CA3089159A1 - Derive de pyrazolo[1,5-a][1,3,5]triazine-2-amine, son procede de preparation et son utilisation medicale - Google Patents

Derive de pyrazolo[1,5-a][1,3,5]triazine-2-amine, son procede de preparation et son utilisation medicale Download PDF

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Publication number
CA3089159A1
CA3089159A1 CA3089159A CA3089159A CA3089159A1 CA 3089159 A1 CA3089159 A1 CA 3089159A1 CA 3089159 A CA3089159 A CA 3089159A CA 3089159 A CA3089159 A CA 3089159A CA 3089159 A1 CA3089159 A1 CA 3089159A1
Authority
CA
Canada
Prior art keywords
group
alkyl
heterocyclyl
compound
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3089159A
Other languages
English (en)
Inventor
Biao Lu
Bin GUI
Junzhen ZHANG
Feng He
Weikang Tao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of CA3089159A1 publication Critical patent/CA3089159A1/fr
Abandoned legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne un dérivé de pyrazolo[1,5-a][1,3,5]triazine-2-amine tel que représenté par la formule générale (I), un procédé de préparation de celui-ci, une composition pharmaceutique contenant le dérivé et son utilisation en tant qu'agent thérapeutique, en particulier son utilisation en tant qu'antagoniste du récepteur A2a ainsi qu'une utilisation associée dans la préparation de médicaments pour le traitement d'états pathologiques ou de maladies atténués par l'inhibition des récepteurs A2a.
CA3089159A 2018-02-06 2019-02-01 Derive de pyrazolo[1,5-a][1,3,5]triazine-2-amine, son procede de preparation et son utilisation medicale Abandoned CA3089159A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810118455 2018-02-06
CN201810118455.1 2018-02-06
PCT/CN2019/074324 WO2019154294A1 (fr) 2018-02-06 2019-02-01 Dérivé de pyrazolo[1,5-a][1,3,5]triazine-2-amine, son procédé de préparation et son utilisation médicale

Publications (1)

Publication Number Publication Date
CA3089159A1 true CA3089159A1 (fr) 2019-08-15

Family

ID=67548154

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3089159A Abandoned CA3089159A1 (fr) 2018-02-06 2019-02-01 Derive de pyrazolo[1,5-a][1,3,5]triazine-2-amine, son procede de preparation et son utilisation medicale

Country Status (7)

Country Link
US (1) US20210032253A1 (fr)
EP (1) EP3750891A4 (fr)
JP (1) JP2021512959A (fr)
CN (1) CN111511745B (fr)
CA (1) CA3089159A1 (fr)
TW (1) TWI701251B (fr)
WO (1) WO2019154294A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020527593A (ja) 2017-07-18 2020-09-10 ニューベイション・バイオ・インコーポレイテッドNuvation Bio Inc. 1,8−ナフチリジノン化合物およびその使用
US11028058B2 (en) 2017-07-18 2021-06-08 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists
WO2020150674A1 (fr) 2019-01-18 2020-07-23 Nuvation Bio Inc. Composés hétérocycliques en tant qu'antagonistes de l'adénosine
JP2022523473A (ja) 2019-01-18 2022-04-25 ニューベイション・バイオ・インコーポレイテッド 1,8-ナフチリジジノン化合物およびそれらの使用
CN112574214B (zh) * 2019-07-30 2021-09-28 杭州阿诺生物医药科技有限公司 腺苷受体拮抗剂的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2244487B (en) * 1990-05-29 1994-02-02 Ici Plc Azole derivatives
US5356894A (en) * 1990-05-29 1994-10-18 Rodney Peter W Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist
ATE375344T1 (de) * 1996-07-24 2007-10-15 Bristol Myers Squibb Pharma Co Azolotriazine und pyrimidine
EP1012151B1 (fr) * 1997-09-02 2002-08-07 Bristol-Myers Squibb Pharma Company Pyridines a cycle fusionne et a substitution heterocyclyle, antagonistes du facteur de liberation de la cortitropine (crf), utiles dans le traitement des troubles lies au snc et au stress
AU4331500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
FR2842809A1 (fr) * 2002-07-26 2004-01-30 Greenpharma Sas NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
WO2004110454A1 (fr) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. Composition de traitement ou de prevention de maladies necessitant l'administration d'un agoniste du recepteur a2a de l'adenosine
KR20080014150A (ko) 2004-06-14 2008-02-13 미쓰이 가가쿠 가부시키가이샤 3-아미노메틸테트라히드로푸란 유도체의 제조방법
WO2007116106A1 (fr) 2006-04-12 2007-10-18 Palobiofarma, S.L. Nouveaux composés utilisés comme antagonistes des récepteurs a1 de l'adénosine
DE102007061763A1 (de) 2007-12-20 2009-06-25 Bayer Healthcare Ag Substituierte azabicyclische Verbindungen und ihre Verwendung
GB0906579D0 (en) * 2009-04-16 2009-05-20 Vernalis R&D Ltd Pharmaceuticals, compositions and methods of making and using the same
JP5914361B2 (ja) 2010-02-05 2016-05-11 ヘプタレス セラピューティックス リミテッド 1,2,4−トリアジン−4−アミン含有誘導体
WO2011159302A1 (fr) 2010-06-17 2011-12-22 Janssen Pharmaceutica Nv Arylindenopyrimidines pour traiter les troubles neurodégénératifs et les troubles du mouvement tout en limitant la toxicité cardiaque
KR20130136504A (ko) 2010-12-07 2013-12-12 바이엘 인텔렉쳐 프로퍼티 게엠베하 치환된 1-벤질사이클로알킬카르복실산 및 그의 용도
TWI577671B (zh) 2011-11-14 2017-04-11 Sunshine Lake Pharma Co Ltd Aminoquinazoline derivatives and salts thereof and methods of use thereof
WO2014101120A1 (fr) 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Composés de 7-méthoxy-[1,2,4]triazolo[1,5-c]quinazoline-5-amine à substitution hétérobicyclo présentant des propriétés d'antagoniste d'a2a
WO2015027431A1 (fr) 2013-08-29 2015-03-05 Merck Sharp & Dohme Corp. Antagonistes 2,2-difluorodioxolo du récepteur a2a
GB201517263D0 (en) * 2015-09-30 2015-11-11 Ucb Biopharma Sprl And Katholieke Universiteit Leuven Therapeutic agents
JP7071389B2 (ja) * 2017-03-07 2022-05-18 グアンジョウ マキシノベル ファーマシューティカルズ カンパニー リミテッド アミノピリミジン縮合5員複素環化合物、その中間体、製造方法、薬物組成物および使用

Also Published As

Publication number Publication date
TWI701251B (zh) 2020-08-11
CN111511745B (zh) 2022-05-27
CN111511745A (zh) 2020-08-07
EP3750891A1 (fr) 2020-12-16
WO2019154294A1 (fr) 2019-08-15
JP2021512959A (ja) 2021-05-20
US20210032253A1 (en) 2021-02-04
TW201934554A (zh) 2019-09-01
EP3750891A4 (fr) 2021-08-11

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Date Code Title Description
FZDE Discontinued

Effective date: 20230802