CA2394650A1 - Nouveaux heterocycles - Google Patents

Nouveaux heterocycles Download PDF

Info

Publication number
CA2394650A1
CA2394650A1 CA002394650A CA2394650A CA2394650A1 CA 2394650 A1 CA2394650 A1 CA 2394650A1 CA 002394650 A CA002394650 A CA 002394650A CA 2394650 A CA2394650 A CA 2394650A CA 2394650 A1 CA2394650 A1 CA 2394650A1
Authority
CA
Canada
Prior art keywords
independently
substituted
occurrence
absent
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002394650A
Other languages
English (en)
Inventor
Chi B. Vu
Chester A. Metcalf, Iii
Tomi K. Sawyer
David C. Dalgarno
George P. Luke
Manfred Weigele
Noriyuki H. Kawahata
Yihan Wang
Rajeswari Sundaramoorthi
Regine Bohacek
William C. Shakespeare
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ariad Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from US09/740,653 external-priority patent/US20020132819A1/en
Publication of CA2394650A1 publication Critical patent/CA2394650A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C07F9/4012—Esters of acyclic acids which can have further substituents on alkyl substituted by B, Si, P or a metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Abstract

La présente invention concerne des composés de ciblage du système osseux, utilisés dans le traitement de troubles et d'états pathologiques divers, par exemble des tissus osseux.
CA002394650A 1999-12-17 2000-12-18 Nouveaux heterocycles Abandoned CA2394650A1 (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US17216199P 1999-12-17 1999-12-17
US17251099P 1999-12-17 1999-12-17
US60/172,161 1999-12-17
US60/172,510 1999-12-17
US24078800P 2000-10-16 2000-10-16
US60/240,788 2000-10-16
US09/741,619 2000-12-18
US09/740,653 US20020132819A1 (en) 1999-12-17 2000-12-18 Novel purinse
US09/740,653 2000-12-18
US09/740,619 US6420384B2 (en) 1999-12-17 2000-12-18 Proton pump inhibitors
PCT/US2000/034487 WO2001044258A1 (fr) 1999-12-17 2000-12-18 Nouveaux heterocycles

Publications (1)

Publication Number Publication Date
CA2394650A1 true CA2394650A1 (fr) 2001-06-21

Family

ID=27538857

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002394650A Abandoned CA2394650A1 (fr) 1999-12-17 2000-12-18 Nouveaux heterocycles

Country Status (6)

Country Link
EP (1) EP1246829A1 (fr)
JP (1) JP2003532632A (fr)
AU (1) AU2439701A (fr)
CA (1) CA2394650A1 (fr)
IL (1) IL150059A0 (fr)
WO (1) WO2001044258A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1417207T3 (da) 2000-08-04 2005-12-27 Warner Lambert Co Fremgangsmåde til fremstilling af 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-oner
AU2002315389A1 (en) * 2001-06-21 2003-01-08 Ariad Pharmaceuticals, Inc. Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
WO2003000011A2 (fr) * 2001-06-21 2003-01-03 Ariad Pharmaceuticals, Inc. Nouvelles pyridopyrimidines et leur utilisation
EP1408985A4 (fr) * 2001-06-21 2006-03-22 Ariad Pharma Inc Nouveaux pyridopyrimidones et leurs utilisations
TW200413381A (en) 2002-11-04 2004-08-01 Hoffmann La Roche Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
US7384937B2 (en) 2002-11-06 2008-06-10 Bristol-Myers Squibb Co. Fused heterocyclic compounds and use thereof
WO2004063195A1 (fr) * 2003-01-03 2004-07-29 Sloan-Kettering Institute For Cancer Research Inhibiteurs de kinases a base de pyridopyrimidine
CA2564994A1 (fr) 2004-04-30 2005-11-10 Warner-Lambert Company Llc Composes de morpholine substitues permettant de traiter des troubles du systeme nerveux central
BRPI0613146B8 (pt) * 2005-06-17 2021-05-25 Univ Texas uso terapêutico de inibidores de src quinase
CN101421269A (zh) 2006-01-13 2009-04-29 环状药物公司 酪氨酸激酶抑制剂及其用途
SI2526934T1 (sl) 2006-09-22 2016-04-29 Pharmacyclics Llc Inhibitorji Bruton tirozin kinaze
WO2008054827A2 (fr) 2006-11-03 2008-05-08 Pharmacyclics, Inc. Sonde d'activité de la tyrosine kinase de bruton et son procédé d'utilisation
US8809273B2 (en) 2007-03-28 2014-08-19 Pharmacyclics, Inc. Inhibitors of Bruton's tyrosine kinase
AU2009270856B2 (en) 2008-07-16 2013-07-25 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors
WO2010019511A2 (fr) 2008-08-13 2010-02-18 Targanta Therapeutics Corp. Rifamycines phosphonées et leurs utilisations pour la prévention et le traitement d'infections des os et des articulations
JP5590040B2 (ja) 2008-11-12 2014-09-17 アリアド・ファーマシューティカルズ・インコーポレイテッド キナーゼ阻害剤としてのピラジノピラジンおよび誘導体
US8674095B2 (en) 2008-12-19 2014-03-18 Afraxis Holdings, Inc. Compounds for treating neuropsychiatric conditions
WO2011044535A2 (fr) 2009-10-09 2011-04-14 Afraxis, Inc. 8-ethyl-6-(aryl)pyrido[2,3-d]pyrimidin-7(8h)-ones pour le traitement de troubles de snc
MX342405B (es) 2010-06-03 2016-09-28 Pharmacyclics Inc El uso de inhibidores de la tirosina quinasa de bruton (btk).
WO2011156646A2 (fr) * 2010-06-09 2011-12-15 Afraxis, Inc. 8-(sulfonylaryl)pyrido[2,3-d]pyrimidin-7(8h)-ones pour le traitement de troubles du snc
WO2012031228A2 (fr) 2010-09-02 2012-03-08 The Regents Of The University Of California Conjugués llp2a-biphosphonate pour traitement de l'ostéoporose
WO2013032527A1 (fr) 2011-09-02 2013-03-07 The Regents Of The University Of California Conjugués llp2a-bisphosphonate pour le traitement de l'ostéoporose
BR112014000653A2 (pt) 2011-07-13 2017-02-14 Pharmacyclics Inc inibidores de tirosina quinase de bruton
JP6113185B2 (ja) 2011-12-22 2017-04-12 ジェロン・コーポレーションＧｅｒｏｎ Ｃｏｒｐｏｒａｔｉｏｎ テロメラーゼ基質およびテロメア長作用因子としてのグアニンアナログ
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
KR20150015021A (ko) 2012-06-04 2015-02-09 파마시클릭스, 인코포레이티드 브루톤 타이로신 키나아제 저해제의 결정 형태
AU2013293087B2 (en) 2012-07-24 2017-08-31 Pharmacyclics Llc Mutations associated with resistance to inhibitors of Bruton's tyrosine kinase (BTK)
PE20151495A1 (es) 2012-11-15 2015-10-23 Pharmacyclics Inc Compuestos de pirrolopirimidina como inhibidores de quinasas
EP3027192A4 (fr) 2013-08-02 2017-03-22 Pharmacyclics, LLC Méthodes permettant de traiter des tumeurs solides
ES2709509T3 (es) 2013-08-12 2019-04-16 Pharmacyclics Llc Procedimientos para el tratamiento de cáncer amplificado por HER2
MA38961A1 (fr) 2013-09-30 2018-05-31 Pharmacyclics Llc Composés 3-phenyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine substitués inhibiteurs de la tyrosine kinase de bruton utilisés pour traiter par exemple les maladies auto-immunes, respiratoires et inflammatoires, cancer, mastocytose et osteoporose
EP4115886A1 (fr) 2013-10-25 2023-01-11 Pharmacyclics LLC Procédés de traitement et de prévention de la maladie du greffon contre l'hôte
WO2015143400A1 (fr) 2014-03-20 2015-09-24 Pharmacyclics, Inc. Mutations de phospholipase c gamma 2 et associées aux résistances
CA2959602A1 (fr) 2014-08-01 2016-02-04 Pharmacyclics Llc Inhibiteurs de la tyrosine kinase de bruton
WO2016022942A1 (fr) 2014-08-07 2016-02-11 Pharmacyclics Llc Nouvelles formulations d'un inhibiteur de la tyrosine kinase de bruton
RU2017133990A (ru) 2015-03-03 2019-04-05 Фармасайкликс Элэлси Фармацевтические лекарственные формы ингибитора тирозинкиназы брутона
CN104829620A (zh) * 2015-04-08 2015-08-12 重庆华邦胜凯制药有限公司 一种制备氨基吡咯[2,3-d]嘧啶衍生物的方法
US10899884B2 (en) 2018-11-29 2021-01-26 International Business Machines Corporation Flame-retardant polyetheretherketone-based compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0085321B1 (fr) * 1982-01-27 1986-08-27 Schering Aktiengesellschaft Dérivés d'acides diphosphoniques et préparations pharmaceutiques les contenant
EP0084822B1 (fr) * 1982-01-27 1986-01-08 Schering Aktiengesellschaft Dérivés d'acides diphosphoniques et préparations pharmaceutiques les contenant
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4687768A (en) * 1984-12-21 1987-08-18 The Procter & Gamble Company Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
AU4859493A (en) * 1992-10-09 1994-05-09 Upjohn Company, The Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories
SE9402001D0 (sv) * 1994-06-09 1994-06-09 Leiras Oy Pyridylbisphosphonates for use as a therapeutical agent

Also Published As

Publication number Publication date
AU2439701A (en) 2001-06-25
WO2001044258A1 (fr) 2001-06-21
IL150059A0 (en) 2002-12-01
JP2003532632A (ja) 2003-11-05
EP1246829A1 (fr) 2002-10-09

Similar Documents

Publication Publication Date Title
CA2394650A1 (fr) Nouveaux heterocycles
US20020103161A1 (en) Novel heterocycles
US7645747B2 (en) Therapeutic phosphonate compounds
US6214812B1 (en) Bisphosphonate conjugates and methods of making and using the same
EP1778249B1 (fr) Prodrogues phosphonate d'un analogue de la 2'-fluoro-2',3'-didéhydro-2',3'-didésoxyadénosine comme agents anti-vih
KR100358327B1 (ko) 포스포네이트뉴클레오티드에스테르유도체
TWI389908B (zh) 抗病毒化合物類
EA011399B1 (ru) Трициклические соединения - ингибиторы интегразы вич, способ их получения (варианты), фармацевтическая композиция на их основе, способ ее получения и способы их использования в лечении болезней
KR20020093824A (ko) 포스포네이트 뉴클레오티드 화합물
EP1259520B1 (fr) Nouvelles purines
TW200408645A (en) Non nucleoside reverse transcriptase inhibitors
CA2394654A1 (fr) Inhibiteurs de la pompe a protons
EP1244679B1 (fr) Derives de la purine
KR20000029705A (ko) 뉴클레오타이드동족체
US7598246B2 (en) Bisphosphonate conjugates and methods of making and using the same
US6197775B1 (en) Phosphonate nucleotide derivatives
US20020142994A1 (en) Bisphosphonate conjugates and methods of making and using the same
CN114516789B (zh) 环丙烯酮类小分子化合物及其合成方法和应用
CA3003741A1 (fr) Conjugues de bortezomib et leurs methodes d'utilisation
US10660884B2 (en) Phosphonate-chloroquine conjugates and methods using same
WO2003077928A1 (fr) Analogues de peptides et utilisations
JP3148139B2 (ja) ホスホナートヌクレオチド化合物
Ndubaku et al. Orally Bioavailable Small Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression Through Blockade of Adenosine Production

Legal Events

Date Code Title Description
FZDE Discontinued