CA2277544A1 - Identification d'inhibiteurs de la proteine tyrosine-kinase 2 - Google Patents

Identification d'inhibiteurs de la proteine tyrosine-kinase 2 Download PDF

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Publication number
CA2277544A1
CA2277544A1 CA002277544A CA2277544A CA2277544A1 CA 2277544 A1 CA2277544 A1 CA 2277544A1 CA 002277544 A CA002277544 A CA 002277544A CA 2277544 A CA2277544 A CA 2277544A CA 2277544 A1 CA2277544 A1 CA 2277544A1
Authority
CA
Canada
Prior art keywords
pyk2
compound
ability
activity
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002277544A
Other languages
English (en)
Inventor
Le T. Duong
Gideon A. Rodan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2277544A1 publication Critical patent/CA2277544A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La présente invention concerne des dosages de composés qui se lient à la protéine tyrosine-kinase 2 ou qui modulent son activité. Ces ligands sont utilisés pour le traitement de l'ostéoporose et/ou de l'inflammation.
CA002277544A 1997-02-11 1998-02-09 Identification d'inhibiteurs de la proteine tyrosine-kinase 2 Abandoned CA2277544A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3756097P 1997-02-11 1997-02-11
US60/037,560 1997-02-11
PCT/US1998/002797 WO1998035056A1 (fr) 1997-02-11 1998-02-09 Identification d'inhibiteurs de la proteine tyrosine-kinase 2

Publications (1)

Publication Number Publication Date
CA2277544A1 true CA2277544A1 (fr) 1998-08-13

Family

ID=21895000

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002277544A Abandoned CA2277544A1 (fr) 1997-02-11 1998-02-09 Identification d'inhibiteurs de la proteine tyrosine-kinase 2

Country Status (5)

Country Link
EP (1) EP0968304A1 (fr)
JP (1) JP2001512309A (fr)
AU (1) AU6163398A (fr)
CA (1) CA2277544A1 (fr)
WO (1) WO1998035056A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6165598A (en) 1997-02-18 1998-09-08 Lxr Biotechnology Inc. Bak promotor expression system
EP1630559A3 (fr) * 1998-12-30 2006-06-07 Sugen, Inc. PYK2 (RAFTK) et inflammation
AU2209899A (en) * 1998-12-30 2000-07-24 Sugen, Inc. Pyk2 (raftk) and inflammation
US6861442B1 (en) 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
AU5951201A (en) * 2000-05-04 2001-11-12 Univ Yale High density protein arrays for screening of protein activity
AU2002236692A1 (en) * 2000-10-23 2002-05-21 Bristol-Myers Squibb Company Modulators of bruton's tyrosine kinase and bruton's tyrosine kinase, their identification and use
JP2004537542A (ja) 2001-06-29 2004-12-16 アブ サイエンス 炎症性腸疾患（ｉｂｄ）を治療するための、チロシンキナーゼ阻害剤の使用
EP1401413B1 (fr) 2001-06-29 2006-11-22 AB Science Utilisation d'inhibiteurs de tyrosine kinase dans le traitement de maladies allergiques
JP2005500041A (ja) 2001-06-29 2005-01-06 アブ サイエンス 強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤
DE60212627T2 (de) 2001-06-29 2007-06-14 Ab Science Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung von entzündlichen Krankheiten
JP2004530722A (ja) * 2001-06-29 2004-10-07 アブ サイエンス 骨喪失を治療するためのチロシンキナーゼ阻害剤の使用法
US20050170431A1 (en) * 2003-02-28 2005-08-04 Plexxikon, Inc. PYK2 crystal structure and uses
CA2571482A1 (fr) * 2004-06-21 2005-12-29 Pharmacia & Upjohn Company Llc Inhibiteurs de pyk2 pour la stimulation de la fonction de l'osteoblaste

Also Published As

Publication number Publication date
AU6163398A (en) 1998-08-26
EP0968304A1 (fr) 2000-01-05
WO1998035056A1 (fr) 1998-08-13
JP2001512309A (ja) 2001-08-21

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Legal Events

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FZDE Dead