CA2896185A1 - Fluoro-[1,3]oxazines servant d'inhibiteurs de la bace1 - Google Patents
Fluoro-[1,3]oxazines servant d'inhibiteurs de la bace1 Download PDFInfo
- Publication number
- CA2896185A1 CA2896185A1 CA2896185A CA2896185A CA2896185A1 CA 2896185 A1 CA2896185 A1 CA 2896185A1 CA 2896185 A CA2896185 A CA 2896185A CA 2896185 A CA2896185 A CA 2896185A CA 2896185 A1 CA2896185 A1 CA 2896185A1
- Authority
- CA
- Canada
- Prior art keywords
- dihydro
- trifluoromethyl
- oxazin
- methyl
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
- C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13152213.8 | 2013-01-22 | ||
| EP13152213 | 2013-01-22 | ||
| PCT/EP2014/050645 WO2014114532A1 (fr) | 2013-01-22 | 2014-01-15 | Fluoro- [1,3] oxazines servant d'inhibiteurs de la bace1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2896185A1 true CA2896185A1 (fr) | 2014-07-31 |
Family
ID=47559345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2896185A Abandoned CA2896185A1 (fr) | 2013-01-22 | 2014-01-15 | Fluoro-[1,3]oxazines servant d'inhibiteurs de la bace1 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20150376172A1 (fr) |
| EP (1) | EP2948446A1 (fr) |
| JP (1) | JP2016505055A (fr) |
| KR (1) | KR20150109429A (fr) |
| CN (1) | CN104968660A (fr) |
| BR (1) | BR112015016315A2 (fr) |
| CA (1) | CA2896185A1 (fr) |
| HK (1) | HK1210609A1 (fr) |
| MX (1) | MX2015008957A (fr) |
| RU (1) | RU2015132181A (fr) |
| WO (1) | WO2014114532A1 (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102119161B (zh) | 2008-06-13 | 2015-07-08 | 盐野义制药株式会社 | 具有β分泌酶抑制作用的含硫杂环衍生物 |
| JPWO2011071135A1 (ja) † | 2009-12-11 | 2013-04-22 | 塩野義製薬株式会社 | オキサジン誘導体 |
| WO2014065434A1 (fr) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dérivés de dihydrooxazine ou d'oxazépine ayant une activité inhibitrice de bace1 |
| MX366855B (es) * | 2013-03-01 | 2019-07-26 | Amgen Inc | Compuestos perfluorados de 5,6-dihidro-4h-1,3-oxazin-2-amina como inhibidores de beta-secretasa y metodos de uso. |
| MX2015011618A (es) | 2013-03-08 | 2015-12-17 | Amgen Inc | Compuestos de 1,3-oxazin-2-amina fusionados con ciclopropilo perfluorado como inhibidores de beta-secretasa y metodos de uso. |
| TW201623295A (zh) | 2014-04-11 | 2016-07-01 | 塩野義製藥股份有限公司 | 具有ｂａｃｅ１抑制活性之二氫噻及二氫衍生物 |
| MX2017001794A (es) | 2014-08-08 | 2017-06-29 | Amgen Inc | Compuestos de tiazin-2-amina fusionados con ciclopropilo como inhibidores de beta-secretasa y metodos de uso. |
| US10047081B2 (en) | 2015-03-20 | 2018-08-14 | Hoffman-La Roche Inc. | BACE1 inhibitors |
| CN107683283B (zh) * | 2015-08-12 | 2021-05-18 | 豪夫迈·罗氏有限公司 | Bace1抑制剂 |
| WO2017061534A1 (fr) | 2015-10-08 | 2017-04-13 | Shionogi & Co., Ltd. | Dérivés de dihydrothiazine |
| MA52119A (fr) | 2015-10-19 | 2018-08-29 | Ncyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| EP3377488B1 (fr) | 2015-11-19 | 2022-08-10 | Incyte Corporation | Composés hétérocycliques utilisés comme immunomodulateurs |
| ES2916874T3 (es) * | 2015-12-17 | 2022-07-06 | Incyte Corp | Derivados de N-fenil-piridina-2-carboxamida y su uso como moduladores de la interacción proteína/proteína PD-1/PD-L1 |
| MD3394033T2 (ro) | 2015-12-22 | 2021-04-30 | Incyte Corp | Compuși heterociclici ca imunomodulatori |
| WO2017148878A1 (fr) * | 2016-03-01 | 2017-09-08 | F. Hoffmann-La Roche Ag | Inhibiteurs de bace1 |
| AR108396A1 (es) | 2016-05-06 | 2018-08-15 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| MA45116A (fr) | 2016-05-26 | 2021-06-02 | Incyte Corp | Composés hétérocycliques comme immunomodulateurs |
| JP7000357B2 (ja) | 2016-06-20 | 2022-01-19 | インサイト・コーポレイション | 免疫調節剤としての複素環化合物 |
| WO2018013789A1 (fr) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Composés hétérocycliques utilisés comme immunomodulateurs |
| MA46045A (fr) | 2016-08-29 | 2021-04-28 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| MX2019007103A (es) * | 2016-12-15 | 2019-11-05 | Amgen Inc | Derivados de tiazina condensados con ciclopropilo como inhibidores de beta-secretasa y metodos de uso. |
| WO2018119221A1 (fr) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Dérivés pyridine utilisés en tant qu'immunomodulateurs |
| WO2018119236A1 (fr) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Dérivés de triazolo[1,5-a]pyridine en tant qu'immunomodulateurs |
| JP7101678B2 (ja) | 2016-12-22 | 2022-07-15 | インサイト・コーポレイション | 免疫調節剤としての複素環式化合物 |
| MD3558990T2 (ro) | 2016-12-22 | 2023-02-28 | Incyte Corp | Derivați tetrahidro imidazo[4,5-c]piridină ca inductori de internalizare a PD-L1 |
| CN110475776B (zh) | 2017-03-31 | 2024-03-19 | 拜耳作物科学股份公司 | 用于防治节肢动物的三环羧酰胺 |
| AU2019245288C1 (en) | 2018-03-30 | 2024-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| TW202014191A (zh) | 2018-04-27 | 2020-04-16 | 日商鹽野義製藥股份有限公司 | 具有選擇性ｂａｃｅ１抑制活性的四氫哌喃并衍生物 |
| PE20211918A1 (es) | 2018-05-11 | 2021-09-28 | Incyte Corp | Derivados de tetrahidro-imidazo[4,5-c]piridin como inmunomoduladores de pd-l1 |
| EP4010342A1 (fr) | 2019-08-09 | 2022-06-15 | Incyte Corporation | Sels d'un inhibiteur de pd-1/pd-l1 |
| EP4037773A1 (fr) | 2019-09-30 | 2022-08-10 | Incyte Corporation | Composés pyrido[3,2-d]pyrimidine en tant qu'immunomodulateurs |
| WO2021096849A1 (fr) | 2019-11-11 | 2021-05-20 | Incyte Corporation | Formes salines et cristallines d'un inhibiteur de pd-1/pd-l1 |
| CN111892550B (zh) * | 2020-08-25 | 2022-07-19 | 苏州大学 | 4-苯基-6h-1,3-噁嗪-6-酮衍生物及其制备和应用 |
| TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式 |
| AR124001A1 (es) | 2020-11-06 | 2023-02-01 | Incyte Corp | Proceso para fabricar un inhibidor pd-1 / pd-l1 y sales y formas cristalinas del mismo |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8785436B2 (en) * | 2011-05-16 | 2014-07-22 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE 1 and/or BACE2 inhibitors |
| AU2012266544A1 (en) * | 2011-06-07 | 2013-11-21 | F. Hoffmann-La Roche Ag | Halogen-alkyl-1,3 oxazines as BACE1 and/or BACE2 inhibitors |
| MX2013014007A (es) * | 2011-06-07 | 2014-03-12 | Hoffmann La Roche | [1,3] oxazinas. |
| US9067926B2 (en) * | 2012-01-26 | 2015-06-30 | Hoffmann-La Roche Inc. | Fluoromethyl-5,6-dihydro-4H-[1,3]OXAZINES |
-
2014
- 2014-01-15 CN CN201480005486.6A patent/CN104968660A/zh active Pending
- 2014-01-15 BR BR112015016315A patent/BR112015016315A2/pt not_active IP Right Cessation
- 2014-01-15 MX MX2015008957A patent/MX2015008957A/es unknown
- 2014-01-15 KR KR1020157022408A patent/KR20150109429A/ko not_active Application Discontinuation
- 2014-01-15 JP JP2015554106A patent/JP2016505055A/ja active Pending
- 2014-01-15 EP EP14700493.1A patent/EP2948446A1/fr not_active Withdrawn
- 2014-01-15 WO PCT/EP2014/050645 patent/WO2014114532A1/fr active Application Filing
- 2014-01-15 US US14/759,980 patent/US20150376172A1/en not_active Abandoned
- 2014-01-15 RU RU2015132181A patent/RU2015132181A/ru unknown
- 2014-01-15 CA CA2896185A patent/CA2896185A1/fr not_active Abandoned
-
2015
- 2015-11-17 HK HK15111336.3A patent/HK1210609A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20150376172A1 (en) | 2015-12-31 |
| KR20150109429A (ko) | 2015-10-01 |
| CN104968660A (zh) | 2015-10-07 |
| WO2014114532A1 (fr) | 2014-07-31 |
| RU2015132181A (ru) | 2017-03-02 |
| MX2015008957A (es) | 2015-09-29 |
| HK1210609A1 (en) | 2016-04-29 |
| BR112015016315A2 (pt) | 2017-07-11 |
| EP2948446A1 (fr) | 2015-12-02 |
| JP2016505055A (ja) | 2016-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20180116 |