AR072117A1 - Procedimiento para preparar una sal de malato 3-pirrol sustituido 2-indolinona, intermediario de sintesis y una composicion farmaceutica que la comprende. - Google Patents

Procedimiento para preparar una sal de malato 3-pirrol sustituido 2-indolinona, intermediario de sintesis y una composicion farmaceutica que la comprende.

Info

Publication number
AR072117A1
AR072117A1 ARP090102129A ARP090102129A AR072117A1 AR 072117 A1 AR072117 A1 AR 072117A1 AR P090102129 A ARP090102129 A AR P090102129A AR P090102129 A ARP090102129 A AR P090102129A AR 072117 A1 AR072117 A1 AR 072117A1
Authority
AR
Argentina
Prior art keywords
salt
prepare
pirrol
indolinone
understands
Prior art date
Application number
ARP090102129A
Other languages
English (en)
Inventor
Bernardino Mangion
Stephen Benedict David Winter
Original Assignee
Medichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa filed Critical Medichem Sa
Publication of AR072117A1 publication Critical patent/AR072117A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Abstract

Sal de  cido m lico de N-[2-(dietilamino)etil]-5-formil-2,4-dimetil-1H-pirrol-3-carboxamida, al uso de la misma como intermediario para preparar la sal de acido m lico de sunitinib, y a composiciones farmaceuticas que comprenden dicha sal de  cido m lico de sunitinib. Reivindicacion 1: Un procedimiento para preparar la sal de  cido m lico de sunitinib (sal de  cido m lico del compuesto de formula 1), dicho procedimiento comprende tratar la sal de  cido m lico de la (2-dietilaminoetil)amida del  cido 5-formil-2,4-dimetil-1H-pirrol-3-carbox¡lico (sal de  cido m lico del compuesto de formula 2) con 5-fluoro-1,3-dihidroindol-2-ona (compuesto de formula 3) en presencia de un solvente org nico y una amina org nica.
ARP090102129A 2008-06-13 2009-06-12 Procedimiento para preparar una sal de malato 3-pirrol sustituido 2-indolinona, intermediario de sintesis y una composicion farmaceutica que la comprende. AR072117A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6143008P 2008-06-13 2008-06-13

Publications (1)

Publication Number Publication Date
AR072117A1 true AR072117A1 (es) 2010-08-04

Family

ID=41055390

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090102129A AR072117A1 (es) 2008-06-13 2009-06-12 Procedimiento para preparar una sal de malato 3-pirrol sustituido 2-indolinona, intermediario de sintesis y una composicion farmaceutica que la comprende.

Country Status (7)

Country Link
US (1) US8153678B2 (es)
EP (1) EP2313371B1 (es)
AR (1) AR072117A1 (es)
ES (1) ES2392762T3 (es)
IL (1) IL209949A0 (es)
SI (1) SI2313371T1 (es)
WO (1) WO2009150523A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011004200A1 (en) * 2009-07-10 2011-01-13 Generics [Uk] Limited Novel pyrrole derivatives
WO2011095802A1 (en) * 2010-02-02 2011-08-11 Generics [Uk] Limited Hplc method for analyzing sunitinib
WO2011104555A2 (en) 2010-02-25 2011-09-01 Generics [Uk] Limited Novel process
US20130123511A1 (en) * 2010-03-04 2013-05-16 Ranbaxy Laboratories Limited Process for the direct preparation of malic acid salt of sunitinib
WO2011114246A1 (en) 2010-03-18 2011-09-22 Ranbaxy Laboratories Limited Process for the preparation of malic acid salt of sunitinib
WO2011128699A2 (en) 2010-04-16 2011-10-20 Generics [Uk] Limited Novel process
EP2635568B1 (en) 2010-11-01 2017-08-16 Scinopharm (Kunshan) Biochemical Technology Co., Ltd. Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ520640A (en) * 2000-02-15 2005-04-29 Upjohn Co Pyrrole substituted 2-indolinone protein kinase inhibitors
PT3168218T (pt) * 2001-08-15 2019-01-11 Pharmacia & Upjohn Co Llc Um cristal compreendendo um sal de ácido l-málico de n-[2- (dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3h-indol- 3-ilideno)metil]-2,4-dimetil-1h-pirrol-3-carboxamida para utilização como um medicamento
EP2098521A1 (en) 2008-03-06 2009-09-09 Ratiopharm GmbH Crystal forms of N-[2-(diethylamino) ethyl]-5-[fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrolle-3-carboxamide and methods for their prepparation

Also Published As

Publication number Publication date
US8153678B2 (en) 2012-04-10
US20090318525A1 (en) 2009-12-24
EP2313371A1 (en) 2011-04-27
EP2313371B1 (en) 2012-08-15
ES2392762T3 (es) 2012-12-13
IL209949A0 (en) 2011-02-28
SI2313371T1 (sl) 2013-02-28
WO2009150523A1 (en) 2009-12-17

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