES2592271T3 (es) | 2005-03-31 | 2016-11-29 | Chugai Seiyaku Kabushiki Kaisha | Métodos de producción de polipéptidos mediante la regulación de la asociación de los polipéptidos |
DE102005028778A1 (de) | 2005-06-22 | 2006-12-28 | SUNJÜT Deutschland GmbH | Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage |
EP1940881B1 (fr) | 2005-10-11 | 2016-11-30 | Amgen Research (Munich) GmbH | Compositions comportant des anticorps specifiques d'especes croisees et leurs utilisations |
US20090182127A1 (en) | 2006-06-22 | 2009-07-16 | Novo Nordisk A/S | Production of Bispecific Antibodies |
WO2008119567A2 (fr) | 2007-04-03 | 2008-10-09 | Micromet Ag | Domaine de liaison spécifique d'espèces croisées |
CN109456410B (zh) | 2007-04-03 | 2022-01-28 | 安进研发(慕尼黑)股份有限公司 | 跨物种特异性CD3-ε结合结构域 |
US20100183615A1 (en) | 2007-04-03 | 2010-07-22 | Micromet Ag | Cross-species-specific bispecific binders |
US10981998B2 (en) | 2008-10-01 | 2021-04-20 | Amgen Research (Munich) Gmbh | Cross-species-specific single domain bispecific single chain antibody |
PT2352763E (pt) | 2008-10-01 | 2016-06-02 | Amgen Res (Munich) Gmbh | Anticorpos biespecíficos de cadeia única com especificidade para antigénios-alvo com elevado peso molecular |
RS54900B1 (sr) | 2008-10-01 | 2016-10-31 | Amgen Res (Munich) Gmbh | Interspecijski specifično psmaxcd3 bispecifično jednolančano antitelo |
CN102459346B (zh) | 2009-04-27 | 2016-10-26 | 昂考梅德药品有限公司 | 制造异源多聚体分子的方法 |
EA201201435A1 (ru) | 2010-04-20 | 2013-04-30 | Генмаб А/С | ГЕТЕРОДИМЕРНЫЕ АНТИТЕЛО-Fc-СОДЕРЖАЩИЕ БЕЛКИ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ |
UA112062C2 (uk) | 2010-10-04 | 2016-07-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Cd33-зв'язувальний агент |
MX352929B (es) | 2010-11-05 | 2017-12-13 | Zymeworks Inc | DISEÑO DE ANTICUERPOS HETERODIMÉRICOS ESTABLES CON MUTACIONES EN EL DOMINIO Fc. |
PT2773671T (pt) | 2011-11-04 | 2021-12-14 | Zymeworks Inc | Geração de anticorpo heterodimérico estável com mutações no domínio fc |
CN104994729B (zh) | 2012-12-14 | 2019-01-11 | Omt公司 | 编码具有人独特型的啮齿动物抗体的多核苷酸以及包含所述多核苷酸的动物 |
TWI688401B (zh) | 2013-09-13 | 2020-03-21 | 美商安進公司 | 用於治療骨髓性白血病的表觀遺傳因子與靶向cd33及cd3之雙特異性化合物的組合 |
EP3461845B1 (fr) | 2013-12-13 | 2020-09-16 | Genentech, Inc. | Anticorps et immunoconjugués anti-cd33 |
US9212225B1 (en) | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
PL3189081T3 (pl) * | 2014-09-05 | 2020-10-05 | Janssen Pharmaceutica Nv | Środki wiążące cd123 i ich zastosowania |
CA2988982A1 (fr) * | 2015-06-12 | 2016-12-15 | Alector Llc | Anticorps anti-cd33 et leurs procedes d'utilisation |
JP2018518491A (ja) * | 2015-06-12 | 2018-07-12 | アレクトル エルエルシー | 抗cd33抗体及びその使用方法 |
CN110662765B (zh) | 2017-08-03 | 2023-09-29 | 艾利妥 | 抗cd33抗体及其使用方法 |
SG11202007943RA (en) | 2018-02-20 | 2020-09-29 | Dragonfly Therapeutics Inc | Antibody variable domains targeting cd33, and use thereof |
EP3802608A2 (fr) * | 2018-05-24 | 2021-04-14 | Janssen Biotech, Inc. | Anticorps anti-cd3 et leurs utilisations |
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CO2020014575A2 (es) | 2020-12-10 |
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UY38242A (es) | 2019-11-29 |
WO2019224711A2 (fr) | 2019-11-28 |
EP3802606A2 (fr) | 2021-04-14 |
BR112020023357A2 (pt) | 2021-04-27 |
AU2019274229A1 (en) | 2020-11-26 |
CN112189022A (zh) | 2021-01-05 |
NI202000088A (es) | 2021-03-23 |
JOP20190116A1 (ar) | 2019-11-24 |
WO2019224711A3 (fr) | 2020-01-02 |
IL278844A (en) | 2021-01-31 |
PH12020552010A1 (en) | 2021-06-14 |
JP2021524244A (ja) | 2021-09-13 |
ECSP20075198A (es) | 2020-12-31 |
CL2020003028A1 (es) | 2021-04-16 |
US20190382481A1 (en) | 2019-12-19 |
MA52771A (fr) | 2021-04-14 |
CR20200567A (es) | 2021-01-20 |
SG11202011210TA (en) | 2020-12-30 |
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