GB1390329A - Pyrazines - Google Patents

Pyrazines

Info

Publication number
GB1390329A
GB1390329A GB2047773A GB2047773A GB1390329A GB 1390329 A GB1390329 A GB 1390329A GB 2047773 A GB2047773 A GB 2047773A GB 2047773 A GB2047773 A GB 2047773A GB 1390329 A GB1390329 A GB 1390329A
Authority
GB
United Kingdom
Prior art keywords
alkyl
pyrazines
optically active
oxazolidine
aminopropanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2047773A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of GB1390329A publication Critical patent/GB1390329A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1390329 Pyrazines MERCK SHARP & DOHME (IA) CORP 30 April 1973 [5 May 1972] 20477/73 Heading C2C Pyrazines are prepared by the following route (R=C 1-5 alkyl, Ph; R<SP>1</SP>=C 3-6 alkyl, hydroxyalkyl or alkynyl, Ph-(C 1-6 alkyl), indolyl-(C 1 _ 6 alkyl); R<SP>2</SP>=C1, R<SP>3</SP>=H or R<SP>2</SP>=OH, R<SP>3</SP>=sulphonyl group; R<SP>4</SP> = residue of aldehyde R 4 CHO), optionally followed by salt formation. An optically active product may be o ained from an optically active oxazolidine or by resolution. The preparation of the oxazolidine starting materials and the 1 ,2-dihydroxy-3.substituted aminopropanes from which they are derived is described. The pyrazines are #-adrenergic blocking agents, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
GB2047773A 1972-05-05 1973-04-30 Pyrazines Expired GB1390329A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA141,471A CA1001631A (en) 1972-05-05 1972-05-05 2-(3-substituted amino-2-hydroxy-propoxy)-3-substituted pyrazines and method for preparation

Publications (1)

Publication Number Publication Date
GB1390329A true GB1390329A (en) 1975-04-09

Family

ID=4093189

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2047773A Expired GB1390329A (en) 1972-05-05 1973-04-30 Pyrazines

Country Status (13)

Country Link
JP (1) JPS584026B2 (en)
AU (1) AU474809B2 (en)
BE (1) BE799099A (en)
CA (1) CA1001631A (en)
CH (1) CH580603A5 (en)
DE (1) DE2322362A1 (en)
ES (1) ES414321A1 (en)
FR (1) FR2183752B1 (en)
GB (1) GB1390329A (en)
HU (1) HU167634B (en)
NL (1) NL7305480A (en)
SE (1) SE398500B (en)
ZA (1) ZA733051B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011236A1 (en) * 1993-10-21 1995-04-27 Chung, Won, Keun New chemopreventive compounds and a preparation method and use thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR208397A1 (en) * 1973-02-20 1976-12-27 Ciba Geigy Ag PROCEDURE FOR THE PREPARATION OF 1-PYRIDYLOXY-2-HYDROXY-3-AMINO-PROPANO1-PIRAZINYLOXY-2-HYDROXY-3-AMINO-PROPANE AND 1-PYRIMIDINYLOXY-2-HYDROXY-3-AMINO-PROPAN COMPOUNDS
JPS5839832B2 (en) * 1974-02-20 1983-09-01 チバ ガイギ− アクチエンゲゼルシヤフト Production method of new pyrazine compound
US4060601A (en) * 1976-06-15 1977-11-29 Merck & Co., Inc. Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines
JP2830387B2 (en) * 1990-06-08 1998-12-02 株式会社明電舎 Tire effective radius measurement method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1473815A (en) * 1962-11-16 1967-03-24 Nl Combinatie Chem Ind Process for preparing tertiary amines and novel compounds thus obtained

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011236A1 (en) * 1993-10-21 1995-04-27 Chung, Won, Keun New chemopreventive compounds and a preparation method and use thereof
US5658913A (en) * 1993-10-21 1997-08-19 Nak Doo Kim Chemopreventive compounds and a preparation method and use thereof
CN1043887C (en) * 1993-10-21 1999-06-30 金洛斗 New chemopreventive compounds and a preparation method and use thereof

Also Published As

Publication number Publication date
SE398500B (en) 1977-12-27
FR2183752A1 (en) 1973-12-21
ZA733051B (en) 1974-12-24
AU474809B2 (en) 1976-08-05
FR2183752B1 (en) 1976-03-05
ES414321A1 (en) 1976-02-01
JPS4961181A (en) 1974-06-13
CA1001631A (en) 1976-12-14
CH580603A5 (en) 1976-10-15
NL7305480A (en) 1973-11-07
DE2322362A1 (en) 1973-11-22
BE799099A (en) 1973-11-05
AU5493973A (en) 1974-10-31
JPS584026B2 (en) 1983-01-24
HU167634B (en) 1975-11-28

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee