AR054834A1 - DERIVATIVES OF 1,1-DIOXIDE-2,3-DIHIDRO-1,2-BENZOISOTIAZOL-6-IL-1H-INDAZOL-4-IL-2,4 PYRIMIDINE DIAMINE - Google Patents

DERIVATIVES OF 1,1-DIOXIDE-2,3-DIHIDRO-1,2-BENZOISOTIAZOL-6-IL-1H-INDAZOL-4-IL-2,4 PYRIMIDINE DIAMINE

Info

Publication number
AR054834A1
AR054834A1 ARP060103014A ARP060103014A AR054834A1 AR 054834 A1 AR054834 A1 AR 054834A1 AR P060103014 A ARP060103014 A AR P060103014A AR P060103014 A ARP060103014 A AR P060103014A AR 054834 A1 AR054834 A1 AR 054834A1
Authority
AR
Argentina
Prior art keywords
benzoisotiazol
dihidro
indazol
dioxide
derivatives
Prior art date
Application number
ARP060103014A
Other languages
Spanish (es)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0514580A external-priority patent/GB0514580D0/en
Priority claimed from GB0524785A external-priority patent/GB0524785D0/en
Priority claimed from GB0601728A external-priority patent/GB0601728D0/en
Priority claimed from GB0606763A external-priority patent/GB0606763D0/en
Priority claimed from GB0610513A external-priority patent/GB0610513D0/en
Priority claimed from GB0610924A external-priority patent/GB0610924D0/en
Priority claimed from GB0611488A external-priority patent/GB0611488D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AR054834A1 publication Critical patent/AR054834A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Abstract

Un compuesto de formula (1) en la que cada uno de R1 y R2 es independientemente H, alquilo C1-6 o CH2-cicloalquilo C3-7; R3 es alquilo C1-3 o alquilo C2-3 sustituido con hidroxi o alcoxi C1-3; y X es halogeno; o una sal o solvato, preferiblemente una sal o solvato farmacéuticamente aceptable, del mismo; util como inhibidor de Syk quinasa y de esta manera util en el tratamiento de enfermedades que son el resultado de una activacion inapropiada de mastocitos, por ejemplo enfermedades alérgicas e inflamatotias.A compound of formula (1) in which each of R1 and R2 is independently H, C1-6 alkyl or CH2- C3-7 cycloalkyl; R3 is C1-3 alkyl or C2-3 alkyl substituted with hydroxy or C1-3 alkoxy; and X is halogen; or a salt or solvate, preferably a pharmaceutically acceptable salt or solvate thereof; useful as a Syk kinase inhibitor and thus useful in the treatment of diseases that are the result of inappropriate mast cell activation, for example allergic diseases and inflammation.

ARP060103014A 2005-07-15 2006-07-13 DERIVATIVES OF 1,1-DIOXIDE-2,3-DIHIDRO-1,2-BENZOISOTIAZOL-6-IL-1H-INDAZOL-4-IL-2,4 PYRIMIDINE DIAMINE AR054834A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0514580A GB0514580D0 (en) 2005-07-15 2005-07-15 Novel compounds
GB0524785A GB0524785D0 (en) 2005-12-05 2005-12-05 Novel compounds
GB0601728A GB0601728D0 (en) 2006-01-27 2006-01-27 Novel Compounds
GB0606763A GB0606763D0 (en) 2006-04-03 2006-04-03 Novel compounds
GB0610513A GB0610513D0 (en) 2006-05-26 2006-05-26 Novel compounds
GB0610924A GB0610924D0 (en) 2006-06-02 2006-06-02 Novel compounds
GB0611488A GB0611488D0 (en) 2006-06-09 2006-06-09 Novel compounds

Publications (1)

Publication Number Publication Date
AR054834A1 true AR054834A1 (en) 2007-07-18

Family

ID=37022880

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103014A AR054834A1 (en) 2005-07-15 2006-07-13 DERIVATIVES OF 1,1-DIOXIDE-2,3-DIHIDRO-1,2-BENZOISOTIAZOL-6-IL-1H-INDAZOL-4-IL-2,4 PYRIMIDINE DIAMINE

Country Status (4)

Country Link
AR (1) AR054834A1 (en)
PE (1) PE20070362A1 (en)
TW (1) TW200740805A (en)
WO (1) WO2007009681A1 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007085540A1 (en) * 2006-01-27 2007-08-02 Glaxo Group Limited 1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
BRPI0814821A2 (en) 2007-07-16 2015-02-03 Astrazeneca Ab COMPOUND, PHARMACEUTICAL COMPOSITION, AND, PROCESS TO PREPARE A COMPOUND
EP2489663A1 (en) 2011-02-16 2012-08-22 Almirall, S.A. Compounds as syk kinase inhibitors
GB201104153D0 (en) * 2011-03-11 2011-04-27 Glaxo Group Ltd Novel compounds
MX2013013090A (en) 2011-05-10 2013-12-16 Merck Sharp & Dohme Aminopyrimidines as syk inhibitors.
EP2707357B1 (en) 2011-05-10 2017-01-18 Merck Sharp & Dohme Corp. Pyridyl aminopyridines as syk inhibitors
EP2706852B1 (en) 2011-05-10 2018-08-22 Merck Sharp & Dohme Corp. Bipyridylaminopyridines as syk inhibitors
WO2013052393A1 (en) 2011-10-05 2013-04-11 Merck Sharp & Dohme Corp. 3-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS
US9006444B2 (en) 2011-10-05 2015-04-14 Merck Sharp & Dohme Corp. Phenyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors
EP2763976B1 (en) 2011-10-05 2016-05-18 Merck Sharp & Dohme Corp. 2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
WO2013192125A1 (en) 2012-06-20 2013-12-27 Merck Sharp & Dohme Corp. Pyrazolyl derivatives as syk inhibitors
US9487504B2 (en) 2012-06-20 2016-11-08 Merck Sharp & Dohme Corp. Imidazolyl analogs as syk inhibitors
EP2863916B1 (en) 2012-06-22 2018-07-18 Merck Sharp & Dohme Corp. Substituted pyridine spleen tyrosine kinase (syk) inhibitors
US9416111B2 (en) 2012-06-22 2016-08-16 Merck Sharp & Dohme Corp. Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors
WO2014031438A2 (en) 2012-08-20 2014-02-27 Merck Sharp & Dohme Corp. SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS
WO2014048065A1 (en) 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Triazolyl derivatives as syk inhibitors
CN103864764A (en) * 2012-12-11 2014-06-18 齐鲁制药有限公司 Indazole-substituted pyrimidinamine derivative, and preparation method and use thereof
US9624210B2 (en) 2012-12-12 2017-04-18 Merck Sharp & Dohme Corp. Amino-pyrimidine-containing spleen tyrosine kinase (Syk) inhibitors
US9598405B2 (en) 2012-12-21 2017-03-21 Merck Sharp & Dohme Corp. Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
US9745295B2 (en) 2013-04-26 2017-08-29 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
WO2014176216A1 (en) 2013-04-26 2014-10-30 Merck Sharp & Dohme Corp. Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
EP3083559B1 (en) 2013-12-20 2021-03-10 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
WO2015095444A1 (en) 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
WO2015094997A1 (en) 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
WO2015138273A1 (en) 2014-03-13 2015-09-17 Merck Sharp & Dohme Corp. 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
EP4054579A1 (en) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432963B1 (en) * 1997-12-15 2002-08-13 Yamanouchi Pharmaceutical Co., Ltd. Pyrimidine-5-carboxamide derivatives
HUP0301117A3 (en) * 2000-02-17 2004-01-28 Amgen Inc Thousand Oaks Imidazole derivatives kinase inhibitors, their use, process for their preparation and pharmaceutical compositions containing them
WO2003030909A1 (en) * 2001-09-25 2003-04-17 Bayer Pharmaceuticals Corporation 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
TWI329105B (en) * 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
DK1534286T3 (en) * 2002-07-29 2010-04-26 Rigel Pharmaceuticals Inc Methods for treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
GB0305929D0 (en) * 2003-03-14 2003-04-23 Novartis Ag Organic compounds
NZ585188A (en) * 2003-08-15 2011-09-30 Novartis Ag 2,4-Pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders

Also Published As

Publication number Publication date
TW200740805A (en) 2007-11-01
WO2007009681A1 (en) 2007-01-25
PE20070362A1 (en) 2007-04-23

Similar Documents

Publication Publication Date Title
AR054834A1 (en) DERIVATIVES OF 1,1-DIOXIDE-2,3-DIHIDRO-1,2-BENZOISOTIAZOL-6-IL-1H-INDAZOL-4-IL-2,4 PYRIMIDINE DIAMINE
AR056691A1 (en) PIRROLOPIRIMIDINE DERIVATIVES AS SYK INHIBITORS
CR20110261A (en) PIRAZOLO COMPOUNDS [1,5-a] PYRIMIDINE REPLACED AS TRK CINASA IHNIBIDORS
PE20051171A1 (en) PROTEIN INHIBITORS KINASES WITH 3-QUINOLINE CARBONITRILE STRUCTURE
PE20090835A1 (en) QUINAZOLINE DERIVATIVES AS PI3 KINASE INHIBITORS
PE20120110A1 (en) [1,2,4] TRIAZOLO [1,5-A] PYRIDINES AS KINASE INHIBITORS
EA200901608A1 (en) DERIVATIVES OF CHINAXOLINE AS AN INHIBITORS THYROZINKINASE ACTIVITY OF JANUS KINASE
AR072016A1 (en) ISOXAZOL DERIVATIVES THAT WORK AS POTENTIALS OF GLUTAMATE RECEIVERS
CO6270288A2 (en) FUNGICIDE COMPOSITION THAT INCLUDES SIGNIFICANTLY EFFECTIVE AMOUNTS OF A CARBOXILIC ACID AMIDA DERIVATIVE OR ITS SALT
PE20120034A1 (en) COMPOUNDS DERIVED FROM N-PHENYLPYRIMIDIN-2-AMINE
ATE413392T1 (en) CONDENSED HETEROYRAL DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS
PE20141973A1 (en) HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS
PE20120120A1 (en) DERIVATIVES OF 2H-PYRAZOLO [3,4-d] PYRIMIDINE-4,6 (5H, 7H) -DIONA, AS PDE1 INHIBITORS
PE20081346A1 (en) SPIROINDOLINONE DERIVATIVES AS ANTAGONISTS OF MDM2
ATE517896T1 (en) P38 KINASE INHIBITORS
PE20090887A1 (en) DERIVATIVES OF 1H-PYRAZOLE- [3,4-d] -PYRIMIDINE, 9H-PURINE AND 7H-PYRROL- [2,3-d] -PYRIMIDINE AS KINASE INHIBITORS P70 S6
PE20120224A1 (en) DERIVATIVES OF 1H-IMIDAZO- [4,5-C] -QUINOLINONE
PE20060651A1 (en) AMINOHETEROARYL COMPOUNDS SUBSTITUTED WITH PIRAZOLE AS PROTEIN KINASE INHIBITORS
PE20121471A1 (en) HELPFUL HETEROCYCLIC SULFONAMIDE DERIVATIVES AS MEK INHIBITORS
PE20120516A1 (en) MAP KINASE INHIBITOR P38
PE20141855A1 (en) DISUSTITUTED BENZOTHENYL-PYRROLOTRIAZINES AND THEIR USES
GT200500218A (en) DERIVATIVES OF TRIAZOLOPIRIDINILSULFANILO AS QUINASA MAP P38 INHIBITORS
PE20100138A1 (en) MORPHOLIN PYRIMIDINE DERIVATIVES USED IN MTOR KINASE AND / OR PI3K-RELATED DISEASES
PE20140161A1 (en) BICYCLE COMPOUND
ECSP10010585A (en) COMPOUNDS OF 2- IMIDO- 3- METHYL PIRROID PYRIMIDINONE PHENYL- REPLACED AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE

Legal Events

Date Code Title Description
FA Abandonment or withdrawal