CA2793359A1 - Procede pour la preparation du sel de l'acide maleique du sunitinib - Google Patents

Procede pour la preparation du sel de l'acide maleique du sunitinib Download PDF

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Publication number
CA2793359A1
CA2793359A1 CA2793359A CA2793359A CA2793359A1 CA 2793359 A1 CA2793359 A1 CA 2793359A1 CA 2793359 A CA2793359 A CA 2793359A CA 2793359 A CA2793359 A CA 2793359A CA 2793359 A1 CA2793359 A1 CA 2793359A1
Authority
CA
Canada
Prior art keywords
malic acid
sunitinib
process according
acid salt
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2793359A
Other languages
English (en)
Inventor
Sudhir Singh Sanwal
Saridi Madhava Dileep Kumar
Swargam Sathyanarayana
Rajesh Kumar Thaper
Mohan Prasad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of CA2793359A1 publication Critical patent/CA2793359A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2793359A 2010-03-18 2011-02-25 Procede pour la preparation du sel de l'acide maleique du sunitinib Abandoned CA2793359A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN635/DEL/2010 2010-03-18
IN635DE2010 2010-03-18
PCT/IB2011/050820 WO2011114246A1 (fr) 2010-03-18 2011-02-25 Procédé pour la préparation du sel de l'acide maléique du sunitinib

Publications (1)

Publication Number Publication Date
CA2793359A1 true CA2793359A1 (fr) 2011-09-22

Family

ID=43983774

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2793359A Abandoned CA2793359A1 (fr) 2010-03-18 2011-02-25 Procede pour la preparation du sel de l'acide maleique du sunitinib

Country Status (6)

Country Link
US (1) US20160185760A1 (fr)
EP (1) EP2547674A1 (fr)
AU (1) AU2011228765A1 (fr)
CA (1) CA2793359A1 (fr)
WO (1) WO2011114246A1 (fr)
ZA (1) ZA201207547B (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ303705B6 (cs) 2000-02-15 2013-03-27 Sugen, Inc. Pyrrolem substituovaná 2-indolinonová sloucenina pro pouzití jako inhibitor proteinkináz a farmaceutická kompozice s jejím obsahem
CN100439360C (zh) 2001-08-15 2008-12-03 法玛西雅厄普约翰美国公司 包括n-[2-(二乙氨基)乙基]-5-[(5-氟-2-氧代-3h-吲哚-3-亚基)甲基]-2,4-二甲基-1h-吡咯-3-甲酰胺的苹果酸盐的晶体、其制备方法和其组合物
CA2699305A1 (fr) 2007-11-21 2009-05-28 Teva Pharmaceutical Industries Ltd. Polymorphes de base de sunitinib et procedes pour les preparer
AR072117A1 (es) 2008-06-13 2010-08-04 Medichem Sa Procedimiento para preparar una sal de malato 3-pirrol sustituido 2-indolinona, intermediario de sintesis y una composicion farmaceutica que la comprende.
WO2009157011A1 (fr) * 2008-06-23 2009-12-30 Natco Pharma Limited Procédé de préparation de sunitinib de haute pureté et de ses sels pharmaceutiquement acceptables
EP2186809A1 (fr) * 2008-11-13 2010-05-19 LEK Pharmaceuticals D.D. Nouvelle forme cristalline du malate de sunitinib

Also Published As

Publication number Publication date
US20160185760A1 (en) 2016-06-30
AU2011228765A1 (en) 2012-10-11
EP2547674A1 (fr) 2013-01-23
ZA201207547B (en) 2013-06-26
WO2011114246A1 (fr) 2011-09-22

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead

Effective date: 20150205