CA1146940A - Derivatives of thiazolidinecarboxylic acids and related acids - Google Patents

Derivatives of thiazolidinecarboxylic acids and related acids

Info

Publication number
CA1146940A
CA1146940A CA000291351A CA291351A CA1146940A CA 1146940 A CA1146940 A CA 1146940A CA 000291351 A CA000291351 A CA 000291351A CA 291351 A CA291351 A CA 291351A CA 1146940 A CA1146940 A CA 1146940A
Authority
CA
Canada
Prior art keywords
hydrogen
acid
compound
carboxylic acid
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000291351A
Other languages
English (en)
French (fr)
Inventor
Miguel A. Ondetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of CA1146940A publication Critical patent/CA1146940A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA000291351A 1976-12-03 1977-11-21 Derivatives of thiazolidinecarboxylic acids and related acids Expired CA1146940A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74728176A 1976-12-03 1976-12-03
US747,281 1976-12-03
US83610777A 1977-09-23 1977-09-23
US836,107 1977-09-23

Publications (1)

Publication Number Publication Date
CA1146940A true CA1146940A (en) 1983-05-24

Family

ID=27114718

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000291351A Expired CA1146940A (en) 1976-12-03 1977-11-21 Derivatives of thiazolidinecarboxylic acids and related acids

Country Status (28)

Country Link
JP (1) JPS5382778A (ro)
AR (1) AR220689A1 (ro)
AT (1) AT363467B (ro)
AU (1) AU518147B2 (ro)
BG (1) BG32269A3 (ro)
CA (1) CA1146940A (ro)
CH (1) CH634062A5 (ro)
DD (1) DD133798A5 (ro)
DE (1) DE2752719C2 (ro)
DK (1) DK152494C (ro)
EG (1) EG13037A (ro)
ES (1) ES464555A1 (ro)
FI (1) FI67378C (ro)
FR (1) FR2372817A1 (ro)
GB (1) GB1578940A (ro)
GR (1) GR72453B (ro)
HK (1) HK55881A (ro)
IE (1) IE46169B1 (ro)
IL (1) IL53352A0 (ro)
IN (1) IN146945B (ro)
IT (1) IT1092179B (ro)
NL (3) NL171055C (ro)
NO (1) NO148416C (ro)
NZ (1) NZ185800A (ro)
PT (1) PT67352B (ro)
RO (2) RO72596A (ro)
SE (1) SE441267B (ro)
YU (1) YU41823B (ro)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1105731B (it) * 1977-06-29 1985-11-04 Yoshitomi Pharmaceutical Composti di tiazolidina
JPS5455565A (en) * 1977-10-06 1979-05-02 Santen Pharmaceut Co Ltd Novel thiazolidine derivative
US4430344A (en) * 1978-04-08 1984-02-07 Santen Pharmaceutical Co., Ltd. Antihypertensive 4-thiazolidinecarboxylic acids
JPS557255A (en) * 1978-07-03 1980-01-19 Santen Pharmaceut Co Ltd Thiazolidine derivative
JPS5531022A (en) * 1978-08-24 1980-03-05 Yoshitomi Pharmaceut Ind Ltd Hydroxamic acid derivative and its preparation
GR73585B (ro) * 1978-09-11 1984-03-26 Univ Miami
JPS5540622A (en) * 1978-09-14 1980-03-22 Santen Pharmaceut Co Ltd Hypotensive agent
JPS5829950B2 (ja) * 1978-10-05 1983-06-25 ウェルファイド株式会社 環状イミノカルボン酸誘導体およびその塩類
JPS5562060A (en) * 1978-10-31 1980-05-10 Santen Pharmaceut Co Ltd Sulfur-containing compound
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
JPS565415A (en) * 1979-06-26 1981-01-20 Santen Pharmaceut Co Ltd Ester-type hypotensor
US4347371A (en) * 1978-12-30 1982-08-31 Santen Pharmaceutical Co., Ltd. Disulfide compounds
JPS55124757A (en) * 1979-03-17 1980-09-26 Santen Pharmaceut Co Ltd Sulfur-containing compound
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
JPS56139455A (en) * 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
DE3152643A1 (de) * 1980-12-29 1982-12-16 Santen Pharmaceutical Co Ltd Heterocyclic 5-membered ring compounds
JPH0662529B2 (ja) * 1984-07-13 1994-08-17 三共株式会社 アミノ酸誘導体
EP0190685B1 (en) * 1985-02-04 1992-07-01 G.D. Searle & Co. Heterocyclic amides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2446100C3 (de) * 1974-09-26 1982-01-14 Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren Phenoxyalkancarbonsäureamide von Thiazolidincarbonsäuren, Verfahren zu ihrer Herstellung und Arzneimittel
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds

Also Published As

Publication number Publication date
YU283777A (en) 1983-01-21
BG32269A3 (en) 1982-06-15
RO72596A (ro) 1983-08-03
IL53352A0 (en) 1978-01-31
SE7713722L (sv) 1978-06-04
IT1092179B (it) 1985-07-06
NO774126L (no) 1978-06-06
AU518147B2 (en) 1981-09-17
SE441267B (sv) 1985-09-23
IE46169B1 (en) 1983-03-09
FR2372817B1 (ro) 1981-06-19
EG13037A (en) 1980-12-31
NO148416C (no) 1983-10-12
ES464555A1 (es) 1978-09-01
DE2752719A1 (de) 1978-06-08
GR72453B (ro) 1983-11-09
NL171055C (nl) 1983-02-01
FR2372817A1 (fr) 1978-06-30
HK55881A (en) 1981-11-20
NO148416B (no) 1983-06-27
FI67378C (fi) 1985-03-11
FI67378B (fi) 1984-11-30
RO72596B (ro) 1983-07-30
FI773640A (fi) 1978-06-04
AT363467B (de) 1981-08-10
DD133798A5 (de) 1979-01-24
JPS5382778A (en) 1978-07-21
DK152494B (da) 1988-03-07
DE2752719C2 (de) 1982-03-25
DK152494C (da) 1988-07-25
ATA857677A (de) 1981-01-15
NZ185800A (en) 1980-04-28
JPS618834B2 (ro) 1986-03-18
NL8201146A (nl) 1982-07-01
PT67352A (fr) 1978-01-01
AU3037977A (en) 1979-05-17
NL7713274A (nl) 1978-06-06
NL8201145A (nl) 1982-07-01
CH634062A5 (en) 1983-01-14
YU41823B (en) 1988-02-29
GB1578940A (en) 1980-11-12
DK538277A (da) 1978-06-04
IN146945B (ro) 1979-10-20
AR220689A1 (es) 1980-11-28
IE46169L (en) 1978-06-03
RO78013A (ro) 1981-12-25
PT67352B (fr) 1979-05-15

Similar Documents

Publication Publication Date Title
US4192878A (en) Derivatives of thiazolidinecarboxylic acids and related acids
CA1146940A (en) Derivatives of thiazolidinecarboxylic acids and related acids
US4154935A (en) Halogen substituted mercaptoacylamino acids
US4108886A (en) Thiopropanoylamino acid derivatives
CA1080728A (en) Amino acid derivatives
FI68221B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara deivat av prolin och pipekolinsyra
JPS604815B2 (ja) プロリン誘導体
US4154934A (en) Mercaptoacylamino derivatives of heterocyclic carboxylic acids
SK278349B6 (en) 2-iminobenzothiazoline derivative, preparation method thereof and pharmaceutical agent containing this derivative
US4282235A (en) Derivatives of thiazolidinecarboxylic acids and related acids
CA1322074C (en) Pharmaceutically useful derivatives of thiazolidine-4- carboxylic acid
CA1124723A (en) Halogen substituted mercaptoacylamino-prolines and pipecolic acids
CS199693B2 (cs) Způsob výroby derivátů thiazolidin-, thiazana morfolinkarboxylových kyselin
US4237129A (en) Derivatives of thiazolidinecarboxylic acids and related acids
CA1102812A (en) Derivatives of thiazolidinecarboxylic acids and related acids
US4237134A (en) Derivatives of thiazolidinecarboxylic acids and related acids
IL31915A (en) Thiazolines, their preparation and pharmaceutical preparations containing them
US4198509A (en) Mercaptoacylpiperazine carboxylic acid compounds
US4397849A (en) Benzothiazine derivatives
US4988701A (en) Cyclic amino-thioacetal amides, a process for the preparation thereof and pharmaceutical compositions
US4242265A (en) Indolylalkyl esters of mercaptoalkanoic acids
GB1600187A (en) N-acylated thiazolidine thiazane and morpholine carboxylic acids and esters
CA1090354A (en) Carboxymethyl esters of mercaptopropanoic acids
CH635087A5 (en) Substituted thiazolidine-, thiazane- and oxazane-carboxylic acids and carboxylic acid esters.
CA1118419A (en) Hexahydro-1-mercaptoacyl-1h-azepine-2- carboxylic acids and esters

Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 20000524