CA2471666C - Methode de synthese amelioree d'oxcarbazepine et d'intermediaires connexes - Google Patents
Methode de synthese amelioree d'oxcarbazepine et d'intermediaires connexes Download PDFInfo
- Publication number
- CA2471666C CA2471666C CA002471666A CA2471666A CA2471666C CA 2471666 C CA2471666 C CA 2471666C CA 002471666 A CA002471666 A CA 002471666A CA 2471666 A CA2471666 A CA 2471666A CA 2471666 C CA2471666 C CA 2471666C
- Authority
- CA
- Canada
- Prior art keywords
- solvent
- compound
- oxcarbazepine
- hydrolysis
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002471666A CA2471666C (fr) | 2004-06-18 | 2004-06-18 | Methode de synthese amelioree d'oxcarbazepine et d'intermediaires connexes |
PCT/CA2005/000932 WO2005122671A2 (fr) | 2004-06-18 | 2005-06-16 | Processus amélioré pour la préparation de l'oxcarbazépine et produits intermédiaires associés |
US11/153,370 US7125987B2 (en) | 2004-06-18 | 2005-06-16 | Process for the preparation of oxcarbazepine and related intermediates |
EP05759468A EP1765786A4 (fr) | 2004-06-18 | 2005-06-16 | Processus amélioré pour la préparation de l'oxcarbazépine et produits intermédiaires associés |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002471666A CA2471666C (fr) | 2004-06-18 | 2004-06-18 | Methode de synthese amelioree d'oxcarbazepine et d'intermediaires connexes |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2471666A1 CA2471666A1 (fr) | 2005-12-18 |
CA2471666C true CA2471666C (fr) | 2009-10-13 |
Family
ID=35481425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002471666A Expired - Fee Related CA2471666C (fr) | 2004-06-18 | 2004-06-18 | Methode de synthese amelioree d'oxcarbazepine et d'intermediaires connexes |
Country Status (4)
Country | Link |
---|---|
US (1) | US7125987B2 (fr) |
EP (1) | EP1765786A4 (fr) |
CA (1) | CA2471666C (fr) |
WO (1) | WO2005122671A2 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2026815B1 (fr) * | 2006-04-26 | 2011-01-26 | Supernus Pharmaceuticals, Inc. | Préparations à libération contrôlée d'oxcarbazépine ayant un profil de libération sigmoïde |
CN103483342B (zh) | 2007-08-02 | 2016-08-31 | 米伦纽姆医药公司 | 合成e1活化酶抑制剂的方法 |
WO2013008194A2 (fr) | 2011-07-13 | 2013-01-17 | Ranbaxy Laboratories Limited | Procédé de préparation et de purification d'acétate d'eslicarbazépine et de ses intermédiaires |
US20150232426A1 (en) | 2012-09-26 | 2015-08-20 | Ranbaxy Laboratories Limited | Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate |
CN114315719B (zh) * | 2020-09-30 | 2024-03-29 | 北京澳合药物研究院有限公司 | 一种新的醋酸艾司利卡西平制备方法 |
CN116626209B (zh) * | 2023-07-26 | 2023-10-31 | 北京四环制药有限公司 | 一种高灵敏度的奥卡西平起始物料含量检测方法及其应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH500196A (de) | 1969-03-10 | 1970-12-15 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Azepinderivaten |
CH633271A5 (en) | 1978-04-18 | 1982-11-30 | Ciba Geigy Ag | Process for the rearrangement of 10,11-epoxy-10,11-dihydro-5H-dibenz[b,f]azepines to give 10-oxo-10,11-dihydro-5H-dibenz(b,f)azepines |
FI75561C (fi) | 1979-10-30 | 1988-07-11 | Ciba Geigy Ag | Foerfarande foer framstaellning av 5- karbamoyl-10-oxo-10,11-dihydro-5h-dibens/b,f/azepin och daertill noedvaendiga mellanprodukter. |
FR2700117B1 (fr) | 1993-01-07 | 1995-02-03 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens. |
FR2702148B1 (fr) | 1993-03-05 | 1995-04-07 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement du neuro-sida. |
IT1272897B (it) | 1995-01-13 | 1997-07-01 | I F C Iniziative Finanziaarie | Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide |
CA2407173C (fr) * | 2001-10-09 | 2009-09-29 | Max India Limited | Mode de preparation de la10-methoxycarbamazepine |
WO2005066133A2 (fr) | 2003-10-20 | 2005-07-21 | Amoli Organics Ltd. | Nouveau procede de preparation de 10-oxo-10, 11-dihydro-5h-dibenz [b,f]azepine-5-carboxamide (oxcarbazepine) via le chlorure de 10-methoxy-5h-dibenz[b,f] azepine-5-carbonyle comme intermediaire |
-
2004
- 2004-06-18 CA CA002471666A patent/CA2471666C/fr not_active Expired - Fee Related
-
2005
- 2005-06-16 US US11/153,370 patent/US7125987B2/en not_active Expired - Fee Related
- 2005-06-16 WO PCT/CA2005/000932 patent/WO2005122671A2/fr not_active Application Discontinuation
- 2005-06-16 EP EP05759468A patent/EP1765786A4/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US7125987B2 (en) | 2006-10-24 |
EP1765786A2 (fr) | 2007-03-28 |
WO2005122671A2 (fr) | 2005-12-29 |
EP1765786A4 (fr) | 2009-08-05 |
US20050282797A1 (en) | 2005-12-22 |
WO2005122671A3 (fr) | 2007-11-08 |
CA2471666A1 (fr) | 2005-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |