CA2374052A1 - Traitement des douleurs chroniques par des inhibiteurs de mek - Google Patents
Traitement des douleurs chroniques par des inhibiteurs de mek Download PDFInfo
- Publication number
- CA2374052A1 CA2374052A1 CA002374052A CA2374052A CA2374052A1 CA 2374052 A1 CA2374052 A1 CA 2374052A1 CA 002374052 A CA002374052 A CA 002374052A CA 2374052 A CA2374052 A CA 2374052A CA 2374052 A1 CA2374052 A1 CA 2374052A1
- Authority
- CA
- Canada
- Prior art keywords
- phenylamino
- iodo
- methyl
- benzamide
- difluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
Abstract
Cette invention concerne un procédé de traitement des douleurs chroniques au moyen d'uncomposé tiré de la formule (I) et de la formule I(A).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14429299P | 1999-07-16 | 1999-07-16 | |
US60/144,292 | 1999-07-16 | ||
PCT/US2000/018347 WO2001005392A2 (fr) | 1999-07-16 | 2000-07-05 | Traitement des douleurs chroniques par des inhibiteurs de mek |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2374052A1 true CA2374052A1 (fr) | 2001-01-25 |
Family
ID=22507940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002374052A Abandoned CA2374052A1 (fr) | 1999-07-16 | 2000-07-05 | Traitement des douleurs chroniques par des inhibiteurs de mek |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1202726A2 (fr) |
JP (1) | JP2003504400A (fr) |
KR (1) | KR20020012315A (fr) |
CN (1) | CN1373660A (fr) |
AR (1) | AR024732A1 (fr) |
AU (1) | AU5786000A (fr) |
CA (1) | CA2374052A1 (fr) |
CO (1) | CO5300398A1 (fr) |
HU (1) | HUP0202623A3 (fr) |
IL (1) | IL147619A0 (fr) |
NZ (1) | NZ515567A (fr) |
PE (1) | PE20010545A1 (fr) |
PL (1) | PL352684A1 (fr) |
TR (1) | TR200200082T2 (fr) |
WO (1) | WO2001005392A2 (fr) |
ZA (1) | ZA200109907B (fr) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001273498B2 (en) | 2000-07-19 | 2006-08-24 | Warner-Lambert Company | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids |
IL149462A0 (en) | 2001-05-09 | 2002-11-10 | Warner Lambert Co | Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor |
SG148857A1 (en) | 2002-03-13 | 2009-01-29 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
CA2532067C (fr) | 2003-07-24 | 2010-12-21 | Stephen Douglas Barrett | Benzimidazoles n-methyle-substitues |
US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
US7538120B2 (en) | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
AU2004279721A1 (en) * | 2003-10-08 | 2005-04-21 | Teijin Pharma Limited | Process for producing aminopyrrolidine derivative and intermediate compound |
EP1682495A1 (fr) | 2003-10-21 | 2006-07-26 | Warner-Lambert Company LLC | Forme polymorphe du i n /i - (r)-2,3-dihydroxy-propoxy|-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide |
US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
AU2004293019B2 (en) | 2003-11-19 | 2010-10-28 | Array Biopharma Inc. | Bicyclic inhibitors of MEK and methods of use thereof |
KR101223914B1 (ko) | 2003-11-21 | 2013-01-18 | 어레이 바이오파마 인크. | Akt 단백질 키나제 억제제 |
MY144232A (en) * | 2004-07-26 | 2011-08-15 | Chugai Pharmaceutical Co Ltd | 5-substituted-2-phenylamino benzamides as mek inhibitors |
TWI441637B (zh) | 2005-05-18 | 2014-06-21 | Array Biopharma Inc | Mek雜環抑制劑及其使用方法 |
EA019983B1 (ru) | 2005-10-07 | 2014-07-30 | Экселиксис, Инк. | Ингибиторы mek и способы их применения |
MY147628A (en) | 2006-07-06 | 2012-12-31 | Array Biopharma Inc | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
WO2008006039A1 (fr) | 2006-07-06 | 2008-01-10 | Array Biopharma Inc. | Dihydrothiéno pyrimidines comme inhibiteurs de la protéine kinase akt |
DE602007011628D1 (de) | 2006-07-06 | 2011-02-10 | Array Biopharma Inc | Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
CA2671982C (fr) | 2006-12-14 | 2016-01-26 | Exelixis, Inc. | Procedes d'utilisation d'inhibiteurs de mek |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
CA2692506C (fr) | 2007-07-05 | 2015-11-24 | Array Biopharma Inc. | Pyrimidyl cyclopentanes utilses comme inhibiteurs de la proteine kinase akt |
CN103396409B (zh) | 2007-07-05 | 2015-03-11 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 |
WO2009037707A2 (fr) * | 2007-09-20 | 2009-03-26 | Ramot At Tel Aviv University Ltd. | Dérivés de l'acide n-phénylanthranilique et leurs utilisations |
JP5511680B2 (ja) | 2007-12-19 | 2014-06-04 | キャンサー・リサーチ・テクノロジー・リミテッド | ピリド[2,3−b]ピラジン−8−置換化合物及びその使用 |
CA2711699A1 (fr) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Pyrimidylcyclopentanes hydroxyles utilises comme inhibiteurs de proteine kinase akt |
EP2240455B1 (fr) | 2008-01-09 | 2012-12-26 | Array Biopharma, Inc. | Pyrimidyl cyclopentane hydroxylé en tant qu'inhibiteur de protéine kinase akt |
ES2399384T3 (es) | 2008-11-10 | 2013-04-01 | Bayer Schering Pharma Ag | Sulfonamido fenoxibenzamidas sustituidas |
US8962606B2 (en) | 2009-10-21 | 2015-02-24 | Bayer Intellectual Property Gmbh | Substituted benzosulphonamides |
CA2777430A1 (fr) | 2009-10-21 | 2011-04-28 | Bayer Pharma Aktiengesellschaft | Benzosulfonamides substitues |
EP2491014A1 (fr) | 2009-10-21 | 2012-08-29 | Bayer Pharma Aktiengesellschaft | Dérivés d'halogénophénoxybenzamide substitués |
PL2531502T3 (pl) | 2010-02-01 | 2014-08-29 | Cancer Research Tech Ltd | 1-(5-tert-Butylo-2-fenylo-2H-pirazol-3-ilo)-3-[2-fluoro-4-(1-metylo-2-okso-2,3-dihydro-1H-imidazo[4,5-b]pirydyn-7-yloksy)-fenylo]-mocznik i związki pokrewne oraz ich zastosowanie w terapii |
WO2012055953A1 (fr) | 2010-10-29 | 2012-05-03 | Bayer Pharma Aktiengesellschaft | Phénoxypyridines substituées |
SG194048A1 (en) | 2011-04-01 | 2013-11-29 | Genentech Inc | Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use |
CN103841976A (zh) | 2011-04-01 | 2014-06-04 | 基因泰克公司 | Akt和mek抑制剂化合物的组合及其使用方法 |
SI2909188T1 (en) | 2012-10-12 | 2018-07-31 | Exelixis, Inc. | A novel process for the manufacture of compounds for use in the treatment of cancer |
CA2923835C (fr) * | 2013-09-11 | 2022-11-29 | The Administrators Of The Tulane Educational Fund | Nouveaux amides anthraniliques et utilisation de ces derniers |
GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
CA3001879A1 (fr) * | 2015-10-27 | 2017-05-04 | Acetylon Pharmaceuticals, Inc. | Inhibiteurs d'hdac pour le traitement de la neuropathie peripherique diabetique |
DK3697405T3 (da) * | 2017-10-17 | 2021-08-23 | Atriva Therapeutics Gmbh | Ny mek-inhibitor til behandlingen af virale og bakterielle infektioner |
CN114008013A (zh) * | 2019-06-28 | 2022-02-01 | 哥本哈根大学 | 伴有睡眠障碍的cns病症的治疗 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6251943B1 (en) * | 1997-02-28 | 2001-06-26 | Warner-Lambert Company | Method of treating or preventing septic shock by administering a MEK inhibitor |
ES2274572T3 (es) * | 1997-07-01 | 2007-05-16 | Warner-Lambert Company Llc | Derivados de acido 2-(4-bromo- o 4-yodo-fenilamino) benzoico y su uso como inhibidor de mek. |
WO1999001426A1 (fr) * | 1997-07-01 | 1999-01-14 | Warner-Lambert Company | Derives d'acide benzhydroxamique phenylamino 4-bromo ou 4-iodo et utilisation de ces derniers en tant qu'inhibiteurs de mek |
JP2002532415A (ja) * | 1998-12-16 | 2002-10-02 | ワーナー−ランバート・カンパニー | Mek阻害剤による関節炎の治療 |
-
2000
- 2000-07-05 HU HU0202623A patent/HUP0202623A3/hu unknown
- 2000-07-05 IL IL14761900A patent/IL147619A0/xx unknown
- 2000-07-05 CA CA002374052A patent/CA2374052A1/fr not_active Abandoned
- 2000-07-05 CN CN00809801A patent/CN1373660A/zh active Pending
- 2000-07-05 NZ NZ515567A patent/NZ515567A/xx unknown
- 2000-07-05 TR TR2002/00082T patent/TR200200082T2/xx unknown
- 2000-07-05 AU AU57860/00A patent/AU5786000A/en not_active Abandoned
- 2000-07-05 KR KR1020027000609A patent/KR20020012315A/ko not_active Application Discontinuation
- 2000-07-05 WO PCT/US2000/018347 patent/WO2001005392A2/fr not_active Application Discontinuation
- 2000-07-05 PL PL00352684A patent/PL352684A1/xx not_active Application Discontinuation
- 2000-07-05 EP EP00943383A patent/EP1202726A2/fr not_active Withdrawn
- 2000-07-05 JP JP2001510449A patent/JP2003504400A/ja active Pending
- 2000-07-13 AR ARP000103604A patent/AR024732A1/es unknown
- 2000-07-14 CO CO00053304A patent/CO5300398A1/es not_active Application Discontinuation
- 2000-07-14 PE PE2000000705A patent/PE20010545A1/es not_active Application Discontinuation
-
2001
- 2001-11-30 ZA ZA200109907A patent/ZA200109907B/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20020012315A (ko) | 2002-02-15 |
CN1373660A (zh) | 2002-10-09 |
HUP0202623A3 (en) | 2003-03-28 |
AR024732A1 (es) | 2002-10-23 |
AU5786000A (en) | 2001-02-05 |
EP1202726A2 (fr) | 2002-05-08 |
PE20010545A1 (es) | 2001-06-04 |
PL352684A1 (en) | 2003-09-08 |
WO2001005392A2 (fr) | 2001-01-25 |
JP2003504400A (ja) | 2003-02-04 |
CO5300398A1 (es) | 2003-07-31 |
NZ515567A (en) | 2004-03-26 |
ZA200109907B (en) | 2003-02-28 |
TR200200082T2 (tr) | 2002-04-22 |
WO2001005392A3 (fr) | 2001-07-19 |
IL147619A0 (en) | 2002-08-14 |
HUP0202623A2 (hu) | 2002-11-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2374052A1 (fr) | Traitement des douleurs chroniques par des inhibiteurs de mek | |
DE60005688T2 (de) | Verfahren zur behandlung von chronischem schmerz durch verabreichung von einem mek hemmer | |
CA2377100A1 (fr) | Methode de traitement de la douleur chronique utilisant des inhibiteurs mek | |
CA2377092A1 (fr) | Methode de traitement de la douleur chronique au moyen d'inhibiteurs de mek | |
DE69926914T2 (de) | 1-heterozyklus-substituierte diarylaminen | |
JP2003527379A (ja) | Mex阻害物質としての5−アミド置換ジアリールアミン類 | |
US6750217B2 (en) | Benzenesulfonamide derivatives and their use as MEK inhibitors | |
US6506798B1 (en) | 4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors | |
US20030225076A1 (en) | 5-Amide substituted diarylamines as mex inhibitors | |
JP2002534497A (ja) | スルホヒドロキサム酸およびスルホヒドロキサメートおよびmek阻害剤としてのその使用 | |
JP2002534491A (ja) | 選択的mek阻害剤としての4−アリールアミノ、4−アリールオキシ、及び4−アリールチオジアリールアミン及びそれらの誘導体 | |
US7030119B1 (en) | Method for treating chronic pain using MEK inhibitors | |
JP2000212141A (ja) | ジアリ―ルアミン | |
JP2004503535A (ja) | インドールおよびベンゾイミダゾール15−リポキシゲナーゼ阻害剤 | |
JP2001055376A (ja) | ジアリールアミン | |
JP2000212157A (ja) | ジアリ―ルアミン | |
ZA200109909B (en) | Method for treating chronic pain using MEK inhibitors. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |