ES2149774T3 - Aportacion dirigida de genes que codifican proteinas secretoras. - Google Patents

Aportacion dirigida de genes que codifican proteinas secretoras.

Info

Publication number
ES2149774T3
ES2149774T3 ES92912929T ES92912929T ES2149774T3 ES 2149774 T3 ES2149774 T3 ES 2149774T3 ES 92912929 T ES92912929 T ES 92912929T ES 92912929 T ES92912929 T ES 92912929T ES 2149774 T3 ES2149774 T3 ES 2149774T3
Authority
ES
Spain
Prior art keywords
gene
cell
binding agent
specific
secretory protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92912929T
Other languages
English (en)
Inventor
George Y Wu
James M Wilson
Catherine H Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Connecticut
University of Michigan
Original Assignee
University of Connecticut
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Connecticut, University of Michigan filed Critical University of Connecticut
Application granted granted Critical
Publication of ES2149774T3 publication Critical patent/ES2149774T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE DESCRIBEN COMPLEJOS MOLECULARES PARA ENTREGAR UN GENE CODIFICANDO UNA PROTEINA SECRETORA A UNA CELULA ESPECIFICA IN VIVO Y OBTENER LA SECRECION DE PROTEINA MEDIANTE LA CELULA PROYECTADA. UN GENE EXPRESABLE CODIFICANDO UNA PROTEINA SECRETORA DESEADA SE UNE A UN CONJUGADO DE UN AGENTE AGLUTINANTE ESPECIFICO DE CELULAS Y UN AGENTE AGLUTINANTE DE GENES. EL AGENTE AGLUTINANTE ESPECIFICO DE CELULAS ES ESPECIFICO PARA UNA ESTRUCTURA SUPERFICIAL CELULAR QUE PROMEDIA LA INCORPORACION DE GRUPOS COORDINADORES MEDIANTE ENDOCITOSIS. UN EJEMPLO ES LA ASIALOGLICOPROTEINA RECEPTORA DE HEPATOCITOS. EL AGENTE AGLUTINANTE DE GENES ES UN COMPUESTO TAL COMO UN POLICATION, EL CUAL SE UNE AL GENE EN CONDICIONES EXTRACELULARES Y ESTABLES, Y LIBERA EL GENE EN CONDICIONES INTRACELULARES, CON LO QUE PUEDE ACTUAR DENTRO DE UNA CELULA. EL COMPLEJO MOLECULAR ES ESTABLE Y SOLUBLE EN FLUIDOS FISIOLOGICOS Y PUEDE USARSE EN TERAPIA GENETICA PARA TRANSFERIR SELECTIVAMENTE CELULAS IN VIVO Y PROPORCIONAR LA PRODUCCION Y SECRECION DE UNA PROTEINA SECRETORA DESEADA.
ES92912929T 1991-06-05 1992-06-05 Aportacion dirigida de genes que codifican proteinas secretoras. Expired - Lifetime ES2149774T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71055891A 1991-06-05 1991-06-05

Publications (1)

Publication Number Publication Date
ES2149774T3 true ES2149774T3 (es) 2000-11-16

Family

ID=24854525

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92912929T Expired - Lifetime ES2149774T3 (es) 1991-06-05 1992-06-05 Aportacion dirigida de genes que codifican proteinas secretoras.

Country Status (10)

Country Link
EP (1) EP0587738B1 (es)
JP (1) JPH06510278A (es)
AT (1) ATE195656T1 (es)
AU (2) AU2160992A (es)
CA (1) CA2103371C (es)
DE (1) DE69231385T2 (es)
DK (1) DK0587738T3 (es)
ES (1) ES2149774T3 (es)
GR (1) GR3034882T3 (es)
WO (1) WO1992022635A1 (es)

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