CA2400447A1 - Kinase inhibitors - Google Patents

Kinase inhibitors Download PDF

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Publication number
CA2400447A1
CA2400447A1 CA002400447A CA2400447A CA2400447A1 CA 2400447 A1 CA2400447 A1 CA 2400447A1 CA 002400447 A CA002400447 A CA 002400447A CA 2400447 A CA2400447 A CA 2400447A CA 2400447 A1 CA2400447 A1 CA 2400447A1
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CA
Canada
Prior art keywords
inhibitors
methods
compositions
kinase inhibitors
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002400447A
Other languages
French (fr)
Other versions
CA2400447C (en
Inventor
David M. Armistead
Jean E. Bemis
Lucian V. Di Pietro
Stephanie D. Geuns-Meyer
Gregory J. Habgood
Joseph L. Kim
Joseph J. Nunes
Vinod F. Patel
Leticia M. Toledo-Sherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc.
David M. Armistead
Jean E. Bemis
Lucian V. Di Pietro
Stephanie D. Geuns-Meyer
Gregory J. Habgood
Joseph L. Kim
Joseph J. Nunes
Vinod F. Patel
Leticia M. Toledo-Sherman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Amgen Inc., David M. Armistead, Jean E. Bemis, Lucian V. Di Pietro, Stephanie D. Geuns-Meyer, Gregory J. Habgood, Joseph L. Kim, Joseph J. Nunes, Vinod F. Patel, Leticia M. Toledo-Sherman filed Critical Amgen Inc.
Publication of CA2400447A1 publication Critical patent/CA2400447A1/en
Application granted granted Critical
Publication of CA2400447C publication Critical patent/CA2400447C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P35/00—Antineoplastic agents
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P37/02—Immunomodulators
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

The invention relates to inhibitors of kinases comprising the formula:

(see formula I) compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptoms.
CA002400447A 2000-02-17 2001-02-16 Kinase inhibitors Expired - Fee Related CA2400447C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18325600P 2000-02-17 2000-02-17
US60/183,256 2000-02-17
PCT/US2001/004983 WO2001060816A1 (en) 2000-02-17 2001-02-16 Kinase inhibitors

Publications (2)

Publication Number Publication Date
CA2400447A1 true CA2400447A1 (en) 2001-08-23
CA2400447C CA2400447C (en) 2008-04-22

Family

ID=22672081

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002400447A Expired - Fee Related CA2400447C (en) 2000-02-17 2001-02-16 Kinase inhibitors

Country Status (12)

Country Link
US (3) US20030004174A9 (en)
EP (1) EP1257546A1 (en)
JP (1) JP2003532635A (en)
KR (1) KR20030024659A (en)
CN (1) CN1429222A (en)
AU (2) AU3704101A (en)
CA (1) CA2400447C (en)
HU (1) HUP0301117A3 (en)
IL (1) IL151104A0 (en)
MX (1) MXPA02007957A (en)
WO (1) WO2001060816A1 (en)
ZA (1) ZA200206386B (en)

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