CA1001631A - 2-(3-substituted amino-2-hydroxy-propoxy)-3-substituted pyrazines and method for preparation - Google Patents

2-(3-substituted amino-2-hydroxy-propoxy)-3-substituted pyrazines and method for preparation

Info

Publication number
CA1001631A
CA1001631A CA141,471A CA141471A CA1001631A CA 1001631 A CA1001631 A CA 1001631A CA 141471 A CA141471 A CA 141471A CA 1001631 A CA1001631 A CA 1001631A
Authority
CA
Canada
Prior art keywords
substituted
propoxy
hydroxy
preparation
pyrazines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA141,471A
Other languages
English (en)
Other versions
CA141471S (en
Inventor
Burton K. Wasson
Leonard M. Weinstock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme IA Corp
Original Assignee
Merck Sharp and Dohme IA Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme IA Corp filed Critical Merck Sharp and Dohme IA Corp
Priority to CA141,471A priority Critical patent/CA1001631A/en
Priority to SE7305384A priority patent/SE398500B/sv
Priority to NL7305480A priority patent/NL7305480A/xx
Priority to AU54939/73A priority patent/AU474809B2/en
Priority to GB2047773A priority patent/GB1390329A/en
Priority to DE2322362A priority patent/DE2322362A1/de
Priority to ES414321A priority patent/ES414321A1/es
Priority to FR7315862A priority patent/FR2183752B1/fr
Priority to CH637073A priority patent/CH580603A5/xx
Priority to HUME1626A priority patent/HU167634B/hu
Priority to JP48049172A priority patent/JPS584026B2/ja
Priority to BE130746A priority patent/BE799099A/xx
Priority to ZA733051A priority patent/ZA733051B/xx
Priority to US05/408,032 priority patent/US3946009A/en
Priority to US05/584,439 priority patent/US4042586A/en
Application granted granted Critical
Publication of CA1001631A publication Critical patent/CA1001631A/en
Priority to US05/775,678 priority patent/US4193995A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA141,471A 1972-05-05 1972-05-05 2-(3-substituted amino-2-hydroxy-propoxy)-3-substituted pyrazines and method for preparation Expired CA1001631A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
CA141,471A CA1001631A (en) 1972-05-05 1972-05-05 2-(3-substituted amino-2-hydroxy-propoxy)-3-substituted pyrazines and method for preparation
SE7305384A SE398500B (sv) 1972-05-05 1973-04-16 Forfarande for framstellning av 2-(3-legre alkylamino-2-hydroxipropyl)-3-fenylpyrazin
NL7305480A NL7305480A (sv) 1972-05-05 1973-04-18
AU54939/73A AU474809B2 (en) 1972-05-05 1973-04-27 2-(3-substituted amino-2-hyddroxypropoxy)-3-substituted pyrazines
GB2047773A GB1390329A (en) 1972-05-05 1973-04-30 Pyrazines
ES414321A ES414321A1 (es) 1972-05-05 1973-05-03 Un procedimiento para la preparacion de un producto pirazi-nico.
FR7315862A FR2183752B1 (sv) 1972-05-05 1973-05-03
DE2322362A DE2322362A1 (de) 1972-05-05 1973-05-03 Pyrazinderivate und verfahren zu ihrer herstellung
CH637073A CH580603A5 (sv) 1972-05-05 1973-05-04
HUME1626A HU167634B (sv) 1972-05-05 1973-05-04
JP48049172A JPS584026B2 (ja) 1972-05-05 1973-05-04 ピラジンユウドウタイ オヨビ セイホウ
BE130746A BE799099A (fr) 1972-05-05 1973-05-04 Derives de pyrazine et procede pour les preparer
ZA733051A ZA733051B (en) 1972-05-05 1973-05-04 Pyrazine derivatives and process for preparing
US05/408,032 US3946009A (en) 1972-05-05 1973-10-19 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines
US05/584,439 US4042586A (en) 1972-05-05 1975-06-06 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines
US05/775,678 US4193995A (en) 1972-05-05 1977-03-08 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds and compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA141,471A CA1001631A (en) 1972-05-05 1972-05-05 2-(3-substituted amino-2-hydroxy-propoxy)-3-substituted pyrazines and method for preparation

Publications (1)

Publication Number Publication Date
CA1001631A true CA1001631A (en) 1976-12-14

Family

ID=4093189

Family Applications (1)

Application Number Title Priority Date Filing Date
CA141,471A Expired CA1001631A (en) 1972-05-05 1972-05-05 2-(3-substituted amino-2-hydroxy-propoxy)-3-substituted pyrazines and method for preparation

Country Status (13)

Country Link
JP (1) JPS584026B2 (sv)
AU (1) AU474809B2 (sv)
BE (1) BE799099A (sv)
CA (1) CA1001631A (sv)
CH (1) CH580603A5 (sv)
DE (1) DE2322362A1 (sv)
ES (1) ES414321A1 (sv)
FR (1) FR2183752B1 (sv)
GB (1) GB1390329A (sv)
HU (1) HU167634B (sv)
NL (1) NL7305480A (sv)
SE (1) SE398500B (sv)
ZA (1) ZA733051B (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR208397A1 (es) * 1973-02-20 1976-12-27 Ciba Geigy Ag Procedimiento para la elaboracion de compuestos de 1-piridiloxi-2-hidroxi-3-amino-propano1-piraziniloxi-2-hidroxi-3-amino-propano y 1-pirimidiniloxi-2-hidroxi-3-amino-propan
JPS5839832B2 (ja) * 1974-02-20 1983-09-01 チバ ガイギ− アクチエンゲゼルシヤフト 新規ピラジン化合物の製法
US4060601A (en) * 1976-06-15 1977-11-29 Merck & Co., Inc. Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines
JP2830387B2 (ja) * 1990-06-08 1998-12-02 株式会社明電舎 タイヤ有効半径測定方法
KR0138005B1 (ko) * 1993-10-21 1998-05-15 김낙두 신규의 화학적 보호제(chemopreventive agent)및 그의 제조방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1473815A (fr) * 1962-11-16 1967-03-24 Nl Combinatie Chem Ind Procédé de préparation d'amines tertiaires et nouveaux composés ainsi obtenus

Also Published As

Publication number Publication date
AU5493973A (en) 1974-10-31
JPS4961181A (sv) 1974-06-13
DE2322362A1 (de) 1973-11-22
GB1390329A (en) 1975-04-09
NL7305480A (sv) 1973-11-07
BE799099A (fr) 1973-11-05
ZA733051B (en) 1974-12-24
HU167634B (sv) 1975-11-28
ES414321A1 (es) 1976-02-01
AU474809B2 (en) 1976-08-05
SE398500B (sv) 1977-12-27
CH580603A5 (sv) 1976-10-15
FR2183752B1 (sv) 1976-03-05
JPS584026B2 (ja) 1983-01-24
FR2183752A1 (sv) 1973-12-21

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